SG11202104752RA - Spiro aromatic ring compound and application thereof - Google Patents
Spiro aromatic ring compound and application thereofInfo
- Publication number
- SG11202104752RA SG11202104752RA SG11202104752RA SG11202104752RA SG11202104752RA SG 11202104752R A SG11202104752R A SG 11202104752RA SG 11202104752R A SG11202104752R A SG 11202104752RA SG 11202104752R A SG11202104752R A SG 11202104752RA SG 11202104752R A SG11202104752R A SG 11202104752RA
- Authority
- SG
- Singapore
- Prior art keywords
- application
- aromatic ring
- ring compound
- spiro aromatic
- spiro
- Prior art date
Links
- -1 Spiro aromatic ring compound Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811314910 | 2018-11-06 | ||
PCT/CN2019/115754 WO2020094018A1 (fr) | 2018-11-06 | 2019-11-05 | Composé spiro cyclique aromatique et utilisation associée |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202104752RA true SG11202104752RA (en) | 2021-06-29 |
Family
ID=70516741
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202104752RA SG11202104752RA (en) | 2018-11-06 | 2019-11-05 | Spiro aromatic ring compound and application thereof |
Country Status (11)
Country | Link |
---|---|
US (3) | US10844079B2 (fr) |
EP (2) | EP3712151B1 (fr) |
JP (1) | JP2022507114A (fr) |
KR (1) | KR20210088639A (fr) |
CN (4) | CN111138412B (fr) |
AU (1) | AU2019374194A1 (fr) |
BR (1) | BR112021008714A2 (fr) |
CA (1) | CA3118925A1 (fr) |
ES (1) | ES2914852T3 (fr) |
SG (1) | SG11202104752RA (fr) |
WO (1) | WO2020094018A1 (fr) |
Families Citing this family (41)
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EP3515916B1 (fr) | 2016-09-22 | 2023-06-07 | Relay Therapeutics, Inc. | Inhibiteurs de phosphatase shp2 et leurs procédés d'utilisation |
TW201819386A (zh) | 2016-10-24 | 2018-06-01 | 美商傳達治療有限公司 | Shp2磷酸酶抑制劑及其使用方法 |
EP3630770A1 (fr) | 2017-05-26 | 2020-04-08 | Relay Therapeutics, Inc. | Dérivés de pyrazolo[3,4-b]pyrazine en tant qu'inhibiteurs de la phosphatase shp2 |
US11701354B2 (en) | 2017-09-29 | 2023-07-18 | D. E. Shaw Research, Llc | Pyrazolo[3,4-b]pyrazine derivatives as SHP2 phosphatase inhibitors |
AU2019222026B2 (en) * | 2018-02-13 | 2022-05-12 | Shanghai Blueray Biopharma Co., Ltd. | Pyrimidine-fused cyclic compound, preparation method therefor and application thereof |
CN115448923B (zh) * | 2018-02-13 | 2024-03-22 | 上海青煜医药科技有限公司 | 嘧啶并环化合物及其制备方法和应用 |
TW202003471A (zh) | 2018-03-21 | 2020-01-16 | 美商傳達治療有限公司 | Shp2磷酸酶抑制劑及其使用方法 |
WO2020072656A1 (fr) | 2018-10-03 | 2020-04-09 | Gilead Sciences, Inc. | Dérivés d'imidozopyrimidine |
CN111138412B (zh) | 2018-11-06 | 2023-09-15 | 上海奕拓医药科技有限责任公司 | 一种螺芳环化合物及其应用 |
JP2022506887A (ja) * | 2018-11-07 | 2022-01-17 | シャンハイ リンジーン バイオファーマ カンパニー リミテッド | 窒素含有縮合複素環系shp2阻害剤化合物、製造方法及び使用 |
BR112021009880A2 (pt) * | 2018-11-30 | 2021-08-17 | Tuojie Biotech (Shanghai) Co., Ltd. | pirimidina e derivado de heterociclo de nitrogênio de cinco membros, método de preparação para os mesmos e usos médicos dos mesmos |
CN111704611B (zh) * | 2019-07-25 | 2022-01-14 | 上海凌达生物医药有限公司 | 一类芳基螺环类shp2抑制剂化合物、制备方法和用途 |
EP3772513A1 (fr) | 2019-08-09 | 2021-02-10 | C.N.C.C.S. S.c.a.r.l. Collezione Nazionale Dei Composti Chimici e Centro Screening | Inhibiteurs d'shp2 |
EP4034539A1 (fr) | 2019-09-24 | 2022-08-03 | Relay Therapeutics, Inc. | Inhibiteurs de phosphatase shp2, procédés de production et d'utilisation associés |
CN112778276A (zh) * | 2019-11-08 | 2021-05-11 | 南京圣和药业股份有限公司 | 作为shp2抑制剂的化合物及其应用 |
