SG11201907285XA - Methods and kits for generating mimetic innate immune cells from pluripotent stem cells - Google Patents
Methods and kits for generating mimetic innate immune cells from pluripotent stem cellsInfo
- Publication number
- SG11201907285XA SG11201907285XA SG11201907285XA SG11201907285XA SG11201907285XA SG 11201907285X A SG11201907285X A SG 11201907285XA SG 11201907285X A SG11201907285X A SG 11201907285XA SG 11201907285X A SG11201907285X A SG 11201907285XA SG 11201907285X A SG11201907285X A SG 11201907285XA
- Authority
- SG
- Singapore
- Prior art keywords
- cells
- mimetic
- international
- innate immune
- harvest
- Prior art date
Links
- 210000002865 immune cell Anatomy 0.000 title abstract 5
- 210000001778 pluripotent stem cell Anatomy 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 10
- 238000003306 harvesting Methods 0.000 abstract 5
- 210000004263 induced pluripotent stem cell Anatomy 0.000 abstract 5
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 4
- 210000000822 natural killer cell Anatomy 0.000 abstract 3
- 239000007858 starting material Substances 0.000 abstract 3
- 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 abstract 2
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 abstract 2
- 241000549556 Nanos Species 0.000 abstract 2
- 230000002950 deficient Effects 0.000 abstract 2
- 230000004069 differentiation Effects 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 210000002536 stromal cell Anatomy 0.000 abstract 2
- 102100036462 Delta-like protein 1 Human genes 0.000 abstract 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 abstract 1
- 101000928537 Homo sapiens Delta-like protein 1 Proteins 0.000 abstract 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000002619 cancer immunotherapy Methods 0.000 abstract 1
- 210000002242 embryoid body Anatomy 0.000 abstract 1
- 230000003394 haemopoietic effect Effects 0.000 abstract 1
- 210000000581 natural killer T-cell Anatomy 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 210000004976 peripheral blood cell Anatomy 0.000 abstract 1
- 102220240796 rs553605556 Human genes 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4613—Natural-killer cells [NK or NK-T]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2307—Interleukin-7 (IL-7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1352—Mesenchymal stem cells
- C12N2502/1358—Bone marrow mesenchymal stem cells (BM-MSC)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/45—Artificially induced pluripotent stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SG10201700937P | 2017-02-07 | ||
SG10201705582S | 2017-07-06 | ||
PCT/SG2018/050051 WO2018147801A1 (en) | 2017-02-07 | 2018-02-07 | Methods and kits for generating mimetic innate immune cells from pluripotent stem cells |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201907285XA true SG11201907285XA (en) | 2019-09-27 |
Family
ID=63107773
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201907285XA SG11201907285XA (en) | 2017-02-07 | 2018-02-07 | Methods and kits for generating mimetic innate immune cells from pluripotent stem cells |
SG10202106515SA SG10202106515SA (en) | 2017-02-07 | 2018-02-07 | Methods and kits for generating mimetic innate immune cells from pluripotent stem cells |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10202106515SA SG10202106515SA (en) | 2017-02-07 | 2018-02-07 | Methods and kits for generating mimetic innate immune cells from pluripotent stem cells |
Country Status (7)
Country | Link |
---|---|
US (1) | US20190359940A1 (zh) |
EP (1) | EP3580332A4 (zh) |
JP (1) | JP7092281B2 (zh) |
CN (1) | CN110691844B (zh) |
MY (1) | MY202222A (zh) |
SG (2) | SG11201907285XA (zh) |
WO (1) | WO2018147801A1 (zh) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018147801A1 (en) * | 2017-02-07 | 2018-08-16 | Agency For Science, Technology And Research | Methods and kits for generating mimetic innate immune cells from pluripotent stem cells |
US20200297871A1 (en) | 2017-09-15 | 2020-09-24 | King's College London | Compositions and methods for enhancing gamma delta t cells in the gut |
US20210130777A1 (en) * | 2018-07-13 | 2021-05-06 | Kyoto University | Method for producing gamma delta t cells |
CN109321531A (zh) * | 2018-11-03 | 2019-02-12 | 上海中溢精准医疗科技有限公司 | 一种将外周血免疫γδT细胞诱导成多能干细胞的方法 |
CN110272871B (zh) * | 2019-05-16 | 2021-08-27 | 安徽瑞达健康产业有限公司 | 一种刺激诱导单个核细胞扩增为γδT细胞的组合物及其应用 |
CN111235105B (zh) * | 2020-03-06 | 2021-08-10 | 安徽中盛溯源生物科技有限公司 | 一种从人多能干细胞分化为自然杀伤细胞的方法及应用 |
TW202214844A (zh) * | 2020-06-17 | 2022-04-16 | 美商健生生物科技公司 | 用於製造多能幹細胞之材料及方法 |
CN111849913B (zh) * | 2020-07-31 | 2021-05-25 | 南京北恒生物科技有限公司 | 工程化免疫细胞及其用途 |
CN112662627B (zh) * | 2021-01-19 | 2022-09-02 | 上海爱萨尔生物科技有限公司 | 多能干细胞分化为自然杀伤细胞的培养液及分化方法 |
CN113440606A (zh) * | 2021-06-02 | 2021-09-28 | 深圳市罗湖区人民医院 | 特异性多能干细胞肿瘤疫苗及其制备方法与应用 |
JPWO2023053994A1 (zh) * | 2021-09-29 | 2023-04-06 | ||
CN115261318B (zh) * | 2021-09-29 | 2024-05-28 | 苏州艾凯利元生物科技有限公司 | 产生自然杀伤细胞的方法 |
KR20230105166A (ko) * | 2022-01-03 | 2023-07-11 | 주식회사 이뮤노맥스 | 감마-델타 t 세포의 증식 배양 방법 |
CN116042527B (zh) * | 2022-09-07 | 2023-08-22 | 广州瑞臻再生医学科技有限公司 | 一种促进NK细胞分化的iPS细胞系及其构建方法与应用 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003111595A (ja) * | 2001-06-25 | 2003-04-15 | Kyogo Ito | 腫瘍抗原 |
JP4616827B2 (ja) * | 2003-03-24 | 2011-01-19 | ザ スクリプス リサーチ インスティチュート | 腫瘍成長に対するdnaワクチン及びその使用方法 |
JPWO2006006720A1 (ja) * | 2004-07-13 | 2008-05-01 | 株式会社メディネット | γδT細胞の培養方法、γδT細胞及び治療・予防剤 |
JP4281071B1 (ja) * | 2008-07-10 | 2009-06-17 | 学校法人兵庫医科大学 | Vγ9Vδ2T細胞の増殖剤、活性化Vγ9Vδ2T細胞の製造方法およびこれらの利用 |
WO2010027094A1 (ja) * | 2008-09-08 | 2010-03-11 | 独立行政法人理化学研究所 | NKT細胞由来iPS細胞およびそれ由来のNKT細胞 |
EP2352816B1 (en) * | 2008-11-07 | 2015-06-24 | Sunnybrook Health Sciences Centre | Human progenitor t-cells |
CN103087991B (zh) * | 2009-06-05 | 2018-06-12 | 富士胶片细胞动力公司 | 重编程t细胞和造血细胞的方法 |
US8518397B2 (en) * | 2009-08-14 | 2013-08-27 | Case Western Reserve University | Notch induced natural killer cell generation and therapeutic uses |
US9206394B2 (en) * | 2010-02-03 | 2015-12-08 | The University Of Tokyo | Method for reconstructing immune function using pluripotent stem cells |
GB201013767D0 (en) * | 2010-08-17 | 2010-09-29 | Isis Innovation | Identification of ligands and their use |
EP2841563B1 (en) * | 2012-04-24 | 2019-06-12 | Dan S. Kaufman | Method for developing natural killer cells from stem cells |
JP6164746B2 (ja) | 2012-05-22 | 2017-07-19 | 国立大学法人 東京大学 | 抗原特異的t細胞の製造方法 |
JP6800859B2 (ja) * | 2015-01-26 | 2020-12-16 | フェイト セラピューティクス,インコーポレイテッド | 造血細胞分化を誘導するための方法および組成物 |
CN108026545A (zh) * | 2015-06-17 | 2018-05-11 | Uab研究基金会 | 用于将功能性多肽引入到血细胞谱系细胞中的crispr/cas9复合物 |
AU2016348342B2 (en) * | 2015-11-04 | 2023-07-06 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
US20180362927A1 (en) * | 2015-12-08 | 2018-12-20 | Bryce R. BKAZAR | Human t cell derived from t cell-derived induced pluripotent stem cell and methods of making and using |
US20200017837A1 (en) * | 2017-02-03 | 2020-01-16 | National University Corporation Kobe University | Method For Producing Induced Pluripotent Stem Cells |
WO2018147801A1 (en) * | 2017-02-07 | 2018-08-16 | Agency For Science, Technology And Research | Methods and kits for generating mimetic innate immune cells from pluripotent stem cells |
-
2018
- 2018-02-07 WO PCT/SG2018/050051 patent/WO2018147801A1/en unknown
- 2018-02-07 SG SG11201907285XA patent/SG11201907285XA/en unknown
- 2018-02-07 SG SG10202106515SA patent/SG10202106515SA/en unknown
- 2018-02-07 US US16/484,349 patent/US20190359940A1/en active Pending
- 2018-02-07 MY MYPI2019004546A patent/MY202222A/en unknown
- 2018-02-07 CN CN201880022790.XA patent/CN110691844B/zh active Active
- 2018-02-07 JP JP2019542694A patent/JP7092281B2/ja active Active
- 2018-02-07 EP EP18751284.3A patent/EP3580332A4/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN110691844B (zh) | 2023-09-08 |
WO2018147801A1 (en) | 2018-08-16 |
JP7092281B2 (ja) | 2022-06-28 |
EP3580332A1 (en) | 2019-12-18 |
CN110691844A (zh) | 2020-01-14 |
EP3580332A4 (en) | 2020-11-25 |
US20190359940A1 (en) | 2019-11-28 |
JP2020506713A (ja) | 2020-03-05 |
SG10202106515SA (en) | 2021-07-29 |
MY202222A (en) | 2024-04-17 |
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