SG11201507474QA - RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS - Google Patents
RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODSInfo
- Publication number
- SG11201507474QA SG11201507474QA SG11201507474QA SG11201507474QA SG11201507474QA SG 11201507474Q A SG11201507474Q A SG 11201507474QA SG 11201507474Q A SG11201507474Q A SG 11201507474QA SG 11201507474Q A SG11201507474Q A SG 11201507474QA SG 11201507474Q A SG11201507474Q A SG 11201507474QA
- Authority
- SG
- Singapore
- Prior art keywords
- thio
- modified nucleotides
- related methods
- ribonucleic acids
- ribonucleic
- Prior art date
Links
- 239000002773 nucleotide Substances 0.000 title 1
- 229920002477 rna polymer Polymers 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361785098P | 2013-03-14 | 2013-03-14 | |
| PCT/US2014/027422 WO2014152513A1 (en) | 2013-03-14 | 2014-03-14 | RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201507474QA true SG11201507474QA (en) | 2015-10-29 |
Family
ID=50639964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201507474QA SG11201507474QA (en) | 2013-03-14 | 2014-03-14 | RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US10266559B2 (es) |
| EP (3) | EP3750903A1 (es) |
| JP (1) | JP6567494B2 (es) |
| KR (1) | KR20150127582A (es) |
| CN (1) | CN105026411A (es) |
| AU (2) | AU2014239562B2 (es) |
| BR (1) | BR112015022507A2 (es) |
| CA (1) | CA2902884C (es) |
| EA (1) | EA201591281A1 (es) |
| ES (2) | ES2797974T3 (es) |
| HK (1) | HK1219955A1 (es) |
| IL (1) | IL240465A0 (es) |
| MX (1) | MX2015011943A (es) |
| SG (1) | SG11201507474QA (es) |
| WO (1) | WO2014152513A1 (es) |
| ZA (1) | ZA201507605B (es) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2506857T (pt) | 2009-12-01 | 2018-05-14 | Translate Bio Inc | Entrega de arnm para o acréscimo de proteínas e enzimas em doenças genéticas humanas |
| US8710200B2 (en) | 2011-03-31 | 2014-04-29 | Moderna Therapeutics, Inc. | Engineered nucleic acids encoding a modified erythropoietin and their expression |
| AU2012267578B2 (en) | 2011-06-08 | 2017-04-20 | Translate Bio, Inc. | Cleavable lipids |
| CA3107288A1 (en) | 2011-06-08 | 2012-12-13 | Translate Bio, Inc. | Lipid nanoparticle compositions and methods for mrna delivery |
| WO2013151667A1 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| WO2013185067A1 (en) | 2012-06-08 | 2013-12-12 | Shire Human Genetic Therapies, Inc. | Nuclease resistant polynucleotides and uses thereof |
| EP2970955B1 (en) | 2013-03-14 | 2018-11-14 | Translate Bio, Inc. | Methods for purification of messenger rna |
| EA037922B1 (ru) | 2013-03-14 | 2021-06-07 | Шир Хьюман Дженетик Терапис, Инк. | мРНК CFTR И КОМПОЗИЦИИ ДЛЯ ЛЕЧЕНИЯ МУКОВИСЦИДОЗА У МЛЕКОПИТАЮЩЕГО |
| US10138507B2 (en) | 2013-03-15 | 2018-11-27 | Modernatx, Inc. | Manufacturing methods for production of RNA transcripts |
| WO2014152030A1 (en) | 2013-03-15 | 2014-09-25 | Moderna Therapeutics, Inc. | Removal of dna fragments in mrna production process |
