SG11202005807QA - Glycolate oxidase inhibitors for the treatment of disease - Google Patents
Glycolate oxidase inhibitors for the treatment of diseaseInfo
- Publication number
- SG11202005807QA SG11202005807QA SG11202005807QA SG11202005807QA SG11202005807QA SG 11202005807Q A SG11202005807Q A SG 11202005807QA SG 11202005807Q A SG11202005807Q A SG 11202005807QA SG 11202005807Q A SG11202005807Q A SG 11202005807QA SG 11202005807Q A SG11202005807Q A SG 11202005807QA
- Authority
- SG
- Singapore
- Prior art keywords
- disease
- treatment
- oxidase inhibitors
- glycolate oxidase
- glycolate
- Prior art date
Links
- 102100038837 2-Hydroxyacid oxidase 1 Human genes 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 108010062584 glycollate oxidase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762611995P | 2017-12-29 | 2017-12-29 | |
| US201862765313P | 2018-08-20 | 2018-08-20 | |
| PCT/US2018/067784 WO2019133770A2 (en) | 2017-12-29 | 2018-12-28 | Glycolate oxidase inhibitors for the treatment of disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202005807QA true SG11202005807QA (en) | 2020-07-29 |
Family
ID=65234672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202005807QA SG11202005807QA (en) | 2017-12-29 | 2018-12-28 | Glycolate oxidase inhibitors for the treatment of disease |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US11384055B2 (es) |
| EP (1) | EP3732167A2 (es) |
| JP (2) | JP7344878B2 (es) |
| KR (1) | KR20200112860A (es) |
| CN (6) | CN117069712A (es) |
| AR (1) | AR114070A1 (es) |
| AU (1) | AU2018395275A1 (es) |
| BR (1) | BR112020013073A2 (es) |
| CA (1) | CA3086401A1 (es) |
| CL (1) | CL2020001742A1 (es) |
| IL (3) | IL297788A (es) |
| MA (1) | MA51418A (es) |
| MX (6) | MX2020006414A (es) |
| PE (1) | PE20201500A1 (es) |
| SG (1) | SG11202005807QA (es) |
| TW (2) | TWI811282B (es) |
| WO (1) | WO2019133770A2 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117069712A (zh) * | 2017-12-29 | 2023-11-17 | 生物马林药物股份有限公司 | 用于疾病治疗的乙醇酸氧化酶抑制剂 |
| US11389456B2 (en) | 2018-02-23 | 2022-07-19 | Oxalurx, Inc. | Compounds and methods for treating oxalate-related diseases |
| SG11202012930RA (en) * | 2018-07-06 | 2021-01-28 | Orfan Biotech Inc | Triazole glycolate oxidase inhibitors |
| CA3151932A1 (en) * | 2019-08-22 | 2021-02-25 | Oxalurx, Inc. | Compounds and methods for treating oxalate-related diseases |
| KR20220097442A (ko) * | 2019-11-01 | 2022-07-07 | 기안알엑스 사이언스 인코포레이티드 | 글리콜레이트 산화효소 억제제로서의 헤테로사이클릭 카르복실레이트 화합물 |
| CN114945559A (zh) * | 2020-01-08 | 2022-08-26 | 坎特罗治疗有限公司 | 三唑乙醇酸氧化酶抑制剂的制备方法 |
| WO2022002131A1 (zh) * | 2020-06-30 | 2022-01-06 | 苏州恩华生物医药科技有限公司 | 5-((1,2,3,4-四氢异喹啉-7-基)氨基)吡啶-2(1h)-酮衍生物及其应用 |
| WO2022066933A1 (en) * | 2020-09-24 | 2022-03-31 | Chinook Therapeutics Canada, Inc. | Pentafluoro-sulfanyl -substituted triazolyl compounds and methods of use thereof |
| CN114478210A (zh) * | 2022-02-26 | 2022-05-13 | 江苏壹药新材料有限公司 | 一种7-氯萘-2-甲醛的合成方法 |
| WO2023170024A1 (en) * | 2022-03-11 | 2023-09-14 | University Of Copenhagen | Camk2 modulators and their use in medicine |
| GB202213162D0 (en) | 2022-09-08 | 2022-10-26 | Cambridge Entpr Ltd | Prodrugs |
| WO2024109917A1 (zh) * | 2022-11-25 | 2024-05-30 | 西藏海思科制药有限公司 | 一种三唑衍生物及其在医药上的应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US149223A (en) * | 1874-03-31 | Improvement in axles for vehicles | ||
| DE2860722D1 (en) * | 1977-11-10 | 1981-08-27 | Beecham Group Plc | Triazolo-quinoline derivatives, processes for their preparation and their pharmaceutical use |
| DE2757929A1 (de) * | 1977-12-24 | 1979-07-05 | Boehringer Sohn Ingelheim | Neue pyrido-eckige klammer auf 1,2-a eckige klammer zu -v-triazolo- eckige klammer auf 4,5-d eckige klammer zu pyrimidinone, deren salze und verfahren zu deren herstellung |
| JPS5519292A (en) * | 1978-07-24 | 1980-02-09 | Beecham Group Ltd | Benzopyranotriazoles*their manufacture and medical composition containing them |
| DE2966444D1 (en) * | 1978-07-24 | 1984-01-05 | Beecham Group Plc | Benzopyranotriazoles, preparation of these compounds and pharmaceutical composition containing them |
| US4431660A (en) * | 1979-06-11 | 1984-02-14 | Merck & Co., Inc. | (4'-Biphenylyloxy and-thio-oxy)-3-hydroxy-3-pyrroline-2,5-diones and a method of treating calcium oxalate renal lithiasis therewith |
| US4349561A (en) * | 1979-11-05 | 1982-09-14 | Merck & Co., Inc. | 4-Substituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase |
| DE3169772D1 (de) * | 1980-01-19 | 1985-05-15 | Beecham Group Plc | Substituted benzopyranotriazoles |
| IL61897A (en) * | 1980-01-19 | 1984-01-31 | Beecham Group Ltd | Benzopyrano(2,3-d)-v-triazoles,their production and pharmaceutical compositions containing them |
| NZ199139A (en) * | 1980-12-13 | 1985-01-31 | Beecham Group Ltd | Benz(phenoxyalkoxy)-9-oxo-1h,9h-benzopyrano-(2,3-d)-v-triazoles |
| US4428956A (en) * | 1980-12-29 | 1984-01-31 | Merck & Co., Inc. | 4-Hydroxy-5-substituted-3-(2H)-isothiazolone-1,1-dioxide derivatives useful in treating urinary tract calcium oxalate lithiasis |
| US4431652A (en) * | 1980-12-29 | 1984-02-14 | Merck & Co., Inc. | 4-Hydroxy-5-substituted-3(2H)-isothiazolone-1,1-dioxide derivatives useful in treating urinary tract calcium oxalate lithiasis |
| JPS57158788A (en) * | 1981-03-03 | 1982-09-30 | Beecham Group Ltd | Novel compound, manufacture and medicinal composition containing same |
| WO1993017681A1 (en) * | 1992-03-02 | 1993-09-16 | Abbott Laboratories | Angiotensin ii receptor antagonists |
| CA2445568A1 (en) | 2001-04-27 | 2002-11-07 | Vertex Pharmaceuticals Incorporated | Triazole-derived kinase inhibitors and uses thereof |
| JP4075357B2 (ja) * | 2001-11-15 | 2008-04-16 | 宇部興産株式会社 | ４，５−ジ置換−１，２，３−トリアゾール及びその製造法 |
| JP2006511554A (ja) * | 2002-12-13 | 2006-04-06 | スミスクライン ビーチャム コーポレーション | Ｃｃｒ５アンタゴニストとしてのピペリジン誘導体 |
| GB0329214D0 (en) * | 2003-12-17 | 2004-01-21 | Glaxo Group Ltd | Novel compounds |
| GB0603891D0 (en) | 2006-02-27 | 2006-04-05 | Syngenta Ltd | Novel herbicides |
| WO2011140296A1 (en) | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals | Triazoles as inhibitors of fatty acid synthase |
| BR112014030685A2 (pt) | 2012-06-20 | 2017-06-27 | Hoffmann La Roche | compostos de n-alquiltriazol como antagonistas de lpar |
