SG11201502602WA - Stable preservative-free mydriatic and anti-inflammatory solutions for injection - Google Patents

Stable preservative-free mydriatic and anti-inflammatory solutions for injection

Info

Publication number
SG11201502602WA
SG11201502602WA SG11201502602WA SG11201502602WA SG11201502602WA SG 11201502602W A SG11201502602W A SG 11201502602WA SG 11201502602W A SG11201502602W A SG 11201502602WA SG 11201502602W A SG11201502602W A SG 11201502602WA SG 11201502602W A SG11201502602W A SG 11201502602WA
Authority
SG
Singapore
Prior art keywords
injection
stable preservative
mydriatic
free
inflammatory
Prior art date
Application number
SG11201502602WA
Other languages
English (en)
Inventor
Gregory A Demopulos
Hui-Rong Shen
Clark E Tedford
Original Assignee
Omeros Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50545210&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201502602W(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Omeros Corp filed Critical Omeros Corp
Publication of SG11201502602WA publication Critical patent/SG11201502602WA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/04Artificial tears; Irrigation solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/08Mydriatics or cycloplegics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Dentistry (AREA)
  • Zoology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
SG11201502602WA 2012-10-24 2013-10-23 Stable preservative-free mydriatic and anti-inflammatory solutions for injection SG11201502602WA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261718026P 2012-10-24 2012-10-24
US201261736179P 2012-12-12 2012-12-12
PCT/US2013/066349 WO2014066485A1 (en) 2012-10-24 2013-10-23 Stable preservative-free mydriatic and anti-inflammatory solutions for injection

Publications (1)

Publication Number Publication Date
SG11201502602WA true SG11201502602WA (en) 2015-05-28

Family

ID=50545210

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201502602WA SG11201502602WA (en) 2012-10-24 2013-10-23 Stable preservative-free mydriatic and anti-inflammatory solutions for injection

Country Status (39)

