SG152239A1 - Compounds for proteasome enzyme inhibition - Google Patents
Compounds for proteasome enzyme inhibitionInfo
- Publication number
- SG152239A1 SG152239A1 SG200902548-7A SG2009025487A SG152239A1 SG 152239 A1 SG152239 A1 SG 152239A1 SG 2009025487 A SG2009025487 A SG 2009025487A SG 152239 A1 SG152239 A1 SG 152239A1
- Authority
- SG
- Singapore
- Prior art keywords
- compounds
- enzyme inhibition
- proteasome enzyme
- proteasome
- inhibition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- AIDS & HIV (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56234004P | 2004-04-15 | 2004-04-15 | |
US56909604P | 2004-05-07 | 2004-05-07 | |
US59940104P | 2004-08-06 | 2004-08-06 | |
US61000204P | 2004-09-14 | 2004-09-14 | |
US61015904P | 2004-09-14 | 2004-09-14 | |
US61000104P | 2004-09-14 | 2004-09-14 | |
US62057304P | 2004-10-20 | 2004-10-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG152239A1 true SG152239A1 (en) | 2009-05-29 |
Family
ID=34965899
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG200902548-7A SG152239A1 (en) | 2004-04-15 | 2005-04-14 | Compounds for proteasome enzyme inhibition |
SG2012076659A SG185306A1 (en) | 2004-04-15 | 2005-04-14 | Compounds for proteasome enzyme inhibition |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG2012076659A SG185306A1 (en) | 2004-04-15 | 2005-04-14 | Compounds for proteasome enzyme inhibition |
Country Status (17)
Country | Link |
---|---|
US (9) | US8129346B2 (fr) |
EP (1) | EP1745064B1 (fr) |
JP (3) | JP5616569B2 (fr) |
CN (2) | CN103554222A (fr) |
AT (1) | ATE494298T1 (fr) |
AU (1) | AU2005238445B2 (fr) |
BR (1) | BRPI0509879A (fr) |
CA (1) | CA2562411A1 (fr) |
CY (1) | CY1117244T1 (fr) |
DE (1) | DE602005025750D1 (fr) |
DK (1) | DK1745064T3 (fr) |
HK (1) | HK1097860A1 (fr) |
IL (3) | IL178400A (fr) |
PL (1) | PL1745064T3 (fr) |
PT (1) | PT1745064E (fr) |
SG (2) | SG152239A1 (fr) |
WO (1) | WO2005105827A2 (fr) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2562411A1 (fr) | 2004-04-15 | 2005-11-10 | Proteolix, Inc. | Composes pour l'inhibition enzymatique |
US8198270B2 (en) | 2004-04-15 | 2012-06-12 | Onyx Therapeutics, Inc. | Compounds for proteasome enzyme inhibition |
US7232818B2 (en) * | 2004-04-15 | 2007-06-19 | Proteolix, Inc. | Compounds for enzyme inhibition |
AU2012203602B2 (en) * | 2004-04-15 | 2015-08-27 | Onyx Therapeutics, Inc. | Compounds for proteasome enzyme inhibition |
EP2030981B1 (fr) | 2004-05-10 | 2014-07-09 | Onyx Therapeutics, Inc. | Composés pour l'inhibition d'une enzyme de proteasome |
PL2261236T3 (pl) | 2004-12-07 | 2015-12-31 | Onyx Therapeutics Inc | Kompozycja do hamowania proteasomu |
PT1948678E (pt) | 2005-11-09 | 2013-07-16 | Onyx Therapeutics Inc | Compostos para inibição de enzimas |
CA2657213C (fr) | 2006-06-19 | 2017-01-03 | Proteolix, Inc. | Peptides epoxycetones pour l'inhibition de proteasomes |
ES2578905T5 (es) | 2007-10-04 | 2020-03-18 | Onyx Therapeutics Inc | Inhibidores de proteasa epoxi cetona peptídicos cristalinos y la síntesis de ceto-epóxidos de aminoácidos |
AP2011005690A0 (en) | 2008-10-21 | 2011-06-30 | Onyx Therapeutics Inc | Combination therapy with peptide epoxyketones. |
WO2010105363A1 (fr) | 2009-03-16 | 2010-09-23 | Andrei Yudin | Molécules d'acides aminés cycliques et leurs méthodes de synthèse |
