SG151249A1 - 6-substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors - Google Patents
6-substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitorsInfo
- Publication number
- SG151249A1 SG151249A1 SG200901531-4A SG2009015314A SG151249A1 SG 151249 A1 SG151249 A1 SG 151249A1 SG 2009015314 A SG2009015314 A SG 2009015314A SG 151249 A1 SG151249 A1 SG 151249A1
- Authority
- SG
- Singapore
- Prior art keywords
- quinoxalinones
- quinolinones
- adp
- ribose
- poly
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Ceramic Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Diabetes (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- Structural Engineering (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Addiction (AREA)
- Endocrinology (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03078859 | 2003-12-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG151249A1 true SG151249A1 (en) | 2009-04-30 |
Family
ID=34639300
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG200901531-4A SG151249A1 (en) | 2003-12-05 | 2004-11-18 | 6-substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors |
Country Status (18)
Country | Link |
---|---|
US (2) | US7879857B2 (fr) |
EP (1) | EP1709012B1 (fr) |
JP (1) | JP4806353B2 (fr) |
KR (1) | KR101159118B1 (fr) |
CN (1) | CN1890224B (fr) |
AU (1) | AU2004295059B2 (fr) |
BR (1) | BRPI0416532A (fr) |
CA (1) | CA2546657C (fr) |
EA (1) | EA010488B1 (fr) |
ES (1) | ES2551299T3 (fr) |
HK (1) | HK1098150A1 (fr) |
IL (1) | IL176060A (fr) |
NO (1) | NO20063028L (fr) |
NZ (1) | NZ547193A (fr) |
SG (1) | SG151249A1 (fr) |
UA (1) | UA89618C2 (fr) |
WO (1) | WO2005054210A1 (fr) |
ZA (1) | ZA200604549B (fr) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101118582B1 (ko) | 2003-11-20 | 2012-02-27 | 얀센 파마슈티카 엔.브이. | 폴리(adp-리보스)폴리머라제 저해제로서의 6-알케닐 및6-페닐알킬 치환된 2-퀴놀리논 및 2-퀴녹살리논 |
WO2005054209A1 (fr) | 2003-11-20 | 2005-06-16 | Janssen Pharmaceutica N.V. | 2-quinolinones et 2 quinoxalinones a substitution 7-phenylalkyl tenant lieu d'inhibiteurs de poly(adp-ribose) polymerase inhibitors |
CN102206180B (zh) * | 2003-12-10 | 2013-05-29 | 詹森药业有限公司 | 作为多聚(adp-核糖)聚合酶抑制剂的被取代的6-环己基烷基取代的2-喹啉酮和2-喹喔啉酮 |
WO2005070430A1 (fr) * | 2004-01-23 | 2005-08-04 | Janssen Pharmaceutica N.V. | Derives de quinoline et utilisation de ceux-ci en tant qu'inhibiteurs mycobacteriens |
CN1980913B (zh) | 2004-06-30 | 2011-12-14 | 詹森药业有限公司 | 作为parp抑制剂的喹唑啉二酮衍生物 |
JP4836946B2 (ja) | 2004-06-30 | 2011-12-14 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Parp阻害剤としての置換2−アルキルキナゾリノン誘導体 |
MXPA06014542A (es) | 2004-06-30 | 2007-03-23 | Janssen Pharmaceutica Nv | Derivados de ftalazina como inhibidores de poli(adp-ribosa) polimerasa-i. |
NZ565654A (en) | 2005-07-18 | 2010-10-29 | Bipar Sciences Inc | Use of iodonitrobenzamide compounds for the treatment of ovarian cancer |
JO2952B1 (en) * | 2005-08-03 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
CN102379884A (zh) | 2006-09-05 | 2012-03-21 | 彼帕科学公司 | Parp抑制剂对脂肪酸合成的抑制及其治疗方法 |
CN101522609A (zh) | 2006-09-05 | 2009-09-02 | 彼帕科学公司 | 癌症的治疗 |
WO2008042422A2 (fr) * | 2006-10-04 | 2008-04-10 | Schering Corporation | Dérivés bicycliques et tricycliques utilisés comme antagonistes du récepteur de la thrombine |
US8299256B2 (en) | 2007-03-08 | 2012-10-30 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP and TANK inhibitors |
WO2009053373A1 (fr) * | 2007-10-26 | 2009-04-30 | Janssen Pharmaceutica Nv | Dérivés de quinolinone en tant qu'inhibiteurs de parp |