Country Link
US (5) US9066856B2 (uk)
EP (2) EP2911511B1 (uk)
JP (7) JP6017053B2 (uk)
KR (4) KR102211784B1 (uk)
CN (2) CN108721210A (uk)
AP (1) AP2015008459A0 (uk)
AR (1) AR093115A1 (uk)
AU (1) AU2013201465B2 (uk)
BR (1) BR112015009228B1 (uk)
CA (1) CA2887772C (uk)
CL (1) CL2015001078A1 (uk)
CR (1) CR20150233A (uk)
CU (1) CU20150037A7 (uk)
CY (1) CY1124481T1 (uk)
DK (1) DK2911511T3 (uk)
EA (1) EA033811B1 (uk)
ES (1) ES2875432T3 (uk)
GE (1) GEP20186891B (uk)
HK (1) HK1213434A1 (uk)
HR (1) HRP20210980T1 (uk)
HU (1) HUE055537T2 (uk)
IL (1) IL238439B2 (uk)
IN (1) IN2015DN03029A (uk)
LT (1) LT2911511T (uk)
MA (1) MA38096B1 (uk)
MD (1) MD20150050A2 (uk)
MX (2) MX2020012591A (uk)
MY (1) MY188474A (uk)
NZ (1) NZ628398A (uk)
PE (1) PE20150958A1 (uk)
PH (1) PH12015500850B1 (uk)
PL (1) PL2911511T3 (uk)
PT (1) PT2911511T (uk)
RS (1) RS62188B1 (uk)
SG (1) SG11201502602WA (uk)
SI (1) SI2911511T1 (uk)
UA (1) UA114650C2 (uk)
WO (1) WO2014066485A1 (uk)
ZA (1) ZA201502684B (uk)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004010894A2 (en) 2002-07-30 2004-02-05 Omeros Corporation Ophthalmologic irrigation solutions and method
AU2013201465B2 (en) * 2012-10-24 2016-03-03 Rayner Surgical (Ireland) Limited Stable preservative-free mydriatic and anti-inflammatory solutions for injection
BR112016007328A2 (pt) 2013-10-03 2017-08-01 Imprimis Pharmaceuticals Inc composições oftálmicas baseadas em epinefrina para administração intraocular e métodos para fabricar as mesmas
TWI705812B (zh) * 2014-12-01 2020-10-01 奥默羅斯公司 用於抑制術後眼睛炎性病況的抗炎和散瞳前房溶液
CN104856990A (zh) * 2015-05-07 2015-08-26 武汉武药科技有限公司 去氧肾上腺素酮咯酸溶液及制备方法
US11213480B1 (en) 2015-08-06 2022-01-04 Hikma Pharmaceuticals International Limited Phenylephrine hydrochloride ready-to-use solution
USD831868S1 (en) 2015-09-17 2018-10-23 Lume Cube, Inc. Compact external light
US10704745B2 (en) 2015-10-13 2020-07-07 Lume Cube, Inc. Mobile light source
CA3034640A1 (en) 2016-08-25 2018-03-01 Imprimis Pharmaceuticals, Inc. Epinephrine-based ophthalmic compositions for intraocular administration and methods for fabricating thereof
US20180318319A1 (en) * 2017-05-04 2018-11-08 Ocular Science, Inc. Compositions and Methods for Treating Eyes and Methods of Preparation
JP7078843B2 (ja) * 2018-03-26 2022-06-01 サミー株式会社 遊技機
EP3870170A4 (en) * 2018-10-26 2022-07-20 Ocuphire Pharma, Inc. METHODS AND COMPOSITIONS FOR THE TREATMENT OF PRESBYOPIA, MYDRIASIS AND OTHER EYE DISEASES
US11071724B2 (en) 2019-05-17 2021-07-27 Ocular Science, Inc. Compositions and methods for treating presbyopia
DE102019125430B3 (de) * 2019-09-20 2020-11-19 Carl Zeiss Meditec Ag Steuerungsvorrichtung für ein ophthalmochirurgisches System, ophthalmochirurgisches System sowie Computerprogrammprodukt
KR20210087352A (ko) 2020-01-02 2021-07-12 삼성전자주식회사 에어 스페이서를 가지는 반도체 소자
US20210228507A1 (en) * 2020-01-22 2021-07-29 Nevakar Inc. Phenylephrine Hydrochloride Compositions and Containers
CN115368310A (zh) 2021-05-18 2022-11-22 奥库菲尔医药公司 合成甲磺酸酚妥拉明的方法
US11793789B2 (en) 2021-07-23 2023-10-24 Somerset Therapeutics, Llc Treatment of ophthalmological conditions using buffer-free ophthalmological compositions of ketorolac and phenylephrine
WO2024086268A1 (en) * 2022-10-19 2024-04-25 Fresenius Kabi Austria Gmbh Phenylephrine liquid formulations
CN115950992B (zh) * 2023-03-15 2023-06-09 苏州朗易生物医药研究有限公司 一种去氧肾上腺素酮咯酸溶液中有关物质的检测方法及其应用