| WO2014144767A1 (en) | 2013-03-15 | 2014-09-18 | Moderna Therapeutics, Inc. | Ion exchange purification of mrna |
| EP2971161B1 (en) | 2013-03-15 | 2018-12-26 | ModernaTX, Inc. | Ribonucleic acid purification |
| US10005779B2 (en) * | 2013-06-05 | 2018-06-26 | Idenix Pharmaceuticals Llc | 1′,4′-thio nucleosides for the treatment of HCV |
| SI3019619T1 (sl) | 2013-07-11 | 2021-12-31 | Modernatx, Inc. | Sestave, ki zajemajo sintetične polinukleotide, ki kodirajo proteine, pozvezane s crispr, in sintetične sgrna, ter metode uporabe |
| US10385088B2 (en) | 2013-10-02 | 2019-08-20 | Modernatx, Inc. | Polynucleotide molecules and uses thereof |
| KR20160067219A (ko) | 2013-10-03 | 2016-06-13 | 모더나 세라퓨틱스, 인코포레이티드 | 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드 |
| EA034103B1 (ru) | 2013-10-22 | 2019-12-27 | Транслейт Био, Инк. | СПОСОБ ЛЕЧЕНИЯ ФЕНИЛКЕТОНУРИИ С ПРИМЕНЕНИЕМ мРНК |
| EP4276176A3 (en) | 2013-10-22 | 2024-01-10 | Translate Bio, Inc. | Mrna therapy for argininosuccinate synthetase deficiency |
| JP6571679B2 (ja) | 2014-04-25 | 2019-09-04 | トランスレイト バイオ， インコーポレイテッド | メッセンジャーｒｎａの精製方法 |
| US10286086B2 (en) | 2014-06-19 | 2019-05-14 | Modernatx, Inc. | Alternative nucleic acid molecules and uses thereof |
| EP3169335B8 (en) | 2014-07-16 | 2019-10-09 | ModernaTX, Inc. | Circular polynucleotides |
| GB201508025D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Fabry disease gene therapy |
| WO2017049286A1 (en) | 2015-09-17 | 2017-03-23 | Moderna Therapeutics, Inc. | Polynucleotides containing a morpholino linker |
| CA3007108A1 (en) | 2015-12-17 | 2017-06-22 | Modernatx, Inc. | Polynucleotides encoding methylmalonyl-coa mutase |
| WO2017127750A1 (en) | 2016-01-22 | 2017-07-27 | Modernatx, Inc. | Messenger ribonucleic acids for the production of intracellular binding polypeptides and methods of use thereof |
| KR102369898B1 (ko) * | 2016-04-08 | 2022-03-03 | 트랜슬레이트 바이오 인코포레이티드 | 다량체 코딩 핵산 및 그 용도 |
| EP3442590A2 (en) | 2016-04-13 | 2019-02-20 | Modernatx, Inc. | Lipid compositions and their uses for intratumoral polynucleotide delivery |
| PL3458083T3 (pl) | 2016-05-18 | 2023-03-13 | Modernatx, Inc. | Polinukleotydy kodujące interleukinę-12 (il12) i ich zastosowania |
| US11801227B2 (en) | 2016-05-18 | 2023-10-31 | Modernatx, Inc. | Polynucleotides encoding cystic fibrosis transmembrane conductance regulator for the treatment of cystic fibrosis |
| EP3458590B9 (en) | 2016-05-18 | 2021-08-18 | ModernaTX, Inc. | Polynucleotides encoding -galactosidase a for the treatment of fabry disease |
| MX2019010155A (es) | 2017-02-27 | 2020-12-10 | Translate Bio Inc | Arnm de cftr optimizado por codón novedoso. |
| HUE059025T2 (hu) | 2017-02-27 | 2022-10-28 | Translate Bio Inc | Módszerek a hírvívõ RNS tisztítására |
| ES2925083T3 (es) | 2017-02-27 | 2022-10-13 | Translate Bio Inc | Métodos de purificación de ARN mensajero |
| EP3592728A1 (en) | 2017-03-07 | 2020-01-15 | Translate Bio, Inc. | Polyanionic delivery of nucleic acids |