AR075899A1 (es) | 2009-03-20 | 2011-05-04 | Onyx Therapeutics Inc | Tripeptidos epoxicetonas cristalinos inhibidores de proteasa |
GB0914883D0 (en) | 2009-08-26 | 2009-09-30 | Univ Belfast | Compound |
US8853147B2 (en) | 2009-11-13 | 2014-10-07 | Onyx Therapeutics, Inc. | Use of peptide epoxyketones for metastasis suppression |
MA34133B1 (fr) | 2010-03-01 | 2013-04-03 | Onyx Therapeutics Inc | Composes pour inhibiteurs de l'immunoproteasome |
WO2011136905A2 (fr) | 2010-04-07 | 2011-11-03 | Onyx Therapeutics, Inc. | Inhibiteur d'immunoprotéasome de peptide époxycétone cristallin |
KR102054329B1 (ko) | 2012-05-08 | 2019-12-10 | 오닉스 세라퓨틱스, 인크. | 펩티드 프로테아좀 억제제 제제화를 위한 사이클로덱스트린 복합체화 방법 |
US9309283B2 (en) | 2012-07-09 | 2016-04-12 | Onyx Therapeutics, Inc. | Prodrugs of peptide epoxy ketone protease inhibitors |
US10076384B2 (en) | 2013-03-08 | 2018-09-18 | Symple Surgical, Inc. | Balloon catheter apparatus with microwave emitter |
MY175418A (en) | 2013-03-13 | 2020-06-24 | Sanofi Sa | Compositions comprising anti-cd38 antibodies and carfilzomib |
CA2918530C (fr) | 2013-07-19 | 2023-10-03 | Onyx Therapeutics, Inc. | Inhibiteurs du proteasome epoxycetones peptidiques en combinaison avec des inhibiteurs de pim kinase pour le traitement de cancers |
CN103360348B (zh) * | 2013-07-25 | 2015-06-24 | 苏州鹏旭医药科技有限公司 | 一种Carfilzomib中间体及其制备方法和制备Carfilzomib的方法 |
CN105518019A (zh) * | 2013-09-06 | 2016-04-20 | 桑多斯股份公司 | 肽环氧基酮的合成 |
WO2015032622A1 (fr) * | 2013-09-06 | 2015-03-12 | Sandoz Ag | Synthèse stéréosélective de diols et de triols par réaction de mannich et utilisation correspondante pour la synthèse de carfilzomib |
CN104710507B (zh) * | 2013-12-11 | 2018-08-14 | 深圳翰宇药业股份有限公司 | 一种卡非佐米的制备方法 |
WO2015121769A1 (fr) | 2014-02-13 | 2015-08-20 | Ranbaxy Laboratories Limited | Procédé pour la préparation de méthyl n-[(benzyloxy)-carbonyl]-l-leucyl-l-phénylalaninate |
EP3166933B1 (fr) * | 2014-07-14 | 2018-08-01 | Centrax International Inc. | Composés d'époxycétone pour l'inhibition d'enzymes |
WO2016046843A1 (fr) | 2014-09-24 | 2016-03-31 | Biophore India Pharmaceuticals Pvt. Ltd. | Procédé pour la préparation de (s)-4-méthyl-n- ((s)-1-(((s)-4-méthyl-1-((r)-2-méthyloxiran-2-yl)-1-oxo-pentan-2-yl)amino)-1-oxo-3-phénylpropan-2-yl)-2-((s)-2-(2-morpholinoacétamido)-4-phénylbutanamido) pentanamide |
US20160115198A1 (en) | 2014-10-27 | 2016-04-28 | Apicore Us Llc | Methods of making carfilzomib and intermediates thereof |
CN107548400A (zh) | 2014-12-02 | 2018-01-05 | 费森尤斯卡比肿瘤学有限公司 | 卡非佐米的纯化方法 |
EP3240575A4 (fr) | 2014-12-31 | 2018-07-25 | Dr. Reddy's Laboratories Ltd. | Co-cristal de carfilzomib avec de l'acide maléique et procédé pour la préparation de carfilzomib pur |
WO2016116882A2 (fr) * | 2015-01-23 | 2016-07-28 | Leiutis Pharmaceuticals Pvt Ltd | Nouvelles compositions de carfilzomib |
WO2016170544A1 (fr) * | 2015-04-22 | 2016-10-27 | Msn Laboratories Private Limited | Procédé de préparation de (2s)-n-((s)-1-((s)-4-méthyl-1-((r)-2-méthyl oxiran-2-yl)-1-oxopentan-2-ylcarbamoyl)-2-phényléthyl)-2-((s)-2-(2-morpholino acétamido)-4-phénylbutanamido)-4-méthylpentanamide |
WO2016170489A1 (fr) | 2015-04-24 | 2016-10-27 | Fresenius Kabi Oncology Ltd. | Compositions pharmaceutiques d'un inhibiteur de protéasome |
