SG11201700507XA - Heterocyclic carboxylic acids as activators of soluble guanylate cyclase - Google Patents
Heterocyclic carboxylic acids as activators of soluble guanylate cyclaseInfo
- Publication number
- SG11201700507XA SG11201700507XA SG11201700507XA SG11201700507XA SG11201700507XA SG 11201700507X A SG11201700507X A SG 11201700507XA SG 11201700507X A SG11201700507X A SG 11201700507XA SG 11201700507X A SG11201700507X A SG 11201700507XA SG 11201700507X A SG11201700507X A SG 11201700507XA
- Authority
- SG
- Singapore
- Prior art keywords
- activators
- carboxylic acids
- guanylate cyclase
- soluble guanylate
- heterocyclic carboxylic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462027376P | 2014-07-22 | 2014-07-22 | |
PCT/US2015/041245 WO2016014463A1 (fr) | 2014-07-22 | 2015-07-21 | Acides carboxyliques hétérocycliques en tant qu'activateurs de la guanylate cyclase soluble |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201700507XA true SG11201700507XA (en) | 2017-02-27 |
Family
ID=53783363
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201806565SA SG10201806565SA (en) | 2014-07-22 | 2015-07-21 | Heterocyclic carboxylic acids as activators of soluble guanylate cyclase |
SG11201700507XA SG11201700507XA (en) | 2014-07-22 | 2015-07-21 | Heterocyclic carboxylic acids as activators of soluble guanylate cyclase |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201806565SA SG10201806565SA (en) | 2014-07-22 | 2015-07-21 | Heterocyclic carboxylic acids as activators of soluble guanylate cyclase |
Country Status (26)
Country | Link |
---|---|
US (1) | US9353090B2 (fr) |
EP (1) | EP3172202B1 (fr) |
JP (1) | JP6602840B2 (fr) |
KR (1) | KR20170035993A (fr) |
CN (1) | CN106459017B (fr) |
AP (1) | AP2016009615A0 (fr) |
AR (1) | AR101265A1 (fr) |
AU (1) | AU2015292833B2 (fr) |
BR (1) | BR112017000943A2 (fr) |
CA (1) | CA2955937A1 (fr) |
CL (1) | CL2017000071A1 (fr) |
CO (1) | CO2017000438A2 (fr) |
DK (1) | DK3172202T3 (fr) |
EA (1) | EA032972B1 (fr) |
ES (1) | ES2784477T3 (fr) |
HU (1) | HUE049231T2 (fr) |
IL (1) | IL249587A0 (fr) |
MX (1) | MX2017000926A (fr) |
PE (1) | PE20170249A1 (fr) |
PH (1) | PH12017500111A1 (fr) |
PL (1) | PL3172202T3 (fr) |
PT (1) | PT3172202T (fr) |
SG (2) | SG10201806565SA (fr) |
TW (1) | TWI711615B (fr) |
UY (1) | UY36226A (fr) |
WO (1) | WO2016014463A1 (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3012001A1 (fr) * | 2016-02-01 | 2017-08-10 | Ironwood Pharmaceuticals, Inc. | Utilisation de stimulateurs de la sgc pour le traitement d'une steatohepatite non alcoolique (shna) |
MX2019002913A (es) | 2016-09-14 | 2019-10-15 | Reg Life Sciences Llc | Compuestos de 1,3-dioles grasos y sus derivados. |
CA3039735A1 (fr) | 2016-10-11 | 2018-04-19 | Bayer Pharma Aktiengesellschaft | Combinaison contenant des activateurs gcs et des antagonistes du recepteur des mineralocorticoides |
CN106495999B (zh) * | 2016-10-18 | 2019-08-16 | 亳州学院 | 一种芳香醛及其合成方法 |
BR112020000772A2 (pt) | 2017-07-14 | 2020-07-21 | Glaxosmithkline Intellectual Property Development Limited | inibidores de cinase 2 de repetição rica em leucina |
WO2019081456A1 (fr) | 2017-10-24 | 2019-05-02 | Bayer Aktiengesellschaft | Utilisation d'activateurs et de stimulateurs de sgc comprenant une sous-unité bêta2 |
EP3498298A1 (fr) | 2017-12-15 | 2019-06-19 | Bayer AG | Utilisation de stimulateurs sgc et d'activateurs sgc seuls ou en combinaison avec des inhibiteurs pde5 pour le traitement de troubles osseux, y compris l'ostéogénèse imparfaite (oi) |