| AU2018268859A1 (en) | 2017-05-16 | 2019-12-12 | Translate Bio, Inc. | Treatment of cystic fibrosis by delivery of codon-optimized mrna encoding CFTR |
| MX2019014412A (es) | 2017-05-31 | 2020-02-10 | Ultragenyx Pharmaceutical Inc | Productos terapeuticos para la enfermedad de almacenamiento de glucogeno de tipo iii. |
| WO2018231709A1 (en) | 2017-06-12 | 2018-12-20 | Translate Bio, Inc. | Poly(phosphoesters) for delivery of nucleic acids |
| WO2018231990A2 (en) | 2017-06-14 | 2018-12-20 | Modernatx, Inc. | Polynucleotides encoding methylmalonyl-coa mutase |
| WO2018236849A1 (en) | 2017-06-19 | 2018-12-27 | Translate Bio, Inc. | MESSENGER RNA THERAPY FOR THE TREATMENT OF FRIEDREICH ATAXIA |
| US11859215B2 (en) | 2017-11-22 | 2024-01-02 | Modernatx, Inc. | Polynucleotides encoding ornithine transcarbamylase for the treatment of urea cycle disorders |
| US11939601B2 (en) | 2017-11-22 | 2024-03-26 | Modernatx, Inc. | Polynucleotides encoding phenylalanine hydroxylase for the treatment of phenylketonuria |
| EP3746496A1 (en) | 2018-02-02 | 2020-12-09 | Translate Bio, Inc. | Cationic polymers |
| JP7448488B2 (ja) * | 2018-05-15 | 2024-03-12 | トランスレイト バイオ， インコーポレイテッド | メッセンジャーｒｎａの皮下送達 |
| CN112384523A (zh) | 2018-05-16 | 2021-02-19 | 川斯勒佰尔公司 | 核糖阳离子脂质 |
| CN112437767B (zh) | 2018-05-24 | 2023-10-27 | 川斯勒佰尔公司 | 硫酯阳离子脂质 |
| WO2019232208A1 (en) | 2018-05-30 | 2019-12-05 | Translate Bio, Inc. | Cationic lipids comprising a steroidal moiety |
| EP3801627A1 (en) | 2018-05-30 | 2021-04-14 | Translate Bio, Inc. | Phosphoester cationic lipids |
| CA3101454A1 (en) * | 2018-05-30 | 2019-12-05 | Translate Bio, Inc. | Messenger rna vaccines and uses thereof |
| JP7441802B2 (ja) | 2018-05-30 | 2024-03-01 | トランスレイト バイオ， インコーポレイテッド | ビタミンカチオン性脂質 |
| EP3826608A1 (en) * | 2018-07-23 | 2021-06-02 | Translate Bio, Inc. | Dry power formulations for messenger rna |
| US11174500B2 (en) | 2018-08-24 | 2021-11-16 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| EP3856146A4 (en) | 2018-09-28 | 2022-07-06 | Nutcracker Therapeutics, Inc. | LIPIDATED CATIONIC PEPTIDE COMPOUNDS FOR NUCLEIC ACID DELIVERY |
| CN113166783A (zh) | 2018-10-09 | 2021-07-23 | 不列颠哥伦比亚大学 | 包含无有机溶剂和去污剂的转染活性囊泡的组合物和系统以及与之相关的方法 |
| WO2020097509A1 (en) | 2018-11-08 | 2020-05-14 | Translate Bio, Inc. | Methods and compositions for messenger rna purification |
| CA3117866A1 (en) | 2018-11-09 | 2020-05-14 | Translate Bio, Inc. | Multi-peg lipid compounds |
| EP3877368A1 (en) | 2018-11-09 | 2021-09-15 | Translate Bio, Inc. | 2,5-dioxopiperazine lipids with intercalated ester, thioester, disulfide and anhydride moieities |
| WO2020097379A2 (en) | 2018-11-09 | 2020-05-14 | Translate Bio, Inc. | Peg lipidoid compounds |
| WO2020106903A1 (en) | 2018-11-21 | 2020-05-28 | Translate Bio, Inc. | Cationic lipid compounds and compositions thereof for use in the delivery of messenger rna |
| US20220177423A1 (en) | 2019-04-18 | 2022-06-09 | Translate Bio, Inc. | Cystine cationic lipids |
| US20220233444A1 (en) | 2019-04-22 | 2022-07-28 | Translate Bio, Inc. | Thioester cationic lipids |
