SG11201810834WA - Hepatitis b antiviral agents - Google Patents
Hepatitis b antiviral agentsInfo
- Publication number
- SG11201810834WA SG11201810834WA SG11201810834WA SG11201810834WA SG11201810834WA SG 11201810834W A SG11201810834W A SG 11201810834WA SG 11201810834W A SG11201810834W A SG 11201810834WA SG 11201810834W A SG11201810834W A SG 11201810834WA SG 11201810834W A SG11201810834W A SG 11201810834WA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- road
- pct
- hepatitis
- hbv
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662348419P | 2016-06-10 | 2016-06-10 | |
| US201762443245P | 2017-01-06 | 2017-01-06 | |
| PCT/US2017/036553 WO2017214395A1 (en) | 2016-06-10 | 2017-06-08 | Hepatitis b antiviral agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201810834WA true SG11201810834WA (en) | 2018-12-28 |
Family
ID=60573663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201810834WA SG11201810834WA (en) | 2016-06-10 | 2017-06-08 | Hepatitis b antiviral agents |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10189846B2 (zh) |
| EP (1) | EP3468561A4 (zh) |
| JP (1) | JP2019521972A (zh) |
| KR (1) | KR20190027814A (zh) |
| CN (1) | CN109843296A (zh) |
| AU (1) | AU2017277664A1 (zh) |
| BR (1) | BR112018075465A2 (zh) |
| CA (1) | CA3028228A1 (zh) |
| CL (1) | CL2018003492A1 (zh) |
| CO (1) | CO2019000069A2 (zh) |
| IL (1) | IL263535A (zh) |
| MX (1) | MX2018015315A (zh) |
| PH (1) | PH12018550201A1 (zh) |
| SG (1) | SG11201810834WA (zh) |
| WO (1) | WO2017214395A1 (zh) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016161268A1 (en) | 2015-04-01 | 2016-10-06 | Enanta Pharmaceuticals, Inc. | Hepatitis b antviral agents |
| US10738035B2 (en) | 2015-05-13 | 2020-08-11 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| WO2017011552A1 (en) | 2015-07-13 | 2017-01-19 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| WO2017136403A1 (en) | 2016-02-02 | 2017-08-10 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| EP3426245B1 (en) | 2016-03-07 | 2022-12-14 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| AU2017277664A1 (en) | 2016-06-10 | 2019-01-24 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| KR102305215B1 (ko) | 2016-10-14 | 2021-09-28 | 프리시젼 바이오사이언시스 인코포레이티드 | B형 간염 바이러스 게놈 내의 인식 서열에 대해 특이적인 조작된 메가뉴클레아제 |
| US11672800B2 (en) | 2017-04-21 | 2023-06-13 | Epizyme, Inc. | Combination therapies with EHMT2 inhibitors |
| UY37861A (es) | 2017-08-28 | 2019-03-29 | Enanta Pharm Inc | Agentes antivirales contra la hepatitis b |
| TW201927789A (zh) * | 2017-12-06 | 2019-07-16 | 美商因那塔製藥公司 | B型肝炎抗病毒試劑 |
| US10723733B2 (en) * | 2017-12-06 | 2020-07-28 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| US11203610B2 (en) | 2017-12-20 | 2021-12-21 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| JP7037667B2 (ja) | 2017-12-20 | 2022-03-16 | インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー エーエスシーアール，ヴイ．ヴイ．アイ． | Ｓｔｉｎｇアダプタータンパク質を活性化するホスホン酸結合を有する３’３’環状ジヌクレオチド |
| US11058678B2 (en) | 2018-01-22 | 2021-07-13 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| KR102526964B1 (ko) | 2018-02-26 | 2023-04-28 | 길리애드 사이언시즈, 인코포레이티드 | Hbv 복제 억제제로서의 치환된 피롤리진 화합물 |
