SG11201912267SA - Nicotinamide riboside derivatives and their uses - Google Patents

Nicotinamide riboside derivatives and their uses

Info

Publication number
SG11201912267SA
SG11201912267SA SG11201912267SA SG11201912267SA SG11201912267SA SG 11201912267S A SG11201912267S A SG 11201912267SA SG 11201912267S A SG11201912267S A SG 11201912267SA SG 11201912267S A SG11201912267S A SG 11201912267SA SG 11201912267S A SG11201912267S A SG 11201912267SA
Authority
SG
Singapore
Prior art keywords
nicotinamide riboside
riboside derivatives
derivatives
nicotinamide
riboside
Prior art date
Application number
SG11201912267SA
Other languages
English (en)
Inventor
Gangadhara Ganapati
Atignal Shankara Rao Arvind
Original Assignee
Gangadhara Ganapati
Atignal Shankara Rao Arvind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gangadhara Ganapati, Atignal Shankara Rao Arvind filed Critical Gangadhara Ganapati
Publication of SG11201912267SA publication Critical patent/SG11201912267SA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048Pyridine radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG11201912267SA 2017-06-19 2018-06-19 Nicotinamide riboside derivatives and their uses SG11201912267SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762521717P 2017-06-19 2017-06-19
PCT/US2018/038201 WO2018236814A2 (fr) 2017-06-19 2018-06-19 Dérivés de nicotinamide riboside et leurs utilisations

Publications (1)

Publication Number Publication Date
SG11201912267SA true SG11201912267SA (en) 2020-01-30

Family

ID=62875307

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201912267SA SG11201912267SA (en) 2017-06-19 2018-06-19 Nicotinamide riboside derivatives and their uses

Country Status (4)

