SG11202005203UA - Artificial antigen presenting cells and methods of use - Google Patents

Artificial antigen presenting cells and methods of use

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Publication number
SG11202005203UA
SG11202005203UA SG11202005203UA SG11202005203UA SG11202005203UA SG 11202005203U A SG11202005203U A SG 11202005203UA SG 11202005203U A SG11202005203U A SG 11202005203UA SG 11202005203U A SG11202005203U A SG 11202005203UA SG 11202005203U A SG11202005203U A SG 11202005203UA
Authority
SG
Singapore
Prior art keywords
methods
presenting cells
antigen presenting
artificial antigen
artificial
Prior art date
Application number
SG11202005203UA
Other languages
English (en)
Inventor
Thomas Wickham
Tiffany Chen
Sivan Elloul
Regina Salvat
Nathan Dowden
Original Assignee
Rubius Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rubius Therapeutics Inc filed Critical Rubius Therapeutics Inc
Publication of SG11202005203UA publication Critical patent/SG11202005203UA/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/18—Erythrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/19—Platelets; Megacaryocytes
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    • A61K39/0011—Cancer antigens
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0641—Erythrocytes
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2239/57—Skin; melanoma
    • C—CHEMISTRY; METALLURGY
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
    • C12N2710/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
SG11202005203UA 2017-12-23 2018-12-22 Artificial antigen presenting cells and methods of use SG11202005203UA (en)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US201762610149P 2017-12-23 2017-12-23
US201862650250P 2018-03-29 2018-03-29
US201862665445P 2018-05-01 2018-05-01
US201862680544P 2018-06-04 2018-06-04
US201862686656P 2018-06-18 2018-06-18
US201862688324P 2018-06-21 2018-06-21
US201862692623P 2018-06-29 2018-06-29
US201862745253P 2018-10-12 2018-10-12
US201862757741P 2018-11-08 2018-11-08
PCT/US2018/067424 WO2019126818A1 (fr) 2017-12-23 2018-12-22 Cellules artificielles présentatrices d'antigènes et méthodes d'utilisation

Publications (1)

Publication Number Publication Date
SG11202005203UA true SG11202005203UA (en) 2020-07-29

Family

ID=65409464

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202005203UA SG11202005203UA (en) 2017-12-23 2018-12-22 Artificial antigen presenting cells and methods of use

Country Status (12)

Country Link
US (1) US20190290686A1 (fr)
EP (1) EP3727434A1 (fr)
JP (2) JP7158483B2 (fr)
KR (1) KR20200104887A (fr)
CN (1) CN111712254A (fr)
AU (1) AU2018389346B2 (fr)
CA (1) CA3084674A1 (fr)
IL (1) IL275433A (fr)
MX (1) MX2020006688A (fr)
RU (2) RU2763798C1 (fr)
SG (1) SG11202005203UA (fr)
WO (1) WO2019126818A1 (fr)

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EP3927354A1 (fr) 2019-02-20 2021-12-29 Rubius Therapeutics, Inc. Cellules érythroïdes modifiées comprenant des polypeptides de présentation d'antigène chargeables et procédés d'utilisation
WO2020219909A1 (fr) 2019-04-26 2020-10-29 Rubius Therapeutics, Inc. Compositions tamponnées comprenant des cellules érythroïdes énucléées
CN112237628A (zh) * 2019-07-17 2021-01-19 四川大学华西医院 靶向EBV的LMP2-mRNA纳米疫苗
KR20220052943A (ko) * 2019-07-30 2022-04-28 유니버시티 헬스 네트워크 Mhc 클래스 ii 분자 및 이의 사용 방법
WO2021026522A2 (fr) * 2019-08-08 2021-02-11 Cedars-Sinai Medical Center Procédé de génération de lymphocytes t activés pour une thérapie anticancéreuse
WO2021073613A1 (fr) * 2019-10-18 2021-04-22 Westlake Therapeutics (Hangzhou) Co. Limited Globules rouges génétiquement modifiés présentant un néo-antigène du cancer spécifique avec un cmh artificiel
EP4056197A4 (fr) * 2019-11-07 2023-09-06 Shenzhen Gino Biotechnology Co., Ltd. Séquence polypeptidique spécifique à une tumeur et utilisation correspondante
WO2021113297A1 (fr) * 2019-12-02 2021-06-10 Regeneron Pharmaceuticals, Inc. Constructions protéiques de peptide-cmh ii et leurs utilisations
JP2023512712A (ja) * 2020-02-07 2023-03-28 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 除核細胞をバイオ操作するための方法および使用
CN111450236B (zh) * 2020-02-25 2023-04-07 西北大学 一种用于阻断冠状病毒感染的制剂
KR20220147107A (ko) * 2020-02-28 2022-11-02 도쿠리츠다이가쿠호징 가나자와다이가쿠 면역 제어법, 면역 제어용 핵산 조성물 및 그의 용도
EP4267725A1 (fr) * 2020-12-22 2023-11-01 National University of Singapore Cellules présentatrice d'antigène artificielles
CN115068503B (zh) * 2021-03-16 2024-03-12 上海交通大学医学院附属仁济医院 具有多重免疫调控功能的仿生纳米颗粒及其制备与应用
CA3218757A1 (fr) * 2021-05-10 2022-11-17 The Regents Of The University Of Colorado, A Body Corporate Methodes de modification de l'antigene leucocytaire humain et compositions pour le traitement de l'auto-immunite
TW202317179A (zh) * 2021-06-03 2023-05-01 美商盧比亞斯治療公司 在個體中治療ｈｐｖ１６－陽性或ｈｐｖ１６－相關的癌症之方法
GB202108585D0 (en) 2021-06-16 2021-07-28 Rockend Ltd Methods and compositions
CN113528436B (zh) * 2021-08-04 2023-01-17 苏州大学 基于淋巴细胞的同源靶向性人工抗原呈递细胞及其构建和应用
KR20240052028A (ko) * 2021-09-01 2024-04-22 도쿠리츠다이가쿠호징 가나자와다이가쿠 면역 제어법, 면역 제어용 핵산 조성물 및 그 용도
CN114113639B (zh) * 2022-01-29 2022-04-19 北京大有天弘科技有限公司 一种血型抗体检测方法及其应用
CN114931633A (zh) * 2022-06-10 2022-08-23 苏州尔生生物医药有限公司 一种来源于预激活抗原提呈细胞的自身免疫疾病疫苗的制备方法及其应用
WO2024092126A1 (fr) * 2022-10-27 2024-05-02 Cargo Therapeutics, Inc. Compositions et méthodes pour immunothérapies améliorées
WO2024096886A1 (fr) * 2022-11-04 2024-05-10 George Mbella Ekema Procédé de prévention et de traitement d'une maladie avec des microbes transformés
CN116496417B (zh) * 2023-06-27 2023-10-10 北京市肿瘤防治研究所 含有膜型il7的融合蛋白及t细胞

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US20190290686A1 (en) 2019-09-26
IL275433A (en) 2020-08-31
JP2021506304A (ja) 2021-02-22
MX2020006688A (es) 2020-09-03
EP3727434A1 (fr) 2020-10-28
WO2019126818A9 (fr) 2020-07-16
CA3084674A1 (fr) 2019-06-27
AU2018389346A1 (en) 2020-07-02
RU2763798C1 (ru) 2022-01-11
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KR20200104887A (ko) 2020-09-04
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