SG11201900328WA - Inhibitors of cyclin-dependent kinase 7 (cdk7) - Google Patents

Inhibitors of cyclin-dependent kinase 7 (cdk7)

Info

Publication number
SG11201900328WA
SG11201900328WA SG11201900328WA SG11201900328WA SG11201900328WA SG 11201900328W A SG11201900328W A SG 11201900328WA SG 11201900328W A SG11201900328W A SG 11201900328WA SG 11201900328W A SG11201900328W A SG 11201900328WA SG 11201900328W A SG11201900328W A SG 11201900328WA
Authority
SG
Singapore
Prior art keywords
quebec
international
avenue
cdk7
cyclin
Prior art date
Application number
SG11201900328WA
Other languages
English (en)
Inventor
Jason Marineau
Robert Zahler
Stephane Ciblat
Dana Winter
Anzhelika Kabro
Stephanie Roy
Darby Schmidt
Claudio Chuaqui
Goran Malojcic
Henri Piras
Kenneth Whitmore
Kate-Iyn Lund
Bill Sinko
Kevin Sprott
Original Assignee
Jason Marineau
Robert Zahler
Stephane Ciblat
Dana Winter
Anzhelika Kabro
Stephanie Roy
Darby Schmidt
Claudio Chuaqui
Goran Malojcic
Henri Piras
Kenneth Whitmore
Lund Kate Iyn
Bill Sinko
Kevin Sprott
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jason Marineau, Robert Zahler, Stephane Ciblat, Dana Winter, Anzhelika Kabro, Stephanie Roy, Darby Schmidt, Claudio Chuaqui, Goran Malojcic, Henri Piras, Kenneth Whitmore, Lund Kate Iyn, Bill Sinko, Kevin Sprott filed Critical Jason Marineau
Publication of SG11201900328WA publication Critical patent/SG11201900328WA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541Non-condensed thiazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
SG11201900328WA 2016-07-13 2017-07-13 Inhibitors of cyclin-dependent kinase 7 (cdk7) SG11201900328WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662361852P 2016-07-13 2016-07-13
PCT/US2017/042017 WO2018013867A1 (en) 2016-07-13 2017-07-13 Inhibitors of cyclin dependnt kinase 7 (cdk7)

Publications (1)

Publication Number Publication Date
SG11201900328WA true SG11201900328WA (en) 2019-02-27

Family

ID=59501528

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201900328WA SG11201900328WA (en) 2016-07-13 2017-07-13 Inhibitors of cyclin-dependent kinase 7 (cdk7)
SG10202012466PA SG10202012466PA (en) 2016-07-13 2017-07-13 Inhibitors of cyclin-dependent kinase 7 (cdk7)

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10202012466PA SG10202012466PA (en) 2016-07-13 2017-07-13 Inhibitors of cyclin-dependent kinase 7 (cdk7)

Country Status (15)

Country Link
US (1) US20230062491A1 (ko)
EP (2) EP3484871B1 (ko)
JP (2) JP7058636B2 (ko)
KR (1) KR102587758B1 (ko)
CN (1) CN110036004A (ko)
AU (2) AU2017295863B2 (ko)
BR (1) BR112019000716A2 (ko)
CA (1) CA3030795A1 (ko)
ES (1) ES2954278T3 (ko)
IL (2) IL264222B (ko)
MX (2) MX2019000527A (ko)
RU (1) RU2019103870A (ko)
SG (2) SG11201900328WA (ko)
WO (1) WO2018013867A1 (ko)
ZA (2) ZA201900874B (ko)

