SG11202005791QA - DIARYL SUBSTITUTED 6,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS - Google Patents

DIARYL SUBSTITUTED 6,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS

Info

Publication number
SG11202005791QA
SG11202005791QA SG11202005791QA SG11202005791QA SG11202005791QA SG 11202005791Q A SG11202005791Q A SG 11202005791QA SG 11202005791Q A SG11202005791Q A SG 11202005791QA SG 11202005791Q A SG11202005791Q A SG 11202005791QA SG 11202005791Q A SG11202005791Q A SG 11202005791QA
Authority
SG
Singapore
Prior art keywords
fused ring
ring compounds
diaryl substituted
c5ar inhibitors
c5ar
Prior art date
Application number
SG11202005791QA
Other languages
English (en)
Inventor
Pingchen Fan
Christopher W Lange
Viengkham Malathong
Venkat Reddy Mali
Sreenivas Punna
Hiroko Tanaka
Yibin Zeng
Penglie Zhang
Original Assignee
Chemocentryx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemocentryx Inc filed Critical Chemocentryx Inc
Publication of SG11202005791QA publication Critical patent/SG11202005791QA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SG11202005791QA 2017-12-22 2018-12-20 DIARYL SUBSTITUTED 6,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS SG11202005791QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762609834P 2017-12-22 2017-12-22
PCT/US2018/066667 WO2019126424A1 (fr) 2017-12-22 2018-12-20 Composés cycliques condensés 6,5 à substitution diaryle, utilisés en tant qu'inhibiteurs du c5ar

Publications (1)

Publication Number Publication Date
SG11202005791QA true SG11202005791QA (en) 2020-07-29

Family

ID=66949183

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202005791QA SG11202005791QA (en) 2017-12-22 2018-12-20 DIARYL SUBSTITUTED 6,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS

Country Status (15)

Country Link
US (3) US10828285B2 (fr)
EP (1) EP3728203B1 (fr)
JP (1) JP7254082B2 (fr)
KR (1) KR20200109316A (fr)
CN (1) CN111788185A (fr)
AU (1) AU2018388655C1 (fr)
BR (1) BR112020012270A2 (fr)
CA (1) CA3085946A1 (fr)
ES (1) ES2980175T3 (fr)
IL (1) IL275500B2 (fr)
MA (1) MA51331A (fr)
MX (1) MX2020006459A (fr)
SG (1) SG11202005791QA (fr)
TW (1) TWI789470B (fr)
WO (1) WO2019126424A1 (fr)

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CN111032658B (zh) 2017-05-31 2022-12-20 凯莫森特里克斯股份有限公司 作为C5a抑制剂的5-5稠合环类
CN110997674B (zh) 2017-05-31 2022-12-20 凯莫森特里克斯股份有限公司 作为C5a抑制剂的6-5稠合环类
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CN111788184B (zh) * 2017-12-22 2023-12-22 凯莫森特里克斯股份有限公司 用作C5aR抑制剂的二芳基取代的5,5-稠合环化合物
CN111788185A (zh) 2017-12-22 2020-10-16 凯莫森特里克斯股份有限公司 作为C5a抑制剂的二芳基取代的6,5稠合环化合物
KR20200139751A (ko) * 2018-04-02 2020-12-14 케모센트릭스, 인크. 융합된-바이사이클릭 C5aR 길항제의 프로드러그
EP3886858B1 (fr) 2019-12-19 2022-05-11 Active Biotech AB Composés pour le traitement de maladies des yeux associées à une vascularisation excessive
DK4097099T3 (da) 2020-02-07 2024-07-15 Gasherbrum Bio Inc Heterocyckliske GLP1-agonister
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WO2022093971A1 (fr) 2020-10-28 2022-05-05 Chemocentryx, Inc. Méthodes de traitement de l'hidradénite suppurée
CN113143920B (zh) * 2021-05-25 2023-04-25 湖北工业大学 Ponesimod化合物在制备抗EV71病毒药物中的应用
CN116983264B (zh) * 2023-09-28 2023-12-22 中国农业科学院农产品加工研究所 一种二氢大麻二酚二苯甲酸酯的包埋体系及其制备方法和应用

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CN111788185A (zh) 2017-12-22 2020-10-16 凯莫森特里克斯股份有限公司 作为C5a抑制剂的二芳基取代的6,5稠合环化合物
KR20200139751A (ko) * 2018-04-02 2020-12-14 케모센트릭스, 인크. 융합된-바이사이클릭 C5aR 길항제의 프로드러그

Also Published As

Publication number Publication date
AU2018388655A1 (en) 2020-07-09
EP3728203A1 (fr) 2020-10-28
CN111788185A (zh) 2020-10-16
CA3085946A1 (fr) 2019-06-27
TW201927782A (zh) 2019-07-16
EP3728203B1 (fr) 2024-03-13
JP2021506893A (ja) 2021-02-22
US20190192491A1 (en) 2019-06-27
KR20200109316A (ko) 2020-09-22
EP3728203A4 (fr) 2021-06-16
MA51331A (fr) 2020-10-28
US11478460B2 (en) 2022-10-25
MX2020006459A (es) 2020-11-06
BR112020012270A2 (pt) 2020-11-24
AU2018388655B2 (en) 2022-11-24
WO2019126424A1 (fr) 2019-06-27
JP7254082B2 (ja) 2023-04-07
IL275500B1 (en) 2023-01-01
IL275500A (en) 2020-08-31
TWI789470B (zh) 2023-01-11
US10828285B2 (en) 2020-11-10
US20210106568A1 (en) 2021-04-15
AU2018388655C1 (en) 2023-03-23
IL275500B2 (en) 2023-05-01
US20230115912A1 (en) 2023-04-13
ES2980175T3 (es) 2024-09-30
NZ765589A (en) 2024-04-26
RU2020124093A (ru) 2022-01-25

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