SG11201609331XA - A plasmonic chip and a diagnostic method for observation of a fluorescence image and raman spectropscopy of cancer-related substance on the plasmonic chips - Google Patents

A plasmonic chip and a diagnostic method for observation of a fluorescence image and raman spectropscopy of cancer-related substance on the plasmonic chips

Info

Publication number
SG11201609331XA
SG11201609331XA SG11201609331XA SG11201609331XA SG11201609331XA SG 11201609331X A SG11201609331X A SG 11201609331XA SG 11201609331X A SG11201609331X A SG 11201609331XA SG 11201609331X A SG11201609331X A SG 11201609331XA SG 11201609331X A SG11201609331X A SG 11201609331XA
Authority
SG
Singapore
Prior art keywords
plasmonic
spectropscopy
raman
cancer
observation
Prior art date
Application number
SG11201609331XA
Other languages
English (en)
Inventor
Yuki Hasegawa
Katsuyuki Hasegawa
Original Assignee
Mytech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP2014/062318 external-priority patent/WO2014181816A1/ja
Application filed by Mytech Co Ltd filed Critical Mytech Co Ltd
Publication of SG11201609331XA publication Critical patent/SG11201609331XA/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G01N21/553—Attenuated total reflection and using surface plasmons
    • G01N21/554—Attenuated total reflection and using surface plasmons detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57473—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving carcinoembryonic antigen, i.e. CEA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Nanotechnology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SG11201609331XA 2014-05-08 2015-05-07 A plasmonic chip and a diagnostic method for observation of a fluorescence image and raman spectropscopy of cancer-related substance on the plasmonic chips SG11201609331XA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/JP2014/062318 WO2014181816A1 (ja) 2013-05-08 2014-05-08 癌関連物質のラマン定量方法
JP2015036645 2015-02-26
PCT/JP2015/063219 WO2015170711A1 (ja) 2014-05-08 2015-05-07 プラズモニックチップおよびそれを用いるがん疾病の蛍光画像ならびにラマン分光による診断方法

Publications (1)

Publication Number Publication Date
SG11201609331XA true SG11201609331XA (en) 2016-12-29

Family

ID=54392561

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201609331XA SG11201609331XA (en) 2014-05-08 2015-05-07 A plasmonic chip and a diagnostic method for observation of a fluorescence image and raman spectropscopy of cancer-related substance on the plasmonic chips

Country Status (14)

Country Link
US (1) US10215700B2 (zh)
EP (1) EP3141888B1 (zh)
JP (2) JP6492066B2 (zh)
KR (1) KR102232197B1 (zh)
CN (1) CN106461556B (zh)
AU (1) AU2015256932B2 (zh)
CA (1) CA2948353C (zh)
ES (1) ES2905092T3 (zh)
HU (1) HUE057218T2 (zh)
IL (1) IL248760B (zh)
MY (1) MY193573A (zh)
NZ (1) NZ726748A (zh)
SG (1) SG11201609331XA (zh)
WO (1) WO2015170711A1 (zh)

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JP2017156104A (ja) * 2016-02-29 2017-09-07 西松建設株式会社 光増強素子とその製造方法ならびに分光分析用キットおよび分光分析方法
GB201704128D0 (en) * 2017-03-15 2017-04-26 Univ Swansea Method and apparatus for use in diagnosis and monitoring of colorectal cancer
CN108169184B (zh) * 2017-09-05 2021-01-05 哈尔滨工业大学 一种肿瘤分类鉴别模型的建立方法及其应用
CN108469429B (zh) * 2018-02-06 2020-11-24 西安电子科技大学 一种双模态拉曼-光学投影断层成像系统
JP2021156576A (ja) * 2018-06-21 2021-10-07 有限会社マイテック 疾病関連タンパク結合体を標的とする自家蛍光によるリキッド・バイオプシィ法
EP4083223A4 (en) * 2019-12-25 2024-01-17 MYTECH Co., Ltd. AUTOFLUORESCENCE-BASED LIQUID BIOPSY METHOD TARGETING NUCLEOSOMES FRAGMENTED BY APOPTOSIS
US11609229B2 (en) * 2020-04-30 2023-03-21 Mytech Co. Ltd. Fluorescence counting system for quantifying viruses or antibodies on an immobilized metal substrate by using an antigen-antibody reaction
CN111624186B (zh) * 2020-06-24 2021-03-16 江南大学 一种基于荧光和拉曼双信号增强的肠毒素光谱分析方法
TWI818278B (zh) * 2020-11-20 2023-10-11 日商米特奇有限公司 透過自體螢光的液態生檢法
KR20220091408A (ko) * 2020-12-22 2022-06-30 두에이아이(주) 인공지능 라만 분석 기법을 이용한 췌장암 조기진단 방법
KR102530499B1 (ko) * 2021-08-26 2023-05-10 한밭대학교 산학협력단 플라즈몬 금속 나노입자를 이용한 세포핵 내 단백질 검출방법
CN114550816B (zh) * 2022-03-01 2022-11-04 上海图灵智算量子科技有限公司 基于光子芯片病毒变异概率的预测方法

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EP2755031B1 (en) * 2007-03-20 2017-05-03 Becton, Dickinson and Company Assay using surface-enhanced raman spectroscopy (sers)-active particles
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Also Published As

Publication number Publication date
HUE057218T2 (hu) 2022-04-28
CA2948353C (en) 2021-12-14
JPWO2015170711A1 (ja) 2017-04-20
EP3141888A4 (en) 2018-03-14
CA2948353A1 (en) 2015-11-12
US20170115216A1 (en) 2017-04-27
EP3141888B1 (en) 2021-11-03
KR102232197B1 (ko) 2021-03-25
NZ726748A (en) 2020-05-29
IL248760A0 (en) 2017-01-31
KR20170007774A (ko) 2017-01-20
AU2015256932B2 (en) 2019-11-07
ES2905092T3 (es) 2022-04-07
JP6492066B2 (ja) 2019-03-27
AU2015256932A1 (en) 2016-12-08
US10215700B2 (en) 2019-02-26
CN106461556A (zh) 2017-02-22
JP2016208959A (ja) 2016-12-15
EP3141888A1 (en) 2017-03-15
MY193573A (en) 2022-10-19
CN106461556B (zh) 2019-12-27
IL248760B (en) 2021-01-31
WO2015170711A1 (ja) 2015-11-12

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