SG11201507474QA - RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS - Google Patents
RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODSInfo
- Publication number
- SG11201507474QA SG11201507474QA SG11201507474QA SG11201507474QA SG11201507474QA SG 11201507474Q A SG11201507474Q A SG 11201507474QA SG 11201507474Q A SG11201507474Q A SG 11201507474QA SG 11201507474Q A SG11201507474Q A SG 11201507474QA SG 11201507474Q A SG11201507474Q A SG 11201507474QA
- Authority
- SG
- Singapore
- Prior art keywords
- thio
- modified nucleotides
- related methods
- ribonucleic acids
- ribonucleic
- Prior art date
Links
- 239000002773 nucleotide Substances 0.000 title 1
- 229920002477 rna polymer Polymers 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361785098P | 2013-03-14 | 2013-03-14 | |
| PCT/US2014/027422 WO2014152513A1 (en) | 2013-03-14 | 2014-03-14 | RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201507474QA true SG11201507474QA (en) | 2015-10-29 |
Family
ID=50639964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201507474QA SG11201507474QA (en) | 2013-03-14 | 2014-03-14 | RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US10266559B2 (pt) |
| EP (3) | EP2970351B1 (pt) |
| JP (1) | JP6567494B2 (pt) |
| KR (1) | KR20150127582A (pt) |
| CN (1) | CN105026411A (pt) |
| AU (2) | AU2014239562B2 (pt) |
| BR (1) | BR112015022507A2 (pt) |
| CA (1) | CA2902884C (pt) |
| EA (1) | EA201591281A1 (pt) |
| ES (2) | ES2797974T3 (pt) |
| HK (1) | HK1219955A1 (pt) |
| IL (1) | IL240465A0 (pt) |
| MX (1) | MX2015011943A (pt) |
| SG (1) | SG11201507474QA (pt) |
| WO (1) | WO2014152513A1 (pt) |
| ZA (1) | ZA201507605B (pt) |
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| EP4212514A1 (en) | 2011-06-08 | 2023-07-19 | Translate Bio, Inc. | Cleavable lipids |
| BR112013031553A2 (pt) | 2011-06-08 | 2020-11-10 | Shire Human Genetic Therapies, Inc. | composições, mrna que codifica para uma hgla e seu uso, uso de pelo menos uma molécula de mrna e um veículo de transferência e uso de um mrna que codifica para proteína exógena |
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| EP2834358A4 (en) | 2012-04-02 | 2016-03-09 | Moderna Therapeutics Inc | MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF NUCLEAR PROTEINS |
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| CN105142676B (zh) | 2013-03-14 | 2022-06-28 | 夏尔人类遗传性治疗公司 | Cftr mrna组合物以及相关方法和用途 |
| SG11201507425RA (en) | 2013-03-14 | 2015-10-29 | Shire Human Genetic Therapies | Methods for purification of messenger rna |
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| US10077439B2 (en) | 2013-03-15 | 2018-09-18 | Modernatx, Inc. | Removal of DNA fragments in mRNA production process |
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| US11377470B2 (en) | 2013-03-15 | 2022-07-05 | Modernatx, Inc. | Ribonucleic acid purification |
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| EP3019619B1 (en) | 2013-07-11 | 2021-08-25 | ModernaTX, Inc. | Compositions comprising synthetic polynucleotides encoding crispr related proteins and synthetic sgrnas and methods of use |
| WO2015051169A2 (en) | 2013-10-02 | 2015-04-09 | Moderna Therapeutics, Inc. | Polynucleotide molecules and uses thereof |
| EP3052521A1 (en) | 2013-10-03 | 2016-08-10 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| EP3501605B1 (en) | 2013-10-22 | 2023-06-28 | Translate Bio, Inc. | Mrna therapy for argininosuccinate synthetase deficiency |
| EP3060258A1 (en) | 2013-10-22 | 2016-08-31 | Shire Human Genetic Therapies, Inc. | Mrna therapy for phenylketonuria |
| JP6571679B2 (ja) | 2014-04-25 | 2019-09-04 | トランスレイト バイオ， インコーポレイテッド | メッセンジャーｒｎａの精製方法 |
| EP3157573A4 (en) | 2014-06-19 | 2018-02-21 | Moderna Therapeutics, Inc. | Alternative nucleic acid molecules and uses thereof |
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| GB201508025D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Fabry disease gene therapy |
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| AU2017266932B2 (en) | 2016-05-18 | 2023-04-20 | Modernatx, Inc. | Polynucleotides encoding alpha-galactosidase A for the treatment of Fabry disease |
| MA45053A (fr) | 2016-05-18 | 2019-03-27 | Modernatx Inc | Polynucléotides codant pour un régulateur de conductance transmembranaire de fibrose kystique pour le traitement de la fibrose kystique |
| JP7246930B2 (ja) | 2016-05-18 | 2023-03-28 | モデルナティエックス インコーポレイテッド | インターロイキン－１２（ｉｌ１２）をコードするポリヌクレオチドおよびその使用 |
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| MA49138A (fr) | 2017-05-16 | 2020-03-25 | Translate Bio Inc | Traitement de la fibrose kystique par administration d'arnm à codons optimisés codant pour la cftr |