ES2888800T3 (es) | 2015-05-21 | 2022-01-07 | Laurus Labs Ltd | Procedimiento mejorado para la preparación de carfilzomib o sales farmacéuticamente aceptables del mismo |
EP3377471A4 (fr) | 2015-11-11 | 2019-11-20 | Encycle Therapeutics, Inc. | Synthèse de fragments de peptides cycliques |
WO2018024645A1 (fr) | 2016-08-02 | 2018-02-08 | Synthon B.V. | Procédé de fabrication du carfilzomib |
ES2874683T3 (es) | 2016-09-14 | 2021-11-05 | Fresenius Kabi Oncology Ltd | Un proceso para la purificación de un intermedio de carfilzomib |
EP3939989A1 (fr) | 2016-11-11 | 2022-01-19 | Zealand Pharma A/S | Multimères de peptides cycliques ciblant l'intégrine alpha 4bêta 7 |
EP3330260A1 (fr) | 2016-12-01 | 2018-06-06 | Enantia, S.L. | Procédé pour la préparation d'un intermédiaire pour la synthèse de i.a. carfilzomib |
CN106946981B (zh) * | 2017-03-08 | 2020-08-21 | 南京陵瑞医药科技有限公司 | 一种四肽环氧丙烷衍生物及其制备方法和用途 |
MX2019013362A (es) | 2017-05-10 | 2020-08-17 | Zealand Pharma As | PÉPTIDOS CÍCLICOS HOMODÉTICOS CON LA INTEGRINA A4ß7 COMO DIANA. |
EP3694878A1 (fr) | 2017-09-14 | 2020-08-19 | GlaxoSmithKline Intellectual Property Development Limited | Polythérapie pour le traitement du cancer |
CN113185575B (zh) * | 2021-05-11 | 2022-07-12 | 四川大学 | 一种花生抗氧化多肽及其制备方法 |
WO2023220641A2 (fr) | 2022-05-11 | 2023-11-16 | Juno Therapeutics, Inc. | Méthodes et utilisations associées à une thérapie par lymphocytes t et leur production |
WO2023220655A1 (fr) | 2022-05-11 | 2023-11-16 | Celgene Corporation | Méthodes pour surmonter la résistance aux médicaments par ré-sensibilisation de cellules cancéreuses à un traitement avec une thérapie antérieure par l'intermédiaire d'un traitement avec une thérapie par lymphocytes t |
WO2024097905A1 (fr) | 2022-11-02 | 2024-05-10 | Celgene Corporation | Méthodes de traitement au moyen d'une thérapie par lymphocytes t et d'une thérapie d'entretien par agent immunomodulateur |
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JPH01136498A (ja) | 1987-11-21 | 1989-05-29 | Nec Corp | 状態監視用情報伝送装置 |
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US8198270B2 (en) | 2004-04-15 | 2012-06-12 | Onyx Therapeutics, Inc. | Compounds for proteasome enzyme inhibition |
CA2562411A1 (fr) * | 2004-04-15 | 2005-11-10 | Proteolix, Inc. | Composes pour l'inhibition enzymatique |
US7232818B2 (en) | 2004-04-15 | 2007-06-19 | Proteolix, Inc. | Compounds for enzyme inhibition |
EP2030981B1 (fr) | 2004-05-10 | 2014-07-09 | Onyx Therapeutics, Inc. | Composés pour l'inhibition d'une enzyme de proteasome |
AU2005243140A1 (en) | 2004-05-10 | 2005-11-24 | Proteolix, Inc. | Synthesis of amino acid keto-epoxides |
WO2006045066A2 (fr) | 2004-10-20 | 2006-04-27 | Proteolix, Inc. | Composes pour inhibition d'enzymes |
PL2261236T3 (pl) | 2004-12-07 | 2015-12-31 | Onyx Therapeutics Inc | Kompozycja do hamowania proteasomu |
WO2006099261A2 (fr) | 2005-03-11 | 2006-09-21 | The University Of North Carolina At Chapel Hill | Inhibiteurs puissants et spécifiques d'immunoprotéasomes |
PT1948678E (pt) | 2005-11-09 | 2013-07-16 | Onyx Therapeutics Inc | Compostos para inibição de enzimas |
AR057227A1 (es) | 2005-12-09 | 2007-11-21 | Centocor Inc | Metodo para usar antagonistas de il6 con inhibidores del proteasoma |
