SG11202101827RA - N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamides useful as ccr6 inhibitors - Google Patents
N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamides useful as ccr6 inhibitorsInfo
- Publication number
- SG11202101827RA SG11202101827RA SG11202101827RA SG11202101827RA SG11202101827RA SG 11202101827R A SG11202101827R A SG 11202101827RA SG 11202101827R A SG11202101827R A SG 11202101827RA SG 11202101827R A SG11202101827R A SG 11202101827RA SG 11202101827R A SG11202101827R A SG 11202101827RA
- Authority
- SG
- Singapore
- Prior art keywords
- dioxocyclobutenylamino
- picolinamides
- hydroxy
- substituted
- useful
- Prior art date
Links
- -1 N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamides Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862734486P | 2018-09-21 | 2018-09-21 | |
PCT/IB2019/057856 WO2020058869A1 (en) | 2018-09-21 | 2019-09-18 | N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamides useful as ccr6 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202101827RA true SG11202101827RA (en) | 2021-04-29 |
Family
ID=68051869
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202101827RA SG11202101827RA (en) | 2018-09-21 | 2019-09-18 | N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamides useful as ccr6 inhibitors |
Country Status (29)
Country | Link |
---|---|
US (2) | US10975065B2 (ko) |
EP (1) | EP3852879A1 (ko) |
JP (1) | JP6989729B2 (ko) |
KR (2) | KR102615234B1 (ko) |
CN (2) | CN116874466A (ko) |
AR (1) | AR116464A1 (ko) |
AU (1) | AU2019344107B2 (ko) |
BR (1) | BR112021003956A2 (ko) |
CA (1) | CA3055805A1 (ko) |
CL (1) | CL2021000683A1 (ko) |
CO (1) | CO2021003391A2 (ko) |
CR (1) | CR20210146A (ko) |
CU (1) | CU20210016A7 (ko) |
DO (1) | DOP2021000045A (ko) |
EA (1) | EA202190586A1 (ko) |
EC (1) | ECSP21018584A (ko) |
GE (1) | GEP20237476B (ko) |
IL (1) | IL281634A (ko) |
MA (1) | MA53643A (ko) |
MX (1) | MX2021003318A (ko) |
NI (1) | NI202100012A (ko) |
NZ (1) | NZ773473A (ko) |
PE (1) | PE20211070A1 (ko) |
PH (1) | PH12021550554A1 (ko) |
SG (1) | SG11202101827RA (ko) |
TW (1) | TWI754172B (ko) |
UY (1) | UY38379A (ko) |
WO (1) | WO2020058869A1 (ko) |
ZA (1) | ZA202101169B (ko) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20211070A1 (es) * | 2018-09-21 | 2021-06-09 | Pfizer | Dioxociclobutenilamino-3-hidroxi-picolinamidas n-sustituidas utiles como inhibidores de ccr6 |
US20230174514A1 (en) | 2020-04-30 | 2023-06-08 | Idorsia Pharmaceuticals Ltd | Azetidin-3-ylmethanol derivatives as ccr6 receptor modulators |
WO2023057548A1 (en) | 2021-10-07 | 2023-04-13 | Idorsia Pharmaceuticals Ltd | Ccr6 receptor modulators |
CN118215662A (zh) | 2021-10-26 | 2024-06-18 | 爱杜西亚药品有限公司 | Ccr6受体调节剂 |
IL312369A (en) | 2021-10-28 | 2024-06-01 | Idorsia Pharmaceuticals Ltd | CCR6 receptor modulators |
CN116162081A (zh) * | 2022-12-13 | 2023-05-26 | 药康众拓(江苏)医药科技有限公司 | 一类氘代吡啶酰胺类ccr6抑制剂药物及用途 |
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ATE176223T1 (de) | 1994-11-16 | 1999-02-15 | American Home Prod | Diaminocyclobuten-3,4-dione |
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US6495576B2 (en) | 2001-02-07 | 2002-12-17 | Abbott Laboratories | Aminal diones as potassium channel openers |
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CA2479126C (en) | 2002-03-18 | 2011-11-15 | Schering Corporation | Combination treatments for chemokine-mediated diseases |