CN114846005B (zh) * | 2020-01-21 | 2024-04-02 | 贝达药业股份有限公司 | Shp2抑制剂及其应用 |
WO2021148010A1 (fr) * | 2020-01-22 | 2021-07-29 | 南京明德新药研发有限公司 | Composé à cycle pyrazolo hétéroaryl et son application |
CN113754683A (zh) * | 2020-06-05 | 2021-12-07 | 上海奕拓医药科技有限责任公司 | 同位素取代的螺芳环化合物及其应用 |
JP2023528990A (ja) * | 2020-06-11 | 2023-07-06 | 貝達薬業股▲ふん▼有限公司 | Shp2阻害剤、ならびにその組成物および使用 |
JP2023532217A (ja) | 2020-06-18 | 2023-07-27 | 上海奕拓醫藥科技有限責任公司 | Shp2阻害剤の結晶形、その組成物、その製造方法及び応用 |
IL299131A (en) | 2020-06-18 | 2023-02-01 | Revolution Medicines Inc | Methods for delaying, preventing and treating acquired resistance to RAS inhibitors |
EP4208261A1 (fr) | 2020-09-03 | 2023-07-12 | Revolution Medicines, Inc. | Utilisation d'inhibiteurs de sos1 pour traiter des malignités à mutations de shp2 |
EP4214209A1 (fr) | 2020-09-15 | 2023-07-26 | Revolution Medicines, Inc. | Dérivés d'indole servant d'inhibiteurs dans le traitement du cancer |
CN113372344B (zh) * | 2020-12-24 | 2022-11-01 | 上海药坦药物研究开发有限公司 | 一种氯代六元含氮杂环并咪唑类化合物的合成方法 |
WO2022156765A1 (fr) * | 2021-01-22 | 2022-07-28 | 南京明德新药研发有限公司 | Composé tricyclique lié à la pyrazolopyrazine et son application |
PE20240634A1 (es) * | 2021-02-05 | 2024-03-26 | Hutchmed Ltd | Compuestos triciclicos y usos de los mismos |
CN113480536B (zh) * | 2021-04-21 | 2024-02-23 | 中国人民解放军海军军医大学 | 螺环哌啶酮类衍生物 |
EP4334321A1 (fr) | 2021-05-05 | 2024-03-13 | Revolution Medicines, Inc. | Inhibiteurs de ras |
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CN117616031A (zh) | 2021-05-05 | 2024-02-27 | 锐新医药公司 | 用于治疗癌症的ras抑制剂 |
CN115340545A (zh) * | 2021-05-14 | 2022-11-15 | 浙江海正药业股份有限公司 | 双环杂芳基类衍生物及其制备方法和用途 |
WO2022241975A1 (fr) * | 2021-05-20 | 2022-11-24 | Etern Biopharma (Shanghai) Co., Ltd. | Procédés de traitement de cancers associés à une mutation d'egfr |
WO2022259157A1 (fr) | 2021-06-09 | 2022-12-15 | Novartis Ag | Combinaison pharmaceutique triple comprenant du dabrafenib, du trametinib et un inhibiteur de shp2 |
TW202317100A (zh) | 2021-06-23 | 2023-05-01 | 瑞士商諾華公司 | 包含kras g12c抑制劑的藥物組合及其用於治療癌症之用途 |
KR20240055778A (ko) | 2021-09-01 | 2024-04-29 | 노파르티스 아게 | Tead 억제제를 포함하는 제약 조합물 및 암의 치료를 위한 이의 용도 |
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WO2023109761A1 (fr) * | 2021-12-15 | 2023-06-22 | 贝达药业股份有限公司 | Cristal de composé pyrazolopyrimidinone et sel de celui-ci |
WO2023172940A1 (fr) | 2022-03-08 | 2023-09-14 | Revolution Medicines, Inc. | Méthodes de traitement du cancer du poumon réfractaire immunitaire |
WO2023230968A1 (fr) * | 2022-06-01 | 2023-12-07 | 上海凌达生物医药有限公司 | Inhibiteur de shp2, forme cristalline de celui-ci, procédé de préparation correspondant et utilisation associée |
WO2023240263A1 (fr) | 2022-06-10 | 2023-12-14 | Revolution Medicines, Inc. | Inhibiteurs de ras macrocycliques |
CN115267037B (zh) * | 2022-07-25 | 2024-02-23 | 宁波熙宁检测技术有限公司 | 一种测定血浆中shp099浓度的方法 |
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CN108570048B (zh) * | 2017-03-10 | 2021-06-08 | 广东东阳光药业有限公司 | 取代的杂芳基化合物及其组合物和用途 |
EP3601239A4 (fr) * | 2017-03-23 | 2020-05-13 | Jacobio Pharmaceuticals Co., Ltd. | Nouveaux dérivés hétérocycliques utiles en tant qu'inhibiteurs de shp2 |
WO2019075265A1 (fr) | 2017-10-12 | 2019-04-18 | Revolution Medicines, Inc. | Pyridine, pyrazine et composés de triazine utilisés en tant qu'inhibiteurs allostériques de shp2 |
MX2020006273A (es) | 2017-12-15 | 2020-09-14 | Revolution Medicines Inc | Compuestos policiclicos como inhibidores alostericos de shp2. |