| US10729688B2 (en) | 2018-03-29 | 2020-08-04 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| WO2019195181A1 (en) | 2018-04-05 | 2019-10-10 | Gilead Sciences, Inc. | Antibodies and fragments thereof that bind hepatitis b virus protein x |
| TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | ２，２，─環二核苷酸 |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| US11142750B2 (en) | 2018-04-12 | 2021-10-12 | Precision Biosciences, Inc. | Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome |
| WO2019211799A1 (en) | 2018-05-03 | 2019-11-07 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide |
| WO2020028097A1 (en) | 2018-08-01 | 2020-02-06 | Gilead Sciences, Inc. | Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid |
| CN112955142A (zh) * | 2018-09-21 | 2021-06-11 | 英安塔制药有限公司 | 官能化杂环化合物作为抗病毒剂 |
| US11071730B2 (en) | 2018-10-31 | 2021-07-27 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds |
| LT3873903T (lt) | 2018-10-31 | 2024-05-10 | Gilead Sciences, Inc. | Pakeistieji 6-azabenzimidazolo junginiai, kaip hpk1 inhibitoriai |
| BR112021009854A2 (pt) | 2018-11-21 | 2021-08-17 | Enanta Pharmaceuticals, Inc. | heterociclos funcionalizados como agentes antivirais |
| US11766447B2 (en) | 2019-03-07 | 2023-09-26 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3′3′-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
| WO2020178769A1 (en) | 2019-03-07 | 2020-09-10 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotides and prodrugs thereof |
| AU2020231115A1 (en) | 2019-03-07 | 2021-08-26 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotides and prodrugs thereof |
| TWI751516B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TWI751517B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| EP3972695A1 (en) | 2019-05-23 | 2022-03-30 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
| WO2020247444A1 (en) | 2019-06-03 | 2020-12-10 | Enanta Pharmaceuticals, Inc, | Hepatitis b antiviral agents |
| US11760755B2 (en) | 2019-06-04 | 2023-09-19 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| WO2020247575A1 (en) * | 2019-06-04 | 2020-12-10 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| CR20210687A (es) | 2019-06-25 | 2022-03-03 | Gilead Sciences Inc | PROTEÍNAS DE FUSIÓN FLT3L-Fc Y MÉTODOS DE USO |
| WO2021007488A1 (en) | 2019-07-11 | 2021-01-14 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
| CN114341137A (zh) * | 2019-08-16 | 2022-04-12 | 西藏天晟泰丰药业有限公司 | 二氢嘧啶衍生物及其用途 |
| WO2021034804A1 (en) | 2019-08-19 | 2021-02-25 | Gilead Sciences, Inc. | Pharmaceutical formulations of tenofovir alafenamide |
| US20230012560A1 (en) * | 2019-09-04 | 2023-01-19 | Taigen Biotechnology Co., Ltd. | Hepatitis b antiviral agents |
| WO2021055425A2 (en) | 2019-09-17 | 2021-03-25 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
| KR20220074917A (ko) | 2019-09-30 | 2022-06-03 | 길리애드 사이언시즈, 인코포레이티드 | Hbv 백신 및 hbv를 치료하는 방법 |
| WO2021113765A1 (en) | 2019-12-06 | 2021-06-10 | Precision Biosciences, Inc. | Optimized engineered meganucleases having specificity for a recognition sequence in the hepatitis b virus genome |
| WO2021188414A1 (en) | 2020-03-16 | 2021-09-23 | Enanta Pharmaceuticals, Inc. | Functionalized heterocyclic compounds as antiviral agents |