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PT2010509E (pt) | 2006-03-31 | 2014-12-12 | Janssen Pharmaceutica Nv | Derivados de 3,4-diamino-3-ciclobuteno-1,2-diona como agentes de dilatação do canal de potássio |
EP2021316A1 (en) | 2006-05-26 | 2009-02-11 | Abbott Laboratories | Inhibitors of polo-like kinases |
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KR20100031718A (ko) | 2007-06-06 | 2010-03-24 | 노파르티스 아게 | 항-염증성 치환된 시클로부텐디온 화합물 |
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JP5292400B2 (ja) | 2007-07-24 | 2013-09-18 | ブリストル−マイヤーズ スクイブ カンパニー | ケモカイン受容体活性のモジュレーターとしてのピペリジン誘導体 |
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FR2961695B1 (fr) | 2010-06-29 | 2012-07-06 | Galderma Res & Dev | Utilisation de composes dans le traitement ou la prevention de troubles cutanes |
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TWI734715B (zh) | 2015-11-19 | 2021-08-01 | 美商卡默森屈有限公司 | 趨化因子受體調節劑 |
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PE20211070A1 (es) * | 2018-09-21 | 2021-06-09 | Pfizer | Dioxociclobutenilamino-3-hidroxi-picolinamidas n-sustituidas utiles como inhibidores de ccr6 |
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2019
- 2019-09-18 PE PE2021000331A patent/PE20211070A1/es unknown
- 2019-09-18 KR KR1020217007932A patent/KR102615234B1/ko active IP Right Grant
- 2019-09-18 SG SG11202101827RA patent/SG11202101827RA/en unknown
- 2019-09-18 JP JP2021514571A patent/JP6989729B2/ja active Active
- 2019-09-18 WO PCT/IB2019/057856 patent/WO2020058869A1/en active Application Filing
- 2019-09-18 CN CN202310857008.9A patent/CN116874466A/zh active Pending
- 2019-09-18 CA CA3055805A patent/CA3055805A1/en active Pending
- 2019-09-18 GE GEAP201915588A patent/GEP20237476B/en unknown
- 2019-09-18 EP EP19773556.6A patent/EP3852879A1/en active Pending
- 2019-09-18 CR CR20210146A patent/CR20210146A/es unknown
- 2019-09-18 EA EA202190586A patent/EA202190586A1/ru unknown
- 2019-09-18 AU AU2019344107A patent/AU2019344107B2/en active Active
- 2019-09-18 MX MX2021003318A patent/MX2021003318A/es unknown
- 2019-09-18 CU CU2021000016A patent/CU20210016A7/es unknown
- 2019-09-18 MA MA053643A patent/MA53643A/fr unknown
- 2019-09-18 CN CN201980058547.8A patent/CN112672791B/zh active Active
- 2019-09-18 BR BR112021003956-2A patent/BR112021003956A2/pt unknown
- 2019-09-18 NZ NZ773473A patent/NZ773473A/en unknown
- 2019-09-18 KR KR1020237043152A patent/KR20230175326A/ko active Application Filing
- 2019-09-19 UY UY0001038379A patent/UY38379A/es not_active Application Discontinuation
- 2019-09-20 TW TW108134010A patent/TWI754172B/zh active
- 2019-09-20 AR ARP190102673A patent/AR116464A1/es unknown
- 2019-09-20 US US16/576,997 patent/US10975065B2/en active Active
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2021
- 2021-02-22 ZA ZA2021/01169A patent/ZA202101169B/en unknown
- 2021-02-24 NI NI202100012A patent/NI202100012A/es unknown
- 2021-03-05 US US17/192,968 patent/US11708360B2/en active Active
- 2021-03-12 PH PH12021550554A patent/PH12021550554A1/en unknown
- 2021-03-16 CO CONC2021/0003391A patent/CO2021003391A2/es unknown
- 2021-03-16 EC ECSENADI202118584A patent/ECSP21018584A/es unknown
- 2021-03-18 IL IL281634A patent/IL281634A/en unknown
- 2021-03-19 DO DO2021000045A patent/DOP2021000045A/es unknown
- 2021-03-19 CL CL2021000683A patent/CL2021000683A1/es unknown
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