PL3303291T3 - Modulatory ROR-gamma - Google Patents

Modulatory ROR-gamma

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Publication number
PL3303291T3
PL3303291T3 PL16726886T PL16726886T PL3303291T3 PL 3303291 T3 PL3303291 T3 PL 3303291T3 PL 16726886 T PL16726886 T PL 16726886T PL 16726886 T PL16726886 T PL 16726886T PL 3303291 T3 PL3303291 T3 PL 3303291T3
Authority
PL
Poland
Prior art keywords
ror
gamma modulators
modulators
gamma
Prior art date
Application number
PL16726886T
Other languages
English (en)
Inventor
Joseph Maria Gerardus Barbara Cals
Vera DE KIMPE
Sander Bernardus NABUURS
Original Assignee
Lead Pharma B.V.
Sanofi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lead Pharma B.V., Sanofi filed Critical Lead Pharma B.V.
Publication of PL3303291T3 publication Critical patent/PL3303291T3/pl

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    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
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    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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EP3101007A1 (en) * 2015-06-05 2016-12-07 Lead Pharma Cel Models IP B.V. Ror gamma (rory) modulators
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TWI728017B (zh) 2015-12-15 2021-05-21 瑞典商阿斯特捷利康公司 異吲哚化合物、包含其之醫藥組成物及其用途
EP3481809A1 (en) 2016-07-14 2019-05-15 Cadila Healthcare Limited Cyclopropyl derivatives as ror-gamma modulators
WO2018011747A1 (en) 2016-07-14 2018-01-18 Cadila Healthcare Limited Polycyclic compounds as ror-gamma modulators
UY37507A (es) 2016-12-05 2018-06-29 Lead Pharma Holding Bv Moduladores de ror gamma (ror¿)
EP3638661A1 (en) 2017-06-14 2020-04-22 Astrazeneca AB 2,3-dihydroisoindole-1-carboxamides useful as ror-gamma modulators
TW201922700A (zh) * 2017-10-31 2019-06-16 日商東麗股份有限公司 醯胺苯衍生物及其醫藥用途
CN109568321B (zh) * 2019-01-14 2022-02-22 山东轩竹医药科技有限公司 RORγ调节剂
TWI839461B (zh) 2019-02-06 2024-04-21 美商戴斯阿爾法股份有限公司 Il-17a調節物及其用途
JP7566889B2 (ja) 2019-09-16 2024-10-15 ダイス・アルファ・インコーポレイテッド Ｉｌ－１７ａモジュレーターおよびその使用
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WO2012100734A1 (en) * 2011-01-24 2012-08-02 Glaxo Group Limited Compounds useful as retinoid-related orphan receptor gamma modulators
WO2013029338A1 (en) * 2011-09-01 2013-03-07 Glaxo Group Limited Novel compounds
AU2013259904A1 (en) * 2012-05-08 2014-10-02 Lycera Corporation Bicyclic sulfone compounds for inhibition of RORy activity and the treatment of disease
NZ702539A (en) 2012-05-31 2016-11-25 Phenex Pharmaceuticals Ag Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ror[gamma]
JO3215B1 (ar) * 2012-08-09 2018-03-08 Phenex Pharmaceuticals Ag حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy
WO2013171729A2 (en) * 2013-01-08 2013-11-21 Glenmark Pharmaceuticals S.A. Aryl and heteroaryl amide compounds as rorgamat modulator
WO2014125426A1 (en) * 2013-02-15 2014-08-21 Aurigene Discovery Technologies Limited Trisubstituted heterocyclic derivatives as ror gamma modulators
WO2014179564A1 (en) * 2013-05-01 2014-11-06 Vitae Pharmaceuticals, Inc. Thiazalopyrrolidine inhibitors of ror-gamma

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KR102575608B1 (ko) 2023-09-05
CN108473429A (zh) 2018-08-31
US10315996B2 (en) 2019-06-11
RU2017145924A3 (pl) 2019-12-04
US20180170877A1 (en) 2018-06-21
IL256034A (en) 2018-01-31
JP2018522837A (ja) 2018-08-16
EP3101006A1 (en) 2016-12-07
BR112017026226A2 (pt) 2018-09-11
EP3303291A1 (en) 2018-04-11
KR20180042213A (ko) 2018-04-25
AR104878A1 (es) 2017-08-23
RU2017145924A (ru) 2019-07-10
AU2016272015B2 (en) 2020-08-27
MX377329B (es) 2025-03-07
WO2016193452A1 (en) 2016-12-08
CN108473429B (zh) 2021-09-10
JP6754778B2 (ja) 2020-09-16
AU2016272015A1 (en) 2018-01-04
MX2017015741A (es) 2018-04-24
TW201710240A (zh) 2017-03-16
UY36708A (es) 2017-01-31
EP3303291B1 (en) 2020-03-18
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IL256034B (en) 2021-02-28
PT3303291T (pt) 2020-04-22

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