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4402949A (en) 1979-11-12 1983-09-06 Sandoz Ltd. Stable solutions of hydrogenated ergotalkaloids
US4550022A (en) 1981-10-05 1985-10-29 Alcon Laboratories, Inc. Tissue irrigating solution
JPS58126810A (ja) 1981-12-24 1983-07-28 Kaken Pharmaceut Co Ltd 抗炎症眼科用液剤およびその製法
US4474751A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
WO1987007141A1 (en) 1986-05-23 1987-12-03 New England Medical Center Hospitals, Inc. Method for treating glaucoma
US5212196A (en) 1986-10-21 1993-05-18 Alcon Laboratories, Inc. Control of post-surgical intraocular pressure using clonidine derivatives
US4938970A (en) 1987-02-06 1990-07-03 Hustead Robert E Painless electrolyte solutions
US5110493A (en) 1987-09-11 1992-05-05 Syntex (U.S.A.) Inc. Ophthalmic NSAID formulations containing a quaternary ammonium preservative and a nonionic surfactant
US4876250A (en) 1988-10-31 1989-10-24 Alcon Laboratories, Inc. Methods for controlling ocular hypertension with angiostatic steroids
US5051443A (en) 1988-10-12 1991-09-24 Eye Research Institute Of Retina Foundation, Inc. Method for enhancing healing of corneal endothelial wounds
US5036046A (en) 1988-10-12 1991-07-30 Eye Research Institute Of Retina Foundation, Inc. Method for enhancing healing of corneal endothelial wounds
US5371078A (en) 1988-10-31 1994-12-06 Alcon Laboratories, Inc. Angiostatic steroids and methods and compositions for controlling ocular hypertension
US5116868A (en) 1989-05-03 1992-05-26 The Johns Hopkins University Effective ophthalmic irrigation solution
ATE135216T1 (de) 1989-08-21 1996-03-15 Beth Israel Hospital Verwendung von spiperone-derivate zur immunosuppression
US5679650A (en) * 1993-11-24 1997-10-21 Fukunaga; Atsuo F. Pharmaceutical compositions including mixtures of an adenosine compound and a catecholamine
DE69114470T2 (de) 1990-09-07 1996-07-18 Univ Alicante Komposition für die behandlung von augenschmerzen.
US5318780A (en) 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
IT1252692B (it) 1991-11-27 1995-06-23 Zambon Spa Composizione farmaceutica per uso oftalmico contenente un antiinfiammatorio non steroideo ed un decongestionante come principi attivi
JPH07502544A (ja) 1992-10-21 1995-03-16 アルコン ラボラトリーズ,インコーポレイテッド 眼内組織潅注用および眼内外科処置中の瞳孔散大維持用組成物
US6117907A (en) 1993-04-14 2000-09-12 Sher; Neal A. Topical treatment of ocular pain after corneal surgery
EP0670732A1 (en) 1993-09-29 1995-09-13 Alcon Laboratories, Inc. Compositions containing growth factors and antimetabolites
CA2149657A1 (en) 1993-09-29 1995-04-06 Billie M. York Compositions containing growth factors and antiplastic agents
US5624893A (en) 1993-10-14 1997-04-29 Alcon Laboratories, Inc. Pharmaceutical compositions and methods of treatment of the cornea following laser irradiation
CA2179147A1 (en) 1993-12-17 1995-06-22 Gerald D. Cagle Improved intraocular irrigating solution containing non-steroidal antiinflammatory agent
US6350781B1 (en) 1994-01-14 2002-02-26 Lee Shahinia, Jr. Method and analgesic preparations for sustained and extended corneal analgesia with subanesthetic concentrations of lidocaine
WO1995034298A1 (en) 1994-06-10 1995-12-21 Telor Ophthalmic Pharmaceuticals, Inc. Inhibition of intraoperative miosis/production of mydriasis by local anesthetics
US5523316A (en) 1994-06-23 1996-06-04 Alcon Laboratories, Inc. Intraocular irrigating solution containing agent for controlling IOP
WO2000023061A2 (en) 1998-10-21 2000-04-27 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain and inflammation
US6492332B1 (en) 1995-12-12 2002-12-10 Omeros Corporation Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation
WO2000023062A2 (en) 1998-10-20 2000-04-27 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain and inflammation