AU2019222026B2 (en) | 2018-02-13 | 2022-05-12 | Shanghai Blueray Biopharma Co., Ltd. | Pyrimidine-fused cyclic compound, preparation method therefor and application thereof |
TW202003471A (zh) * | 2018-03-21 | 2020-01-16 | 美商傳達治療有限公司 | Shp2磷酸酶抑制劑及其使用方法 |
CN112203689A (zh) | 2018-04-10 | 2021-01-08 | 锐新医药公司 | 治疗癌症的shp2抑制剂组合物和方法 |
CN110143949A (zh) * | 2018-05-09 | 2019-08-20 | 北京加科思新药研发有限公司 | 可用作shp2抑制剂的新型杂环衍生物 |
WO2020063760A1 (fr) | 2018-09-26 | 2020-04-02 | Jacobio Pharmaceuticals Co., Ltd. | Nouveaux dérivés hétérocycliques utiles en tant qu'inhibiteurs de shp2 |
WO2020072656A1 (fr) | 2018-10-03 | 2020-04-09 | Gilead Sciences, Inc. | Dérivés d'imidozopyrimidine |
CN111138412B (zh) | 2018-11-06 | 2023-09-15 | 上海奕拓医药科技有限责任公司 | 一种螺芳环化合物及其应用 |
JP2022506887A (ja) * | 2018-11-07 | 2022-01-17 | シャンハイ リンジーン バイオファーマ カンパニー リミテッド | 窒素含有縮合複素環系shp2阻害剤化合物、製造方法及び使用 |
BR112021009880A2 (pt) | 2018-11-30 | 2021-08-17 | Tuojie Biotech (Shanghai) Co., Ltd. | pirimidina e derivado de heterociclo de nitrogênio de cinco membros, método de preparação para os mesmos e usos médicos dos mesmos |
CN111704611B (zh) * | 2019-07-25 | 2022-01-14 | 上海凌达生物医药有限公司 | 一类芳基螺环类shp2抑制剂化合物、制备方法和用途 |
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2019
- 2019-08-01 CN CN201910705880.5A patent/CN111138412B/zh active Active
- 2019-08-01 CN CN202311094903.6A patent/CN117143079A/zh active Pending
- 2019-11-05 EP EP19881313.1A patent/EP3712151B1/fr active Active
- 2019-11-05 ES ES19881313T patent/ES2914852T3/es active Active
- 2019-11-05 AU AU2019374194A patent/AU2019374194A1/en active Pending
- 2019-11-05 JP JP2021525321A patent/JP2022507114A/ja active Pending
- 2019-11-05 WO PCT/CN2019/115754 patent/WO2020094018A1/fr active Application Filing
- 2019-11-05 BR BR112021008714-1A patent/BR112021008714A2/pt unknown
- 2019-11-05 SG SG11202104752RA patent/SG11202104752RA/en unknown
- 2019-11-05 CN CN201980005853.5A patent/CN111566104B/zh active Active
- 2019-11-05 CN CN202010535577.8A patent/CN111592525B/zh active Active
- 2019-11-05 KR KR1020217017152A patent/KR20210088639A/ko active Search and Examination
- 2019-11-05 CA CA3118925A patent/CA3118925A1/fr active Pending
- 2019-11-05 EP EP22159530.9A patent/EP4074713A1/fr active Pending
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2020
- 2020-06-22 US US16/908,604 patent/US10844079B2/en active Active
- 2020-09-08 US US17/014,883 patent/US11685748B2/en active Active
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2023
- 2023-05-11 US US18/196,357 patent/US20240116949A1/en active Pending
Also Published As
Publication number | Publication date |
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BR112021008714A2 (pt) | 2021-08-10 |
CA3118925A1 (fr) | 2020-05-14 |
EP3712151B1 (fr) | 2022-03-02 |
CN111138412A (zh) | 2020-05-12 |
US10844079B2 (en) | 2020-11-24 |
US20240116949A1 (en) | 2024-04-11 |
US20210238196A1 (en) | 2021-08-05 |
CN111592525A (zh) | 2020-08-28 |
CN111138412B (zh) | 2023-09-15 |
CN111592525B (zh) | 2020-12-08 |
ES2914852T3 (es) | 2022-06-17 |
US11685748B2 (en) | 2023-06-27 |
EP3712151A1 (fr) | 2020-09-23 |
WO2020094018A1 (fr) | 2020-05-14 |
EP3712151A4 (fr) | 2020-12-30 |
JP2022507114A (ja) | 2022-01-18 |
EP4074713A1 (fr) | 2022-10-19 |
AU2019374194A1 (en) | 2021-05-27 |
CN111566104B (zh) | 2024-05-17 |
CN111566104A (zh) | 2020-08-21 |
CN117143079A (zh) | 2023-12-01 |
US20200317695A1 (en) | 2020-10-08 |
KR20210088639A (ko) | 2021-07-14 |
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