DE102006026464A1 (de) | 2006-06-01 | 2007-12-06 | Virologik Gmbh Innovationszentrum Medizintechnik Und Pharma | Pharmazeutische Zusammensetzung zur Behandlung von Virusinfektionen und / oder Tumorerkrankungen durch Inhibition der Proteinfaltung und des Proteinabbaus |
CA2657213C (fr) | 2006-06-19 | 2017-01-03 | Proteolix, Inc. | Peptides epoxycetones pour l'inhibition de proteasomes |
JP4325683B2 (ja) * | 2007-02-14 | 2009-09-02 | セイコーエプソン株式会社 | 画像表示装置、及び画像表示装置の制御方法 |
WO2008140782A2 (fr) | 2007-05-10 | 2008-11-20 | Proteolix, Inc. | Composés d'inhibition enzymatique |
ES2578905T5 (es) | 2007-10-04 | 2020-03-18 | Onyx Therapeutics Inc | Inhibidores de proteasa epoxi cetona peptídicos cristalinos y la síntesis de ceto-epóxidos de aminoácidos |
AP2011005690A0 (en) | 2008-10-21 | 2011-06-30 | Onyx Therapeutics Inc | Combination therapy with peptide epoxyketones. |
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2005
- 2005-04-14 CA CA002562411A patent/CA2562411A1/fr not_active Abandoned
- 2005-04-14 BR BRPI0509879-3A patent/BRPI0509879A/pt not_active Application Discontinuation
- 2005-04-14 JP JP2007508543A patent/JP5616569B2/ja active Active
- 2005-04-14 SG SG200902548-7A patent/SG152239A1/en unknown
- 2005-04-14 CN CN201310512372.8A patent/CN103554222A/zh active Pending
- 2005-04-14 US US11/578,626 patent/US8129346B2/en active Active
- 2005-04-14 PT PT05735686T patent/PT1745064E/pt unknown
- 2005-04-14 EP EP05735686A patent/EP1745064B1/fr active Active
- 2005-04-14 PL PL05735686T patent/PL1745064T3/pl unknown
- 2005-04-14 AU AU2005238445A patent/AU2005238445B2/en active Active
- 2005-04-14 SG SG2012076659A patent/SG185306A1/en unknown
- 2005-04-14 DE DE602005025750T patent/DE602005025750D1/de active Active
- 2005-04-14 CN CN201110037869XA patent/CN102174076A/zh active Pending
- 2005-04-14 AT AT05735686T patent/ATE494298T1/de active
- 2005-04-14 WO PCT/US2005/012740 patent/WO2005105827A2/fr active Application Filing
- 2005-04-14 DK DK05735686.7T patent/DK1745064T3/da active
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2006
- 2006-09-28 IL IL178400A patent/IL178400A/en active IP Right Grant
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2007
- 2007-05-14 HK HK07105045.7A patent/HK1097860A1/xx unknown
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2011
- 2011-02-18 CY CY20111100205T patent/CY1117244T1/el unknown
- 2011-09-12 JP JP2011198810A patent/JP2012041346A/ja active Pending
- 2011-12-22 US US13/334,466 patent/US8207126B2/en active Active
- 2011-12-22 US US13/334,469 patent/US8207297B2/en active Active
- 2011-12-22 US US13/334,288 patent/US8207125B2/en active Active
- 2011-12-22 US US13/334,372 patent/US8324174B2/en active Active
- 2011-12-22 US US13/334,263 patent/US8207124B2/en active Active
- 2011-12-22 US US13/334,544 patent/US8207127B2/en active Active
- 2011-12-26 IL IL217210A patent/IL217210A0/en unknown
- 2011-12-26 IL IL217211A patent/IL217211A0/en unknown
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2012
- 2012-03-02 US US13/411,044 patent/US20120277146A1/en not_active Abandoned
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2013
- 2013-03-12 US US13/797,740 patent/US20130324459A1/en not_active Abandoned
- 2013-08-05 JP JP2013162017A patent/JP2014012676A/ja active Pending
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