US7091181B2 (en) 1994-12-12 2006-08-15 Omeros Corporation Method of inhibition of pain and inflammation during surgery comprising administration of soluble TNF receptors
KR100517210B1 (ko) 1994-12-12 2006-06-07 오메로스 코포레이션 통증,염증및경련억제용관주용액
MX9703988A (es) 1994-12-12 1998-02-28 Omeros Med Sys Inc SOLUCIaN Y MÉTODO DE IRRIGACIaN PARA LA INHIBICIaN DEL DOLOR, LA INFLAMACIaN Y ES ESPASMO.
JPH10510540A (ja) 1994-12-12 1998-10-13 オメロス メディカル システムズ,インコーポレーテッド 灌注用溶液並びに疼痛、炎症及びけいれんの抑制法
US5972326A (en) 1995-04-18 1999-10-26 Galin; Miles A. Controlled release of pharmaceuticals in the anterior chamber of the eye
US5612027A (en) 1995-04-18 1997-03-18 Galin; Miles A. Controlled release of miotic and mydriatic drugs in the anterior chamber
US5767105A (en) 1995-05-03 1998-06-16 Peyman; Gholam A. Ocular solution
US5798356A (en) 1995-08-07 1998-08-25 Alcon Laboratories, Inc. Angiostatic compounds
US5849761A (en) 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US6413961B1 (en) 1995-12-12 2002-07-02 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain and inflammation
US6280745B1 (en) 1997-12-23 2001-08-28 Alliance Pharmaceutical Corp. Methods and compositions for the delivery of pharmaceutical agents and/or the prevention of adhesions
EP1039818A4 (en) 1996-07-26 2001-11-07 Schein Dental Equipment Co ARMREST MECHANISM FOR DENTAL ARMCHAIRS
GB9704352D0 (en) 1997-03-03 1997-04-23 Chiroscience Ltd Levobupivacaine and its use
US6030974A (en) 1997-04-02 2000-02-29 The Regents Of The University Of California Method of anesthesia
US5811446A (en) 1997-04-18 1998-09-22 Cytos Pharmaceuticals Llc Prophylactic and therapeutic methods for ocular degenerative diseases and inflammations and histidine compositions therefor
US6034256A (en) 1997-04-21 2000-03-07 G.D. Searle & Co. Substituted benzopyran derivatives for the treatment of inflammation
US6495598B1 (en) 1997-04-22 2002-12-17 Ophtecs Corporation Perfusate preparation for ophthalmic operation
EP0903151A1 (en) 1997-09-22 1999-03-24 ASTA Medica Aktiengesellschaft Use of combinations comprising non-sedating antihistamines and alpha-adrenergic drugs for the topical treatment of rhinitis/conjunctivitis and cold, cold-like and/or flu symptoms
EP1091733B1 (en) 1998-07-01 2005-12-07 Warner-Lambert Company Llc (-)-pseudoephedrine as a sympathomimetic drug
AU742237B2 (en) 1998-07-14 2001-12-20 Alcon Manufacturing Limited Use of 11-(3-dimenthylaminopropylidene)-6,11-dihydrodibenz (B,E)oxepin-2-acetic acid for the manufacture of medicament for treating non-allergic opthalmic inflammatory disorders and for the prevention of ocular neovascularization
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
FR2782721B1 (fr) 1998-09-01 2000-11-03 Inst Nat Sante Rech Med Nouveaux composes phosphohalohydrines, procede de fabrication et applications
US6395746B1 (en) 1998-09-30 2002-05-28 Alcon Manufacturing, Ltd. Methods of treating ophthalmic, otic and nasal infections and attendant inflammation
EP1227807B1 (en) 1998-10-20 2005-03-30 Omeros Corporation Irrigation solution and method for inhibition of pain and inflammation
EP1261334A1 (en) 1998-10-20 2002-12-04 Omeros Corporation Irrigation solution containing mapk inhibitors and their use for treating pain and inflammation
US20030087962A1 (en) 1998-10-20 2003-05-08 Omeros Corporation Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
US7973068B2 (en) 1998-10-20 2011-07-05 Omeros Corporation Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
EP1206275B1 (en) 1998-11-05 2007-09-05 Omeros Corporation Irrigation solution and method for inhibition of pain and inflammation
WO2000035433A2 (en) 1998-12-17 2000-06-22 Alcon Laboratories, Inc. Methods for the prevention and treatment of post-surgical complications