| JP2023518433A (ja) | 2020-03-20 | 2023-05-01 | ギリアード サイエンシーズ， インコーポレイテッド | ４’－ｃ－置換－２－ハロ－２’－デオキシアデノシンヌクレオシドのプロドラッグ並びにその製造法及び使用法 |
| AU2021320236A1 (en) | 2020-08-07 | 2023-04-13 | Gilead Sciences, Inc. | Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use |
| TWI815194B (zh) | 2020-10-22 | 2023-09-11 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
| WO2022121844A1 (zh) * | 2020-12-09 | 2022-06-16 | 上海维申医药有限公司 | 一种二氢嘧啶类化合物、其制备方法及应用 |
| EP4337223A1 (en) | 2021-05-13 | 2024-03-20 | Gilead Sciences, Inc. | Combination of a tlr8 modulating compound and anti-hbv sirna therapeutics |
| CA3222439A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| EP4359389A1 (en) | 2021-06-23 | 2024-05-01 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| KR20240005901A (ko) | 2021-06-23 | 2024-01-12 | 길리애드 사이언시즈, 인코포레이티드 | 디아실글리세롤 키나제 조절 화합물 |
| CA3222277A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
Family Cites Families (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3375160A (en) | 1965-06-07 | 1968-03-26 | Monsanto Co | Methods of combatting gastropods with nitro substituted salicylanilides |
| US3975532A (en) | 1973-06-14 | 1976-08-17 | Ici United States Inc. | Hexahydro-1H-furo(3,4-c) pyrrole compounds for treating pain |
| DE2853220A1 (de) | 1978-12-09 | 1980-07-03 | Hoechst Ag | Neue amino-pyrimidin-carbanilide, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung |
| US4507481A (en) * | 1983-07-29 | 1985-03-26 | Pennwalt Corporation | Pyrrolo[1,2-a]imidazoles and imidazo[1,2-a]pyridines |
| EP0243449A1 (en) | 1985-10-18 | 1987-11-04 | The Upjohn Company | Cyclic hydrocarbons with an aminoalkyl sidechain |
| US5656644A (en) | 1994-07-20 | 1997-08-12 | Smithkline Beecham Corporation | Pyridyl imidazoles |
| JP2609434B2 (ja) | 1992-11-16 | 1997-05-14 | ボリソビッチ レオニドフ，ニコライ | 抗菌性インターフェロン誘発性医薬品 |
| GB9315595D0 (en) | 1993-07-28 | 1993-09-08 | Res Inst Medicine Chem | New compounds |
| FR2765577A1 (fr) | 1997-07-02 | 1999-01-08 | Hoechst Schering Agrevo Sa | Nouveaux amides aromatiques, leur procede de preparation et leur application comme pesticides |
| GB9805520D0 (en) | 1998-03-17 | 1998-05-13 | Zeneca Ltd | Chemical compounds |
| DE19817262A1 (de) * | 1998-04-18 | 1999-10-21 | Bayer Ag | Neue 2-heterocyclisch substituierte Dihydropyrimidine |
| US6525069B1 (en) | 1998-12-18 | 2003-02-25 | Bristol-Myers Squibb Pharma Co. | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| ATE253915T1 (de) | 1999-06-30 | 2003-11-15 | Merck & Co Inc | Src-kinase hemmende verbindungen |
| DE10012549A1 (de) | 2000-03-15 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
| DE10012823A1 (de) | 2000-03-16 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
| DE10013126A1 (de) | 2000-03-17 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
| EP1505966A4 (en) | 2002-05-10 | 2006-08-30 | Bristol Myers Squibb Co | 1,1-DISUBSTITUTED CYCLOALKYL DERIVATIVES AS FACTOR XA HEMMER |
| US20040209930A1 (en) | 2002-10-02 | 2004-10-21 | Carboni Joan M. | Synergistic methods and compositions for treating cancer |
| US7232825B2 (en) | 2003-05-02 | 2007-06-19 | Guoqing P Chen | Phenylaminopyrimidine derivatives and methods of use |