| JP7284101B2 (ja) | 2017-05-31 | 2023-05-30 | ウルトラジェニクス ファーマシューティカル インク． | 糖原病ｉｉｉ型のための治療薬 |
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| EP3793689A1 (en) * | 2018-05-15 | 2021-03-24 | Translate Bio, Inc. | Subcutaneous delivery of messenger rna |
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| US12076439B2 (en) | 2018-05-24 | 2024-09-03 | Translate Bio, Inc. | Thioester cationic lipids |
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| US20210378977A1 (en) * | 2018-07-23 | 2021-12-09 | Translate Bio, Inc. | Dry Powder Formulations for Messenger RNA |
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| WO2020077007A1 (en) | 2018-10-09 | 2020-04-16 | The University Of British Columbia | Compositions and systems comprising transfection-competent vesicles free of organic-solvents and detergents and methods related thereto |
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| CN111041025B (zh) | 2019-12-17 | 2021-06-18 | 深圳市瑞吉生物科技有限公司 | 基于结合N-乙酰半乳糖胺多肽的mRNA靶向分子及其制备方法 |
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| CN111744019B (zh) | 2020-07-01 | 2023-08-04 | 深圳瑞吉生物科技有限公司 | 基于甘露糖的mRNA靶向递送系统及其应用 |
| CN114736260B (zh) * | 2022-03-29 | 2024-08-23 | 上海吉量医药工程有限公司 | 一种三磷酸核苷酸盐的制备方法 |
| KR20230170587A (ko) * | 2022-06-10 | 2023-12-19 | 주식회사 피노바이오 | 4'-티오-5-아자-2'-데옥시사이티딘의 제조방법 |
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| BR112013031553A2 (pt) | 2011-06-08 | 2020-11-10 | Shire Human Genetic Therapies, Inc. | composições, mrna que codifica para uma hgla e seu uso, uso de pelo menos uma molécula de mrna e um veículo de transferência e uso de um mrna que codifica para proteína exógena |
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-
2014
- 2014-03-14 ES ES17189627T patent/ES2797974T3/es active Active
- 2014-03-14 CN CN201480010106.8A patent/CN105026411A/zh active Pending
- 2014-03-14 EP EP14721635.2A patent/EP2970351B1/en active Active
- 2014-03-14 US US14/776,506 patent/US10266559B2/en active Active
- 2014-03-14 CA CA2902884A patent/CA2902884C/en active Active
- 2014-03-14 JP JP2016502430A patent/JP6567494B2/ja active Active
- 2014-03-14 BR BR112015022507A patent/BR112015022507A2/pt not_active IP Right Cessation
- 2014-03-14 EA EA201591281A patent/EA201591281A1/ru unknown
- 2014-03-14 EP EP17189627.7A patent/EP3301102B1/en active Active
- 2014-03-14 KR KR1020157021965A patent/KR20150127582A/ko not_active Application Discontinuation
- 2014-03-14 EP EP20169380.1A patent/EP3750903A1/en active Pending
- 2014-03-14 SG SG11201507474QA patent/SG11201507474QA/en unknown
- 2014-03-14 WO PCT/US2014/027422 patent/WO2014152513A1/en active Application Filing
- 2014-03-14 AU AU2014239562A patent/AU2014239562B2/en active Active
- 2014-03-14 ES ES14721635.2T patent/ES2647832T3/es active Active
- 2014-03-14 MX MX2015011943A patent/MX2015011943A/es unknown
-
2015
- 2015-08-10 IL IL240465A patent/IL240465A0/en unknown
- 2015-10-13 ZA ZA2015/07605A patent/ZA201507605B/en unknown
-
2016
- 2016-07-07 HK HK16107939.1A patent/HK1219955A1/zh unknown
-
2018
- 2018-06-05 AU AU2018203985A patent/AU2018203985B2/en active Active
-
2019
- 2019-02-21 US US16/282,106 patent/US10822368B2/en active Active
-
2020
- 2020-09-25 US US17/032,485 patent/US11447520B2/en active Active
-
2022
- 2022-08-10 US US17/818,858 patent/US20230192753A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL240465A0 (en) | 2015-09-24 |
| US20190263850A1 (en) | 2019-08-29 |
| WO2014152513A1 (en) | 2014-09-25 |
| EP2970351A1 (en) | 2016-01-20 |
| CA2902884C (en) | 2021-05-25 |
| AU2018203985A1 (en) | 2018-06-21 |
| HK1219955A1 (zh) | 2017-04-21 |
| KR20150127582A (ko) | 2015-11-17 |
| EP3750903A1 (en) | 2020-12-16 |
| CA2902884A1 (en) | 2014-09-25 |
| AU2014239562B2 (en) | 2018-07-05 |
| US20230192753A1 (en) | 2023-06-22 |
| US20210009629A1 (en) | 2021-01-14 |
| ES2797974T3 (es) | 2020-12-04 |
| ES2647832T3 (es) | 2017-12-26 |
| CN105026411A (zh) | 2015-11-04 |
| US10822368B2 (en) | 2020-11-03 |
| EP3301102B1 (en) | 2020-04-15 |
| EA201591281A1 (ru) | 2016-02-29 |
| EP3301102A1 (en) | 2018-04-04 |
| US11447520B2 (en) | 2022-09-20 |
| BR112015022507A2 (pt) | 2017-10-24 |
| JP2016513470A (ja) | 2016-05-16 |
| US20160031928A1 (en) | 2016-02-04 |
| ZA201507605B (en) | 2017-01-25 |
| MX2015011943A (es) | 2015-12-01 |
| JP6567494B2 (ja) | 2019-08-28 |
| EP2970351B1 (en) | 2017-09-13 |
| AU2018203985B2 (en) | 2019-09-19 |
| AU2014239562A1 (en) | 2015-08-27 |
| US10266559B2 (en) | 2019-04-23 |
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