BR0008674A (pt) * 1999-03-02 2002-02-13 Vitreo Retinal Technologies In Método para tratar ou prevenir a proliferação de fibroblastos dentro do olho, tratar ou prevenir a neovascularização de tecidos oculares, acelerar a clarificação do sangue hemorrágico do humor vìtreo, causar a dissolução não-enzimática da interface hialóide e/ou causar a separação ou a desinserção do vìtreo posterior
CA2368593A1 (en) 1999-05-14 2000-11-23 Regents Of The University Of California Anti-inflammatory therapy for inflammatory mediated infection
US7273887B1 (en) 1999-10-22 2007-09-25 Transdermatech, Inc. Topical anesthetic formulation
US6218428B1 (en) 2000-04-28 2001-04-17 Emil Chynn Ophthalmic composition
JP2004512260A (ja) 2000-04-28 2004-04-22 メモリアル スローン−ケッタリング キャンサー センター 局所麻酔/オピオイド製剤およびその使用方法
CA2414674A1 (en) 2000-07-13 2002-01-24 Pharmacia Corporation Use of cox-2 inhibitors in the treatment and prevention of ocular cox-2 mediated disorders
PE20020146A1 (es) 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
BR0112461A (pt) 2000-07-14 2003-07-22 Allergan Inc Composições que contém componentes terapeuticamente ativos tendo uma solubilidade aumentada
CA2417489A1 (en) 2000-07-28 2002-02-07 Maria A. Peral Use of indole derivatives for the manufacture of a medicament for reducing intracular pressure
JP2002161032A (ja) 2000-09-14 2002-06-04 Taisho Pharmaceut Co Ltd 粘膜適用組成物
CN1390124A (zh) 2000-09-20 2003-01-08 永光制药有限公司 近视眼的预防、治疗药
US20020183279A1 (en) 2001-04-18 2002-12-05 Koichiro Tanaka Pharmaceutical composition containing viscoelastic substance and medication
US20020198209A1 (en) 2001-05-03 2002-12-26 Allergan Sales Inc. Compositions having enhanced pharmacokinetic characteristics
US20030191187A1 (en) 2002-04-01 2003-10-09 Lee Fang Yu Injectable pharmaceutical composition containing a non-steroidal anti-inflammatory drug and method for preparing the same
WO2004010894A2 (en) 2002-07-30 2004-02-05 Omeros Corporation Ophthalmologic irrigation solutions and method
US7439241B2 (en) 2003-05-27 2008-10-21 Galderma Laboratories, Inc. Compounds, formulations, and methods for treating or preventing rosacea
WO2006069213A1 (en) * 2004-12-22 2006-06-29 Schering Corporation Pharmaceutical formulations
CA2587792C (en) 2004-12-23 2010-07-06 Roxro Pharma, Inc. Therapeutic compositions for intranasal administration of ketorolac
FR2882930B1 (fr) 2005-03-09 2009-03-27 Walid Katib Nouvelles compositions ophtalmologiques et leur mode d'utilisation
DOP2007000055A (es) * 2006-04-10 2007-10-31 Senosiain S A De C V Lab Composición farmaceutica que comprende un analgésico y vitaminas
CA2697160A1 (en) 2007-08-21 2009-02-26 Harbor Biosciences, Inc. Stabilized therapeutic compositions and formulations
CN101977595A (zh) 2007-11-08 2011-02-16 阿西克斯医疗公司 用于治疗以及预防眼睑肿胀的组合物
US7842714B2 (en) 2008-03-03 2010-11-30 Allergan, Inc. Ketorolac tromethamine compositions for treating ocular pain
US9192571B2 (en) 2008-03-03 2015-11-24 Allergan, Inc. Ketorolac tromethamine compositions for treating or preventing ocular pain
KR20110125664A (ko) * 2009-03-06 2011-11-21 메디뮨 엘엘씨 인간화된 항-cd19 항체 제형
US8277781B2 (en) 2009-03-13 2012-10-02 Luitpold Pharmaceuticals, Inc. Device for intranasal administration
CA2764473A1 (en) * 2009-06-05 2010-12-09 Aciex Therapeutics, Inc. Ophthalmic formulations of fluticasone and methods of use
EP2437602A4 (en) * 2009-06-05 2014-02-19 Aciex Therapeutics Inc OPHTHALMIC FORMULATIONS, METHOD FOR THE PRODUCTION THEREOF AND METHOD FOR THEIR USE
US8680510B2 (en) 2010-06-28 2014-03-25 International Business Machines Corporation Method of forming compound semiconductor
PL2598119T3 (pl) 2010-07-29 2019-03-29 Allergan, Inc. Niezawierające konserwantów roztwory brymonidyny i timololu
AU2013201465B2 (en) * 2012-10-24 2016-03-03 Rayner Surgical (Ireland) Limited Stable preservative-free mydriatic and anti-inflammatory solutions for injection
TWI705812B (zh) 2014-12-01 2020-10-01 奥默羅斯公司 用於抑制術後眼睛炎性病況的抗炎和散瞳前房溶液

