SG11201907321TA - Anti-gprc5d antibody and molecule comprising the antibody - Google Patents

Anti-gprc5d antibody and molecule comprising the antibody

Info

Publication number
SG11201907321TA
SG11201907321TA SG11201907321TA SG11201907321TA SG11201907321TA SG 11201907321T A SG11201907321T A SG 11201907321TA SG 11201907321T A SG11201907321T A SG 11201907321TA SG 11201907321T A SG11201907321T A SG 11201907321TA SG 11201907321T A SG11201907321T A SG 11201907321TA
Authority
SG
Singapore
Prior art keywords
antibody
molecule
gprc5d
provides
present
Prior art date
Application number
SG11201907321TA
Other languages
English (en)
Inventor
Takashi Chaen
Toshiaki Ohtsuka
Kenji Iida
Kensuke Nakamura
Takahide Aburatani
Junya Ichikawa
Shota Kudo
Chayne Lee Piscitelli
Mario Sanches
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of SG11201907321TA publication Critical patent/SG11201907321TA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11201907321TA 2017-02-07 2018-02-06 Anti-gprc5d antibody and molecule comprising the antibody SG11201907321TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2017020220 2017-02-07
PCT/JP2018/003888 WO2018147245A1 (ja) 2017-02-07 2018-02-06 抗ｇｐｒｃ５ｄ抗体及び該抗体を含む分子

Publications (1)

Publication Number Publication Date
SG11201907321TA true SG11201907321TA (en) 2019-09-27

Family

ID=63108300

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201912368XA SG10201912368XA (en) 2017-02-07 2018-02-06 Anti-gprc5d antibody and molecule comprising the antibody
SG11201907321TA SG11201907321TA (en) 2017-02-07 2018-02-06 Anti-gprc5d antibody and molecule comprising the antibody

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201912368XA SG10201912368XA (en) 2017-02-07 2018-02-06 Anti-gprc5d antibody and molecule comprising the antibody

Country Status (17)

