SG11202002460QA - Selective p2x3 modulators - Google Patents
Selective p2x3 modulatorsInfo
- Publication number
- SG11202002460QA SG11202002460QA SG11202002460QA SG11202002460QA SG11202002460QA SG 11202002460Q A SG11202002460Q A SG 11202002460QA SG 11202002460Q A SG11202002460Q A SG 11202002460QA SG 11202002460Q A SG11202002460Q A SG 11202002460QA SG 11202002460Q A SG11202002460Q A SG 11202002460QA
- Authority
- SG
- Singapore
- Prior art keywords
- modulators
- selective
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Amplifiers (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Oscillators With Electromechanical Resonators (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762560077P | 2017-09-18 | 2017-09-18 | |
| US15/936,316 US10111883B1 (en) | 2017-09-18 | 2018-03-26 | Selective P2X3 modulators |
| PCT/IB2018/001513 WO2019064079A2 (en) | 2017-09-18 | 2018-09-14 | SELECTIVE MODULATORS OF P2X3 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202002460QA true SG11202002460QA (en) | 2020-04-29 |
Family
ID=63894683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202002460QA SG11202002460QA (en) | 2017-09-18 | 2018-09-14 | Selective p2x3 modulators |
Country Status (12)
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2021003686A (es) * | 2018-10-05 | 2021-06-04 | Shionogi & Co | Medicamento para el tratamiento de la tos cronica. |
| KR20210074315A (ko) * | 2018-10-10 | 2021-06-21 | 벨루스 헬스 코프 인크. | P2x3 길항제를 사용한 소양증의 치료 |
| SI3880678T1 (sl) * | 2018-11-13 | 2025-08-29 | GlaxoSmithkline Intellectual Property (No.3) Limited, GSK Medicines Research Centre | Kristalne oblike p2x3 modulatorja metil (s)-2-((2-(2,6-difluoro-4-(metilkarbamoil)fenil)-7-metilimidazo[1,2-a]piridin-3-il)metil)morfolin-4-karboksilata |
| KR102797127B1 (ko) * | 2018-12-29 | 2025-04-21 | 우한 크리에이터나 사이언스 앤드 테크놀로지 컴퍼니, 리미티드 | 헤테로고리계 화합물, 중간체, 이의 제조 방법 및 용도 |
| CN113727716A (zh) * | 2019-02-25 | 2021-11-30 | 贝卢斯医疗咳嗽病公司 | 采用p2x3调节剂的治疗 |
| CN112409331B (zh) * | 2019-08-21 | 2024-02-20 | 上海翰森生物医药科技有限公司 | 杂环类衍生物抑制剂、其制备方法和应用 |
| IL295393A (en) * | 2020-02-14 | 2022-10-01 | Bellus Health Cough Inc | P2x3 modulators |
| KR20230017781A (ko) | 2020-04-27 | 2023-02-06 | 트위스트 바이오사이언스 코포레이션 | 코로나바이러스에 대한 변이체 핵산 라이브러리 |
| CN113754654A (zh) * | 2020-06-05 | 2021-12-07 | 武汉人福创新药物研发中心有限公司 | 咪唑并吡啶类化合物及其用途 |
| CN114085220B (zh) * | 2020-06-22 | 2023-06-16 | 上海海雁医药科技有限公司 | 取代的吗啉-4-羧酸酯衍生物、其组合物及医药上的用途 |
| AU2021302056B2 (en) * | 2020-06-29 | 2023-12-14 | Wuhan Ll Science And Technology Development Co., Ltd. | Crystalline form of heterocyclic compound, preparation method therefor and application thereof |
| US20230218661A1 (en) * | 2022-01-10 | 2023-07-13 | Sensory Cloud, Inc. | Isotonic or hypertonic salt-based compositions, treatments, devices, and articles for delivery of same to larynx |