EP3784238A4 (fr) * | 2018-04-27 | 2021-12-29 | Hetero Labs Ltd. | Procédé de préparation de ((3r, 11br) -1,3,4,6,7,11b-hexahydro-9,10-di(méthoxy-d 3)-3-(2-méthylpropyl)-2h-benzo[a]quinolizin-2-one |
US20210052528A1 (en) | 2018-04-30 | 2021-02-25 | Bayer Aktiengesellschaft | The use of sgc activators and sgc stimulators for the treatment of cognitive impairment |
CA3100096A1 (fr) | 2018-05-15 | 2019-11-21 | Bayer Aktiengesellschaft | Benzamides a substitution 1,3-thiazol-2-yl pour le traitement de maladies associees a la sensibilisation de fibres nerveuses |
EP3574905A1 (fr) | 2018-05-30 | 2019-12-04 | Adverio Pharma GmbH | Procédé d'identification d'un sous-groupe de patients souffrant de dcssc qui bénéficie d'un traitement comportant des stimulateurs sgc et des activateurs sgc à un degré supérieur à celui d'un groupe de contrôle |
EA202191554A1 (ru) | 2018-12-03 | 2021-09-02 | Фмк Корпорейшн | Способ получения n-фенилпиразол-1-карбоксамидов |
CA3126778A1 (fr) | 2019-01-17 | 2020-07-23 | Bayer Aktiengesellschaft | Procedes permettant de determiner si un sujet est apte a etre traite avec un agoniste de guanylyle cyclase soluble (sgc) |
EP4010333A1 (fr) | 2019-08-09 | 2022-06-15 | Kalvista Pharmaceuticals Limited | Inhibiteurs de la kallicréine plasmatique |
CN114957087A (zh) * | 2022-04-13 | 2022-08-30 | 湖南复瑞生物医药技术有限责任公司 | 一种帕罗韦德中间体制备方法 |
WO2023237577A1 (fr) | 2022-06-09 | 2023-12-14 | Bayer Aktiengesellschaft | Activateurs de guanylate cyclase soluble destinés à être utilisés dans le traitement de l'insuffisance cardiaque à fraction d'éjection préservée chez les femmes |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040067938A1 (en) | 2000-09-29 | 2004-04-08 | Penglie Zhang | Quaternary amines and related inhibitors of factor xa |
EP1906957A1 (fr) | 2005-07-18 | 2008-04-09 | Bayer HealthCare AG | Nouvelle utilisation d'activateurs et de stimulateurs de la guanylate cyclase soluble permettant de prevenir ou de traiter des troubles renaux |
US20080045560A1 (en) | 2006-08-15 | 2008-02-21 | Wyeth | Pyrrolidine and related derivatives useful as PR modulators |
WO2008138483A1 (fr) | 2007-05-12 | 2008-11-20 | Bayer Schering Pharma Aktiengesellschaft | Stimulateurs de la sgc, activateurs de la sgc et combinaisons pour le traitement de troubles urologiques |
WO2009032249A1 (fr) | 2007-09-06 | 2009-03-12 | Merck & Co., Inc. | Activateurs de la guanylate cyclase soluble |
EP2207541B1 (fr) | 2007-10-05 | 2014-10-29 | Sanofi-Aventis Deutschland GmbH | Utilisation de n-phénylamides d'acide 2-sulfonylaminobenzoïque sulfonyl-substituées dans le traitement de la douleur |
WO2009068652A1 (fr) | 2007-11-30 | 2009-06-04 | Smithkline Beecham Corporation | Pyridines 2, 6-disubstituées et pyrimidines 2, 4-disubstituées en tant qu'activateurs de guanylate cyclase soluble |
AR069517A1 (es) | 2007-12-03 | 2010-01-27 | Smithkline Beecham Corp | Compuesto del acido fenil metiloxifenil piridinil carboxilico substituido, composiciones farmaceuticas que lo comprenden y su uso para la prepara-cion de un medicamento util para el tratamiento de una enfermedad mediada por la actividad de la enzima sgc |
EP2264017A4 (fr) | 2008-04-04 | 2011-07-27 | Takeda Pharmaceutical | Dérivé hétérocyclique et son utilisation |
WO2010015652A2 (fr) | 2008-08-07 | 2010-02-11 | Smithkline Beecham Corporation | Composés thiazole utilisés comme activateurs de la guanylate cyclase soluble |
