SG158111A1 - Novel spirotropane compounds and methods for the modulation of chemokine receptor activity - Google Patents

Novel spirotropane compounds and methods for the modulation of chemokine receptor activity

Info

Publication number
SG158111A1
SG158111A1 SG200908088-8A SG2009080888A SG158111A1 SG 158111 A1 SG158111 A1 SG 158111A1 SG 2009080888 A SG2009080888 A SG 2009080888A SG 158111 A1 SG158111 A1 SG 158111A1
Authority
SG
Singapore
Prior art keywords
modulation
chemokine receptor
receptor activity
methods
compounds
Prior art date
Application number
SG200908088-8A
Other languages
English (en)
Inventor
Laval Chan Chun Kong
Christophe Moinet
Marc Courchesne
Louis Vaillancourt
Charles Blais
Monica Bubenik
Original Assignee
Virochem Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virochem Pharma Inc filed Critical Virochem Pharma Inc
Publication of SG158111A1 publication Critical patent/SG158111A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SG200908088-8A 2004-12-09 2005-12-09 Novel spirotropane compounds and methods for the modulation of chemokine receptor activity SG158111A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63426604P 2004-12-09 2004-12-09
US69305105P 2005-06-23 2005-06-23

Publications (1)

Publication Number Publication Date
SG158111A1 true SG158111A1 (en) 2010-01-29

Family

ID=36577643

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200908088-8A SG158111A1 (en) 2004-12-09 2005-12-09 Novel spirotropane compounds and methods for the modulation of chemokine receptor activity

Country Status (13)

Country Link
US (1) US7960403B2 (fr)
EP (1) EP1831222A4 (fr)
JP (1) JP2008522986A (fr)
KR (1) KR20070095310A (fr)
AP (1) AP2007004058A0 (fr)
AU (1) AU2005313813B2 (fr)
BR (1) BRPI0518859A2 (fr)
CA (1) CA2587508A1 (fr)
EA (1) EA200701248A1 (fr)
MX (1) MX2007006776A (fr)
NZ (1) NZ555624A (fr)
SG (1) SG158111A1 (fr)
WO (1) WO2006060919A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7709642B2 (en) 2004-06-25 2010-05-04 Virochem Pharma, Inc. Spirohydantoin compounds and methods for the modulation of chemokine receptor activity
WO2006060918A1 (fr) 2004-12-09 2006-06-15 Virochem Pharma Inc. Nouveaux dérivés de spirotropane et méthodes de modulation de l’activité des récepteurs de la chimiokine
JP2008522986A (ja) 2004-12-09 2008-07-03 ヴァイロケム・ファーマ・インコーポレーテッド 新規スピロトロパン化合物およびケモカイン受容体活性を調節するための方法
WO2007143847A1 (fr) * 2006-06-14 2007-12-21 Virochem Pharma Inc. Composés de spirotropane
RU2565766C1 (ru) * 2014-11-17 2015-10-20 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии и регенеративной медицины имени Е.Л. Гольдберга" 4-(3,4-дибромтиофенкарбонил)-2,6,8,12-тетраацетил-2,4,6,8,10,12-гексаазатетрацикло[5,5,0,03,11,05,9]додекан в качестве анальгетического средства и способ его получения
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852029A (en) * 1990-04-10 1998-12-22 Israel Institute For Biological Research Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
US5407938A (en) * 1990-04-10 1995-04-18 Israel Institute For Biological Research Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines)
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
US6166209A (en) * 1997-12-11 2000-12-26 Hoffmann-La Roche Inc. Piperidine derivatives
WO2001066546A1 (fr) 2000-03-09 2001-09-13 Mitsubishi Pharma Corporation Composes spiro, leur procede de preparation et leur utilisation comme medicaments
WO2002013824A1 (fr) 2000-08-17 2002-02-21 Merck & Co., Inc. Modulateurs cyclopentyles de l'activite du recepteur de la chimiokine
JP2006511500A (ja) * 2002-10-30 2006-04-06 メルク　エンド　カムパニー　インコーポレーテッド γ−アミノアミド系のケモカイン受容体活性調節剤
CA2573951A1 (fr) * 2003-07-18 2005-01-27 Virochem Pharma Inc. Composes spiro et procedes pour moduler une activite de recepteur de chimiokime
WO2005023809A1 (fr) 2003-09-10 2005-03-17 Virochem Pharma Inc. Composes spiro et procedes pour la modulation de l'activite de recepteur de chimiokine
EP1786816A4 (fr) * 2003-09-10 2009-11-04 Virochem Pharma Inc Composes de spirohydantoine et procedes de modulation de l'activite des recepteurs de chimiokine
US7709642B2 (en) 2004-06-25 2010-05-04 Virochem Pharma, Inc. Spirohydantoin compounds and methods for the modulation of chemokine receptor activity
JP2008522986A (ja) 2004-12-09 2008-07-03 ヴァイロケム・ファーマ・インコーポレーテッド 新規スピロトロパン化合物およびケモカイン受容体活性を調節するための方法
WO2006060918A1 (fr) 2004-12-09 2006-06-15 Virochem Pharma Inc. Nouveaux dérivés de spirotropane et méthodes de modulation de l’activité des récepteurs de la chimiokine
WO2007143847A1 (fr) 2006-06-14 2007-12-21 Virochem Pharma Inc. Composés de spirotropane

Also Published As

Publication number Publication date
US7960403B2 (en) 2011-06-14
WO2006060919A1 (fr) 2006-06-15
CA2587508A1 (fr) 2006-06-15
BRPI0518859A2 (pt) 2008-12-09
AU2005313813B2 (en) 2011-04-14
KR20070095310A (ko) 2007-09-28
AU2005313813A1 (en) 2006-06-15
MX2007006776A (es) 2007-07-09
EP1831222A1 (fr) 2007-09-12
NZ555624A (en) 2009-09-25
EP1831222A4 (fr) 2009-10-21
EA200701248A1 (ru) 2007-12-28
US20080267906A1 (en) 2008-10-30
AP2007004058A0 (en) 2007-08-31
JP2008522986A (ja) 2008-07-03

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