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US10913983B2 (en) 2017-07-18 2021-02-09 University Of South Carolina Sensitivity markers and uses for CDK7 inhibitors in breast cancers
AU2019209470A1 (en) 2018-01-16 2020-08-13 Syros Pharmaceuticals, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
WO2019143730A1 (en) 2018-01-16 2019-07-25 Syros Pharmaceuticals, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
KR102661053B1 (ko) 2018-04-26 2024-04-26 화이자 인코포레이티드 사이클린 의존성 키나제 억제제로서 2-아미노-피리딘 또는 2-아미노-피리미딘 유도체
JP2021151955A (ja) * 2018-05-22 2021-09-30 株式会社カネカ 光学活性−cis−アミノピペリジンの製造方法
CN109206427A (zh) * 2018-09-25 2019-01-15 安徽医科大学 芳香杂环乙烯基吡唑并嘧啶类化合物、药物制剂及制备方法与应用
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
TWI835909B (zh) * 2018-11-01 2024-03-21 美商錫羅斯製藥公司 週期素依賴性激酶7(cdk7)之抑制劑
CA3118324A1 (en) 2018-11-01 2020-05-07 Syros Pharmaceuticals, Inc. Methods of treating cancer in biomarker-identified patients with non-covalent inhibitors of cyclin-dependent kinase 7 (cdk7)
US11384083B2 (en) 2019-02-15 2022-07-12 Incyte Corporation Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors
WO2020180959A1 (en) 2019-03-05 2020-09-10 Incyte Corporation Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors
WO2020205560A1 (en) 2019-03-29 2020-10-08 Incyte Corporation Sulfonylamide compounds as cdk2 inhibitors
JP2022529700A (ja) * 2019-04-23 2022-06-23 ダナ-ファーバー キャンサー インスティテュート,インコーポレイテッド サイクリン依存性キナーゼ12(cdk12)の分解剤およびその使用
WO2020223558A1 (en) 2019-05-01 2020-11-05 Incyte Corporation Tricyclic amine compounds as cdk2 inhibitors
US11440914B2 (en) 2019-05-01 2022-09-13 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
KR20220064369A (ko) 2019-08-14 2022-05-18 인사이트 코포레이션 Cdk2 저해제로서의 이미다졸릴 피리디미딘일아민 화합물
CN112430208A (zh) * 2019-08-26 2021-03-02 东莞市东阳光仿制药研发有限公司 一种pf-06651600中间体的制备方法
WO2021072232A1 (en) 2019-10-11 2021-04-15 Incyte Corporation Bicyclic amines as cdk2 inhibitors
IL292519A (en) * 2019-10-29 2022-06-01 Syros Pharmaceuticals Inc Methods for treating cancer in patients identified with a biomarker with cyclin-dependent kinase 7 (cdk7) inhibitors
CN111393415B (zh) * 2020-04-30 2020-11-20 苏州信诺维医药科技有限公司 一种杂芳腈类化合物及其应用
CN111675708A (zh) * 2020-06-10 2020-09-18 南京合巨药业有限公司 一种6-氰基-7-氮杂吲哚及其衍生物的制备方法
CN112661745A (zh) * 2020-07-24 2021-04-16 浙江同源康医药股份有限公司 用作cdk7激酶抑制剂的化合物及其应用
CN114133394B (zh) * 2020-08-12 2023-12-08 赛诺哈勃药业(成都)有限公司 一种选择性针对细胞周期依赖性激酶12活性的化合物、制备方法及医药用途
CN114249712A (zh) * 2020-09-24 2022-03-29 广州费米子科技有限责任公司 嘧啶基衍生物、其制备方法及其用途
WO2022089444A1 (zh) * 2020-10-28 2022-05-05 恒元生物医药科技(苏州)有限公司 一种含氮杂环化合物及其应用
US20240132489A1 (en) * 2020-12-24 2024-04-25 Gt Apeiron Therapeutics Limited Aromatic heterocyclic compound, pharmaceutical composition, and use thereof
US11981671B2 (en) 2021-06-21 2024-05-14 Incyte Corporation Bicyclic pyrazolyl amines as CDK2 inhibitors
WO2023049691A1 (en) * 2021-09-23 2023-03-30 Zeno Management, Inc. Cdk7 inhibitors and methods of treating cancer
CN116082312A (zh) * 2021-11-05 2023-05-09 浙江同源康医药股份有限公司 用作cdk7激酶抑制剂的化合物及其应用
WO2023091726A1 (en) * 2021-11-18 2023-05-25 Syros Pharmaceuticals, Inc. Inhibitors of cyclin‑dependent kinase 12 (cdk12)
US11976073B2 (en) 2021-12-10 2024-05-07 Incyte Corporation Bicyclic amines as CDK2 inhibitors
AR128066A1 (es) * 2021-12-22 2024-03-20 Insilico Medicine Ip Ltd Compuesto heterocíclico de pirimidina y método de preparación y uso médico de los mismos
WO2023116862A1 (zh) * 2021-12-24 2023-06-29 江苏恒瑞医药股份有限公司 氢化吲哚类化合物、其制备方法及其在医药上的应用
EP4242195A1 (en) * 2022-03-09 2023-09-13 EuroChem Antwerpen Use of pyrazolo[3,4-b]pyridine compounds as nitrification inhibitor
WO2024007985A1 (zh) * 2022-07-08 2024-01-11 成都苑东生物制药股份有限公司 一种嘧啶类衍生物、其制备方法及用途
WO2024125551A1 (zh) * 2022-12-16 2024-06-20 杭州阿诺生物医药科技有限公司 细胞周期蛋白k降解剂及其应用
CN115819406B (zh) * 2023-02-24 2023-06-02 淄博百极荣创医药科技有限公司 3-(4-嘧啶)-1h-吲哚类化合物的合成方法
CN116082337B (zh) * 2023-03-16 2023-06-23 英矽智能科技(上海)有限公司 炔基取代的杂环化合物,其制法与医药上的用途

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Also Published As

Publication number Publication date
ZA201900874B (en) 2023-12-20
SG10202012466PA (en) 2021-01-28
EP3484871B1 (en) 2023-06-07
EP3484871A1 (en) 2019-05-22
JP2022020860A (ja) 2022-02-01
CA3030795A1 (en) 2018-01-18
ES2954278T3 (es) 2023-11-21
JP7460593B2 (ja) 2024-04-02
MX2022005898A (es) 2022-06-27
JP2019527217A (ja) 2019-09-26
JP7058636B2 (ja) 2022-04-22
RU2019103870A (ru) 2020-08-14
BR112019000716A2 (pt) 2019-05-07
IL292422A (en) 2022-06-01
KR102587758B1 (ko) 2023-10-12
EP4295852A3 (en) 2024-06-12
CN110036004A (zh) 2019-07-19
AU2022246416B2 (en) 2024-06-27
WO2018013867A8 (en) 2018-11-15
AU2017295863B2 (en) 2022-07-07
AU2017295863A1 (en) 2019-02-07
IL264222A (en) 2019-02-28
MX2019000527A (es) 2019-08-12
WO2018013867A1 (en) 2018-01-18
RU2019103870A3 (ko) 2020-11-09
ZA202301672B (en) 2024-06-26
KR20190038841A (ko) 2019-04-09
IL264222B (en) 2022-05-01
EP4295852A2 (en) 2023-12-27
US20230062491A1 (en) 2023-03-02
AU2022246416A1 (en) 2022-11-03

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