SG11201900270YA - Method of quantitative measurement of particle content using hydrated state imaging - Google Patents

Method of quantitative measurement of particle content using hydrated state imaging

Info

Publication number
SG11201900270YA
SG11201900270YA SG11201900270YA SG11201900270YA SG11201900270YA SG 11201900270Y A SG11201900270Y A SG 11201900270YA SG 11201900270Y A SG11201900270Y A SG 11201900270YA SG 11201900270Y A SG11201900270Y A SG 11201900270YA SG 11201900270Y A SG11201900270Y A SG 11201900270YA
Authority
SG
Singapore
Prior art keywords
international
particle content
state imaging
vlps
pct
Prior art date
Application number
SG11201900270YA
Other languages
English (en)
Inventor
Mathieu Colomb-Delsuc
Lars Haag
Rickard Nordström
Martin Ryner
Original Assignee
Intelligent Virus Imaging Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intelligent Virus Imaging Inc filed Critical Intelligent Virus Imaging Inc
Publication of SG11201900270YA publication Critical patent/SG11201900270YA/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/42—Low-temperature sample treatment, e.g. cryofixation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/698—Matching; Classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14123—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2806—Means for preparing replicas of specimens, e.g. for microscopal analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0038—Investigating nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses
    • G01N2333/075—Adenoviridae

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Signal Processing (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Multimedia (AREA)
  • Theoretical Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
SG11201900270YA 2017-03-02 2018-01-25 Method of quantitative measurement of particle content using hydrated state imaging SG11201900270YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762465981P 2017-03-02 2017-03-02
PCT/US2018/015263 WO2018160298A1 (en) 2017-03-02 2018-01-25 Method of quantitative measurement of particle content using hydrated state imaging

Publications (1)

Publication Number Publication Date
SG11201900270YA true SG11201900270YA (en) 2019-02-27

Family

ID=63370196

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201900270YA SG11201900270YA (en) 2017-03-02 2018-01-25 Method of quantitative measurement of particle content using hydrated state imaging

Country Status (17)

Country Link
US (2) US11125672B2 (zh)
EP (1) EP3589643A4 (zh)
JP (1) JP6865769B2 (zh)
KR (1) KR102149623B1 (zh)
CN (1) CN108884133A (zh)
AU (1) AU2018228346A1 (zh)
BR (1) BR112019001151A2 (zh)
CA (1) CA3015803A1 (zh)
CL (1) CL2018002809A1 (zh)
EA (1) EA037471B1 (zh)
HK (1) HK1256983A1 (zh)
IL (1) IL263737A (zh)
MA (1) MA44418B1 (zh)
MX (1) MX2019001354A (zh)
SG (1) SG11201900270YA (zh)
WO (1) WO2018160298A1 (zh)
ZA (1) ZA201900102B (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA44418B1 (fr) * 2017-03-02 2021-11-30 Intelligent Virus Imaging Inc Procédé permettant la mesure quantitative de contenu particulaire à l'aide d'une imagerie à l'état hydraté
CN112183433B (zh) * 2020-10-12 2024-02-23 水木未来(北京)科技有限公司 一种实心和空心病毒颗粒的表征量化方法
CN113009184A (zh) * 2021-04-20 2021-06-22 浙江科技学院 一种基于低共熔溶剂制备冷冻电镜检测样品的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8712140B2 (en) * 2005-04-15 2014-04-29 Intelligent Virus Imaging Inc. Method of analyzing cell structures and their components
RU2461063C2 (ru) * 2007-05-30 2012-09-10 Интеллигент Вирус Имагинг Инк. Способ подсчета и сегментации частиц вирусов на изображении
US20130191037A1 (en) * 2011-07-26 2013-07-25 Nanoimaging Services Characterization of particulates using electron microscopy and image processing methods
US10192025B2 (en) * 2013-07-08 2019-01-29 Novartis Ag Rotavirus particles with chimeric surface proteins
ES2705574T3 (es) * 2013-10-22 2019-03-26 Hoffmann La Roche Procedimientos para medir partículas de virus libres de células a partir de gotas de sangre seca
JP6452630B2 (ja) * 2014-01-29 2019-01-16 国立研究開発法人科学技術振興機構 含水状態の生物試料の電子顕微鏡観察用保護剤、電子顕微鏡観察用キット、電子顕微鏡による観察、診断、評価、定量の方法並びに試料台
CN104537713B (zh) * 2015-01-05 2017-10-03 清华大学 一种新型三维重构系统
MA44418B1 (fr) * 2017-03-02 2021-11-30 Intelligent Virus Imaging Inc Procédé permettant la mesure quantitative de contenu particulaire à l'aide d'une imagerie à l'état hydraté