Country Link
US (1) US11286274B2 (fr)
EP (1) EP3642214A2 (fr)
SG (1) SG11201912267SA (fr)
WO (1) WO2018236814A2 (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018237383A1 (fr) * 2017-06-23 2018-12-27 The Trustees Of Columbia University In The City Of New York Procédés de prévention et de traitement de maladies caractérisées par un dysfonctionnement synaptique et une neurodégénérescence, y compris la maladie d'alzheimer
US20200261483A1 (en) * 2017-10-30 2020-08-20 Elysium Health, Inc. Methods and compositions for treating cystic fibrosis
WO2019108875A1 (fr) * 2017-12-01 2019-06-06 Elysium Health, Inc. Méthodes et compositions pour le traitement du glaucome
CN108841781A (zh) * 2018-06-13 2018-11-20 延边大学 藏红花素在提高猪卵母细胞抗氧化能力及卵裂率中的应用
EP3897666A2 (fr) 2018-12-17 2021-10-27 Mitopower LLC Composés nicotinyl riboside et leurs utilisations
US11266696B2 (en) * 2019-01-18 2022-03-08 Americord Registry Llc Method of treating stem cells with NAD
CN109674808A (zh) * 2019-01-30 2019-04-26 四川大学 β-烟酰胺单核苷酸或其前体在制备延缓肺衰老药物中的用途
JP2022524930A (ja) * 2019-02-26 2022-05-11 ウニベルシタット デ バレンシア―エストゥディ ジェネラル 運動ニューロン疾患を処置するための方法及び組成物
WO2020190703A1 (fr) * 2019-03-21 2020-09-24 Elysium Health, Inc. Méthodes pour le traitement de plaies
US20220125814A1 (en) * 2019-03-21 2022-04-28 Fred Hutchinson Cancer Research Center Cancer combination therapies utilizing a nicotinamide phosphoribosyltransferase inhibitor in combination with a nicotinamide adenine dinucleotide salvage pathway precursor
AU2020286602A1 (en) * 2019-06-05 2021-11-11 Société des Produits Nestlé S.A. Reduced nicotinamideribosides for treating or preventing kidney disease
CN113840612A (zh) * 2019-06-05 2021-12-24 雀巢产品有限公司 用于治疗/预防肝脏疾病的还原型烟酰胺核糖核苷
JP2022534863A (ja) * 2019-06-05 2022-08-04 ソシエテ・デ・プロデュイ・ネスレ・エス・アー 骨格筋の疾患を治療/予防するための還元型ニコチンアミドリボシド
EP3986420A1 (fr) * 2019-06-18 2022-04-27 Mitopower LLC Composés nicotinyl riboside et leurs utilisations
CA3145870A1 (fr) * 2019-07-26 2021-02-04 Hampar L. Karageozian Peptides pour le traitement de la degenerescence maculaire non-exsudative et d'autres troubles de l'?il
FR3102058A1 (fr) * 2019-10-18 2021-04-23 Nuvamid Sa Utilisation de NMN pour la prévention et/ou le traitement de la polyarthrite rhumatoïde et compositions correspondantes
CA3158767A1 (fr) * 2019-10-30 2021-05-06 Perfuse Therapeutics, Inc. Traitement de maladies oculaires a l'aide d'antagonistes du recepteur de l'endotheline
CN113490676A (zh) * 2019-11-19 2021-10-08 清华大学 Nmn衍生物的合成方法和nmn及其衍生物的医学应用
JP2023512763A (ja) 2020-02-06 2023-03-29 パフューズ セラピューティクス, インコーポレイテッド 眼疾患の処置のための組成物
KR20220151628A (ko) * 2020-03-06 2022-11-15 알레그로 파마슈티칼스, 엘엘씨 미토콘드리아 기능의 손상을 개선하거나 감소시키기 위한 치료
EP4117679A1 (fr) * 2020-03-09 2023-01-18 Société des Produits Nestlé S.A. Compositions et procédés contenant du nicotinamide riboside réduit pour la prévention et le traitement d'infections virales et bactériennes
EP4117681A1 (fr) * 2020-03-09 2023-01-18 Société des Produits Nestlé S.A. Compositions contenant un nicotinamide riboside et méthodes destinées à la prévention et au traitement des maladies et affections pancréatiques
FR3108502B1 (fr) * 2020-03-27 2022-09-23 Nuvamid Sa Dérivés de nicotinamide mononucléotides dans le traitement et la prévention des infections bactériennes
CN111454311B (zh) 2020-04-03 2021-10-19 深圳市迪克曼科技开发有限公司 烟酰胺核糖的有机酸盐及其组合物与制备方法
US20210353656A1 (en) * 2020-05-12 2021-11-18 Nuvamid Sa Combination of nicotinamide mononucleotide derivatives and histamine h2 receptor antagonists for viral infections
EP3949964A1 (fr) * 2020-08-06 2022-02-09 Nuvamid SA Combinaison de dérivés de nicotinamide mononucléotidique et d'autres agents thérapeutiques pour leur utilisation dans le traitement des infections virales
WO2022029275A1 (fr) * 2020-08-06 2022-02-10 Nuvamid Sa Combinaison de dérivés de nicotinamide mononucléotide et d'autres agents thérapeutiques destinée à être utilisée dans le traitement d'infections à coronavirus et de la covid-19
CN112500445B (zh) * 2020-12-04 2022-11-29 黄冈鲁班药业股份有限公司 β-烟酰胺核糖的制备方法
CN113274363B (zh) * 2021-04-29 2023-02-10 珠海润都制药股份有限公司 一种吲达帕胺制剂
KR20240004643A (ko) 2021-04-30 2024-01-11 퍼퓨즈 세라퓨틱스, 인크. 안구 질환의 치료를 위한 제약 조성물 및 유리체내 약물 전달 시스템
EP4313067A1 (fr) * 2021-06-18 2024-02-07 Mitopower LLC Traitement de troubles liés à l?immunité, de troubles rénaux, de troubles hépatiques, de troubles hémolytiques et de troubles liés au stress oxydatif à l'aide de nrh, narh et de leurs dérivés réduits
WO2022269064A1 (fr) * 2021-06-24 2022-12-29 Vestlandets Innovasjonsselskap As (Vis) Traitement d'augmentation de nad pour la maladie de parkinson
AU2022401717A1 (en) * 2021-12-01 2024-05-23 University Of Florida Research Foundation, Incorporated Combinatorial therapeutic approach for friedreich's ataxia
CN115232184A (zh) * 2021-12-06 2022-10-25 宁波熙健医药科技有限公司 呋喃核糖基吡啶衍生物及其药物组合物和用途
WO2024050120A2 (fr) * 2022-09-02 2024-03-07 The Regents Of The University Of California Combinaisons de nicotinamide-riboside et de ptérostilbène pour traiter l'arthrose