| WO2005025507A2 (en) | 2003-09-10 | 2005-03-24 | Synta Phamaceuticals Corp. | Dihydropyridine compounds for treating or preventing metabolic disorders |
| AU2004296764B2 (en) | 2003-12-02 | 2011-04-28 | The Ohio State University Research Foundation | Zn2+ -chelating motif-tethered short -chain fatty acids as a novel class of histone deacetylase inhibitors |
| US8013006B2 (en) | 2004-07-14 | 2011-09-06 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| WO2006033995A2 (en) | 2004-09-16 | 2006-03-30 | Valeant Research And Development | Thiazolidin-4-ones having anti-hepatitis b activity |
| BRPI0613429A2 (pt) | 2005-07-14 | 2009-02-10 | Takeda San Diego Inc | inibidores de histona desacetilase |
| CA2620179C (en) | 2005-08-16 | 2013-10-29 | Icagen, Inc. | Inhibitors of voltage-gated sodium channels |
| WO2008054454A2 (en) | 2006-02-10 | 2008-05-08 | Transtech Pharma, Inc. | Nitrogen-containing heterocycle derivatives, pharmaceutical compositions, and methods of use thereof as antiviral agents |
| US8202876B2 (en) | 2006-10-02 | 2012-06-19 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| US20080120759A1 (en) | 2006-11-27 | 2008-05-29 | Tolton Gary A | Waterproof cuff assembly for outer wear garment |
| WO2008120759A1 (ja) | 2007-03-30 | 2008-10-09 | Japan Tobacco Inc. | ウレア化合物およびその用途 |
| TWI394575B (zh) | 2007-07-09 | 2013-05-01 | Golden Biotechnology Corp | Application of Cynanchum auranthone Cyclohexenone Compounds in the Preparation of Drugs for the Suppression of Hepatitis B Virus |
| EP2173743A2 (en) | 2007-07-13 | 2010-04-14 | Icagen, Inc. | Sodium channel inhibitors |
| WO2009064848A1 (en) | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-heterocyclic substituted indole derivatives and methods of use thereof |
| JP5501226B2 (ja) | 2008-04-24 | 2014-05-21 | Ｍｓｄ株式会社 | アリールスルホニル誘導体を有効成分とする長鎖脂肪酸伸長酵素阻害剤 |
| US20110281950A1 (en) | 2010-05-11 | 2011-11-17 | Baiocchi Robert A | Compositions and methods for reducing proliferation and viability of lymphoblastoid cells |
| EP2726459B1 (en) | 2011-07-01 | 2019-09-11 | Baruch S. Blumberg Institute | Sulfamoylbenzamide derivatives as antiviral agents against hbv infection |
| KR101939710B1 (ko) | 2011-12-21 | 2019-01-17 | 노비라 테라퓨틱스, 인코포레이티드 | B형 간염의 항바이러스성 제제 |
| WO2013102655A1 (en) * | 2012-01-06 | 2013-07-11 | Janssen R&D Ireland | 4,4-disubstituted-1,4-dihydropyrimidines and the use thereof as medicaments for the treatment of hepatitis b |
| WO2013130703A2 (en) | 2012-02-29 | 2013-09-06 | Institute For Hepatitis And Virus Research | Binhibitors of hepatitis b virus convalently closed circular dna formation and their method of use |
| JP6141402B2 (ja) | 2012-03-31 | 2017-06-07 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｂ型肝炎ウイルス感染の治療および予防のための新規４−メチル−ジヒドロピリミジン |
| US20130267517A1 (en) | 2012-03-31 | 2013-10-10 | Hoffmann-La Roche Inc. | Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection |
| JP6431478B2 (ja) | 2012-06-01 | 2018-11-28 | ドレクセル ユニバーシティ | Ｂ型肝炎ウイルスのｃｃｃｄｎａの転写の調節 |
| US9340538B2 (en) | 2012-08-24 | 2016-05-17 | Sunshine Lake Pharma Co., Ltd. | Dihydropyrimidine compounds and their application in pharmaceuticals |