| CN113912601B (zh) * | 2020-07-10 | 2023-06-06 | 上海拓界生物医药科技有限公司 | 一类新的咪唑并[1,2-a]吡啶类衍生物、其制备方法及医药用途 |
| TW202214619A (zh) * | 2020-08-13 | 2022-04-16 | 大陸商上海拓界生物醫藥科技有限公司 | 苯并咪唑類衍生物、其製備方法及醫藥用途 |
| WO2022161462A1 (zh) * | 2021-01-29 | 2022-08-04 | 上海海雁医药科技有限公司 | 吗啉衍生物及其药物组合物和用途 |
| WO2022258059A1 (zh) * | 2021-06-10 | 2022-12-15 | 武汉朗来科技发展有限公司 | 一种药物组合物、制剂及其制备方法和应用 |
| CN115043836B (zh) * | 2021-08-20 | 2023-07-18 | 苏州璞正医药有限公司 | 一种咪唑并吡啶衍生物的p2x3受体选择性调节剂及其药物用途 |
| WO2024194352A1 (en) | 2023-03-23 | 2024-09-26 | Glaxosmithkline Intellectual Property (No.3) Limited | Deuterated p2x3 modulators |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2501697B1 (en) * | 2009-11-18 | 2013-10-23 | Neomed Institute | Benzoimidazole compounds and uses thereof |
| JP2013522324A (ja) * | 2010-03-19 | 2013-06-13 | ユニバーシティー オブ マイアミ | 膵臓β細胞におけるインスリン分泌を高めるためのＰ２Ｘプリン受容体アゴニストの使用 |
| EP3998267A1 (en) * | 2013-01-31 | 2022-05-18 | Bellus Health Cough Inc. | Imidazopyridine compounds and uses thereof |
| UA118851C2 (uk) * | 2013-08-23 | 2019-03-25 | Ефферент Фармасьютікалз Інк. | Способи застосування діамінопіримідинових модуляторів р2х3 та р2х2/3 рецепторів для лікування гострого та підгострого кашлю, позиву до кашлю та хронічного кашлю при респіраторних хворобах |
| HUE055290T2 (hu) * | 2014-12-09 | 2021-11-29 | Bayer Ag | 1,3-Tiazol-2-il-csoporttal szubsztituált benzamid-származékok |
| AU2016330466B2 (en) * | 2015-09-29 | 2021-01-28 | Afferent Pharmaceuticals, Inc. | Diaminopyrimidine P2x3 and P2x2/3 receptor modulators for use in the treatment of cough |
| US9907795B2 (en) * | 2016-01-08 | 2018-03-06 | Nerre Therapeutics Limited | Method of treatment of chronic cough administering orvepitant in combination with other therapeutic agents |
| CA3037748A1 (en) * | 2016-09-30 | 2018-04-05 | Asana Biosciences, Llc | P2x3 and/or p2x2/3 compounds and methods |
-
2018
- 2018-03-26 US US15/936,316 patent/US10111883B1/en active Active
- 2018-09-14 CN CN201880073147.XA patent/CN111601601A/zh active Pending
- 2018-09-14 IL IL303257A patent/IL303257A/en unknown
- 2018-09-14 IL IL273348A patent/IL273348B2/en unknown
- 2018-09-14 JP JP2020537064A patent/JP7242681B2/ja active Active
- 2018-09-14 MX MX2020002968A patent/MX2020002968A/es unknown
- 2018-09-14 AU AU2018342751A patent/AU2018342751B2/en active Active
- 2018-09-14 KR KR1020207010982A patent/KR102713354B1/ko active Active
- 2018-09-14 EP EP23219770.7A patent/EP4331669A3/en active Pending
- 2018-09-14 WO PCT/IB2018/001513 patent/WO2019064079A2/en not_active Application Discontinuation
- 2018-09-14 ES ES18860273T patent/ES2969868T3/es active Active
- 2018-09-14 US US16/647,821 patent/US20200230148A1/en not_active Abandoned
- 2018-09-14 CA CA3076150A patent/CA3076150C/en active Active
- 2018-09-14 EP EP18860273.4A patent/EP3684368B8/en active Active
