SG11201510157YA - T cell receptors - Google Patents

T cell receptors

Info

Publication number
SG11201510157YA
SG11201510157YA SG11201510157YA SG11201510157YA SG11201510157YA SG 11201510157Y A SG11201510157Y A SG 11201510157YA SG 11201510157Y A SG11201510157Y A SG 11201510157YA SG 11201510157Y A SG11201510157Y A SG 11201510157YA SG 11201510157Y A SG11201510157Y A SG 11201510157YA
Authority
SG
Singapore
Prior art keywords
cell receptors
receptors
cell
Prior art date
Application number
SG11201510157YA
Other languages
English (en)
Inventor
Peter Molloy
Original Assignee
Adaptimmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adaptimmune Ltd filed Critical Adaptimmune Ltd
Publication of SG11201510157YA publication Critical patent/SG11201510157YA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/7051T-cell receptor (TcR)-CD3 complex
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • A61K39/4611T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/463Cellular immunotherapy characterised by recombinant expression
    • A61K39/4632T-cell receptors [TCR]; antibody T-cell receptor constructs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/4644Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/4644Cancer antigens
    • A61K39/46448Cancer antigens from embryonic or fetal origin
    • A61K39/464481Alpha-feto protein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • C12N5/0637Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/15011Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
SG11201510157YA 2013-07-26 2014-07-18 T cell receptors SG11201510157YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1313377.2A GB201313377D0 (en) 2013-07-26 2013-07-26 T cell receptors
PCT/GB2014/052199 WO2015011450A1 (en) 2013-07-26 2014-07-18 T cell receptors

Publications (1)

Publication Number Publication Date
SG11201510157YA true SG11201510157YA (en) 2016-02-26

Family

ID=49166992

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201510157YA SG11201510157YA (en) 2013-07-26 2014-07-18 T cell receptors

Country Status (22)

Country Link
US (3) US10344074B2 (zh)
EP (2) EP3578188B1 (zh)
JP (3) JP6635311B2 (zh)
KR (2) KR20210073612A (zh)
CN (2) CN111153984A (zh)
AU (2) AU2014294830B2 (zh)
CA (1) CA2916027C (zh)
CY (1) CY1121962T1 (zh)
DK (2) DK3578188T3 (zh)
ES (2) ES2912743T3 (zh)
GB (1) GB201313377D0 (zh)
HK (1) HK1222338A1 (zh)
HR (1) HRP20191371T1 (zh)
HU (1) HUE045399T2 (zh)
LT (1) LT3024468T (zh)
NZ (1) NZ715038A (zh)
PL (1) PL3024468T3 (zh)
PT (1) PT3024468T (zh)
RS (1) RS59177B1 (zh)
SG (1) SG11201510157YA (zh)
SI (1) SI3024468T1 (zh)
WO (1) WO2015011450A1 (zh)

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GB201313377D0 (en) * 2013-07-26 2013-09-11 Adaptimmune Ltd T cell receptors
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CN106279404A (zh) * 2015-05-20 2017-01-04 广州市香雪制药股份有限公司 一种可溶且稳定的异质二聚tcr
GB201516277D0 (en) 2015-09-15 2015-10-28 Adaptimmune Ltd And Immunocore Ltd TCR libraries
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WO2017059557A1 (en) * 2015-10-09 2017-04-13 Peking University Methods for enhancing in vivo persistence and efficacy of exogenously administered t cells, genetically modified t cells and method and method of use
SG10201913247XA (en) 2015-10-23 2020-02-27 Eureka Therapeutics Inc Antibody/t-cell receptor chimeric constructs and uses thereof
JP6777841B2 (ja) * 2015-10-23 2020-10-28 国立大学法人金沢大学 細胞傷害性t細胞の作製方法
JP6970417B2 (ja) * 2015-10-23 2021-11-24 国立大学法人金沢大学 細胞傷害性t細胞の作製方法
WO2018026691A1 (en) 2016-08-02 2018-02-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-kras-g12d t cell receptors
CA3059753A1 (en) 2017-04-26 2018-11-01 Eureka Therapeutics, Inc. Chimeric antibody/t-cell receptor constructs and uses thereof
SG11201909751TA (en) * 2017-05-12 2019-11-28 Augusta University Research Institute Inc Human alpha fetoprotein-specific t cell receptors and uses thereof
JP2021514188A (ja) 2018-02-15 2021-06-10 メモリアル スローン ケタリング キャンサー センター Foxp3標的因子組成物と養子細胞療法のための使用方法
CN110407927B (zh) * 2018-04-26 2022-09-09 香雪生命科学技术(广东)有限公司 一种识别afp抗原的tcr
CN110776562B (zh) * 2018-07-30 2022-06-17 香雪生命科学技术(广东)有限公司 一种识别afp抗原的t细胞受体
SG11202102903QA (en) * 2018-09-21 2021-04-29 Xlifesc Ltd High affinity t cell receptor for recognizing afp antigen
CN110950949B (zh) * 2018-09-26 2022-04-05 香雪生命科学技术(广东)有限公司 一种识别ssx2抗原的t细胞受体
WO2020098717A1 (zh) * 2018-11-14 2020-05-22 广东香雪精准医疗技术有限公司 一种识别afp的高亲和力tcr
CN111662374B (zh) * 2019-03-08 2023-01-24 香雪生命科学技术(广东)有限公司 一种识别afp抗原的高亲和力tcr
CN111748027A (zh) * 2019-03-29 2020-10-09 天津亨佳生物科技发展有限公司 一种针对egfr l858r基因突变的特异性t细胞受体及其应用
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JP7429462B2 (ja) * 2019-07-30 2024-02-08 エックスライフエスシー リミテッド Ssx2抗原の短いペプチドを識別するt細胞受容体
WO2021022447A1 (zh) * 2019-08-05 2021-02-11 广东香雪精准医疗技术有限公司 识别afp抗原短肽的t细胞受体
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CN112390875B (zh) * 2019-08-16 2023-01-24 香雪生命科学技术(广东)有限公司 一种识别afp的高亲和力t细胞受体
CN113072636B (zh) * 2020-01-06 2024-05-28 香雪生命科学技术(广东)有限公司 一种识别afp的t细胞受体及其编码序列
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CN115160432A (zh) * 2021-04-02 2022-10-11 香雪生命科学技术(广东)有限公司 识别afp的t细胞受体
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KR20240097895A (ko) 2021-10-29 2024-06-27 길리애드 사이언시즈, 인코포레이티드 Cd73 화합물
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Also Published As

Publication number Publication date
EP3578188B1 (en) 2022-02-23
JP6956164B2 (ja) 2021-10-27
US20160137715A1 (en) 2016-05-19
SI3024468T1 (sl) 2019-10-30
JP2016525537A (ja) 2016-08-25
KR20160034329A (ko) 2016-03-29
US11084862B2 (en) 2021-08-10
US20190330301A1 (en) 2019-10-31
PL3024468T3 (pl) 2019-12-31
CN105408353B (zh) 2020-05-19
CN105408353A (zh) 2016-03-16
EP3024468A1 (en) 2016-06-01
AU2014294830A1 (en) 2016-01-21
US20210324036A1 (en) 2021-10-21
JP2021151248A (ja) 2021-09-30
US10344074B2 (en) 2019-07-09
JP2020054364A (ja) 2020-04-09
PT3024468T (pt) 2019-08-01
RS59177B1 (sr) 2019-10-31
CA2916027A1 (en) 2015-01-29
DK3024468T3 (da) 2019-07-22
WO2015011450A1 (en) 2015-01-29
EP3578188A1 (en) 2019-12-11
KR20210073612A (ko) 2021-06-18
DK3578188T3 (da) 2022-05-02
AU2014294830B2 (en) 2020-01-16
HRP20191371T1 (hr) 2019-11-01
HUE045399T2 (hu) 2019-12-30
CY1121962T1 (el) 2020-10-14
ES2734190T3 (es) 2019-12-04
GB201313377D0 (en) 2013-09-11
KR102267345B1 (ko) 2021-06-22
AU2020202538A1 (en) 2020-05-07
CA2916027C (en) 2022-11-29
EP3024468B1 (en) 2019-05-08
LT3024468T (lt) 2019-09-25
ES2912743T3 (es) 2022-05-27
JP6635311B2 (ja) 2020-01-22
HK1222338A1 (zh) 2017-06-30
NZ715038A (en) 2021-12-24
CN111153984A (zh) 2020-05-15

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