Also Published As

Publication number Publication date
EP3589643A1 (en) 2020-01-08
MX2019001354A (es) 2019-06-03
MA44418A1 (fr) 2020-04-30
US20190331584A1 (en) 2019-10-31
IL263737A (en) 2019-01-31
US20210341372A1 (en) 2021-11-04
CA3015803A1 (en) 2018-09-02
AU2018228346A1 (en) 2018-10-04
EA037471B1 (ru) 2021-03-31
MA44418B1 (fr) 2021-11-30
KR102149623B1 (ko) 2020-08-28
EA201891845A1 (ru) 2020-03-02
US11125672B2 (en) 2021-09-21
BR112019001151A2 (pt) 2019-04-30
EP3589643A4 (en) 2020-12-16
ZA201900102B (en) 2019-09-25
JP2020513230A (ja) 2020-05-14
KR20190038541A (ko) 2019-04-08
HK1256983A1 (zh) 2019-10-11
CL2018002809A1 (es) 2019-01-18
CN108884133A (zh) 2018-11-23
JP6865769B2 (ja) 2021-04-28
WO2018160298A1 (en) 2018-09-07

Similar Documents

Publication Publication Date Title
SG11201809344QA (en) Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde
SG11201807401RA (en) Therapeutic membrane vesicles
SG11201803983UA (en) Transformable tagging compositions, methods, and processes incorporating same
SG11201808990QA (en) Compositions for topical application of compounds
SG11201810600WA (en) Fxr (nr1h4) modulating compounds
SG11201903697WA (en) Liver organoid compositions and methods of making and using same
SG11201900772YA (en) Gene editing of car-t cells for the treatment of t cell malignancies with chimeric antigen receptors
SG11201807784SA (en) 3-desoxy derivative and pharmaceutical compositions thereof
SG11201803703UA (en) Anti-complement factor c1q fab fragments and uses thereof
SG11201407580YA (en) Composition comprising two antibodies engineered to have reduced and increased effector function
SG11201907023UA (en) Method of reducing neutropenia
SG11201909155VA (en) Ask1 inhibitor compounds and uses thereof
SG11201806284TA (en) Low pressure separator having an internal divider and uses therefor
SG11201906238TA (en) Split sector level sweep using beamforming refinement frames
SG11201907776WA (en) Replication lag-constrained deletion of data in a large-scale distributed data storage system
SG11201900270YA (en) Method of quantitative measurement of particle content using hydrated state imaging
SG11201904535VA (en) Prevention and treatment of bone and cartilage damage or disease
SG11201901228QA (en) Chromatography method for quantifying a non-ionic surfactant in a composition comprising the non-ionic surfactant and a polypeptide
SG11202000263QA (en) Immunomodulatory retinoid and rexinoid compounds in combination with immune modulators for cancer immunotherapy
SG11201900361RA (en) Methods of treating prostate cancer
SG11201811329UA (en) Spheroids including biologically-relevant materials and related methods
SG11201900609PA (en) Method and system for providing buffer solutions
SG11201811416VA (en) Crystalline solid forms of a bet inhibitor
SG11201809474TA (en) Compositions and methods for bioengineered tissues
SG11201807596YA (en) Gitr antibodies, methods, and uses