KR20100102609A (ko) | 2007-11-12 | 2010-09-24 | 바이파 사이언스 인코포레이티드 | Parp 억제제를 단독으로 사용하거나 항종양제와 병용하여 유방암을 치료하는 방법 |
WO2009085216A2 (fr) | 2007-12-20 | 2009-07-09 | Squicor | Compositions et méthodes de détection ou d'élimination de cellules sénescentes pour le diagnostic ou le traitement de maladies |
US8168644B2 (en) | 2008-03-27 | 2012-05-01 | Janssen Pharmaceutica Nv | Quinazolinone derivatives as tubulin polymerization inhibitors |
DK2271626T3 (en) | 2008-03-27 | 2015-02-23 | Janssen Pharmaceutica Nv | TETRAHYDROPHENANTHRIDINONES AND TETRAHYDROCYCLOPENTAQUINOLINONES AS INHIBITORS OF POLYMERIZATION OF PARP AND TUBULIN |
WO2011058367A2 (fr) | 2009-11-13 | 2011-05-19 | Astrazeneca Ab | Test de diagnostic pour prédire la sensibilité à un traitement par un inhibiteur de poly(adp-ribose) polymérase |
US20140189897A1 (en) | 2011-06-21 | 2014-07-03 | Mayo Foundation For Medical Education And Research | Transgenic animals capable of being induced to delete senescent cells |
WO2013049565A1 (fr) * | 2011-09-30 | 2013-04-04 | Endo Pharmaceuticals Inc. | Dérivés imidazoles en tant qu'inhibiteurs de cyp17 pour le traitement du cancer |
US9199975B2 (en) | 2011-09-30 | 2015-12-01 | Asana Biosciences, Llc | Biaryl imidazole derivatives for regulating CYP17 |
CN103130723B (zh) | 2011-11-30 | 2015-01-14 | 成都地奥制药集团有限公司 | 一种多聚(adp-核糖)聚合酶抑制剂 |
EP2790725A4 (fr) | 2011-12-13 | 2015-11-04 | Buck Inst For Res On Aging | Procédés d'amélioration de thérapies médicales |
WO2013158664A2 (fr) | 2012-04-17 | 2013-10-24 | Kythera Biopharmaceuticals, Inc. | Utilisation de virus modifiés pour tuer spécifiquement les cellules sénescentes |
US9901081B2 (en) | 2012-08-23 | 2018-02-27 | Buck Institute For Research On Aging | Transgenic mouse for determining the role of senescent cells in cancer |
US9901080B2 (en) | 2012-08-23 | 2018-02-27 | Buck Institute For Research On Aging | Transgenic mouse having a transgene that converts a prodrug into a cytotoxic compound in senescent cells |
CN105073729A (zh) | 2012-10-16 | 2015-11-18 | 詹森药业有限公司 | RORγt的苯基连接的喹啉基调节剂 |
EP2909192B1 (fr) | 2012-10-16 | 2017-05-17 | Janssen Pharmaceutica NV | Modulateurs de ror-gamma-t de type quinolinyle à liaison méthylène |
JP6250686B2 (ja) | 2012-10-16 | 2017-12-20 | ヤンセン ファーマシューティカ エヌ.ベー. | Rorγtのヘテロアリール結合させたキノリニルモジュレータ |
EP3057422B1 (fr) | 2013-10-15 | 2019-05-15 | Janssen Pharmaceutica NV | Modulateurs quinolinyl de ror(gamma)t |
US9284308B2 (en) | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
CA2926339A1 (fr) | 2013-10-15 | 2015-04-23 | Janssen Pharmaceutica Nv | Modulateurs quinolinyl a liaison alkyle de roryt |
US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
US9221804B2 (en) | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
PL3325623T6 (pl) | 2015-07-23 | 2022-05-30 | Institut Curie | Zastosowanie skojarzenia cząsteczki dbait i inhibitorów parp do leczenia nowotworu |
GB201519573D0 (en) | 2015-11-05 | 2015-12-23 | King S College London | Combination |
US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
US10874641B2 (en) | 2016-07-28 | 2020-12-29 | Mitobridge, Inc. | Methods of treating acute kidney injury |
CA3041843A1 (fr) | 2016-11-02 | 2018-05-11 | Immunogen, Inc. | Traitement combine avec des conjugues anticorps-medicament et des inhibiteurs de parp |
WO2018162439A1 (fr) | 2017-03-08 | 2018-09-13 | Onxeo | Nouveau biomarqueur prédictif de la sensibilité à un traitement du cancer avec une molécule dbait |
