SG11201901460UA - Method for producing the crystalline form of modification a of calcobutrol - Google Patents
Method for producing the crystalline form of modification a of calcobutrolInfo
- Publication number
- SG11201901460UA SG11201901460UA SG11201901460UA SG11201901460UA SG11201901460UA SG 11201901460U A SG11201901460U A SG 11201901460UA SG 11201901460U A SG11201901460U A SG 11201901460UA SG 11201901460U A SG11201901460U A SG 11201901460UA SG 11201901460U A SG11201901460U A SG 11201901460UA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- modification
- crystalline form
- pct
- str
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- 230000004048 modification Effects 0.000 title abstract 4
- 238000012986 modification Methods 0.000 title abstract 4
- GCLKDXFGQNCFQW-CTHHTMFSSA-L calcium 2-[4,10-bis(carboxylatomethyl)-7-[(2R,3S)-1,3,4-trihydroxybutan-2-yl]-1,4,7,10-tetrazacyclododec-1-yl]acetate hydron Chemical compound [H+].[Ca+2].OC[C@@H](O)[C@@H](CO)N1CCN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC([O-])=O)CC1 GCLKDXFGQNCFQW-CTHHTMFSSA-L 0.000 title abstract 3
- 229950006450 calcobutrol Drugs 0.000 title abstract 2
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- ZPDFIIGFYAHNSK-CTHHTMFSSA-K 2-[4,10-bis(carboxylatomethyl)-7-[(2r,3s)-1,3,4-trihydroxybutan-2-yl]-1,4,7,10-tetrazacyclododec-1-yl]acetate;gadolinium(3+) Chemical compound [Gd+3].OC[C@@H](O)[C@@H](CO)N1CCN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC([O-])=O)CC1 ZPDFIIGFYAHNSK-CTHHTMFSSA-K 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 229910052688 Gadolinium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 159000000007 calcium salts Chemical class 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- ZPDFIIGFYAHNSK-UHFFFAOYSA-K gadobutrol Chemical compound [Gd+3].OCC(O)C(CO)N1CCN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC([O-])=O)CC1 ZPDFIIGFYAHNSK-UHFFFAOYSA-K 0.000 abstract 1
- 229960003411 gadobutrol Drugs 0.000 abstract 1
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 235000006408 oxalic acid Nutrition 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/04—Calcium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
- A61K49/108—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA the metal complex being Gd-DOTA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16190812 | 2016-09-27 | ||
| PCT/EP2017/072683 WO2018059914A1 (en) | 2016-09-27 | 2017-09-11 | Method for producing the crystalline form of modification a of calcobutrol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201901460UA true SG11201901460UA (en) | 2019-03-28 |
Family
ID=57003447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201901460UA SG11201901460UA (en) | 2016-09-27 | 2017-09-11 | Method for producing the crystalline form of modification a of calcobutrol |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US10793532B2 (pt) |
| EP (1) | EP3519394B1 (pt) |
| JP (2) | JP7053590B2 (pt) |
| KR (1) | KR102395523B1 (pt) |
| CN (1) | CN109803958B (pt) |
| AR (1) | AR109729A1 (pt) |
| AU (1) | AU2017333698B2 (pt) |
| BR (1) | BR112019006066A2 (pt) |
| CA (1) | CA3038036C (pt) |
| CY (1) | CY1123317T1 (pt) |
| DK (1) | DK3519394T3 (pt) |
| ES (1) | ES2809736T3 (pt) |
| HR (1) | HRP20200922T1 (pt) |
| HU (1) | HUE050553T2 (pt) |
| IL (1) | IL265536B (pt) |
| LT (1) | LT3519394T (pt) |
| MX (1) | MX2019003540A (pt) |
| NZ (1) | NZ751256A (pt) |
| PL (1) | PL3519394T3 (pt) |
| PT (1) | PT3519394T (pt) |
| RS (1) | RS60392B1 (pt) |
| SG (1) | SG11201901460UA (pt) |
| SI (1) | SI3519394T1 (pt) |
| TW (1) | TWI765913B (pt) |
| UY (1) | UY37421A (pt) |
| WO (1) | WO2018059914A1 (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3519394T (pt) * | 2016-09-27 | 2020-08-03 | Bayer Pharma AG | Método para produzir a forma cristalina de modificação a de calcobutrol |
| US20210284662A1 (en) * | 2018-07-10 | 2021-09-16 | Biophore India Pharmaceuticals Pvt. Ltd | Process for the preparation of 2,2',2''-(10-((2r,3s)-1,3,4-trihydroxy butan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl) triacetic acid and its complexes |
| EP3870569A4 (en) * | 2018-10-24 | 2022-08-24 | Biophore India Pharmaceuticals Pvt. Ltd. | NEW PROCESS FOR THE PREPARATION OF MACROCYCLIC CHELATING TRIACETIC ACID 2,2',2''-(10-(2-HYDROXYPROPYL)-1,4,7,10-TETRA AZACYCLODODECANE-1,4,7-TRIYL) AND ITS COMPLEXES WITH PARAMAGNETIC METALLIC IONS |
| CN111039885B (zh) * | 2019-12-06 | 2021-03-05 | 广州康瑞泰药业有限公司 | 一种制备高纯度考布曲钙的方法 |
| KR20210112910A (ko) * | 2020-03-06 | 2021-09-15 | 주식회사 엔지켐생명과학 | 가도부트롤 주사제 제조를 위한 부형제인 칼코부트롤의 제조 방법 |
| KR20210114742A (ko) * | 2020-03-11 | 2021-09-24 | 주식회사 엔지켐생명과학 | 칼테리돌의 제조방법 |
| CN114573522A (zh) * | 2020-11-30 | 2022-06-03 | 江苏恒瑞医药股份有限公司 | 一种考布曲钙的新晶型及其制备方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1491129A (en) | 1975-06-04 | 1977-11-09 | Guerbet Sa | Iodo-benzene derivatives and an x-ray contrast medium containing them |
| US4284620A (en) | 1979-03-23 | 1981-08-18 | Mallinckrodt, Inc. | N-(2-Hydroxyethyl)-2,4,6-triiodo-3,5-bis-(2-keto-L-gulonamido)benzamide and radiological compositions containing same |
| NO161560C (no) | 1980-04-17 | 1989-09-06 | Univ California | Symmetriske trijodisoftaldiamid-derivater og roentgenkontrastmidler inneholdende disse. |
| DE3150916A1 (de) | 1981-12-18 | 1983-06-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel" |
| US5064633A (en) | 1984-06-04 | 1991-11-12 | The Dow Chemical Company | Macrocyclic aminophosphonic acid complexes, their formulations and use |
| US5059412A (en) | 1984-06-04 | 1991-10-22 | The Dow Chemical Company | Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors |
| MX174467B (es) | 1986-01-23 | 1994-05-17 | Squibb & Sons Inc | 1,4,7-triscarboximetil-1,4,7,10-tetraazaciclodo decano substituido en 1 y compuestos analogos |
| US4885363A (en) | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
| DE3625417C2 (de) | 1986-07-28 | 1998-10-08 | Schering Ag | Tetraazacyclododecan-Derivate |
| DE3640708C2 (de) | 1986-11-28 | 1995-05-18 | Schering Ag | Verbesserte metallhaltige Pharmazeutika |
| DE4009119A1 (de) | 1990-03-19 | 1991-09-26 | Schering Ag | 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| PT97124A (pt) | 1990-03-23 | 1991-12-31 | Gist Brocades Nv | Processo para a prparacao de composicoes inibidoras de interleucina - 6 (il-6) |
| DE4035760A1 (de) | 1990-11-08 | 1992-05-14 | Schering Ag | Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| US5410043A (en) | 1991-12-06 | 1995-04-25 | Schering Aktiengesellschaft | Process for the production of mono-N-substituted tetraaza macrocycles |
| DE4237943C2 (de) | 1992-11-06 | 1997-10-23 | Schering Ag | Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate |
| DE4218744C2 (de) | 1992-06-04 | 1997-11-06 | Schering Ag | Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe |
| DE4318369C1 (de) | 1993-05-28 | 1995-02-09 | Schering Ag | Verwendung von makrocyclischen Metallkomplexen als Temperatursonden |
| US5358704A (en) | 1993-09-30 | 1994-10-25 | Bristol-Myers Squibb | Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents |
| IT1275426B (it) | 1995-05-16 | 1997-08-07 | Bracco Spa | Recupero del gadolinio e dei suoi agenti complessanti da soluzioni acquose contenenti i loro complessi |
| DE19724186C2 (de) | 1997-06-02 | 2002-07-18 | Schering Ag | Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe |
| US9016221B2 (en) | 2004-02-17 | 2015-04-28 | University Of Florida Research Foundation, Inc. | Surface topographies for non-toxic bioadhesion control |
| DE102009053171B4 (de) | 2009-11-04 | 2011-07-21 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Verfahren zur Herstellung des Calcium-Komplexes von Dihydroxy-hydroxy-methylpropyl-tetraazacyclododecan-triessigsäure (Calcobutrol) |
| EA201600272A1 (ru) * | 2011-04-21 | 2016-12-30 | Байер Интеллектчуал Проперти Гмбх | Получение гадобутрола высокой чистоты |
| JP2014516080A (ja) * | 2011-06-08 | 2014-07-07 | エスティーアイ ファーマ， エルエルシー | 一日一回の投与のための吸収が制御された水溶性の薬学的に活性な有機化合物製剤 |
| KR101693400B1 (ko) * | 2014-09-17 | 2017-01-05 | 에스티팜 주식회사 | 칼코부트롤의 제조방법 |
| CN105037288B (zh) * | 2015-07-23 | 2017-11-03 | 上海现代制药海门有限公司 | 一种布醇的制备方法 |
| CN106187930B (zh) * | 2016-07-12 | 2018-10-19 | 嘉实（湖南）医药科技有限公司 | 高纯度考布曲钙的制备方法 |
| PT3519394T (pt) | 2016-09-27 | 2020-08-03 | Bayer Pharma AG | Método para produzir a forma cristalina de modificação a de calcobutrol |
-
2017
- 2017-09-11 PT PT177687332T patent/PT3519394T/pt unknown
- 2017-09-11 HU HUE17768733A patent/HUE050553T2/hu unknown
- 2017-09-11 CN CN201780058632.5A patent/CN109803958B/zh active Active
- 2017-09-11 DK DK17768733.2T patent/DK3519394T3/da active
- 2017-09-11 ES ES17768733T patent/ES2809736T3/es active Active
- 2017-09-11 SI SI201730298T patent/SI3519394T1/sl unknown
- 2017-09-11 EP EP17768733.2A patent/EP3519394B1/en active Active
- 2017-09-11 AU AU2017333698A patent/AU2017333698B2/en active Active
- 2017-09-11 WO PCT/EP2017/072683 patent/WO2018059914A1/en active Application Filing
- 2017-09-11 RS RS20200654A patent/RS60392B1/sr unknown
- 2017-09-11 BR BR112019006066A patent/BR112019006066A2/pt not_active Application Discontinuation
- 2017-09-11 US US16/336,217 patent/US10793532B2/en active Active
- 2017-09-11 MX MX2019003540A patent/MX2019003540A/es unknown
- 2017-09-11 IL IL265536A patent/IL265536B/en unknown
- 2017-09-11 PL PL17768733T patent/PL3519394T3/pl unknown
- 2017-09-11 CA CA3038036A patent/CA3038036C/en active Active
- 2017-09-11 SG SG11201901460UA patent/SG11201901460UA/en unknown
- 2017-09-11 LT LTEP17768733.2T patent/LT3519394T/lt unknown
- 2017-09-11 JP JP2019516489A patent/JP7053590B2/ja active Active
- 2017-09-11 NZ NZ751256A patent/NZ751256A/en unknown
- 2017-09-11 KR KR1020197008763A patent/KR102395523B1/ko active IP Right Grant
- 2017-09-27 UY UY0001037421A patent/UY37421A/es unknown
- 2017-09-27 AR ARP170102671A patent/AR109729A1/es unknown
- 2017-09-27 TW TW106133043A patent/TWI765913B/zh active
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2020
- 2020-06-09 HR HRP20200922TT patent/HRP20200922T1/hr unknown
- 2020-07-30 CY CY20201100709T patent/CY1123317T1/el unknown
- 2020-09-22 US US17/028,467 patent/US11390592B2/en active Active
-
2022
- 2022-03-03 JP JP2022032582A patent/JP7444914B2/ja active Active
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