| KR20210081451A (ko) | 2012-08-28 | 2021-07-01 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 설파모일-아릴아미드 및 b형 간염 치료제로서의 그 용도 |
| CA2881322A1 (en) | 2012-09-10 | 2014-03-13 | F. Hoffmann-La Roche Ag | 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection |
| HUE056251T2 (hu) * | 2012-10-25 | 2022-02-28 | Tetra Discovery Partners Llc | Heteroaril PDE4 inhibitorok |
| EA201591220A1 (ru) | 2012-12-27 | 2016-01-29 | Дрексел Юниверсити | Новые противовирусные агенты против инфекции вирусом гепатита в |
| MX2015015692A (es) * | 2013-05-17 | 2016-03-04 | Hoffmann La Roche | Novedosas heteroarildihidropirimidinas, unidas por puentes en 6 para el tratamiento y la profilaxis de infeccion por el virus de hepatitis b. |
| JO3603B1 (ar) | 2013-05-17 | 2020-07-05 | Janssen Sciences Ireland Uc | مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي |
| JP6441315B2 (ja) | 2013-05-17 | 2018-12-19 | ヤンセン・サイエンシズ・アイルランド・ユーシー | スルファモイルチオフェンアミド誘導体およびｂ型肝炎を治療するための医薬品としてのその使用 |
| KR20160077050A (ko) * | 2013-11-19 | 2016-07-01 | 선샤인 레이크 파르마 컴퍼니 리미티드 | 다이하이드로피리미딘 화합물 및 이의 약제학적 용도 |
| EP3074393B1 (en) | 2013-11-27 | 2018-08-15 | Sunshine Lake Pharma Co., Ltd. | Processes for preparing dihydropyrimidine derivatives and intermediates thereof |
| US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| CN105899508B (zh) | 2014-01-30 | 2017-07-04 | 豪夫迈·罗氏有限公司 | 用于治疗和预防乙型肝炎病毒感染的新型二氢喹嗪酮类化合物 |
| SG11201607332UA (en) | 2014-03-07 | 2016-10-28 | Hoffmann La Roche | Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection |
| KR20160133563A (ko) | 2014-03-28 | 2016-11-22 | 선샤인 레이크 파르마 컴퍼니 리미티드 | 다이하이드로피리미딘 화합물 및 이의 약제학적 용도 |
| KR20160148715A (ko) | 2014-05-13 | 2016-12-26 | 에프. 호프만-라 로슈 아게 | B형 간염 바이러스 감염의 치료 또는 예방을 위한 신규한 다이하이드로퀴놀리진온 |
| RU2693897C2 (ru) | 2014-05-30 | 2019-07-05 | Килу Фармасьютикал Ко., Лтд. | Производное на основе дигидропиримидо-кольца в качестве ингибитора hbv |
| CA2956417C (en) | 2014-07-31 | 2022-09-13 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Flt3 receptor antagonists |
| US9637485B2 (en) | 2014-11-03 | 2017-05-02 | Hoffmann-La Roche Inc. | 6,7-dihydrobenzo[a]quinolizin-2-one derivatives for the treatment and prophylaxis of hepatitis B virus infection |
| US9518057B2 (en) | 2014-12-30 | 2016-12-13 | Novira Therapeutics, Inc. | Derivatives and methods of treating hepatitis B infections |
| CN107207505B (zh) | 2015-02-11 | 2018-12-14 | 豪夫迈·罗氏有限公司 | 治疗和预防乙型肝炎病毒感染的 2-氧代-6,7-二氢苯并[a]喹嗪-3-甲酸衍生物 |
| WO2016161268A1 (en) | 2015-04-01 | 2016-10-06 | Enanta Pharmaceuticals, Inc. | Hepatitis b antviral agents |
| US10738035B2 (en) | 2015-05-13 | 2020-08-11 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| WO2017011552A1 (en) | 2015-07-13 | 2017-01-19 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| CN107849037B (zh) | 2015-07-21 | 2020-04-17 | 豪夫迈·罗氏有限公司 | 用于治疗和预防乙型肝炎病毒感染的三环4-吡啶酮-3-甲酸衍生物 |
| US10301255B2 (en) | 2015-07-22 | 2019-05-28 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| EP3328855B1 (en) | 2015-07-27 | 2019-05-15 | H. Hoffnabb-La Roche Ag | Novel tetracyclic 4-oxo-pyridine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection |
| WO2017017043A1 (en) | 2015-07-28 | 2017-02-02 | F. Hoffmann-La Roche Ag | Novel 6,7-dihydropyrido[2,1-a]phthalazin-2-ones for the treatment and prophylaxis of hepatitis b virus infection |
| ES2794639T3 (es) | 2015-11-04 | 2020-11-18 | Qilu Pharmaceutical Co Ltd | Forma cristalina, método de preparación y compuesto intermedio de compuesto con anillo dihidropirido |
| WO2017136403A1 (en) | 2016-02-02 | 2017-08-10 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| JOP20170045B1 (ar) | 2016-02-19 | 2021-08-17 | Novartis Ag | مركبات بيريدون رباعية الحلقة كمضادات فيروسية |
| EP3426245B1 (en) | 2016-03-07 | 2022-12-14 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| BR102017010009A2 (pt) | 2016-05-27 | 2017-12-12 | Gilead Sciences, Inc. | Compounds for the treatment of hepatitis b virus infection |
| AU2017277664A1 (en) | 2016-06-10 | 2019-01-24 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| WO2017216685A1 (en) | 2016-06-16 | 2017-12-21 | Novartis Ag | Pentacyclic pyridone compounds as antivirals |
| WO2017216686A1 (en) | 2016-06-16 | 2017-12-21 | Novartis Ag | 8,9-fused 2-oxo-6,7-dihydropyrido-isoquinoline compounds as antivirals |
| EP3490987B1 (en) | 2016-07-29 | 2022-09-21 | Guangzhou Lupeng Pharmaceutical Company Ltd. | Novel therapeutic agents for the treatment of hbv infection |
| WO2018019297A1 (zh) | 2016-07-29 | 2018-02-01 | 银杏树药业(苏州)有限公司 | 异喹啉酮类化合物及其制备抗病毒药物的应用 |
| WO2018047109A1 (en) | 2016-09-09 | 2018-03-15 | Novartis Ag | Polycyclic pyridone compounds as antivirals |
| WO2018073753A1 (en) | 2016-10-18 | 2018-04-26 | Novartis Ag | Fused tetracyclic pyridone compounds as antivirals |
| SG11201902944TA (en) | 2016-11-07 | 2019-05-30 | Arbutus Biopharma Corp | Substituted pyridinone-containing tricyclic compounds, and methods using same |
| CN106810548B (zh) | 2017-01-13 | 2019-02-15 | 苏州爱科百发生物医药技术有限公司 | 一种二氢异喹啉类化合物 |
| CN106928245B (zh) | 2017-03-06 | 2019-06-11 | 河南春风医药科技有限公司 | 一种喹嗪酮类化合物及其制备方法和应用 |
| CN106928215B (zh) | 2017-03-06 | 2019-03-22 | 河南春风医药科技有限公司 | 一种喹嗪酮类化合物的制备方法 |
| EP3594214A4 (en) | 2017-04-28 | 2020-09-30 | Qilu Pharmaceutical Co., Ltd | COMPOUND POLYMORPH, RELATED PREPARATION PROCESS AND USE THEREOF |
| US10723733B2 (en) | 2017-12-06 | 2020-07-28 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
| TW201927789A (zh) | 2017-12-06 | 2019-07-16 | 美商因那塔製藥公司 | B型肝炎抗病毒試劑 |
-
2017
- 2017-06-08 AU AU2017277664A patent/AU2017277664A1/en not_active Abandoned
- 2017-06-08 WO PCT/US2017/036553 patent/WO2017214395A1/en unknown
- 2017-06-08 JP JP2018563674A patent/JP2019521972A/ja not_active Withdrawn
- 2017-06-08 CN CN201780048555.5A patent/CN109843296A/zh active Pending
- 2017-06-08 SG SG11201810834WA patent/SG11201810834WA/en unknown
- 2017-06-08 KR KR1020197000474A patent/KR20190027814A/ko unknown
- 2017-06-08 BR BR112018075465-0A patent/BR112018075465A2/pt not_active IP Right Cessation
- 2017-06-08 EP EP17811015.1A patent/EP3468561A4/en not_active Withdrawn
- 2017-06-08 CA CA3028228A patent/CA3028228A1/en not_active Abandoned
- 2017-06-08 US US15/617,445 patent/US10189846B2/en active Active
- 2017-06-08 MX MX2018015315A patent/MX2018015315A/es unknown
-
2018
- 2018-12-03 PH PH12018550201A patent/PH12018550201A1/en unknown
