ATE523506T1 - Amingebundene pyridyl- und phenylsubstituierte piperazin-piperidine mit cxcr3-antagonistischer aktivität - Google Patents
Amingebundene pyridyl- und phenylsubstituierte piperazin-piperidine mit cxcr3-antagonistischer aktivitätInfo
- Publication number
- ATE523506T1 ATE523506T1 AT06735089T AT06735089T ATE523506T1 AT E523506 T1 ATE523506 T1 AT E523506T1 AT 06735089 T AT06735089 T AT 06735089T AT 06735089 T AT06735089 T AT 06735089T AT E523506 T1 ATE523506 T1 AT E523506T1
- Authority
- AT
- Austria
- Prior art keywords
- piperidines
- phenyl substituted
- antagonistic activity
- substituted piperazine
- amine bonded
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65333905P | 2005-02-16 | 2005-02-16 | |
| PCT/US2006/005266 WO2006088920A1 (en) | 2005-02-16 | 2006-02-14 | Amine-linked pyridyl and phenyl substituted piperazine-piperidines with cxcr3 antagonist activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE523506T1 true ATE523506T1 (de) | 2011-09-15 |
Family
ID=36499283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06735089T ATE523506T1 (de) | 2005-02-16 | 2006-02-14 | Amingebundene pyridyl- und phenylsubstituierte piperazin-piperidine mit cxcr3-antagonistischer aktivität |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7566718B2 (de) |
| EP (1) | EP1853583B1 (de) |
| JP (2) | JP4688889B2 (de) |
| CN (1) | CN101203509B (de) |
| AR (1) | AR054185A1 (de) |
| AT (1) | ATE523506T1 (de) |
| CA (1) | CA2598460C (de) |
| MX (1) | MX2007009948A (de) |
| TW (1) | TWI316514B (de) |
| WO (1) | WO2006088920A1 (de) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1663197T1 (sl) | 2003-09-09 | 2008-06-30 | Biogen Idec Internat Gmbh | Uporaba derivatov fumarne kisline za zdravljenje sräśne insuficience in astme |
| AU2005234596B8 (en) | 2004-04-13 | 2011-06-16 | Incyte Holdings Corporation | Piperazinylpiperidine derivatives as chemokine receptor antagonists |
| GB2418427A (en) | 2004-09-02 | 2006-03-29 | Univ Cambridge Tech | Ligands for G-protein coupled receptors |
| AU2006214477A1 (en) * | 2005-02-16 | 2006-08-24 | Pharmacopeia, Inc. | Heterocyclic substituted piperazines with CXCR3 antagonist activity |
| AU2006214380A1 (en) * | 2005-02-16 | 2006-08-24 | Pharmacopeia, Inc. | Pyrazinyl substituted piperazine-piperidines with CXCR3 antagonist activity |
| AU2006216941B2 (en) * | 2005-02-16 | 2009-12-03 | Pharmacopeia, Llc | Heteroaryl substituted pyrazinyl-piperazine-piperidines with CXCR3 antagonist activity |
| MX2007010068A (es) * | 2005-02-16 | 2007-10-10 | Schering Corp | Piperazino-piperidinas con actividad antagonista de cxcr3. |
| KR20070107056A (ko) * | 2005-02-16 | 2007-11-06 | 쉐링 코포레이션 | Ｃｘｃｒ３ 길항제 활성을 지닌 피리딜 및 페닐 치환된피페라진-피페리딘 |
| EP1853587B1 (de) * | 2005-02-16 | 2011-08-03 | Schering Corporation | Neue heterozyklische substituierte pyridin- oder phenylverbindungen mit cxcr3-antagonistischer aktivität |
| TW200714610A (en) * | 2005-02-16 | 2007-04-16 | Univ Maryland | CXCR3 is a gliadin receptor |
| EP1937666B1 (de) * | 2005-10-11 | 2012-02-22 | Schering Corporation | Substituierte heterocyclische verbindungen mit cxcr3-antagonistischer wirkung |
| RU2008141368A (ru) * | 2006-03-21 | 2010-04-27 | Шеринг Корпорейшн (US) | Новые гетероциклические соединения замещенного пиридина с антагонистической активностью схсr3 |
| CN101516869A (zh) * | 2006-07-14 | 2009-08-26 | 先灵公司 | 具有cxcr3拮抗剂活性的杂环取代的哌嗪化合物 |
| WO2008079279A1 (en) * | 2006-12-22 | 2008-07-03 | Schering Corporation | Heterocyclic compounds with cxcr3 antagonist activity |