| WO2020227085A1 (en) | 2019-05-03 | 2020-11-12 | Translate Bio, Inc. | Di-thioester cationic lipids |
| US20220226244A1 (en) | 2019-05-31 | 2022-07-21 | Translate Bio, Inc. | Macrocyclic lipids |
| WO2020257611A1 (en) | 2019-06-21 | 2020-12-24 | Translate Bio, Inc. | Cationic lipids comprising an hydroxy moiety |
| JP2022537580A (ja) | 2019-06-21 | 2022-08-26 | トランスレイト バイオ， インコーポレイテッド | トリシンおよびクエン酸脂質 |
| CN111041025B (zh) | 2019-12-17 | 2021-06-18 | 深圳市瑞吉生物科技有限公司 | 基于结合N-乙酰半乳糖胺多肽的mRNA靶向分子及其制备方法 |
| WO2021202788A2 (en) * | 2020-04-03 | 2021-10-07 | Ionis Pharmaceuticals, Inc. | Modified oligomeric compounds and uses thereof |
| WO2021231697A1 (en) | 2020-05-14 | 2021-11-18 | Translate Bio, Inc. | Peg lipidoid compounds |
| CN111744019B (zh) | 2020-07-01 | 2023-08-04 | 深圳瑞吉生物科技有限公司 | 基于甘露糖的mRNA靶向递送系统及其应用 |
| CN114736260A (zh) * | 2022-03-29 | 2022-07-12 | 上海吉量医药工程有限公司 | 一种三磷酸核苷酸盐的制备方法 |
| WO2023239190A1 (ko) * | 2022-06-10 | 2023-12-14 | 주식회사 피노바이오 | 4'-티오-5-아자-2'-데옥시사이티딘의 제조방법 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ210501A (en) * | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
| FR2687679B1 (fr) | 1992-02-05 | 1994-10-28 | Centre Nat Rech Scient | Oligothionucleotides. |
| JP5379347B2 (ja) * | 2003-09-18 | 2013-12-25 | アイシス ファーマシューティカルズ， インコーポレーテッド | ４’−チオヌクレオシドおよびオリゴマー化合物 |
| WO2008103276A2 (en) * | 2007-02-16 | 2008-08-28 | Merck & Co., Inc. | Compositions and methods for potentiated activity of biologicaly active molecules |
| WO2010053572A2 (en) | 2008-11-07 | 2010-05-14 | Massachusetts Institute Of Technology | Aminoalcohol lipidoids and uses thereof |
| DE102009032885A1 (de) | 2009-07-13 | 2011-02-03 | Siemens Aktiengesellschaft | Ringförmiger Rotor für eine elektrische Maschine |
| PT2506857T (pt) * | 2009-12-01 | 2018-05-14 | Translate Bio Inc | Entrega de arnm para o acréscimo de proteínas e enzimas em doenças genéticas humanas |
| CA3107288A1 (en) | 2011-06-08 | 2012-12-13 | Translate Bio, Inc. | Lipid nanoparticle compositions and methods for mrna delivery |
| AU2012267578B2 (en) | 2011-06-08 | 2017-04-20 | Translate Bio, Inc. | Cleavable lipids |
| RU2648950C2 (ru) | 2011-10-03 | 2018-04-02 | Модерна Терапьютикс, Инк. | Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение |
| US20160264614A1 (en) | 2013-10-02 | 2016-09-15 | Moderna Therapeutics, Inc. | Polynucleotide molecules and uses thereof |
| US10385088B2 (en) | 2013-10-02 | 2019-08-20 | Modernatx, Inc. | Polynucleotide molecules and uses thereof |
| US20150167017A1 (en) | 2013-12-13 | 2015-06-18 | Moderna Therapeutics, Inc. | Alternative nucleic acid molecules and uses thereof |
| WO2016164762A1 (en) | 2015-04-08 | 2016-10-13 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor egf-a and intracellular domain mutants and methods of using the same |
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2014
- 2014-03-14 EP EP20169380.1A patent/EP3750903A1/en active Pending
- 2014-03-14 AU AU2014239562A patent/AU2014239562B2/en active Active
