SG11201507247WA - Combination therapy with 7-benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3h)-one - Google Patents

Combination therapy with 7-benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3h)-one

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Publication number
SG11201507247WA
SG11201507247WA SG11201507247WA SG11201507247WA SG11201507247WA SG 11201507247W A SG11201507247W A SG 11201507247WA SG 11201507247W A SG11201507247W A SG 11201507247WA SG 11201507247W A SG11201507247W A SG 11201507247WA SG 11201507247W A SG11201507247W A SG 11201507247WA
Authority
SG
Singapore
Prior art keywords
hexahydroimidazo
pyrido
methylbenzyl
pyrimidin
benzyl
Prior art date
Application number
SG11201507247WA
Other languages
English (en)
Inventor
Martin Stogniew
Joshua E Allen
Richard S Pottorf
Bhaskara Rao Nallaganchu
Gary L Olson
Original Assignee
Oncoceutics Inc
Provid Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncoceutics Inc, Provid Pharmaceuticals Inc filed Critical Oncoceutics Inc
Publication of SG11201507247WA publication Critical patent/SG11201507247WA/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41881,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SG11201507247WA 2013-03-13 2014-03-13 Combination therapy with 7-benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3h)-one SG11201507247WA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361779828P 2013-03-13 2013-03-13
US201361904718P 2013-11-15 2013-11-15
PCT/US2014/025885 WO2014160130A1 (en) 2013-03-13 2014-03-13 Combination therapy with 7-benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3h)-one

Publications (1)

Publication Number Publication Date
SG11201507247WA true SG11201507247WA (en) 2015-10-29

Family

ID=51527915

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201808496VA SG10201808496VA (en) 2013-03-13 2014-03-13 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pytido[3.4-e]pyrimidin-5(1h)-one, salts thereof and methods of using the same in combination therapy
SG11201507247WA SG11201507247WA (en) 2013-03-13 2014-03-13 Combination therapy with 7-benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3h)-one

Family Applications Before (1)

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SG10201808496VA SG10201808496VA (en) 2013-03-13 2014-03-13 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pytido[3.4-e]pyrimidin-5(1h)-one, salts thereof and methods of using the same in combination therapy

Country Status (26)

Country Link
US (1) US9265765B2 (pl)
EP (2) EP3572083A1 (pl)
JP (3) JP6446025B2 (pl)
KR (2) KR20220123335A (pl)
CN (1) CN105530937A (pl)
AU (3) AU2014244117B2 (pl)
BR (1) BR112015023256A2 (pl)
CA (2) CA3204801A1 (pl)
CY (1) CY1121735T1 (pl)
DK (1) DK2968294T3 (pl)
EA (1) EA037937B1 (pl)
ES (1) ES2734568T3 (pl)
HK (1) HK1217653A1 (pl)
HR (1) HRP20191181T1 (pl)
HU (1) HUE044238T2 (pl)
IL (2) IL241452B (pl)
LT (1) LT2968294T (pl)
ME (1) ME03470B (pl)
MX (2) MX2015012636A (pl)
NZ (2) NZ751509A (pl)
PL (1) PL2968294T3 (pl)
PT (1) PT2968294T (pl)
RS (1) RS59013B1 (pl)
SG (2) SG10201808496VA (pl)
SI (1) SI2968294T1 (pl)
WO (1) WO2014160130A1 (pl)

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US9265765B2 (en) 2016-02-23
ME03470B (me) 2020-01-20
EP2968294B1 (en) 2019-05-01
CA3204801A1 (en) 2014-10-02
BR112015023256A2 (pt) 2017-07-18
HRP20191181T1 (hr) 2019-10-04
AU2020233606A1 (en) 2020-10-01
EP2968294A1 (en) 2016-01-20
NZ711948A (en) 2020-02-28
JP2020172510A (ja) 2020-10-22
KR102438135B1 (ko) 2022-08-29
AU2014244117A1 (en) 2015-10-08
NZ751509A (en) 2023-03-31
EP3572083A1 (en) 2019-11-27
ES2734568T3 (es) 2019-12-10
JP2018184411A (ja) 2018-11-22
DK2968294T3 (da) 2019-07-15
SI2968294T1 (sl) 2019-08-30
PL2968294T3 (pl) 2019-10-31
AU2019201896A1 (en) 2019-04-11
EA201591715A1 (ru) 2016-07-29
IL241452B (en) 2020-07-30
CN105530937A (zh) 2016-04-27
SG10201808496VA (en) 2018-10-30
CA2905037A1 (en) 2014-10-02
IL275623A (en) 2020-08-31
RS59013B1 (sr) 2019-08-30
KR20150136602A (ko) 2015-12-07
KR20220123335A (ko) 2022-09-06
US20140271540A1 (en) 2014-09-18
HK1217653A1 (zh) 2017-01-20
WO2014160130A1 (en) 2014-10-02
CA2905037C (en) 2023-08-29
HUE044238T2 (hu) 2019-10-28
MX2019013643A (es) 2020-02-03
MX2015012636A (es) 2017-02-06
JP6446025B2 (ja) 2018-12-26
IL241452A0 (en) 2015-11-30
LT2968294T (lt) 2019-07-25
CY1121735T1 (el) 2020-07-31
JP2016512563A (ja) 2016-04-28
EP2968294A4 (en) 2016-10-19
AU2014244117B2 (en) 2018-12-20
PT2968294T (pt) 2019-07-19
EA037937B1 (ru) 2021-06-09

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