| PL2653873T3 (pl) | 2007-02-08 | 2022-08-22 | Biogen Idec Ma Inc. | Kompozycje i zastosowania do leczenia stwardnienia rozsianego |
| EP2125750B1 (de) * | 2007-02-26 | 2014-05-21 | Vitae Pharmaceuticals, Inc. | Zyklische harnstoff- und carbamat-hemmer aus 11-beta-hydroxysteroid-dehydrogenase 1 |
| EP2136832B1 (de) | 2007-03-26 | 2015-09-02 | General Regeneratives Limited | Verfahren zur förderung des schutzes und der regeneration von knochenmark mit cxcl9 und anti-cxcl9-antikörpern |
| ATE554078T1 (de) * | 2007-07-26 | 2012-05-15 | Vitae Pharmaceuticals Inc | Synthese von 11-beta-hydroxysteroid-dehydrogenase-1-hemmern |
| AR069207A1 (es) * | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
| EP2229368A1 (de) | 2007-12-11 | 2010-09-22 | Vitae Pharmaceuticals, Inc. | Cyclische harnstoffe als inhibitoren von 11beta-hydroxysteroiddehydrogenase 1 |
| GB2455539B (en) * | 2007-12-12 | 2012-01-18 | Cambridge Entpr Ltd | Anti-inflammatory compositions and combinations |
| JP2011506445A (ja) * | 2007-12-13 | 2011-03-03 | アムジエン・インコーポレーテツド | γ−セクレターゼ調節剤 |
| TW200934490A (en) * | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| EP2252601B1 (de) | 2008-01-24 | 2012-12-19 | Vitae Pharmaceuticals, Inc. | Cyclische carbazate und semicarbazide als inhibitoren von 11beta-hydroxysteroiddehydrogenase 1 |
| CA2714532A1 (en) * | 2008-02-11 | 2009-08-20 | Vitae Pharmaceuticals, Inc. | 1,3-oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| JP5730021B2 (ja) * | 2008-02-15 | 2015-06-03 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としてのシクロアルキルラクタム誘導体 |
| CA2718264A1 (en) * | 2008-03-18 | 2009-09-24 | Vitae Pharmaceuticals, Inc. | Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 |
| JP5451752B2 (ja) * | 2008-05-01 | 2014-03-26 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター |
| JP5538365B2 (ja) | 2008-05-01 | 2014-07-02 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤 |
| CL2009001058A1 (es) | 2008-05-01 | 2010-09-10 | Vitae Pharmaceuticals Inc | Compuestos derivados de oxazinas sustituidas, inhibidores de la 11b-hidroxiesteroide deshidrogenasa de tipo-1; composicion farmaceutica; y uso del compuesto para inhibir la actividad de 11b-hsd1, como en el tratamiento de la diabetes, dislipidemia, hipertension, obesidad, cancer, glaucoma, entre otras. |
| US8138178B2 (en) | 2008-05-01 | 2012-03-20 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| TWI433838B (zh) * | 2008-06-25 | 2014-04-11 | 必治妥美雅史谷比公司 | 作為趨化因子受體活性調節劑之六氫吡啶衍生物 |
| TW201016691A (en) | 2008-07-25 | 2010-05-01 | Boehringer Ingelheim Int | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| NZ590495A (en) | 2008-07-25 | 2012-10-26 | Vitae Pharmaceuticals Inc | Dihydropyridin-phenyl-3-oxazinan-2-ones as inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| UA103198C2 (en) | 2008-08-04 | 2013-09-25 | Новартис Аг | Squaramide derivatives as cxcr2 antagonists |
| CA2744946A1 (en) | 2009-02-04 | 2010-08-12 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| TW201039034A (en) * | 2009-04-27 | 2010-11-01 | Chunghwa Picture Tubes Ltd | Pixel structure and the method of forming the same |
| MA33216B1 (fr) | 2009-04-30 | 2012-04-02 | Boehringer Ingelheim Int | Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1 |
| KR20120061771A (ko) * | 2009-04-30 | 2012-06-13 | 비타이 파마슈티컬즈, 인코포레이티드 | 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제 |
| WO2011011123A1 (en) | 2009-06-11 | 2011-01-27 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure |
| WO2011002910A1 (en) | 2009-07-01 | 2011-01-06 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| WO2011159760A1 (en) | 2010-06-16 | 2011-12-22 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| JP5813106B2 (ja) | 2010-06-25 | 2015-11-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 代謝障害の処置のための１１−β−ＨＳＤ１のインヒビターとしてのアザスピロヘキサノン |
| US9095591B2 (en) | 2010-06-28 | 2015-08-04 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Pharmaceutical composition for use in the treatment of glaucoma |
| GB201017345D0 (en) | 2010-10-14 | 2010-11-24 | Proximagen Ltd | Receptor antagonists |
| WO2012059416A1 (en) | 2010-11-02 | 2012-05-10 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations for the treatment of metabolic disorders |
| BR112014004963A2 (pt) | 2011-09-02 | 2017-03-21 | Novartis Ag | sal de colina do composto anti-inflamatório ciclobutanodiona substituído |
| EP2771484A1 (de) | 2011-10-28 | 2014-09-03 | Galderma Research & Development | Neue leukozyteninfiltratmarker für rosacea und verwendungen davon |
| UA113638C2 (xx) | 2012-02-02 | 2017-02-27 | 4-(бензоімідазол-2-іл)-тіазольні сполуки та споріднені азапохідні | |
| WO2013135674A1 (en) * | 2012-03-12 | 2013-09-19 | Syngenta Participations Ag | Insecticidal 2-aryl-acetamide compounds |
| EP2948134B1 (de) | 2013-01-24 | 2020-03-04 | Palvella Therapeutics, Inc. | Zusammensetzungen zur transdermalen verabreichung von mtor-inhibitoren |
| MX363432B (es) | 2013-07-22 | 2019-03-22 | Idorsia Pharmaceuticals Ltd | Derivados 1-(piperazin-1-il)-2-([1,2,4]triazol-1-il)-etanona. |
| WO2015051458A1 (en) * | 2013-10-08 | 2015-04-16 | Lu qing-bin | Non-platimun-based anti-cancer compounds for use in targeted chemotherapy |
| US9763992B2 (en) | 2014-02-13 | 2017-09-19 | Father Flanagan's Boys' Home | Treatment of noise induced hearing loss |
| AR099789A1 (es) | 2014-03-24 | 2016-08-17 | Actelion Pharmaceuticals Ltd | Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina |
| WO2016113344A1 (en) | 2015-01-15 | 2016-07-21 | Actelion Pharmaceuticals Ltd | Hydroxyalkyl-piperazine derivatives as cxcr3 receptor modulators |
| AR103399A1 (es) | 2015-01-15 | 2017-05-10 | Actelion Pharmaceuticals Ltd | Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3 |
| MX2017011981A (es) | 2015-04-02 | 2018-01-10 | Proximagen Ltd | Terapias novedosas para cancer. |
| TW202246215A (zh) | 2015-12-18 | 2022-12-01 | 美商亞德利克斯公司 | 作為非全身ｔｇｒ５促效劑之經取代之４－苯基吡啶化合物 |
| CN110520097B (zh) | 2017-01-06 | 2023-10-27 | 帕尔维拉治疗股份有限公司 | Mtor抑制剂的无水组合物及其使用方法 |
| WO2020010073A1 (en) | 2018-07-02 | 2020-01-09 | Palvella Therapeutics, Inc. | ANHYDROUS COMPOSITIONS OF mTOR INHIBITORS AND METHODS OF USE |
| GEP20237476B (en) | 2018-09-21 | 2023-03-27 | Pfizer | N-substituted-dioxocyclobutenylamino-3-hydroxypicolinamides useful as ccr6 inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6498161B1 (en) * | 1999-04-06 | 2002-12-24 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
| CA2371583C (en) * | 1999-05-04 | 2005-09-13 | Schering Corporation | Piperazine derivatives useful as ccr5 antagonists |
| GB0203994D0 (en) | 2002-02-20 | 2002-04-03 | Celltech R&D Ltd | Chemical compounds |
| EP1485370B1 (de) * | 2002-03-13 | 2009-03-04 | Janssen Pharmaceutica N.V. | Aminoderivate als histone-deacetylase-inhibitoren |
| AU2003220968A1 (en) * | 2002-03-28 | 2003-10-13 | Kyowa Hakko Kogyo Co., Ltd. | Anti-inflammatory agent |
| KR20060009390A (ko) * | 2003-06-13 | 2006-01-31 | 쉐링 악티엔게젤샤프트 | Ｃｃｒ-５ 길항제로서의 퀴놀릴 아미드 유도체 |
| GB0315203D0 (en) * | 2003-06-28 | 2003-08-06 | Celltech R&D Ltd | Chemical compounds |
| EP1853587B1 (de) * | 2005-02-16 | 2011-08-03 | Schering Corporation | Neue heterozyklische substituierte pyridin- oder phenylverbindungen mit cxcr3-antagonistischer aktivität |