| KR101537296B1 (ko) * | 2012-10-26 | 2015-07-17 | 삼성전자 주식회사 | 반도체 나노결정 및 그 제조방법 |
| TW201418242A (zh) * | 2012-10-26 | 2014-05-16 | Du Pont | 作為除草劑之經取代的三唑 |
| JP2017095366A (ja) | 2015-11-18 | 2017-06-01 | 持田製薬株式会社 | 新規ビアリールアミド誘導体 |
| EP3386949A4 (en) | 2015-12-07 | 2019-11-20 | Wake Forest University Health Sciences | GLYCOLATE OXIDASE INHIBITORS AND METHODS OF USE FOR THE TREATMENT OF RENAL CALCULATIONS |
| CN105541796B (zh) * | 2016-03-03 | 2017-11-14 | 武汉工程大学 | 一种nh‑1,2,3‑三唑联吡啶化合物的合成方法 |
| CN105669569B (zh) * | 2016-03-03 | 2017-12-12 | 武汉工程大学 | 一种nh‑1,2,3‑三唑化合物的合成方法 |
| CN117069712A (zh) * | 2017-12-29 | 2023-11-17 | 生物马林药物股份有限公司 | 用于疾病治疗的乙醇酸氧化酶抑制剂 |
| US20230088214A1 (en) * | 2019-06-19 | 2023-03-23 | Biomarin Pharmaceutical Inc. | Glycolate oxidase inhibitors for the treatment of disease |
-
2018
- 2018-12-28 CN CN202310936523.6A patent/CN117069712A/zh active Pending
- 2018-12-28 CA CA3086401A patent/CA3086401A1/en active Pending
- 2018-12-28 KR KR1020207022038A patent/KR20200112860A/ko not_active Application Discontinuation
- 2018-12-28 CN CN202310936618.8A patent/CN117126151A/zh active Pending
- 2018-12-28 PE PE2020000860A patent/PE20201500A1/es unknown
- 2018-12-28 CN CN201880090533.XA patent/CN111788187A/zh active Pending
- 2018-12-28 AU AU2018395275A patent/AU2018395275A1/en active Pending
- 2018-12-28 CN CN202310936652.5A patent/CN117069713A/zh active Pending
- 2018-12-28 SG SG11202005807QA patent/SG11202005807QA/en unknown
- 2018-12-28 MA MA051418A patent/MA51418A/fr unknown
- 2018-12-28 IL IL297788A patent/IL297788A/en unknown
- 2018-12-28 US US16/958,511 patent/US11384055B2/en active Active
- 2018-12-28 TW TW107147699A patent/TWI811282B/zh active
- 2018-12-28 EP EP18840000.6A patent/EP3732167A2/en active Pending
- 2018-12-28 IL IL297802A patent/IL297802A/en unknown
- 2018-12-28 BR BR112020013073-7A patent/BR112020013073A2/pt unknown
- 2018-12-28 CN CN202310936604.6A patent/CN117024420A/zh active Pending
- 2018-12-28 CN CN202310936668.6A patent/CN117126152A/zh active Pending
- 2018-12-28 WO PCT/US2018/067784 patent/WO2019133770A2/en active Application Filing
- 2018-12-28 TW TW112107812A patent/TW202340155A/zh unknown
- 2018-12-28 AR ARP180103914A patent/AR114070A1/es unknown
- 2018-12-28 MX MX2020006414A patent/MX2020006414A/es unknown
- 2018-12-28 JP JP2020535997A patent/JP7344878B2/ja active Active
-
2020
- 2020-06-18 IL IL275496A patent/IL275496A/en unknown
- 2020-06-25 CL CL2020001742A patent/CL2020001742A1/es unknown
- 2020-07-13 MX MX2022016427A patent/MX2022016427A/es unknown
- 2020-07-13 MX MX2022016422A patent/MX2022016422A/es unknown
- 2020-07-13 MX MX2022016415A patent/MX2022016415A/es unknown
- 2020-07-13 MX MX2022016463A patent/MX2022016463A/es unknown
- 2020-07-13 MX MX2022016434A patent/MX2022016434A/es unknown
-
2022
- 2022-05-23 US US17/751,136 patent/US20230079913A1/en not_active Abandoned
- 2022-05-23 US US17/751,144 patent/US20230089374A1/en not_active Abandoned
-
2023
- 2023-08-04 JP JP2023127874A patent/JP2023159181A/ja active Pending
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