- 2014-03-14 JP JP2016502430A patent/JP6567494B2/ja active Active
- 2014-03-14 MX MX2015011943A patent/MX2015011943A/es unknown
- 2014-03-14 ES ES17189627T patent/ES2797974T3/es active Active
- 2014-03-14 SG SG11201507474QA patent/SG11201507474QA/en unknown
- 2014-03-14 CA CA2902884A patent/CA2902884C/en active Active
- 2014-03-14 WO PCT/US2014/027422 patent/WO2014152513A1/en active Application Filing
- 2014-03-14 EP EP17189627.7A patent/EP3301102B1/en active Active
- 2014-03-14 EP EP14721635.2A patent/EP2970351B1/en active Active
- 2014-03-14 CN CN201480010106.8A patent/CN105026411A/zh active Pending
- 2014-03-14 ES ES14721635.2T patent/ES2647832T3/es active Active
- 2014-03-14 KR KR1020157021965A patent/KR20150127582A/ko not_active Application Discontinuation
- 2014-03-14 EA EA201591281A patent/EA201591281A1/ru unknown
- 2014-03-14 US US14/776,506 patent/US10266559B2/en active Active
- 2014-03-14 BR BR112015022507A patent/BR112015022507A2/pt not_active IP Right Cessation
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2015
- 2015-08-10 IL IL240465A patent/IL240465A0/en unknown
- 2015-10-13 ZA ZA2015/07605A patent/ZA201507605B/en unknown
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2016
- 2016-07-07 HK HK16107939.1A patent/HK1219955A1/zh unknown
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2018
- 2018-06-05 AU AU2018203985A patent/AU2018203985B2/en active Active
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2019
- 2019-02-21 US US16/282,106 patent/US10822368B2/en active Active
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2020
- 2020-09-25 US US17/032,485 patent/US11447520B2/en active Active
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2022
- 2022-08-10 US US17/818,858 patent/US20230192753A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US10822368B2 (en) | 2020-11-03 |
| WO2014152513A1 (en) | 2014-09-25 |
| JP6567494B2 (ja) | 2019-08-28 |
| AU2014239562A1 (en) | 2015-08-27 |
| EP3301102A1 (en) | 2018-04-04 |
| AU2014239562B2 (en) | 2018-07-05 |
| CA2902884A1 (en) | 2014-09-25 |
| BR112015022507A2 (pt) | 2017-10-24 |
| MX2015011943A (es) | 2015-12-01 |
| EP3301102B1 (en) | 2020-04-15 |
| EP3750903A1 (en) | 2020-12-16 |
| US20210009629A1 (en) | 2021-01-14 |
| US10266559B2 (en) | 2019-04-23 |
| CA2902884C (en) | 2021-05-25 |
| ES2647832T3 (es) | 2017-12-26 |
| ES2797974T3 (es) | 2020-12-04 |
| US11447520B2 (en) | 2022-09-20 |
| ZA201507605B (en) | 2017-01-25 |
| CN105026411A (zh) | 2015-11-04 |
| AU2018203985A1 (en) | 2018-06-21 |
| AU2018203985B2 (en) | 2019-09-19 |
| US20160031928A1 (en) | 2016-02-04 |
| HK1219955A1 (zh) | 2017-04-21 |
| EP2970351A1 (en) | 2016-01-20 |
| US20190263850A1 (en) | 2019-08-29 |
| IL240465A0 (en) | 2015-09-24 |
| EA201591281A1 (ru) | 2016-02-29 |
| EP2970351B1 (en) | 2017-09-13 |
| US20230192753A1 (en) | 2023-06-22 |
| KR20150127582A (ko) | 2015-11-17 |
| JP2016513470A (ja) | 2016-05-16 |
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