AU2018260094A1 (en) | 2017-04-28 | 2019-11-07 | Akribes Biomedical Gmbh | A PARP inhibitor in combination with a glucocorticoid and/or ascorbic acid and/or a protein growth factor for the treatment of impaired wound healing |
CN109081828B (zh) * | 2017-06-14 | 2021-03-26 | 上海时莱生物技术有限公司 | 聚(adp-核糖)聚合酶抑制剂、制备方法及用途 |
EP3765613A1 (fr) | 2018-03-13 | 2021-01-20 | Onxeo | Molécule dbait contre la résistance acquise dans le traitement du cancer |
AU2020318599B2 (en) | 2019-07-19 | 2023-09-07 | Astrazeneca Ab | PARP1 inhibitors |
JP2023503613A (ja) | 2019-11-25 | 2023-01-31 | ザ・リサーチ・ファウンデーション・フォア・ザ・ステイト・ユニバーシティー・オブ・ニューヨーク | 癌の処置のためにタキサンと共にfabp5阻害剤を使用する併用療法 |
WO2021148581A1 (fr) | 2020-01-22 | 2021-07-29 | Onxeo | Nouvelle molécule dbait et son utilisation |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3274194A (en) * | 1963-03-29 | 1966-09-20 | Miles Lab | Quinazolinedione derivatives |
GB1293565A (en) * | 1969-05-03 | 1972-10-18 | Aspro Nicholas Ltd | Aminophthalazines and pharmaceutical compositions thereof |
US3919425A (en) * | 1971-04-09 | 1975-11-11 | Miles Lab | Method of producing vasodilation using certain 3-substituted-quinazoline derivatives |
DE2355084A1 (de) * | 1972-11-06 | 1974-05-16 | Guidotti & C Spa Labor | Verbindungen mit magensaeuresekretionshemmender wirkung und verfahren zu deren herstellung |
US3879393A (en) * | 1973-06-18 | 1975-04-22 | Miles Lab | Derivatives of 1,3-disubstituted 2,4(1h,3h)-quinazolinediones |
US4335127A (en) * | 1979-01-08 | 1982-06-15 | Janssen Pharmaceutica, N.V. | Piperidinylalkyl quinazoline compounds, composition and method of use |
DK623586A (da) * | 1985-12-27 | 1987-06-28 | Eisai Co Ltd | Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne |
US5231184A (en) * | 1987-11-23 | 1993-07-27 | Janssen Pharmaceutica N.V. | Pridazinamine derivatives |
US5177075A (en) | 1988-08-19 | 1993-01-05 | Warner-Lambert Company | Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process |
KR0149162B1 (ko) * | 1988-11-29 | 1998-10-15 | 구스타프 반 리이트 | (1h-아졸-1-일메틸) 치환된 퀴놀린, 퀴나졸린 또는 퀴녹살린 유도체 |
GB8827822D0 (en) * | 1988-11-29 | 1988-12-29 | Janssen Pharmaceutica Nv | (1h-azol-1-ylmethyl)substituted quinoline derivatives |
CA2002864C (fr) * | 1988-11-29 | 1999-11-16 | Eddy J. E. Freyne | Derives de quinoline, quinazoline ou quinoxaline (1h-azol-1-ylmethyl) substitues |
US5374637A (en) * | 1989-03-22 | 1994-12-20 | Janssen Pharmaceutica N.V. | N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives |
IE913473A1 (en) * | 1990-10-15 | 1992-04-22 | Fujisawa Pharmaceutical Co | Quinazoline derivatives and their preparation |
DE69330272T2 (de) * | 1992-04-23 | 2001-10-25 | Merrell Pharmaceuticals Inc., Bridgewater | 4-imidomethyl-1-[2'-phenyl-2-oxoethyl]-piperidine als serotonin-5ht2-antagonisten, ihre herstellung und therapeutische anwendung |
JPH06239858A (ja) * | 1993-02-16 | 1994-08-30 | Otsuka Pharmaceut Co Ltd | 末梢血管拡張剤 |
ID21045A (id) * | 1996-09-10 | 1999-04-08 | Thomae Gmbh Dr K | Asam amino termodifikasi, obat-obatan yang mengandung senyawa ini dan proses pembuatannya |
US6417362B1 (en) * | 1997-05-30 | 2002-07-09 | Meiji Seika Kaisha, Ltd. | Nitrogenous heterocyclic compounds and hyperlipemia remedy containing the same |
US20020022636A1 (en) * | 1997-09-03 | 2002-02-21 | Jia-He Li | Oxo-substituted compounds, process of making, and compositions and methods for inhibiting parp activity |
US6635642B1 (en) * | 1997-09-03 | 2003-10-21 | Guilford Pharmaceuticals Inc. | PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same |