WO2010015653A1 (fr) | 2008-08-07 | 2010-02-11 | Smithkline Beecham Corporation | Dérivés de pyrimidine comme activateurs de guanylate cyclase soluble |
EP2373317B1 (fr) | 2008-11-25 | 2016-12-14 | Merck Sharp & Dohme Corp. | Dérivés de 4-amino-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one ou 4-amino-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one en tant qu'activateurs de la cyclase du guanylat soluble pour le traitement de maladies cardio-vasculaires |
CA2749730C (fr) | 2009-01-17 | 2017-02-14 | Bayer Schering Pharma Aktiengesellschaft | Stimulateurs sgc d'activateurs sgc en combinaison avec des inhibiteurs pde5 dans le traitement du dysfonctionnement erectile |
CN102414194A (zh) | 2009-02-26 | 2012-04-11 | 默沙东公司 | 可溶性鸟苷酸环化酶激活剂 |
RS54336B1 (en) | 2010-02-05 | 2016-02-29 | Adverio Pharma Gmbh | SGC STIMULATORS OR SGC ACTIVATORS, ONLY FOR YOURSELF AND COMBINED WITH PDE5 INHIBITORS FOR CYST FIBROSIS TREATMENT |
WO2011095553A1 (fr) | 2010-02-05 | 2011-08-11 | Bayer Schering Pharma Aktiengesellschaft | Stimulateurs de sgc ou activateurs de sgc en combinaison avec des inhibiteurs de pde5 pour le traitement du dysfonctionnement érectile |
UA116521C2 (uk) | 2010-05-26 | 2018-04-10 | Адверіо Фарма Гмбх | Застосування sgc-стимуляторів, sgc-активаторів окремо і в комбінації з інгібіторами фде5 для лікування системної склеродермії (ssc) |
WO2011161099A1 (fr) | 2010-06-25 | 2011-12-29 | Bayer Pharma Aktiengesellschaft | Utilisation de stimulateurs et d'activateurs de la guanylate-cyclase soluble pour le traitement de la drépanocytose et la conservation de substituts sanguins |
WO2012058132A1 (fr) | 2010-10-28 | 2012-05-03 | Merck Sharp & Dohme Corp. | Activateurs de la guanylate cyclase soluble |
JP5715713B2 (ja) * | 2011-03-10 | 2015-05-13 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 可溶性グアニル酸シクラーゼ活性化因子 |
JP5826393B2 (ja) * | 2011-08-12 | 2015-12-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 可溶性グアニル酸シクラーゼ活性化因子 |
EP2594270A3 (fr) | 2011-11-18 | 2013-07-31 | BIP Patents | Utilisation de stimulateurs de la sGC ou d'activateurs de la sGC, seuls et en combinaison avec des inhibiteurs de PDE5 pour le traitement de la sclérose systémique (Ssc) |
PE20151001A1 (es) * | 2012-09-07 | 2015-07-15 | Boehringer Ingelheim Int | Alcoxipirazoles como activadores de guanilato ciclasa soluble |
WO2015095515A1 (fr) | 2013-12-20 | 2015-06-25 | Novartis Ag | Activateurs sgc pour le traitement de glaucome |
-
2015
- 2015-07-21 EA EA201790246A patent/EA032972B1/ru not_active IP Right Cessation
- 2015-07-21 US US14/804,363 patent/US9353090B2/en active Active
- 2015-07-21 AU AU2015292833A patent/AU2015292833B2/en not_active Ceased
- 2015-07-21 KR KR1020177004761A patent/KR20170035993A/ko not_active Application Discontinuation
- 2015-07-21 DK DK15747311.7T patent/DK3172202T3/da active
- 2015-07-21 HU HUE15747311A patent/HUE049231T2/hu unknown
- 2015-07-21 EP EP15747311.7A patent/EP3172202B1/fr active Active
- 2015-07-21 SG SG10201806565SA patent/SG10201806565SA/en unknown
- 2015-07-21 WO PCT/US2015/041245 patent/WO2016014463A1/fr active Application Filing
- 2015-07-21 PT PT157473117T patent/PT3172202T/pt unknown
- 2015-07-21 AP AP2016009615A patent/AP2016009615A0/en unknown
- 2015-07-21 SG SG11201700507XA patent/SG11201700507XA/en unknown
- 2015-07-21 BR BR112017000943A patent/BR112017000943A2/pt not_active Application Discontinuation
- 2015-07-21 ES ES15747311T patent/ES2784477T3/es active Active
