SG11201804671SA - Aza-benzimidazole inhibitors of pad4 - Google Patents

Aza-benzimidazole inhibitors of pad4

Info

Publication number
SG11201804671SA
SG11201804671SA SG11201804671SA SG11201804671SA SG11201804671SA SG 11201804671S A SG11201804671S A SG 11201804671SA SG 11201804671S A SG11201804671S A SG 11201804671SA SG 11201804671S A SG11201804671S A SG 11201804671SA SG 11201804671S A SG11201804671S A SG 11201804671SA
Authority
SG
Singapore
Prior art keywords
international
oxfordshire
abingdon
milton
park
Prior art date
Application number
SG11201804671SA
Other languages
English (en)
Inventor
Rajesh Devraj
Gnanasambandam Kumaravel
Laura Gleave
Adrian Kotey
Thomas Krulle
Cristina Lecci
Heather Tye
Ian Wigginton
Original Assignee
Padlock Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Padlock Therapeutics Inc filed Critical Padlock Therapeutics Inc
Publication of SG11201804671SA publication Critical patent/SG11201804671SA/en

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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AR107694A1 (es) * 2016-02-23 2018-05-23 Padlock Therapeutics Inc Heteroarilos inhibidores de pad4
KR102398941B1 (ko) 2016-07-27 2022-05-17 패들락 테라퓨틱스, 인코포레이티드 Pad4의 공유결합성 억제제
ES2924522T3 (es) 2016-09-12 2022-10-07 Padlock Therapeutics Inc Inhibidores heteroarilo de PAD4
AR115920A1 (es) 2018-08-08 2021-03-10 Bristol Myers Squibb Co Inhibidores tipo indol y azaindol de enzimas pad
ES2929200T3 (es) 2018-08-08 2022-11-25 Bristol Myers Squibb Co Tienopirroles sustituidos como inhibidores de PAD4
AU2019318415A1 (en) * 2018-08-08 2021-03-25 Bristol-Myers Squibb Company Substituted benzimidazoles as PAD4 inhibitors
US20230203039A1 (en) * 2020-02-06 2023-06-29 Bristol-Myers Squibb Company Macrocyclic pad4 inhibitors useful as immunosuppressant
TW202140477A (zh) * 2020-02-12 2021-11-01 美商必治妥美雅史谷比公司 雜環pad4抑制劑
BR112022021963A2 (pt) 2020-04-30 2022-12-13 Gilead Sciences Inc Inibidores macrocíclicos de peptidilarginina desiminases
EP4267562A1 (en) 2020-12-22 2023-11-01 Gilead Sciences, Inc. Inhibitors of peptidylarginine deiminases

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FR2826653B1 (fr) * 2001-06-29 2005-10-14 Servier Lab Nouveaux derives de pyrido-pyrido-pyrrolo[3,2-g]pyrrolo [3,4-e]-indole et pyrido-pyrrolo[2,3-a]pyrrolo[3,4-c] carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
IL161576A0 (en) 2001-10-26 2004-09-27 Aventis Pharma Inc Benzimidazoles and analogues and their use as protein kinases inhibitors
FR2862971B1 (fr) * 2003-11-28 2006-03-24 Sod Conseils Rech Applic Nouveaux derives de benzimidazole et d'imidazo-pyridine et leur utilisation en tant que medicament
EP2358202B1 (en) * 2008-11-03 2016-06-15 Merck Sharp & Dohme Corp. Benzimidazole and aza-benzimidazole carboxamides
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US20170166592A1 (en) 2017-06-15
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IL259796A (en) 2018-07-31
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EP3386505B1 (en) 2020-09-23
AU2016366405A1 (en) 2018-07-19
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EA201891347A1 (ru) 2018-12-28
BR112018011633A2 (pt) 2018-11-27
EP3386505A4 (en) 2019-06-26
JP2018537535A (ja) 2018-12-20
KR20180098573A (ko) 2018-09-04
CN108601770B (zh) 2021-06-04

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