US20030069231A1 (en) * | 1999-10-12 | 2003-04-10 | Klaus Rudolf | Modified aminoacids, pharmaceuticals containing these compounds and method for their production |
US7265115B2 (en) * | 1999-01-29 | 2007-09-04 | Abbott Laboratories | Diazabicyclic CNS active agents |
US6566372B1 (en) * | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
AU2001264595A1 (en) * | 2000-05-19 | 2001-12-03 | Guilford Pharmaceuticals Inc. | Sulfonamide and carbamide derivatives of 6(5h)phenanthridinones and their uses |
AU2001293847B2 (en) * | 2000-10-02 | 2007-05-24 | Janssen Pharmaceutica N.V. | Metabotropic glutamate receptor antagonists |
AUPR201600A0 (en) * | 2000-12-11 | 2001-01-11 | Fujisawa Pharmaceutical Co., Ltd. | Quinazolinone derivative |
WO2002094790A1 (fr) * | 2001-05-23 | 2002-11-28 | Mitsubishi Pharma Corporation | Compose heterocyclique condense et son utilisation medicale |
US6713462B2 (en) * | 2001-06-21 | 2004-03-30 | Ariad Pharmaceuticals, Inc. | Quinolinones and uses thereof |
AUPS137402A0 (en) * | 2002-03-26 | 2002-05-09 | Fujisawa Pharmaceutical Co., Ltd. | Novel tricyclic compounds |
ATE540928T1 (de) * | 2002-11-22 | 2012-01-15 | Mitsubishi Tanabe Pharma Corp | Isochinolinverbindungen und ihre medizinische verwendung |
WO2005054209A1 (fr) * | 2003-11-20 | 2005-06-16 | Janssen Pharmaceutica N.V. | 2-quinolinones et 2 quinoxalinones a substitution 7-phenylalkyl tenant lieu d'inhibiteurs de poly(adp-ribose) polymerase inhibitors |
KR101118582B1 (ko) * | 2003-11-20 | 2012-02-27 | 얀센 파마슈티카 엔.브이. | 폴리(adp-리보스)폴리머라제 저해제로서의 6-알케닐 및6-페닐알킬 치환된 2-퀴놀리논 및 2-퀴녹살리논 |
DE102004023332A1 (de) * | 2004-05-12 | 2006-01-19 | Bayer Cropscience Gmbh | Chinoxalin-2-on-derivate, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung und deren Verwendung |
CN1980913B (zh) * | 2004-06-30 | 2011-12-14 | 詹森药业有限公司 | 作为parp抑制剂的喹唑啉二酮衍生物 |
CA2607727A1 (fr) * | 2005-04-28 | 2006-11-09 | Mitsubishi Tanabe Pharma Corporation | Derive de cyanopyridine et emploi dudit derive au titre de medicament |
US8198448B2 (en) * | 2006-07-14 | 2012-06-12 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
US8466150B2 (en) * | 2006-12-28 | 2013-06-18 | Abbott Laboratories | Inhibitors of poly(ADP-ribose)polymerase |
CA2690378A1 (fr) * | 2007-06-25 | 2008-12-31 | Amgen Inc. | Composes de phthalazine, compositions et procedes d'utilisation |
-
2004
- 2004-11-18 SG SG200901531-4A patent/SG151249A1/en unknown
- 2004-11-18 BR BRPI0416532-2A patent/BRPI0416532A/pt not_active Application Discontinuation
- 2004-11-18 EA EA200601100A patent/EA010488B1/ru not_active IP Right Cessation
- 2004-11-18 UA UAA200603730A patent/UA89618C2/ru unknown
- 2004-11-18 JP JP2006541830A patent/JP4806353B2/ja not_active Expired - Fee Related
- 2004-11-18 US US10/596,086 patent/US7879857B2/en not_active Expired - Fee Related
- 2004-11-18 KR KR1020067011234A patent/KR101159118B1/ko not_active IP Right Cessation
- 2004-11-18 CA CA2546657A patent/CA2546657C/fr not_active Expired - Fee Related
- 2004-11-18 CN CN2004800358571A patent/CN1890224B/zh not_active Expired - Fee Related
- 2004-11-18 WO PCT/EP2004/013164 patent/WO2005054210A1/fr active Application Filing
- 2004-11-18 AU AU2004295059A patent/AU2004295059B2/en not_active Ceased
- 2004-11-18 ES ES04819602.6T patent/ES2551299T3/es active Active
- 2004-11-18 NZ NZ547193A patent/NZ547193A/en not_active IP Right Cessation
- 2004-11-18 EP EP04819602.6A patent/EP1709012B1/fr active Active
-
2006