Country Link
US (1) US20190367612A1 (ja)
EP (1) EP3581651A4 (ja)
JP (1) JPWO2018147245A1 (ja)
KR (1) KR20190133160A (ja)
CN (1) CN110462038A (ja)
AU (1) AU2018218753A1 (ja)
BR (1) BR112019016204A2 (ja)
CA (1) CA3052938A1 (ja)
CO (1) CO2019009680A2 (ja)
IL (1) IL268588A (ja)
MX (1) MX2019009358A (ja)
PH (1) PH12019501824A1 (ja)
RU (1) RU2019128134A (ja)
SG (2) SG10201912368XA (ja)
TW (1) TW201837174A (ja)
WO (1) WO2018147245A1 (ja)
ZA (1) ZA201905905B (ja)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI781108B (zh) 2016-07-20 2022-10-21 比利時商健生藥品公司 抗ｇｐｒｃ５ｄ抗體、結合ｇｐｒｃ５ｄ與ｃｄ３之雙特異性抗原結合分子及其用途
EP4342978A2 (en) 2016-09-01 2024-03-27 Chimera Bioengineering Inc. Gold optimized car t-cells
WO2019160815A1 (en) 2018-02-13 2019-08-22 Chimera Bioengineering, Inc. Coordinating gene expression using rna destabilizing elements
KR20220080044A (ko) 2018-05-16 2022-06-14 얀센 바이오테크 인코포레이티드 암 요법에 사용하기 위한 bcma/cd3 및 gprdc5d/cd3 이중특이성 항체
US20210277118A1 (en) * 2018-06-21 2021-09-09 Daiichi Sankyo Company, Limited Compositions including cd3 antigen binding fragments and uses thereof
EA202191939A1 (ru) * 2019-01-18 2021-10-12 Янссен Байотек, Инк. Химерные антигенные рецепторы gprc5d и экспрессирующие их клетки
CN114174338A (zh) * 2019-07-31 2022-03-11 豪夫迈·罗氏有限公司 与gprc5d结合的抗体
CA3144524A1 (en) * 2019-07-31 2021-02-04 F. Hoffmann-La Roche Ag Antibodies binding to gprc5d
EP4013431A4 (en) 2019-08-18 2024-05-01 Chimera Bioengineering Inc COMBINATION THERAPY WITH GOLD-CONTROLLED TRANSGENES
WO2022125392A1 (en) * 2020-12-09 2022-06-16 Chimera Bioengineering, Inc. Compositions and methods for activating t-cells
IL304052A (en) 2021-01-05 2023-08-01 Lanova Medicines Dev Co Ltd ANTI-GPRC5D MONOCLONAL ANTIBODIES AND THEIR USES
WO2022148370A1 (en) * 2021-01-05 2022-07-14 Lanova Medicines Development Co., Ltd. Anti-gprc5d monoclonal antibodies and uses thereof
CN117279953A (zh) 2021-02-16 2023-12-22 詹森药业有限公司 靶向bcma、gprc5d和cd3的三特异性抗体
KR20230162597A (ko) 2021-03-29 2023-11-28 다이이찌 산쿄 가부시키가이샤 안정적인 다중 특이성 분자 및 그 이용
WO2022247804A1 (zh) * 2021-05-23 2022-12-01 上海祥耀生物科技有限责任公司 抗gprc5d抗体、其制备方法与用途
WO2022247756A1 (zh) * 2021-05-23 2022-12-01 上海邦耀生物科技有限公司 靶向gprc5d的嵌合抗原受体及其用途
WO2022260968A1 (en) * 2021-06-10 2022-12-15 Chimera Bioengineering, Inc. Compositions and methods for activating natural killer cells
CN116063500A (zh) * 2021-08-30 2023-05-05 原启生物科技(上海)有限责任公司 抗gprc5d抗原结合蛋白及其用途
WO2023078382A1 (zh) * 2021-11-05 2023-05-11 正大天晴药业集团股份有限公司 结合gprc5d的抗体及其用途
AU2022401024A1 (en) 2021-11-30 2024-05-16 Daiichi Sankyo Company, Limited Protease-cleavable masked antibodies
WO2023173272A1 (zh) * 2022-03-15 2023-09-21 上海驯鹿生物技术有限公司 靶向gprc5d的全人源嵌合抗原受体(car)及其应用
WO2023115347A1 (zh) * 2021-12-21 2023-06-29 上海驯鹿生物技术有限公司 靶向gprc5d的全人源抗体
WO2023125728A1 (zh) * 2021-12-31 2023-07-06 康源博创生物科技(北京)有限公司 抗gprc5d抗体及其应用
CN116375868A (zh) * 2021-12-31 2023-07-04 康源博创生物科技(北京)有限公司 一种抗cd3的人源化抗体及其在制备双特异性抗体中的应用
WO2023125888A1 (zh) * 2021-12-31 2023-07-06 山东先声生物制药有限公司 一种gprc5d抗体及其应用
WO2023143537A1 (zh) * 2022-01-29 2023-08-03 恺兴生命科技(上海)有限公司 Gprc5d抗体及其应用
TW202400645A (zh) * 2022-03-14 2024-01-01 大陸商江蘇恆瑞醫藥股份有限公司 特異性結合ｇｐｒｃ５ｄ和ｃｄ３的抗原結合分子及其醫藥用途
WO2023227062A1 (en) * 2022-05-27 2023-11-30 Antengene (Hangzhou) Biologics Co., Ltd. Novel anti-gprc5d antibodies, bispecific antigen binding molecules that bind gprc5d and cd3, and uses thereof
WO2024002308A1 (zh) * 2022-06-30 2024-01-04 康诺亚生物医药科技（成都）有限公司 一种新型多特异肿瘤抑制剂的开发和应用
WO2024031091A2 (en) 2022-08-05 2024-02-08 Juno Therapeutics, Inc. Chimeric antigen receptors specific for gprc5d and bcma
CN116003598B (zh) * 2022-08-30 2024-04-26 苏州缔码生物科技有限公司 靶向人gprc5d的重组人源化单克隆抗体及其应用
WO2024102954A1 (en) 2022-11-10 2024-05-16 Massachusetts Institute Of Technology Activation induced clipping system (aics)

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
ES2139598T3 (es) 1990-07-10 2000-02-16 Medical Res Council Procedimientos para la produccion de miembros de parejas de union especifica.
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
AU665025B2 (en) 1991-09-23 1995-12-14 Cambridge Antibody Technology Limited Production of chimeric antibodies - a combinatorial approach
ES2227512T3 (es) 1991-12-02 2005-04-01 Medical Research Council Produccion de anticuerpos contra auto-antigenos a partir de repertorios de segmentos de anticuerpos fijados en un fago.
CA2131151A1 (en) 1992-03-24 1994-09-30 Kevin S. Johnson Methods for producing members of specific binding pairs
GB9313509D0 (en) 1993-06-30 1993-08-11 Medical Res Council Chemisynthetic libraries
EP0731842A1 (en) 1993-12-03 1996-09-18 Medical Research Council Recombinant binding proteins and peptides
US6214388B1 (en) 1994-11-09 2001-04-10 The Regents Of The University Of California Immunoliposomes that optimize internalization into target cells
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US6972323B1 (en) 1997-04-01 2005-12-06 Sankyo Company, Limited Anti-Fas antibodies
DE59809673D1 (de) 1997-07-25 2003-10-23 Zahnradfabrik Friedrichshafen Stufenloses Reibradgetriebe
DE19819846B4 (de) 1998-05-05 2016-11-24 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Multivalente Antikörper-Konstrukte
EP2264166B1 (en) 1999-04-09 2016-03-23 Kyowa Hakko Kirin Co., Ltd. Method for controlling the activity of immunologically functional molecule
DK2314686T4 (da) 2000-10-06 2023-08-21 Kyowa Kirin Co Ltd Celler, der danner antistofsammensætninger
MXPA05006724A (es) 2003-01-07 2005-09-08 Symphogen As Metodo para producir proteinas policlonales recombinantes.
ES2540733T3 (es) 2007-10-11 2015-07-13 Daiichi Sankyo Company, Limited Anticuerpo que se dirige a la proteína Siglec-15 relacionada con osteoclastos
EP3663318A1 (en) 2008-01-07 2020-06-10 Amgen Inc. Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
DK2631297T3 (en) 2008-05-15 2017-08-07 Nat Res Council Canada PROCEDURE, VECTORS AND MANIPULATED CELL LINES TO IMPROVE LARGE SCALE TRANSFECTION
EP2445936A1 (en) 2009-06-26 2012-05-02 Regeneron Pharmaceuticals, Inc. Readily isolated bispecific antibodies with native immunoglobulin format
KR102052774B1 (ko) 2011-11-04 2019-12-04 자임워크스 인코포레이티드 Ｆｃ 도메인 내의 돌연변이를 갖는 안정한 이종이합체 항체 설계
EP2832856A4 (en) 2012-03-29 2016-01-27 Chugai Pharmaceutical Co Ltd ANTI-LAMP5 ANTIBODIES AND USE THEREOF
KR102391731B1 (ko) 2013-01-14 2022-04-27 젠코어 인코포레이티드 신규한 이형이량체 단백질
AU2014273817B2 (en) 2013-05-31 2019-03-14 Zymeworks Bc Inc. Heteromultimers with reduced or silenced effector function
US20170335281A1 (en) * 2014-03-15 2017-11-23 Novartis Ag Treatment of cancer using chimeric antigen receptor
IL252621B1 (en) * 2014-12-05 2024-02-01 Memorial Sloan Kettering Cancer Center G-protein receptor-directed chimeric antigen receptors and their use
IL285101B2 (en) 2014-12-05 2024-03-01 Memorial Sloan Kettering Cancer Center G protein-coupled receptor-directed antibodies and methods of use
BR112017014805A2 (pt) * 2015-01-23 2018-01-09 Sanofi anticorpos anti-cd3, anticorpos anti-cd123 e anticorpos biespecíficos que se ligam especificamente a cd3 e/ou cd123
TWI781108B (zh) * 2016-07-20 2022-10-21 比利時商健生藥品公司 抗ｇｐｒｃ５ｄ抗體、結合ｇｐｒｃ５ｄ與ｃｄ３之雙特異性抗原結合分子及其用途

Also Published As

Publication number Publication date
IL268588A (en) 2019-09-26
WO2018147245A1 (ja) 2018-08-16
US20190367612A1 (en) 2019-12-05
CA3052938A1 (en) 2018-08-16
JPWO2018147245A1 (ja) 2019-11-21
RU2019128134A (ru) 2021-03-09
CN110462038A (zh) 2019-11-15
TW201837174A (zh) 2018-10-16
BR112019016204A2 (pt) 2020-07-07
EP3581651A4 (en) 2021-05-12
PH12019501824A1 (en) 2020-09-14
EP3581651A1 (en) 2019-12-18
RU2019128134A3 (ja) 2021-12-27
SG10201912368XA (en) 2020-02-27
AU2018218753A1 (en) 2019-09-26
CO2019009680A2 (es) 2020-02-07
ZA201905905B (en) 2022-05-25
MX2019009358A (es) 2019-12-02
KR20190133160A (ko) 2019-12-02

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