SG11202007524QA - Il-2 conjugates - Google Patents
Il-2 conjugatesInfo
- Publication number
- SG11202007524QA SG11202007524QA SG11202007524QA SG11202007524QA SG11202007524QA SG 11202007524Q A SG11202007524Q A SG 11202007524QA SG 11202007524Q A SG11202007524Q A SG 11202007524QA SG 11202007524Q A SG11202007524Q A SG 11202007524QA SG 11202007524Q A SG11202007524Q A SG 11202007524QA
- Authority
- SG
- Singapore
- Prior art keywords
- conjugates
- Prior art date
Links
- 101150083678 IL2 gene Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18164682 | 2018-03-28 | ||
| PCT/EP2019/057709 WO2019185705A1 (en) | 2018-03-28 | 2019-03-27 | Il-2 conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202007524QA true SG11202007524QA (en) | 2020-09-29 |
Family
ID=61832449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202007524QA SG11202007524QA (en) | 2018-03-28 | 2019-03-27 | Il-2 conjugates |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20210024602A1 (ja) |
| EP (1) | EP3773680A1 (ja) |
| JP (2) | JP7490563B2 (ja) |
| KR (1) | KR20200139730A (ja) |
| CN (1) | CN111918665A (ja) |
| AU (1) | AU2019246389B2 (ja) |
| BR (1) | BR112020019639A2 (ja) |
| CA (1) | CA3093722A1 (ja) |
| IL (2) | IL308797A (ja) |
| MA (1) | MA52662A (ja) |
| MX (1) | MX2020009857A (ja) |
| SG (1) | SG11202007524QA (ja) |
| WO (1) | WO2019185705A1 (ja) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102687649B1 (ko) | 2017-08-03 | 2024-07-26 | 신톡스, 인크. | 증식성 질환 및 감염성 질환의 치료를 위한 사이토카인 접합체 |
| CN113557033A (zh) | 2019-01-04 | 2021-10-26 | 阿森迪斯药物肿瘤股份有限公司 | 模式识别受体激动剂的缀合物 |
| MX2021007707A (es) | 2019-01-04 | 2021-08-05 | Ascendis Pharma Oncology Div A/S | Niveles de farmacos locales sostenidos para los agonistas inmunitarios innatos. |
| AU2020205029A1 (en) | 2019-01-04 | 2021-06-24 | Ascendis Pharma Oncology Division A/S | Minimization of systemic inflammation |
| WO2020254607A1 (en) | 2019-06-21 | 2020-12-24 | Ascendis Pharma Oncology Division A/S | Anti-ctla4 compounds with localized pd properties |
| US20220305136A1 (en) | 2019-06-21 | 2022-09-29 | Ascendis Pharma Oncology Division A/S | Anti-ctla4 conjugates |
| AU2020401371A1 (en) * | 2019-12-13 | 2022-07-21 | Synthekine, Inc. | IL-2 orthologs and methods of use |
| CN114437198A (zh) * | 2019-12-17 | 2022-05-06 | 北京志道生物科技有限公司 | 白介素-2衍生物 |
| BR112022021482A2 (pt) | 2020-04-22 | 2022-12-13 | Merck Sharp & Dohme Llc | Conjugados de interleucina-2 humana enviesados para o dímero beta gamac do receptor de interleucina-2 e conjugados a um polímero não peptídico solúvel em água |
| CA3178074A1 (en) | 2020-06-03 | 2021-12-09 | Nina Gunnarsson | Il-2 sequences and uses thereof |
| IL300668A (en) | 2020-08-28 | 2023-04-01 | Ascendis Pharma Oncology Div A/S | Glycosylated IL-2 proteins and their uses |
| JP2024528917A (ja) | 2021-08-13 | 2024-08-01 | サイチューン ファーマ | 癌を治療するための抗体－薬物コンジュゲートとのＩＬ－２／ＩＬ－１５Ｒβγアゴニストの組み合わせ |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| US4902502A (en) | 1989-01-23 | 1990-02-20 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| US5089261A (en) | 1989-01-23 | 1992-02-18 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| US6624142B2 (en) | 1997-12-30 | 2003-09-23 | Enzon, Inc. | Trimethyl lock based tetrapartate prodrugs |
| DZ2788A1 (fr) | 1998-05-15 | 2003-12-01 | Bayer Ag | Agonistes et antagonistes selectifs à IL-2. |
| US6689353B1 (en) | 2000-06-28 | 2004-02-10 | Bayer Pharmaceuticals Corporation | Stabilized interleukin 2 |
| JP2004534721A (ja) | 2000-10-31 | 2004-11-18 | ピーアール ファーマシューティカルズ，インク． | 生理活性分子の向上した送達のための方法及び組成物 |
| CA2456470A1 (en) * | 2001-08-13 | 2003-02-27 | University Of Southern California | Interleukin-2 mutants with reduced toxicity |
| US7332164B2 (en) | 2003-03-21 | 2008-02-19 | Enzon Pharmaceuticals, Inc. | Heterobifunctional polymeric bioconjugates |
| ES2512499T3 (es) | 2003-04-08 | 2014-10-24 | Yeda Research And Development Co., Ltd. | Fármacos pegilados reversibles |
| US7690003B2 (en) | 2003-08-29 | 2010-03-30 | Fuller Jeffrey C | System and method for increasing data throughput using thread scheduling |
| BRPI0414539B8 (pt) | 2003-09-19 | 2021-05-25 | Novo Nordisk As | composto, composição farmacêutica, e, uso de um composto |
| AU2005227263A1 (en) * | 2004-03-05 | 2005-10-06 | Novartis Vaccines And Diagnostics, Inc. | In vitro test system for predicting patient tolerability of therapeutic agents |
| CA2824093C (en) * | 2004-03-23 | 2016-10-25 | Complex Biosystems Gmbh | Polymeric prodrug with a self-immolative linker |
| US7385028B2 (en) | 2004-12-22 | 2008-06-10 | Ambrx, Inc | Derivatization of non-natural amino acids and polypeptides |
| US8450269B2 (en) | 2006-02-03 | 2013-05-28 | Prolor Biotech Ltd. | Long-acting growth hormone and methods of producing same |
| WO2008034122A2 (en) | 2006-09-15 | 2008-03-20 | Enzon Pharmaceuticals, Inc. | Hindered ester-based biodegradable linkers for oligonucleotide delivery |
| PL2173890T3 (pl) | 2007-06-21 | 2011-07-29 | Univ Muenchen Tech | Białka czynne biologicznie o zwiększonej stabilności in vivo i (lub) in vitro |
| JP2010533202A (ja) | 2007-07-11 | 2010-10-21 | エンゾン ファーマシューティカルズ，インコーポレーテッド | 多置換芳香族部分を含むポリマー性薬剤送達システム |
| US8906847B2 (en) | 2008-02-01 | 2014-12-09 | Ascendis Pharma A/S | Prodrug comprising a drug linker conjugate |
| LT3050576T (lt) * | 2008-04-29 | 2021-07-12 | Ascendis Pharma Endocrinology Division A/S | Pegiliuoti rekombinantinio žmogaus augimo hormono junginiai |
| EP2288261A4 (en) | 2008-05-23 | 2013-09-25 | Enzon Pharmaceuticals Inc | POLYMER SYSTEMS CONTAINING INTRA-CELLULAR RELEASE DISULFID LINKERS FOR THE DISPOSAL OF OLIGONUCLEOTIDES |
| CA2748314C (en) | 2009-02-03 | 2018-10-02 | Amunix Operating Inc. | Extended recombinant polypeptides and compositions comprising same |
| SI2459220T1 (sl) | 2009-07-31 | 2020-12-31 | Ascendis Pharma A/S | Biorazgradljivi v vodi netopni hidrogeli na osnovi polietilenglikola |
| EP2549276B1 (en) | 2009-08-10 | 2015-02-25 | UCL Business PLC | Reversible covalent linkage of functional molecules |
| CU23734A1 (es) * | 2009-11-27 | 2011-11-15 | Centro Inmunologia Molecular | Polipéptidos inmunomoduladores derivados de la il-2 con actividad antagonista de esta citocina útiles en la terapia del cáncer y enfermedades infecciosas crónicas |
| AU2010332958B2 (en) * | 2009-12-15 | 2014-09-18 | Ascendis Pharma Endocrinology Division A/S | Dry growth hormone composition transiently linked to a polymer carrier |
| EP2519228A4 (en) | 2009-12-31 | 2013-06-19 | Enzon Pharmaceuticals Inc | POLYMER CONJUGATES FROM AN AROMATIC AMINE WITH COMPOUNDS WITH A CLEANER UREA CONTAINER |
| US9561285B2 (en) * | 2010-01-22 | 2017-02-07 | Ascendis Pharma As | Carrier-linked carbamate prodrug linkers |
| CN103025164B (zh) | 2010-05-05 | 2017-03-08 | 普罗林科斯有限责任公司 | 从固体支撑物中药物的控制释放 |
| CN103025165B (zh) | 2010-05-05 | 2016-06-08 | 普罗林科斯有限责任公司 | 自大分子共轭物的控释 |
| PL2571510T3 (pl) | 2010-05-21 | 2019-03-29 | Xl-Protein Gmbh | Biosyntetyczne polipeptydy prolinowo/alaninowe o strukturze kłębka statystycznego i ich zastosowania |
| WO2012002047A1 (ja) | 2010-06-30 | 2012-01-05 | Ｎｅｃソフト株式会社 | 属性判定方法、属性判定装置、プログラム、記録媒体および属性判定システム |
| RS61854B1 (sr) * | 2010-11-12 | 2021-06-30 | Nektar Therapeutics | Konjugati il-2 dela i polimera |
| SG192673A1 (en) * | 2011-02-10 | 2013-09-30 | Roche Glycart Ag | Mutant interleukin-2 polypeptides |
| CA2843503C (en) | 2011-08-12 | 2020-12-22 | Ulrich Hersel | Polymeric hyperbranched carrier-linked prodrugs |
| WO2013036857A1 (en) | 2011-09-07 | 2013-03-14 | Prolynx Llc | Sulfone linkers |
| WO2014056926A1 (en) | 2012-10-11 | 2014-04-17 | Ascendis Pharma A/S | Hydrogel prodrugs |
| NZ706853A (en) | 2012-10-11 | 2018-04-27 | Ascendis Pharma Ophthalmology Div A/S | Vegf neutralizing prodrugs for the treatment of ocular conditions |
| EP2908845A1 (en) | 2012-10-17 | 2015-08-26 | Novo Nordisk Health Care AG | Fatty acid acylated amino acids for growth hormone delivery |
| WO2015042707A1 (en) * | 2013-09-24 | 2015-04-02 | Medicenna Therapeutics Pte Ltd | Interleukin-2 fusion proteins and uses thereof |
| EP3134123B1 (en) * | 2014-02-21 | 2021-02-17 | Nektar Therapeutics (India) Pvt. Ltd. | Il-2rbeta-selective agonists in combination with an anti-ctla-4 antibody or an an anti-pd-1 antibody |
| CA2955569C (en) | 2014-08-06 | 2023-02-14 | Ascendis Pharma A/S | Prodrugs comprising an aminoalkyl glycine linker |
| EP3180020B1 (en) * | 2014-08-11 | 2018-12-26 | Delinia, Inc. | Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| EP4218823A3 (en) * | 2014-11-18 | 2023-11-15 | Ascendis Pharma Endocrinology Division A/S | Novel polymeric hgh prodrugs |
| MX2018008061A (es) * | 2016-01-08 | 2018-08-23 | Ascendis Pharma Growth Disorders As | Profarmacos de peptido natriuretico tipo c (cnp) con porciones portadoras grandes. |
| RU2747316C2 (ru) * | 2016-03-01 | 2021-05-04 | Асцендис Фарма Боун Дизизис А/С | Пролекарства pth |
| EP3518982A1 (en) * | 2016-09-29 | 2019-08-07 | Ascendis Pharma Bone Diseases A/S | Incremental dose finding in controlled-release pth compounds |
| CN110891611B (zh) | 2017-03-22 | 2024-03-29 | 阿森迪斯制药公司 | 水凝胶交联透明质酸前药组合物和方法 |
| CA3093083A1 (en) * | 2018-03-28 | 2019-10-03 | Ascendis Pharma A/S | Conjugates |
-
2019
- 2019-03-27 CA CA3093722A patent/CA3093722A1/en active Pending
- 2019-03-27 CN CN201980022172.XA patent/CN111918665A/zh active Pending
- 2019-03-27 JP JP2020552812A patent/JP7490563B2/ja active Active
- 2019-03-27 US US17/042,610 patent/US20210024602A1/en active Pending
- 2019-03-27 MA MA052662A patent/MA52662A/fr unknown
- 2019-03-27 BR BR112020019639-8A patent/BR112020019639A2/pt unknown
- 2019-03-27 WO PCT/EP2019/057709 patent/WO2019185705A1/en unknown
- 2019-03-27 EP EP19713040.4A patent/EP3773680A1/en active Pending
- 2019-03-27 MX MX2020009857A patent/MX2020009857A/es unknown
- 2019-03-27 KR KR1020207031136A patent/KR20200139730A/ko not_active Application Discontinuation
- 2019-03-27 IL IL308797A patent/IL308797A/en unknown
- 2019-03-27 SG SG11202007524QA patent/SG11202007524QA/en unknown
- 2019-03-27 IL IL277572A patent/IL277572B2/en unknown
- 2019-03-27 AU AU2019246389A patent/AU2019246389B2/en active Active
-
2024
- 2024-02-22 JP JP2024025984A patent/JP2024073467A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20210024602A1 (en) | 2021-01-28 |
| AU2019246389B2 (en) | 2024-08-22 |
| JP2024073467A (ja) | 2024-05-29 |
| WO2019185705A1 (en) | 2019-10-03 |
| EP3773680A1 (en) | 2021-02-17 |
| BR112020019639A2 (pt) | 2021-01-05 |
| JP7490563B2 (ja) | 2024-05-27 |
| MX2020009857A (es) | 2021-01-08 |
| KR20200139730A (ko) | 2020-12-14 |
| MA52662A (fr) | 2021-02-17 |
| IL277572A (en) | 2020-11-30 |
| JP2021519336A (ja) | 2021-08-10 |
| CN111918665A (zh) | 2020-11-10 |
| AU2019246389A1 (en) | 2020-08-27 |
| CA3093722A1 (en) | 2019-10-03 |
| IL277572B2 (en) | 2024-05-01 |
| RU2020135268A (ru) | 2022-04-28 |
| IL277572B1 (en) | 2024-01-01 |
| IL308797A (en) | 2024-01-01 |
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