SG11201708680PA - Non-activated t cells expressing exogenous virus-specific t cell receptor (tcr) - Google Patents

Non-activated t cells expressing exogenous virus-specific t cell receptor (tcr)

Info

Publication number
SG11201708680PA
SG11201708680PA SG11201708680PA SG11201708680PA SG11201708680PA SG 11201708680P A SG11201708680P A SG 11201708680PA SG 11201708680P A SG11201708680P A SG 11201708680PA SG 11201708680P A SG11201708680P A SG 11201708680PA SG 11201708680P A SG11201708680P A SG 11201708680PA
Authority
SG
Singapore
Prior art keywords
tcr
activated
specific
cells expressing
cell receptor
Prior art date
Application number
SG11201708680PA
Other languages
English (en)
Inventor
Antonio Bertoletti
Sarene Koh
Original Assignee
Lion Tcr Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lion Tcr Pte Ltd filed Critical Lion Tcr Pte Ltd
Publication of SG11201708680PA publication Critical patent/SG11201708680PA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/464838—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/02—Hepadnaviridae, e.g. hepatitis B virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
SG11201708680PA 2016-03-31 2016-03-31 Non-activated t cells expressing exogenous virus-specific t cell receptor (tcr) SG11201708680PA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/SG2016/050164 WO2017171631A1 (fr) 2016-03-31 2016-03-31 Lymphocytes t non activés exprimant un récepteur exogène de lymphocytes t (tcr) spécifique à un virus

Publications (1)

Publication Number Publication Date
SG11201708680PA true SG11201708680PA (en) 2017-11-29

Family

ID=59965039

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201708680PA SG11201708680PA (en) 2016-03-31 2016-03-31 Non-activated t cells expressing exogenous virus-specific t cell receptor (tcr)

Country Status (7)

Country Link
US (1) US11576932B2 (fr)
EP (1) EP3436572A4 (fr)
JP (1) JP2019509753A (fr)
KR (1) KR20190006952A (fr)
CN (2) CN109477073B (fr)
SG (1) SG11201708680PA (fr)
WO (1) WO2017171631A1 (fr)

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* Cited by examiner, † Cited by third party
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US11186624B2 (en) * 2016-09-23 2021-11-30 Lion Tcr Pte. Ltd. HBV antigen specific binding molecules and fragments thereof
US20190119636A1 (en) 2017-10-23 2019-04-25 Poseida Therapeutics, Inc. Modified stem cell memory t cells, methods of making and methods of using same
EA201991431A1 (ru) 2016-12-16 2020-01-17 Б-Моген Биотехнолоджис, Инк. УСИЛЕННЫЙ ОПОСРЕДОВАННЫЙ ТРАНСПОЗОНАМИ СЕМЕЙСТВА hAT ПЕРЕНОС ГЕНОВ И АССОЦИИРОВАННЫЕ КОМПОЗИЦИИ, СИСТЕМЫ И СПОСОБЫ
US11278570B2 (en) 2016-12-16 2022-03-22 B-Mogen Biotechnologies, Inc. Enhanced hAT family transposon-mediated gene transfer and associated compositions, systems, and methods
CA3104288A1 (fr) 2018-06-21 2019-12-26 B-Mogen Biotechnologies, Inc. Transfert ameliore de genes medie par transposon de la famille hat et compositions, systemes et methodes associes
JP7227374B2 (ja) 2018-08-13 2023-02-21 ルートパス・ジェノミクス，インコーポレーテッド 対合二分免疫受容体ポリヌクレオチドのハイスループットクローニングおよびその適用
SG11202110956RA (en) 2019-04-05 2021-10-28 Rootpath Genomics Inc Compositions and methods for t-cell receptor gene assembly
WO2021148110A1 (fr) 2020-01-21 2021-07-29 Lion Tcr Pte. Ltd. Bibliothèque de tcr spécifique du virus de l'hépatite b et son utilisation en tant que médicament personnalisé
US20230174934A1 (en) * 2020-04-27 2023-06-08 Vanderbilt University Lymphocytes lacking perforin function
US20230338532A1 (en) * 2020-09-11 2023-10-26 National University Of Singapore Immunosuppressant drug resistant armored tcr t cells for immune-therapy of organ transplant patients