| AU2006214477A1 (en) * | 2005-02-16 | 2006-08-24 | Pharmacopeia, Inc. | Heterocyclic substituted piperazines with CXCR3 antagonist activity |
-
2006
- 2006-02-14 WO PCT/US2006/005266 patent/WO2006088920A1/en active Application Filing
- 2006-02-14 AT AT06735089T patent/ATE523506T1/de not_active IP Right Cessation
- 2006-02-14 CA CA2598460A patent/CA2598460C/en not_active Expired - Fee Related
- 2006-02-14 US US11/354,328 patent/US7566718B2/en active Active
- 2006-02-14 JP JP2007556254A patent/JP4688889B2/ja not_active Expired - Fee Related
- 2006-02-14 CN CN2006800124667A patent/CN101203509B/zh not_active Expired - Fee Related
- 2006-02-14 EP EP06735089A patent/EP1853583B1/de active Active
- 2006-02-14 MX MX2007009948A patent/MX2007009948A/es active IP Right Grant
- 2006-02-15 AR ARP060100548A patent/AR054185A1/es not_active Application Discontinuation
- 2006-02-15 TW TW095105139A patent/TWI316514B/zh not_active IP Right Cessation
-
2010
- 2010-12-28 JP JP2010294310A patent/JP2011068686A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| TWI316514B (en) | 2009-11-01 |
| CA2598460A1 (en) | 2006-08-24 |
| JP2008530219A (ja) | 2008-08-07 |
| CN101203509B (zh) | 2013-05-08 |
| AR054185A1 (es) | 2007-06-06 |
| US20060276480A1 (en) | 2006-12-07 |
| TW200640902A (en) | 2006-12-01 |
| CA2598460C (en) | 2013-05-07 |
| MX2007009948A (es) | 2007-09-26 |
| EP1853583A1 (de) | 2007-11-14 |
| CN101203509A (zh) | 2008-06-18 |
| JP2011068686A (ja) | 2011-04-07 |
| EP1853583B1 (de) | 2011-09-07 |
| US7566718B2 (en) | 2009-07-28 |
| JP4688889B2 (ja) | 2011-05-25 |
| WO2006088920A1 (en) | 2006-08-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE523506T1 (de) | Amingebundene pyridyl- und phenylsubstituierte piperazin-piperidine mit cxcr3-antagonistischer aktivität | |
| IL185074A0 (en) | Pyridyl and phenyl substituted piperazine piperidines with cxcr3 antagonist activity | |
| IL185072A0 (en) | Heterocyclic substituted piperazines with cxcr3 antagonist activity | |
| ATE424383T1 (de) | Cyclische amine mit benzamidsubstituent als bace- 1-inhibitoren | |
| NO20054720L (no) | Informasjonstilgang med bruksdrevet metadatatilbakekobling | |
| ATE382611T1 (de) | Piperazin mit or-substituierter phenylgruppe und deren verwendung als glyt1-inhibitoren | |
| DK1963369T3 (da) | Il-21-antagonister | |
| ATE402921T1 (de) | Cyclische amine mit einem heterocyclischen substituenten als bace-1-inhibitoren | |
| IL185073A0 (en) | Pyrazinyl substituted piperazine-piperidines with cxcr3 antagonist activity | |
| DE602005026993D1 (de) | Klebstoffzusammensetzung auf polypropylenbasis | |
| ATE440093T1 (de) | 1-alkinyl-2-aryloxyalkylamide und ihre verwendung als fungizide | |
| DE112005000241A5 (de) | Möbel | |
| DE602005010714D1 (de) | Der p38-map-kinase | |
| ATE428710T1 (de) | Substituierte phenylaminothiazole und ihre verwendung | |
| DE602006014125D1 (de) | Banksitz mit beweglichen polstern | |
| ATE479681T1 (de) | Substituierte piperidine | |
| NO20044358D0 (no) | Tracing injected fluids | |
| FI20045329A0 (fi) | Juoksumatto | |
| DE502005006784D1 (de) | Elastisches Element | |
| DE502004008739D1 (de) | Blattfederaufhängung | |
| DE502005005513D1 (de) | Federelement | |
| ATE435208T1 (de) | Cyanopyridinpestizide | |
| DE502005002058D1 (de) | Sauerstoffhaltige annelierte phenylpiperazin- und phenyldiazepancarboxamide als dopamin d3 antagonisten | |
| DE112006002662A5 (de) | Blattfeder mit im Querschnitt konvexer Ober-und Unterseite | |
| ATE459811T1 (de) | Verbindungselement und zugehöriges werkzeugteil |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |