SG11201908114UA - Pyrimidopyrimidinones useful as wee-1 kinase inhibitors - Google Patents

Pyrimidopyrimidinones useful as wee-1 kinase inhibitors

Info

Publication number
SG11201908114UA
SG11201908114UA SG11201908114UA SG11201908114UA SG 11201908114U A SG11201908114U A SG 11201908114UA SG 11201908114U A SG11201908114U A SG 11201908114UA SG 11201908114U A SG11201908114U A SG 11201908114UA
Authority
SG
Singapore
Prior art keywords
almac
craigavon
house
international
seagoe
Prior art date
Application number
Other languages
English (en)
Inventor
Peter Hewitt
Frank Burkamp
Andrew Wilkinson
Hugues Miel
Colin O'dowd
Original Assignee
Almac Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almac Discovery Ltd filed Critical Almac Discovery Ltd
Publication of SG11201908114UA publication Critical patent/SG11201908114UA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11201908114U 2017-03-10 2018-03-12 Pyrimidopyrimidinones useful as wee-1 kinase inhibitors SG11201908114UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1703881.1A GB201703881D0 (en) 2017-03-10 2017-03-10 Pharmaceutical compounds
PCT/GB2018/050620 WO2018162932A1 (en) 2017-03-10 2018-03-12 Pyrimidopyrimidinones useful as wee-1 kinase inhibitors

Publications (1)

Publication Number Publication Date
SG11201908114UA true SG11201908114UA (en) 2019-10-30

Family

ID=58605309

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201908114U SG11201908114UA (en) 2017-03-10 2018-03-12 Pyrimidopyrimidinones useful as wee-1 kinase inhibitors

Country Status (30)

Country Link
US (2) US11208413B2 (ja)
EP (1) EP3592745B1 (ja)
JP (1) JP7244430B2 (ja)
KR (1) KR102605546B1 (ja)
CN (1) CN110603256B (ja)
AU (1) AU2018231671B2 (ja)
BR (1) BR112019018753A2 (ja)
CA (1) CA3055874A1 (ja)
CL (1) CL2019002557A1 (ja)
CY (1) CY1124613T1 (ja)
DK (1) DK3592745T3 (ja)
EA (1) EA201992137A1 (ja)
ES (1) ES2895365T3 (ja)
GB (1) GB201703881D0 (ja)
HR (1) HRP20211652T1 (ja)
HU (1) HUE056220T2 (ja)
IL (1) IL269063B (ja)
LT (1) LT3592745T (ja)
MA (1) MA47736B1 (ja)
MX (1) MX2019010554A (ja)
MY (1) MY195580A (ja)
PH (1) PH12019502049A1 (ja)
PL (1) PL3592745T3 (ja)
PT (1) PT3592745T (ja)
RS (1) RS62464B1 (ja)
SA (1) SA519410093B1 (ja)
SG (1) SG11201908114UA (ja)
SI (1) SI3592745T1 (ja)
UA (1) UA125093C2 (ja)
WO (1) WO2018162932A1 (ja)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201703881D0 (en) * 2017-03-10 2017-04-26 Almac Discovery Ltd Pharmaceutical compounds
US11299493B2 (en) 2017-10-09 2022-04-12 Nuvation Bio Inc. Heterocyclic compounds and uses thereof
EP3694509A4 (en) 2017-10-09 2021-07-14 Nuvation Bio Inc. HETEROCYCLIC COMPOUNDS AND THEIR USES
EP3952879A4 (en) * 2019-04-09 2023-01-04 Nuvation Bio Inc. HETEROCYCLIC COMPOUNDS AND USES THEREOF
EP3952878A4 (en) * 2019-04-09 2023-01-04 Nuvation Bio Inc. HETEROCYCLIC COMPOUNDS AND USES THEREOF
WO2020210375A1 (en) 2019-04-09 2020-10-15 Nuvation Bio Inc. Heterocyclic compounds and uses thereof
AU2022384370A1 (en) * 2021-11-09 2024-06-13 Hangzhou Glubio Pharmaceutical Co. Ltd. Wee1 protein kinase degradation agent and use thereof
AU2023232376A1 (en) * 2022-03-07 2024-10-10 Debiopharm International S.A. Methods of treating small cell lung cancer
WO2023217201A2 (zh) * 2022-05-10 2023-11-16 杭州德睿智药科技有限公司 作为Wee1抑制剂的新型嘧啶并杂环类新化合物及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8577501A1 (es) 2002-07-25 2004-02-07 Warner Lambert Co Inhibidores de quinasas
AR060635A1 (es) * 2006-04-27 2008-07-02 Banyu Pharma Co Ltd Derivados de 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-ona, composiciones farmaceuticas que los comprenden y su uso en el tratamiento del cancer
EP2376494A4 (en) * 2008-12-12 2012-07-11 Msd Kk DIHYDROPYRIMIDOPIRYMIDINE DERIVATIVES
MX2014010176A (es) * 2012-02-23 2014-11-10 Abbvie Inc Inhibidores de cinasas de piridopirimidinona.
GB201306610D0 (en) * 2013-04-11 2013-05-29 Almac Discovery Ltd Pharmaceutical compounds
GB201322602D0 (en) * 2013-12-19 2014-02-05 Almac Discovery Ltd Pharmaceutical compounds
GB201703881D0 (en) * 2017-03-10 2017-04-26 Almac Discovery Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
MX2019010554A (es) 2019-12-16
HRP20211652T1 (hr) 2022-02-04
US20220194947A1 (en) 2022-06-23
ES2895365T3 (es) 2022-02-21
KR102605546B1 (ko) 2023-11-22
AU2018231671A1 (en) 2019-09-26
EP3592745B1 (en) 2021-07-28
IL269063B (en) 2022-04-01
PL3592745T3 (pl) 2022-01-03
CY1124613T1 (el) 2022-07-22
CN110603256A (zh) 2019-12-20
US20210128560A1 (en) 2021-05-06
DK3592745T3 (da) 2021-10-18
EP3592745A1 (en) 2020-01-15
MA47736B1 (fr) 2021-10-29
UA125093C2 (uk) 2022-01-05
PT3592745T (pt) 2021-10-20
JP2020510040A (ja) 2020-04-02
MA47736A (fr) 2021-04-21
SI3592745T1 (sl) 2021-12-31
JP7244430B2 (ja) 2023-03-22
CA3055874A1 (en) 2018-09-13
MY195580A (en) 2023-02-02
WO2018162932A1 (en) 2018-09-13
CN110603256B (zh) 2022-10-28
GB201703881D0 (en) 2017-04-26
US11208413B2 (en) 2021-12-28
HUE056220T2 (hu) 2022-02-28
RS62464B1 (sr) 2021-11-30
PH12019502049A1 (en) 2020-06-29
LT3592745T (lt) 2021-11-10
AU2018231671B2 (en) 2022-03-24
IL269063A (en) 2019-11-28
SA519410093B1 (ar) 2022-07-16
KR20190128673A (ko) 2019-11-18
CL2019002557A1 (es) 2019-12-27
EA201992137A1 (ru) 2020-02-05
BR112019018753A2 (pt) 2020-04-07

Similar Documents

Publication Publication Date Title
SG11201908114UA (en) Pyrimidopyrimidinones useful as wee-1 kinase inhibitors
SG11201805300QA (en) Heterocyclic compounds as immunomodulators
SG11201811414TA (en) Heterocyclic compounds as immunomodulators
SG11201809064QA (en) Chimeric neurotoxins
SG11201901747VA (en) Inhibitors of cellular metabolic processes
SG11201903456WA (en) Piperidine derivatives as inhibitors of ubiquitin specific protease 7
SG11201809344QA (en) Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde
SG11201809559UA (en) Substituted pyridines as inhibitors of dnmt1
SG11201907544VA (en) Jak inhibitors containing a 4-membered heterocyclic amide
SG11201903857UA (en) Antibodies to pd-1 and uses thereof
SG11201810423XA (en) Pd-1 / pd-l1 inhibitors for cancer treatment
SG11201901390TA (en) Tetracycline compounds and methods of treatment
SG11201805044WA (en) Compounds useful as kinase inhibitors
SG11201803920TA (en) Compounds and compositions useful for treating disorders related to ntrk
SG11201809499UA (en) Processes for preparing phosphorodiamidate morpholino oligomers
SG11201908640TA (en) Pyrrolidinones and a process to prepare them
SG11201908743SA (en) Methods and compositions for modulation of immune cells
SG11201808222RA (en) Methods of treatment of cholestatic diseases
SG11201806267QA (en) Organic reactions carried out in aqueous solution in the presence of a hydroxyalkyl(alkyl)cellulose or an alkylcellulose
SG11201805149XA (en) Compositions comprising 15-hepe and methods of using the same
SG11201906436VA (en) Novel heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same
SG11201408750VA (en) NOVEL FUSED PYRIDINE DERIVATIVES USEFUL AS c-MET TYROSINE KINASE INHIBITORS
SG11201903061YA (en) Combination treatments comprising administration of imidazopyrazinones
SG11201908918WA (en) Novel pyridazinone herbicides
SG11201806480UA (en) Derivatives of pyrroloimidazole or analogues thereof which are useful for the treatment of inter alia cancer