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WO2003006632A2 (fr) * 2001-07-12 2003-01-23 Canvac Methodes et compositions permettant de moduler la stimulation de lymphocytes t humaines in vitro et implications de cette modulation dans des strategies therapeutiques ex vivo et in vivo
GB0509318D0 (en) * 2005-05-06 2005-06-15 Chiron Srl TCR-independent activation of T cells
CA2608193A1 (fr) * 2005-05-11 2006-11-23 The Trustees Of The University Of Pennsylvania Procedes permettant l'expansion rapide de lymphocytes t specifiques a l'antigene
US7868159B2 (en) * 2005-06-23 2011-01-11 Baylor College Of Medicine Modulation of negative immune regulators and applications for immunotherapy
EP1795599A1 (fr) * 2005-12-09 2007-06-13 Schuler, Gerold, Prof. Dr. Procédé pour la préparation de cellules T effectrices
CN101361969B (zh) * 2008-01-29 2011-05-11 广州市恺泰生物科技有限公司 一种治疗性乙肝疫苗及其制备方法和用途
ES2622505T3 (es) * 2008-05-09 2017-07-06 Agency For Science, Technology And Research Receptor de linfocito T (RLT) exógeno reactivo contra epítopo de VHB y usos del mismo
PL2563932T3 (pl) * 2010-04-29 2018-07-31 Epiontis Gmbh Wykrywanie komórek odpornościowych, w szczególności komórek T poprzez analizę metylacji DNA genów CCR6
CA2849045C (fr) * 2011-09-29 2020-11-17 Institut National De La Sante Et De La Recherche Medicale (Inserm) Vecteurs lentiviraux pseudotypes par des glycoproteines baev mutantes
LT2884999T (lt) * 2012-08-20 2021-04-12 Fred Hutchinson Cancer Research Center Ląstelinės imunoterapijos būdas ir kompozicijos
JP2015529685A (ja) * 2012-09-17 2015-10-08 ザ・リサーチ・インスティテュート・アット・ネイションワイド・チルドレンズ・ホスピタルＴｈｅ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ Ａｔｎａｔｉｏｎｗｉｄｅ Ｃｈｉｌｄｒｅｎ’Ｓ Ｈｏｓｐｉｔａｌ 筋萎縮性側索硬化症の処置のための組成物および方法
CN102964326B (zh) * 2012-11-06 2015-11-18 北京大学 具有mek抑制功能的化合物及其制备方法与应用
AU2014362231B2 (en) * 2013-12-11 2019-04-04 Biogen Ma Inc. Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology
EP3083674B1 (fr) * 2013-12-19 2018-10-03 Friedrich-Alexander-Universität Erlangen-Nürnberg Récepteurs de lymphocytes t spécifiques à la grippe et leurs utilisations dans la détection, prévention et/ou le traitement de la grippe
CA2959168A1 (fr) * 2014-09-02 2016-03-10 Bellicum Pharmaceuticals, Inc. Costimulation de recepteurs d'antigenes chimeriques par des polypeptides derives de myd88 et cd40
CN107106670A (zh) * 2014-10-31 2017-08-29 宾夕法尼亚大学董事会 用于修饰的t细胞的方法和组合物
CA3020830A1 (fr) * 2016-04-13 2017-10-19 Vivia Biotech, S.L Lymphocytes t actives ex vivo par bite.rtm.
US11186624B2 (en) * 2016-09-23 2021-11-30 Lion Tcr Pte. Ltd. HBV antigen specific binding molecules and fragments thereof
SG10201705285SA (en) * 2017-06-27 2019-01-30 Agency Science Tech & Res Antisense oligonucleotides
CA3069557A1 (fr) * 2017-07-21 2019-01-24 Cellectis Cellules immunitaires modifiees resistantes au micro-environnement tumoral
AU2020226714A1 (en) * 2019-02-19 2021-08-26 European Molecular Biology Laboratory Cell penetrating transposase
CN111607565A (zh) * 2020-06-04 2020-09-01 河南大学 一种北平顶猴t细胞的体外扩增方法

Also Published As

Publication number Publication date
WO2017171631A1 (fr) 2017-10-05
CN109477073B (zh) 2024-04-12
EP3436572A4 (fr) 2019-11-20
CN118147079A (zh) 2024-06-07
JP2019509753A (ja) 2019-04-11
KR20190006952A (ko) 2019-01-21
EP3436572A1 (fr) 2019-02-06
CN109477073A (zh) 2019-03-15
US11576932B2 (en) 2023-02-14
US20190192566A1 (en) 2019-06-27

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