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1190079A (en) 1966-07-29 1970-04-29 Kyowa Hakko Kogyo Company Ltd Process for producing Nicotinamide Adenine Dinucleotide
US6589948B1 (en) 2000-11-28 2003-07-08 Eukarion, Inc. Cyclic salen-metal compounds: reactive oxygen species scavengers useful as antioxidants in the treatment and prevention of diseases
WO2005009510A2 (fr) 2003-07-23 2005-02-03 The Regents Of The University Of California Combinaisons d'amplificateurs de penetration pour administration transdermique
EP1723227A4 (fr) 2004-02-10 2007-09-19 Dartmouth College Compositions de nicotinamide riboside kinase et procedes d'utilisation
EP1877054A2 (fr) 2005-03-30 2008-01-16 Sirtris Pharmaceuticals, Inc. Nicotinamide riboside et analogues
US20070099830A1 (en) * 2005-04-21 2007-05-03 Massachusetts Institute Of Technology Sirt4 activities
US20130216542A1 (en) 2005-05-06 2013-08-22 Zymogenetics, Inc. Variable region sequences of il-31 monoclonal antibodies and methods of use
DK1957086T3 (en) 2005-11-18 2018-06-06 Cornell Res Foundation Inc NICOTINOYL RIBOSIDE COMPOSITIONS AND METHODS OF USE
JP2011518200A (ja) 2008-04-22 2011-06-23 メルク フロスト カナダ リミテツド ステアロイル−補酵素aデルタ−9デサチュラーゼの阻害剤としての新規な置換複素環式芳香族化合物
CA2725481A1 (fr) 2008-06-18 2009-12-23 Pfizer Limited Derives de nicotinamide
WO2012114204A2 (fr) * 2011-02-15 2012-08-30 Ecole Polytechnique Federale De Lausanne (Epfl) Epfl-Tto Procédés de traitement d'une dysfonction mitochondriale
MX2015011195A (es) 2013-03-15 2016-03-11 Nusirt Sciences Inc La leucina y el acido nicotinico reducen los niveles de lipidos.
GB201313465D0 (en) 2013-07-29 2013-09-11 Queens University Of The Belfast Methods of preparing nicotinamide riboside and derivatives thereof
EP3063163B1 (fr) 2013-10-30 2022-08-10 Chromadex Inc. Compositions de nicotinamide riboside à usage topique pour traiter les affections cutanées
EP3149016A1 (fr) 2014-06-02 2017-04-05 Glaxosmithkline Intellectual Property (No. 2) Limited Préparation et utilisation de bêta-d-nicotinamide riboside cristallin
JP6559713B2 (ja) * 2014-06-06 2019-08-14 グラクソスミスクライン、インテレクチュアル、プロパティー、(ナンバー2)、リミテッドGlaxosmithkline Intellectual Property (No.2) Limited ニコチンアミドリボシド類似体ならびにその医薬組成物および使用
CN106715454B (zh) 2014-07-24 2020-06-16 格雷斯公司 烟酰胺核苷的结晶形式
WO2016122832A1 (fr) 2015-01-30 2016-08-04 Natural Formulations Compositions, méthodes thérapeutiques et prophylactiques pour le traitement de maladies neurodégénératives et de lésions cérébrales
AU2016229319B2 (en) 2015-03-09 2020-05-07 W.R. Grace & Co.-Conn. Crystalline form of nicotinamide riboside
CA2979057C (fr) 2015-03-16 2023-01-24 ChromaDex Inc. Compositions d'acide nicotinique riboside ou de nicotinamide riboside, derives reduits de ceux-ci, et utilisation de ceux-ci
AU2016271481A1 (en) 2015-06-04 2017-12-14 Chromadex, Inc. Selective solvent free phosphorylation
US10392414B2 (en) * 2015-07-15 2019-08-27 Cornell University Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives
JP6949002B6 (ja) 2015-08-05 2021-11-17 メトロ インターナショナル バイオテック,エルエルシー ニコチンアミドモノヌクレオチド誘導体及びそれらの使用
RU2768936C2 (ru) 2015-10-07 2022-03-25 Джоэль УЙСЕНГА Нормализация функций биологических путей для защиты от и устранения нарушений, возникающих вследствие старения человека
US10611790B2 (en) * 2015-11-02 2020-04-07 Mitobridge, Inc. Nicotinamide riboside and nicotinamide mononucleotide derivatives for use in the treatments of mitochondrial-related diseases
AU2016375177B2 (en) 2015-12-24 2022-09-01 Amazentis Sa Compositions comprising nicotinamide riboside and a urolithin
WO2017161165A1 (fr) * 2016-03-16 2017-09-21 ChromaDex Inc. Conjugués de vitamine b et d'acides aminés de ribosides de nicotinoyle et de ribosides de nicotinoyle réduits, dérivés de ceux-ci, et leurs procédés de préparation
MX2018012527A (es) 2016-04-14 2019-08-21 Chromadex Inc Uso de ribosido de nicotinamida, ribosido de acido nicotinico, mononucleotido de nicotinamida y derivados de compuestos nicotinoílo en formula para lactantes.
KR20190008246A (ko) 2016-04-20 2019-01-23 크로마덱스 아이엔씨. Nad+ 증가용 전구체로서 니코틴산 리보사이드 또는 니코틴아미드 리보사이트 유도체 및 이의 환원된 유도체의 용도
WO2017218580A1 (fr) 2016-06-14 2017-12-21 Rejuvenation Therapeutics Corporation Procédés synthétiques pour la préparation de nicotinamide riboside et de composés apparentés
WO2018002215A1 (fr) 2016-06-30 2018-01-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques pour le traitement de cardiomyopathies
GB2553001A (en) 2016-08-19 2018-02-21 The Queen's Univ Of Belfast Lactone intermediates of nicotinamide riboside and nicotinate riboside
MX2019002211A (es) 2016-08-22 2019-10-30 Elysium Health Inc Composiciones de nicotinamida ribosido y pterostilbeno y metodos para el tratamiento de trastornos neurodegenerativos.
CA3045876A1 (fr) 2016-11-11 2018-05-17 The Queen's University Of Belfast Syntheses evolutives de nicotinoyle ribosides et de nicotin oyle ribosides reduits, de leurs derives modifies, de leurs analogues phosphoryles, de leurs conjugues avec de l'adenylyle dinucleotide et de nouvelles formes cristallines de ceux-ci
US11071747B2 (en) 2016-11-29 2021-07-27 University Of Iowa Research Foundation Use of NAD precursors for breast enhancement
CA3044814A1 (fr) 2016-11-29 2018-06-07 Charles M. Brenner Utilisation de precurseurs de nad pour ameliorer la sante maternelle et/ou la sante de la descendance
US11389468B2 (en) 2017-03-17 2022-07-19 Elysium Health, Inc. Nicotinamide riboside for use in treating or preventing liver damage