- 2015-07-21 JP JP2017503554A patent/JP6602840B2/ja active Active
- 2015-07-21 PE PE2017000087A patent/PE20170249A1/es unknown
- 2015-07-21 CN CN201580033515.4A patent/CN106459017B/zh active Active
- 2015-07-21 AR ARP150102304A patent/AR101265A1/es unknown
- 2015-07-21 CA CA2955937A patent/CA2955937A1/fr not_active Abandoned
- 2015-07-21 MX MX2017000926A patent/MX2017000926A/es unknown
- 2015-07-21 TW TW104123596A patent/TWI711615B/zh not_active IP Right Cessation
- 2015-07-21 PL PL15747311T patent/PL3172202T3/pl unknown
- 2015-07-22 UY UY0001036226A patent/UY36226A/es unknown
-
2016
- 2016-12-15 IL IL249587A patent/IL249587A0/en unknown
-
2017
- 2017-01-11 CL CL2017000071A patent/CL2017000071A1/es unknown
- 2017-01-18 PH PH12017500111A patent/PH12017500111A1/en unknown
- 2017-01-19 CO CONC2017/0000438A patent/CO2017000438A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN106459017B (zh) | 2020-07-17 |
PL3172202T3 (pl) | 2020-07-13 |
CN106459017A (zh) | 2017-02-22 |
AR101265A1 (es) | 2016-12-07 |
CA2955937A1 (fr) | 2016-01-28 |
EP3172202B1 (fr) | 2020-01-29 |
EP3172202A1 (fr) | 2017-05-31 |
EA032972B1 (ru) | 2019-08-30 |
US9353090B2 (en) | 2016-05-31 |
HUE049231T2 (hu) | 2020-09-28 |
WO2016014463A1 (fr) | 2016-01-28 |
IL249587A0 (en) | 2017-02-28 |
JP2017521457A (ja) | 2017-08-03 |
DK3172202T3 (da) | 2020-04-27 |
CL2017000071A1 (es) | 2017-06-30 |
JP6602840B2 (ja) | 2019-11-06 |
MX2017000926A (es) | 2017-05-04 |
KR20170035993A (ko) | 2017-03-31 |
PH12017500111A1 (en) | 2017-05-29 |
BR112017000943A2 (pt) | 2017-11-14 |
ES2784477T3 (es) | 2020-09-28 |
TWI711615B (zh) | 2020-12-01 |
CO2017000438A2 (es) | 2017-08-31 |
US20160024059A1 (en) | 2016-01-28 |
AU2015292833B2 (en) | 2019-11-28 |
PE20170249A1 (es) | 2017-04-05 |
TW201617340A (zh) | 2016-05-16 |
EA201790246A1 (ru) | 2017-07-31 |
AU2015292833A1 (en) | 2016-12-22 |
SG10201806565SA (en) | 2018-08-30 |
UY36226A (es) | 2016-01-29 |
PT3172202T (pt) | 2020-05-06 |
AP2016009615A0 (en) | 2016-12-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL249587A0 (en) | Heterocyclic carboxylic acids as activators of soluble quanylate cyclase | |
EP3152214A4 (fr) | Dérivés d'imidazo-pyrazine utiles en tant qu'activateurs de guanylate cyclases solubles | |
IL272130B (en) | Inhibitors of specific lysine demethylase-1 | |
IL247970A (en) | Quinoline history as smo inhibitors | |
IL248505B (en) | Inhibitors of specific lysine demethylase-1 | |
IL250876B (en) | Inhibitors of specific lysine demethylase-1 | |
IL249733A0 (en) | Inhibitors of specific lysine demethylase-1 | |
IL249876B (en) | Inhibitors of specific lysine demethylase-1 | |
ZA201701835B (en) | Novel soluble guanylate cyclase activators and their use | |
EP3310782A4 (fr) | Dérivés d'imidazo-pyrazinyle utiles à titre d'activateurs de guanylate cyclase solubles | |
EP3303342A4 (fr) | Dérivés d'imidazo-pyrazinyle utiles à titre d'activateurs de guanylate cyclase solubles | |
GB201613513D0 (en) | Fire extringuishing composition comprising Carboxylic acid derivative | |
HK1253572A1 (zh) | 作為tnap抑制劑的吡啶並噁嗪酮化合物 | |
PT3134396T (pt) | Derivados de amino piridina como inibidores da fosfatidilinositol 3-quinase | |
ZA201703243B (en) | Process for the manufacture of carboxylic anhydride | |
IL251099A0 (en) | A salt of phenylglycine methyl ester | |
GB201501544D0 (en) | Carboxylic acid composition | |
GB201406592D0 (en) | Inhibitor of citrate transporter | |
GB201406590D0 (en) | Inhibitor of citrate transporter |