- 2006-05-31 IL IL176060A patent/IL176060A/en not_active IP Right Cessation
- 2006-06-02 ZA ZA2006/04549A patent/ZA200604549B/en unknown
- 2006-06-28 NO NO20063028A patent/NO20063028L/no not_active Application Discontinuation
-
2007
- 2007-04-30 HK HK07104616.9A patent/HK1098150A1/xx not_active IP Right Cessation
-
2010
- 2010-12-17 US US12/971,319 patent/US20110230491A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR20060118534A (ko) | 2006-11-23 |
AU2004295059A1 (en) | 2005-06-16 |
EA200601100A1 (ru) | 2006-10-27 |
CN1890224A (zh) | 2007-01-03 |
EP1709012B1 (fr) | 2015-07-29 |
EP1709012A1 (fr) | 2006-10-11 |
US20070129375A1 (en) | 2007-06-07 |
IL176060A0 (en) | 2006-10-05 |
IL176060A (en) | 2012-10-31 |
WO2005054210A1 (fr) | 2005-06-16 |
EA010488B1 (ru) | 2008-10-30 |
CN1890224B (zh) | 2011-06-08 |
US7879857B2 (en) | 2011-02-01 |
CA2546657C (fr) | 2013-05-14 |
AU2004295059B2 (en) | 2010-12-16 |
ES2551299T3 (es) | 2015-11-17 |
UA89618C2 (ru) | 2010-02-25 |
KR101159118B1 (ko) | 2012-06-22 |
US20110230491A1 (en) | 2011-09-22 |
CA2546657A1 (fr) | 2005-06-16 |
JP2007513101A (ja) | 2007-05-24 |
ZA200604549B (en) | 2008-04-30 |
NO20063028L (no) | 2006-06-28 |
HK1098150A1 (en) | 2007-07-13 |
JP4806353B2 (ja) | 2011-11-02 |
NZ547193A (en) | 2010-03-26 |
BRPI0416532A (pt) | 2007-01-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG151249A1 (en) | 6-substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors | |
SG151250A1 (en) | Substituted 6-cyclohexylalkyl substituted 2-quinolinones and 2- quinoxalinones as poly(adp-ribose) polymerase inhibitors | |
UA88012C2 (uk) | Похідні хіназоліндіону як інгібітори parp | |
SG154434A1 (en) | Quinazolinone derivatives as parp inhibitors | |
UA91002C2 (ru) | 7-фенилалкилзамещенные 2-хинолиноны и 2-хиноксалиноны как ингибиторы поле(адф-рибоза)полимеразы | |
SG154433A1 (en) | Phthalazine derivatives as parp inhibitors | |
WO2004074244A3 (fr) | Composes de pyrimidine | |
RS20050117A (en) | Novel benzonaphthyridines | |
WO2006084017A3 (fr) | Composes pyrimidine a substitution phenyle utilises en tant qu'inhibiteurs de kinases | |
WO2007023111A3 (fr) | Inhibiteurs de la map-kinase p38 et leurs methodes d'utilisation | |
UA83091C2 (en) | Pyrido[2,3-d]pyrimidine-2,4-diamines as pde 2 inhibitors | |
WO2004106293A3 (fr) | Composes tricycliques a base d'oxazolo[4,5-b]pyridine condensee a un imidazo et de thiazolo[4,5-b]pyridine condensee a un imidazo, et compositions pharmaceutiques renfermant ceux-ci | |
WO2002024686A3 (fr) | Derives de la quinoleine et de la quinazoline 6-heterocyclylmethyle inhibiteurs de la farnesyle transferase | |
ATE413388T1 (de) | Muskarin antagonisten | |
WO2002085906A3 (fr) | Phtalazinones | |
ATE319704T1 (de) | Farnesyltransferase hemmende, in der 4-stellung substituierte chinolin- und chinazolinderivate | |
TW200604197A (en) | New compounds | |
MY136297A (en) | Piperazine derivatives having sst1 antagonistic activity | |
WO2005011609A3 (fr) | Composes tricycliques a base de triazolopurine et compositions pharmaceutiques contenant ces composes | |
WO2004075846A3 (fr) | Composes tricycliques a base de pyrazolopurine et compositions pharmaceutiques renfermant ces composes | |
SI1377574T1 (fr) | ||
DE60201074D1 (en) | Pyrazolopyridinderivate | |
MXPA04005151A (es) | Compuestos terapeuticos. | |
MY154363A (en) | 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly (adp-ribose) polymerase inhibitors | |
UA86777C2 (en) | 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors |