SG11201900551WA - Spiro-lactam nmda receptor modulators and uses thereof - Google Patents
Spiro-lactam nmda receptor modulators and uses thereofInfo
- Publication number
- SG11201900551WA SG11201900551WA SG11201900551WA SG11201900551WA SG11201900551WA SG 11201900551W A SG11201900551W A SG 11201900551WA SG 11201900551W A SG11201900551W A SG 11201900551WA SG 11201900551W A SG11201900551W A SG 11201900551WA SG 11201900551W A SG11201900551W A SG 11201900551WA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- pct
- compounds
- nmda receptor
- spiro
- Prior art date
Links
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 title abstract 3
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000009472 formulation Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 241000208140 Acer Species 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 102220240796 rs553605556 Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/499—Spiro-condensed pyrazines or piperazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662369456P | 2016-08-01 | 2016-08-01 | |
| PCT/US2017/044841 WO2018026782A1 (en) | 2016-08-01 | 2017-08-01 | Spiro-lactam nmda receptor modulators and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201900551WA true SG11201900551WA (en) | 2019-02-27 |
Family
ID=59593191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201900551WA SG11201900551WA (en) | 2016-08-01 | 2017-08-01 | Spiro-lactam nmda receptor modulators and uses thereof |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US10918637B2 (de) |
| EP (1) | EP3490993B1 (de) |
| JP (1) | JP7032378B2 (de) |
| KR (1) | KR102465757B1 (de) |
| CN (1) | CN109890825B (de) |
| AU (1) | AU2017305240B2 (de) |
| CA (1) | CA3031539C (de) |
| CL (1) | CL2019000247A1 (de) |
| CO (1) | CO2019000943A2 (de) |
| EA (1) | EA201990428A1 (de) |
| IL (2) | IL286107B1 (de) |
| MX (1) | MX2019001321A (de) |
| PE (1) | PE20190504A1 (de) |
| PH (1) | PH12019500206A1 (de) |
| SG (1) | SG11201900551WA (de) |
| WO (1) | WO2018026782A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009293164B2 (en) | 2008-09-18 | 2015-07-09 | Northwestern University | NMDA receptor modulators and uses thereof |
| BR112015018087B1 (pt) | 2013-01-29 | 2022-09-20 | Aptinyx Inc | Compostos moduladores de receptor n-metil-d-aspartato (nmda) de espiro-lactama, composição farmacêutica e uso dos mesmos |
| KR101518972B1 (ko) | 2014-08-01 | 2015-05-18 | 제이더블유크레아젠 주식회사 | 수지상세포의 제조방법, 이에 의해 제조된 수지상세포 및 그 용도 |
| SG11201900551WA (en) | 2016-08-01 | 2019-02-27 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and uses thereof |
| PE20190501A1 (es) | 2016-08-01 | 2019-04-10 | Aptinyx Inc | Moduladores nmda espiro-lactam y metodos de uso de los mismos |
| PE20190502A1 (es) | 2016-08-01 | 2019-04-10 | Aptinyx Inc | Moduladores del receptor nmda spiro-lactam y bis-spiro-lactam y uso de los mismos |
| PE20190503A1 (es) | 2016-08-01 | 2019-04-10 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactam y uso de los mismos |
| PE20190500A1 (es) | 2016-08-01 | 2019-04-10 | Aptinyx Inc | Moduladores del receptor nmda spiro-lactam y uso de los mismos |
| US11578072B2 (en) | 2018-01-31 | 2023-02-14 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
| PE20240926A1 (es) | 2020-06-03 | 2024-04-30 | Aptinyx Inc | Compuestos de espirolactama y metodos para tratar infecciones virales usando los mismos |
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| CA2898863A1 (en) | 2013-01-29 | 2014-08-07 | Naurex, Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| BR112015018087B1 (pt) | 2013-01-29 | 2022-09-20 | Aptinyx Inc | Compostos moduladores de receptor n-metil-d-aspartato (nmda) de espiro-lactama, composição farmacêutica e uso dos mesmos |
