MX2022016415A - Inhibidores de glicolato oxidasa para el tratamiento de enfermedades. - Google Patents

Inhibidores de glicolato oxidasa para el tratamiento de enfermedades.

Info

Publication number
MX2022016415A
MX2022016415A MX2022016415A MX2022016415A MX2022016415A MX 2022016415 A MX2022016415 A MX 2022016415A MX 2022016415 A MX2022016415 A MX 2022016415A MX 2022016415 A MX2022016415 A MX 2022016415A MX 2022016415 A MX2022016415 A MX 2022016415A
Authority
MX
Mexico
Prior art keywords
compounds
glycolate oxidase
disease
treatment
oxidase inhibitors
Prior art date
Application number
MX2022016415A
Other languages
English (en)
Inventor
Bing Wang
Qi Chao
Original Assignee
Biomarin Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomarin Pharm Inc filed Critical Biomarin Pharm Inc
Publication of MX2022016415A publication Critical patent/MX2022016415A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

En este documento se describen compuestos, métodos para fabricar dichos compuestos, composiciones farmacéuticas y medicamentos que contienen dichos compuestos, y métodos para usar dichos compuestos para tratar o prevenir enfermedades o trastornos asociados con la enzima glicolato oxidasa (GO). Dichas enfermedades o trastornos incluyen, por ejemplo, trastornos del metabolismo del glioxilato, incluida la hiperoxaluria primaria, que están asociados con la producción de cantidades excesivas de oxalato.
MX2022016415A 2017-12-29 2020-07-13 Inhibidores de glicolato oxidasa para el tratamiento de enfermedades. MX2022016415A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762611995P 2017-12-29 2017-12-29
US201862765313P 2018-08-20 2018-08-20

Publications (1)

Publication Number Publication Date
MX2022016415A true MX2022016415A (es) 2023-01-30

Family

ID=65234672

Family Applications (6)

Application Number Title Priority Date Filing Date
MX2020006414A MX2020006414A (es) 2017-12-29 2018-12-28 Inhibidores de glicolato oxidasa para el tratamiento de enfermedades.
MX2022016427A MX2022016427A (es) 2017-12-29 2020-07-13 Inhibidores de glicolato oxidasa para el tratamiento de enfermedades.
MX2022016422A MX2022016422A (es) 2017-12-29 2020-07-13 Inhibidores de glicolato oxidasa para el tratamiento de enfermedades.
MX2022016415A MX2022016415A (es) 2017-12-29 2020-07-13 Inhibidores de glicolato oxidasa para el tratamiento de enfermedades.
MX2022016463A MX2022016463A (es) 2017-12-29 2020-07-13 Inhibidores de glicolato oxidasa para el tratamiento de enfermedades.
MX2022016434A MX2022016434A (es) 2017-12-29 2020-07-13 Inhibidores de glicolato oxidasa para el tratamiento de enfermedades.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
MX2020006414A MX2020006414A (es) 2017-12-29 2018-12-28 Inhibidores de glicolato oxidasa para el tratamiento de enfermedades.
MX2022016427A MX2022016427A (es) 2017-12-29 2020-07-13 Inhibidores de glicolato oxidasa para el tratamiento de enfermedades.
MX2022016422A MX2022016422A (es) 2017-12-29 2020-07-13 Inhibidores de glicolato oxidasa para el tratamiento de enfermedades.

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2022016463A MX2022016463A (es) 2017-12-29 2020-07-13 Inhibidores de glicolato oxidasa para el tratamiento de enfermedades.
MX2022016434A MX2022016434A (es) 2017-12-29 2020-07-13 Inhibidores de glicolato oxidasa para el tratamiento de enfermedades.

Country Status (17)

Country Link
US (3) US11384055B2 (es)
EP (1) EP3732167A2 (es)
JP (2) JP7344878B2 (es)
KR (1) KR20200112860A (es)
CN (6) CN117069712A (es)
AR (1) AR114070A1 (es)
AU (1) AU2018395275A1 (es)
BR (1) BR112020013073A2 (es)
CA (1) CA3086401A1 (es)
CL (1) CL2020001742A1 (es)
IL (3) IL297788A (es)
MA (1) MA51418A (es)
MX (6) MX2020006414A (es)
PE (1) PE20201500A1 (es)
SG (1) SG11202005807QA (es)
TW (2) TWI811282B (es)
WO (1) WO2019133770A2 (es)

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Publication number Publication date
JP7344878B2 (ja) 2023-09-14
US20210171474A1 (en) 2021-06-10
CL2020001742A1 (es) 2021-01-29
MX2022016427A (es) 2023-01-30
AR114070A1 (es) 2020-07-15
CA3086401A1 (en) 2019-07-04
US20230079913A1 (en) 2023-03-16
IL297802A (en) 2022-12-01
US20230089374A1 (en) 2023-03-23
US11384055B2 (en) 2022-07-12
CN117126151A (zh) 2023-11-28
IL297788A (en) 2022-12-01
TW201930272A (zh) 2019-08-01
JP2023159181A (ja) 2023-10-31
TW202340155A (zh) 2023-10-16
BR112020013073A2 (pt) 2020-12-01
KR20200112860A (ko) 2020-10-05
EP3732167A2 (en) 2020-11-04
MA51418A (fr) 2020-11-04
CN117024420A (zh) 2023-11-10
JP2021509401A (ja) 2021-03-25
TWI811282B (zh) 2023-08-11
PE20201500A1 (es) 2020-12-29
MX2022016422A (es) 2023-01-30
CN117069712A (zh) 2023-11-17
WO2019133770A2 (en) 2019-07-04
CN111788187A (zh) 2020-10-16
MX2022016434A (es) 2023-01-30
SG11202005807QA (en) 2020-07-29
RU2020120974A (ru) 2022-01-31
WO2019133770A3 (en) 2019-08-15
CN117126152A (zh) 2023-11-28
IL275496A (en) 2020-08-31
CN117069713A (zh) 2023-11-17
AU2018395275A1 (en) 2020-07-16
MX2022016463A (es) 2023-02-01
RU2020120974A3 (es) 2022-01-31
MX2020006414A (es) 2020-09-17

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