- 2018-12-05 CL CL2018003492A patent/CL2018003492A1/es unknown
- 2018-12-06 IL IL263535A patent/IL263535A/en unknown
- 2018-12-14 US US16/220,267 patent/US10640511B2/en not_active Expired - Fee Related
-
2019
- 2019-01-04 CO CONC2019/0000069A patent/CO2019000069A2/es unknown
-
2020
- 2020-03-30 US US16/834,259 patent/US20200317678A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3468561A1 (en) | 2019-04-17 |
| WO2017214395A1 (en) | 2017-12-14 |
| MX2018015315A (es) | 2019-04-25 |
| IL263535A (en) | 2019-01-31 |
| US20170355701A1 (en) | 2017-12-14 |
| AU2017277664A1 (en) | 2019-01-24 |
| CN109843296A (zh) | 2019-06-04 |
| US20200317678A1 (en) | 2020-10-08 |
| US10640511B2 (en) | 2020-05-05 |
| EP3468561A4 (en) | 2019-12-04 |
| KR20190027814A (ko) | 2019-03-15 |
| CL2018003492A1 (es) | 2019-04-05 |
| JP2019521972A (ja) | 2019-08-08 |
| US20190119288A1 (en) | 2019-04-25 |
| CO2019000069A2 (es) | 2019-02-08 |
| BR112018075465A2 (pt) | 2019-03-19 |
| US10189846B2 (en) | 2019-01-29 |
| PH12018550201A1 (en) | 2019-04-08 |
| CA3028228A1 (en) | 2017-12-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG11201810834WA (en) | Hepatitis b antiviral agents | |
| SG11201807543YA (en) | Hepatitis b antiviral agents | |
| SG11201806863WA (en) | Tetracyclic pyridone compounds as antivirals | |
| SG11201809912UA (en) | Hybrid carriers for nucleic acid cargo | |
| SG11201900163PA (en) | Macrocycle kinase inhibitors | |
| SG11201909011PA (en) | Niraparib compositions | |
| SG11201909432SA (en) | Compounds for increasing genome editing efficiency | |
| SG11201908547VA (en) | Hydrogel cross-linked hyaluronic acid prodrug compositions and methods | |
| SG11201808622SA (en) | Chimeric receptors to flt3 and methods of use thereof | |
| SG11201900844UA (en) | Amino pyrimidine ssao inhibitors | |
| SG11201906386XA (en) | Combination therapy involving diaryl macrocyclic compounds | |
| SG11201809751XA (en) | Egfr inhibitor compounds | |
| SG11201907032RA (en) | Amino pyrimidine compounds useful as ssao inhibitors | |
| SG11201807708SA (en) | Estrogen receptor modulators | |
| SG11201908598PA (en) | Compounds useful in the treatment or prevention of a prmt5-mediated disorder | |
| SG11201803627XA (en) | N-substituted indole derivatives as pge2 receptor modulators | |
| SG11201900633XA (en) | Piperidine cxcr7 receptor modulators | |
| SG11201810371XA (en) | ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF | |
| SG11201907889YA (en) | Glycan-interacting compounds and methods of use | |
| SG11201811230RA (en) | Compositions and methods for reducing ocular neovascularization | |
| SG11201811737SA (en) | Novel fatty acid modified urocortin-2 analogs for the treatment of diabetes and chronic kidney disease | |
| SG11201805595TA (en) | Process for the preparation of 4-phenyl-5-alkoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]-3-oxo-5,6,8,8a-tetrahydro-1h-imidazo[1,5-a]pyrazin-2-yl]-carboxylic acid | |
| SG11201906163TA (en) | Nucleotide hemi-sulfate salt for the treatment of hepatitis c virus | |
| SG11201903348UA (en) | Therapeutic compounds and methods of use thereof | |
| SG11201404836QA (en) | Long-acting coagulation factors and methods of producing same |