- 2018-09-14 SG SG11202002460QA patent/SG11202002460QA/en unknown
-
2020
- 2020-11-17 US US16/950,742 patent/US20210069201A1/en not_active Abandoned
-
2021
- 2021-06-29 US US17/362,063 patent/US20210322432A1/en not_active Abandoned
-
2022
- 2022-02-11 US US17/669,806 patent/US20220160724A1/en not_active Abandoned
- 2022-09-14 US US17/932,200 patent/US20230248736A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20200092938A (ko) | 2020-08-04 |
| EP3684368B1 (en) | 2024-01-03 |
| EP4331669A3 (en) | 2024-05-01 |
| MX2020002968A (es) | 2020-08-17 |
| EP3684368B8 (en) | 2024-02-14 |
| US20220160724A1 (en) | 2022-05-26 |
| CA3076150C (en) | 2024-01-02 |
| CN111601601A (zh) | 2020-08-28 |
| EP3684368A2 (en) | 2020-07-29 |
| IL273348B2 (en) | 2023-11-01 |
| AU2018342751B2 (en) | 2023-06-15 |
| JP7242681B2 (ja) | 2023-03-20 |
| WO2019064079A3 (en) | 2019-05-16 |
| US10111883B1 (en) | 2018-10-30 |
| US20200230148A1 (en) | 2020-07-23 |
| EP4331669A2 (en) | 2024-03-06 |
| AU2018342751A1 (en) | 2020-04-23 |
| US20210322432A1 (en) | 2021-10-21 |
| US20230248736A1 (en) | 2023-08-10 |
| KR102713354B1 (ko) | 2024-10-02 |
| ES2969868T3 (es) | 2024-05-23 |
| CA3076150A1 (en) | 2019-04-04 |
| US20210069201A1 (en) | 2021-03-11 |
| IL303257A (en) | 2023-07-01 |
| IL273348A (en) | 2020-05-31 |
| JP2020534355A (ja) | 2020-11-26 |
| IL273348B1 (en) | 2023-07-01 |
| WO2019064079A2 (en) | 2019-04-04 |
| EP3684368A4 (en) | 2021-05-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL273348A (en) | Selective P2X3 modulators | |
| DK3506981T3 (en) | Et transportabelt automatiseret eksternt defibrillator-apparat til engangsbrug | |
| DK3410992T3 (en) | Tilbagetrækkeligt udløb til stomipose | |
| ZA201707966B (en) | Ccr2 modulators | |
| DK3770053T3 (en) | Batterilås til en elcykel | |
| DK3688240T3 (en) | Konstruktionssystem til et bygningsmodul | |
| DK3343955T3 (en) | Anordning til et høreapparat | |
| PL3303293T3 (pl) | Modulatory ROR-gamma | |
| PL3303291T3 (pl) | Modulatory ROR-gamma | |
| PL3303290T3 (pl) | Modulatory ROR-gamma | |
| DK3457555T3 (en) | Drev til et transportsystem | |
| IL251067A0 (en) | p2x7 modulators | |
| GB201716468D0 (en) | Modulators | |
| DK3456957T3 (en) | Modvægtssystem til balanceret navvindmølleinstallation | |
| IL266261A (en) | ror-gamma modulators | |
| PL3319942T3 (pl) | MODULATORY ROR-GAMMA (RORγ) | |
| DK3726976T3 (en) | Klimareguleringssystem til insektopdræt | |
| DK3481437T3 (en) | Precursorer til radiofluorering | |
| GB201710621D0 (en) | Spacer | |
| GB201703036D0 (en) | Methods | |
| SG11201911553VA (en) | Adsorption method | |
| DK3615520T3 (en) | Methods | |
| DK3430280T3 (en) | Magnetisk leje til en turbomaskine | |
| GB2563095B (en) | Modulators | |
| DK3558418T3 (en) | Et infusionssystem til kortlivede radiofarmaceutika |