Also Published As

Publication number Publication date
WO2018236814A2 (fr) 2018-12-27
EP3642214A2 (fr) 2020-04-29
US20180362570A1 (en) 2018-12-20
US11286274B2 (en) 2022-03-29
WO2018236814A3 (fr) 2019-02-07

Similar Documents

Publication Publication Date Title
SG11201912267SA (en) Nicotinamide riboside derivatives and their uses
ZA201801196B (en) Nicotinamide mononucleotide derivatives and their uses
ZA201808131B (en) Amide-substituted pyridinyltriazole derivatives and uses thereof
HK1248240A1 (zh) 烟酸核苷或烟酰胺核苷組合物、其還原衍生物及其用途
HK1254654A1 (zh) 4,6-亞嘧啶基衍生物及其用途
IL253656A0 (en) Mono- and polyazanephthalene modified histories and their use
EP3268362A4 (fr) Pyridines substituées et leurs utilisations
HK1246156B (zh) Fgf21衍生物及其用途
HK1250164A1 (zh) 苯胺嘧啶衍生物及其用途
IL273839A (en) Benzimidazole derivatives and their uses
HK1251226A1 (zh) 吡啶和嘧啶衍生物
GB2577419B (en) Lipo-glycopeptide cleavable derivatives and uses thereof
EP3526215A4 (fr) Dérivés de n-acyléthanolamide et leurs utilisations
LT3487851T (lt) Aminopiridino dariniai ir jų naudojimas kaip selektyvių alk-2 inhibitorių
SG11202008543RA (en) Pyrrolidineamide derivatives and uses thereof
EP3383401A4 (fr) Dérivés de thiéno-pyrimidine et utilisations de ceux-ci
IL274722A (en) History of pyridinones and their use as selective inhibitors of ALK-2
EP3556764A4 (fr) Dérivé de nucléoside et utilisation associée
EP3712160A4 (fr) Dérivé de nucléoside et utilisation associée