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| WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| WO2017201283A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| PE20190503A1 (es) | 2016-08-01 | 2019-04-10 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactam y uso de los mismos |
| PE20190502A1 (es) | 2016-08-01 | 2019-04-10 | Aptinyx Inc | Moduladores del receptor nmda spiro-lactam y bis-spiro-lactam y uso de los mismos |
| PE20190501A1 (es) | 2016-08-01 | 2019-04-10 | Aptinyx Inc | Moduladores nmda espiro-lactam y metodos de uso de los mismos |
| PE20190500A1 (es) | 2016-08-01 | 2019-04-10 | Aptinyx Inc | Moduladores del receptor nmda spiro-lactam y uso de los mismos |
| SG11201900551WA (en) | 2016-08-01 | 2019-02-27 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and uses thereof |
| EP3746442A1 (de) | 2018-01-31 | 2020-12-09 | Aptinyx Inc. | Spiro-lactam-nmda-rezeptor-modulatoren und verwendungen davon |
| US11578072B2 (en) | 2018-01-31 | 2023-02-14 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
| US20210139489A1 (en) | 2019-11-11 | 2021-05-13 | Aptinyx Inc. | Methods of treating painful diabetic peripheral neuropathy |
-
2017
- 2017-08-01 SG SG11201900551WA patent/SG11201900551WA/en unknown
- 2017-08-01 KR KR1020197005662A patent/KR102465757B1/ko active IP Right Grant
- 2017-08-01 PE PE2019000297A patent/PE20190504A1/es unknown
- 2017-08-01 WO PCT/US2017/044841 patent/WO2018026782A1/en unknown
- 2017-08-01 IL IL286107A patent/IL286107B1/en unknown
- 2017-08-01 EA EA201990428A patent/EA201990428A1/ru unknown
- 2017-08-01 CN CN201780048070.6A patent/CN109890825B/zh active Active
- 2017-08-01 US US16/321,903 patent/US10918637B2/en active Active
- 2017-08-01 AU AU2017305240A patent/AU2017305240B2/en not_active Ceased
- 2017-08-01 EP EP17751913.9A patent/EP3490993B1/de active Active
- 2017-08-01 CA CA3031539A patent/CA3031539C/en active Active
- 2017-08-01 JP JP2019505249A patent/JP7032378B2/ja active Active
- 2017-08-01 MX MX2019001321A patent/MX2019001321A/es unknown
-
2019
- 2019-01-27 IL IL264495A patent/IL264495B/en unknown
- 2019-01-28 PH PH12019500206A patent/PH12019500206A1/en unknown
- 2019-01-30 CO CONC2019/0000943A patent/CO2019000943A2/es unknown
- 2019-01-30 CL CL2019000247A patent/CL2019000247A1/es unknown
-
2020
- 2020-12-01 US US17/108,199 patent/US11376250B2/en active Active
-
2022
- 2022-06-03 US US17/831,544 patent/US20230131402A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA3031539C (en) | 2023-11-28 |
| JP2019527234A (ja) | 2019-09-26 |
| IL286107B1 (en) | 2024-05-01 |
| PE20190504A1 (es) | 2019-04-10 |
| AU2017305240B2 (en) | 2021-12-09 |
| EP3490993B1 (de) | 2023-12-06 |
| IL264495B (en) | 2021-09-30 |
| PH12019500206A1 (en) | 2019-06-17 |
| US20190175588A1 (en) | 2019-06-13 |
| AU2017305240A1 (en) | 2019-02-28 |
| CN109890825B (zh) | 2022-03-11 |
| US10918637B2 (en) | 2021-02-16 |
| EP3490993C0 (de) | 2023-12-06 |
| WO2018026782A1 (en) | 2018-02-08 |
| KR102465757B1 (ko) | 2022-11-09 |
| EP3490993A1 (de) | 2019-06-05 |
| US20230131402A1 (en) | 2023-04-27 |
| KR20190033594A (ko) | 2019-03-29 |
| MX2019001321A (es) | 2019-07-04 |
| EA201990428A1 (ru) | 2019-08-30 |
| US20210322406A1 (en) | 2021-10-21 |
| JP7032378B2 (ja) | 2022-03-08 |
| US11376250B2 (en) | 2022-07-05 |
| IL286107A (en) | 2021-10-31 |
| CN109890825A (zh) | 2019-06-14 |
| CA3031539A1 (en) | 2018-02-08 |
| CO2019000943A2 (es) | 2019-02-08 |
| CL2019000247A1 (es) | 2019-06-21 |
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