Also Published As

Publication number Publication date
US20180085349A1 (en) 2018-03-29
EP2911511A4 (en) 2015-12-16
NZ628398A (en) 2016-03-31
PH12015500850A1 (en) 2015-06-22
GEP20186891B (en) 2018-09-10
LT2911511T (lt) 2021-07-26
RS62188B1 (sr) 2021-08-31
JP6282699B2 (ja) 2018-02-21
AR093115A1 (es) 2015-05-20
CY1124481T1 (el) 2022-07-22
US20170196838A1 (en) 2017-07-13
US9066856B2 (en) 2015-06-30
US20150342928A1 (en) 2015-12-03
IN2015DN03029A (uk) 2015-10-02
SI2911511T1 (sl) 2021-09-30
EA033811B1 (ru) 2019-11-27
JP2017014294A (ja) 2017-01-19
MX2015005089A (es) 2015-07-17
US9855246B2 (en) 2018-01-02
CN104822265A (zh) 2015-08-05
BR112015009228A2 (pt) 2017-07-04
CR20150233A (es) 2015-08-14
US20140235691A1 (en) 2014-08-21
UA114650C2 (uk) 2017-07-10
KR20210018954A (ko) 2021-02-18
IL238439A0 (en) 2015-06-30
US9486406B2 (en) 2016-11-08
PH12015500850B1 (en) 2015-06-22
KR20150068990A (ko) 2015-06-22
ES2875432T3 (es) 2021-11-10
JP2019081798A (ja) 2019-05-30
EA201590807A1 (ru) 2015-11-30
PE20150958A1 (es) 2015-07-09
EP2911511A1 (en) 2015-09-02
KR101808394B1 (ko) 2017-12-12
KR102211784B1 (ko) 2021-02-04
JP2018058905A (ja) 2018-04-12
US20220175726A1 (en) 2022-06-09
CU20150037A7 (es) 2015-08-27
HK1213434A1 (zh) 2016-07-08
WO2014066485A1 (en) 2014-05-01
EP2911511B1 (en) 2021-04-14
MX2020012591A (es) 2022-11-04
AU2013201465B2 (en) 2016-03-03
IL238439B1 (en) 2023-07-01
HRP20210980T1 (hr) 2021-09-17
MY188474A (en) 2021-12-13
EP3909572A1 (en) 2021-11-17
MA38096B1 (fr) 2019-12-31
JP2020147606A (ja) 2020-09-17
PL2911511T3 (pl) 2021-11-15
KR102496463B1 (ko) 2023-02-06
JP2016196511A (ja) 2016-11-24
BR112015009228B1 (pt) 2022-07-19
BR112015009228A8 (pt) 2022-07-12
AP2015008459A0 (en) 2015-05-31
IL238439B2 (en) 2023-11-01
JP2023041804A (ja) 2023-03-24
CA2887772A1 (en) 2014-05-01
CN108721210A (zh) 2018-11-02
CL2015001078A1 (es) 2015-09-04
ZA201502684B (en) 2016-01-27
JP6017053B2 (ja) 2016-10-26
PT2911511T (pt) 2021-07-06
KR20200000487A (ko) 2020-01-02
CA2887772C (en) 2017-02-21
AU2013201465A1 (en) 2014-05-08
MD20150050A2 (ro) 2015-09-30
MA38096A1 (fr) 2016-10-31
DK2911511T3 (en) 2021-06-28
HUE055537T2 (hu) 2021-12-28
KR20170128640A (ko) 2017-11-22
JP2015535250A (ja) 2015-12-10

Similar Documents

Publication Publication Date Title
HK1213434A1 (zh) 穩定的不含防腐劑的瞳孔散大劑和用於注射的抗炎溶液
HK1205690A1 (en) Pharmaceutical composition and administration thereof
DK2844222T3 (da) Lægemiddelformulering med forsinket udløsning
EP2932993A4 (en) MEDICATION INJECTION DEVICE
EP2862588A4 (en) DRUGS INJECTION DEVICE
AU343318S (en) Medicine injector
EP2776115A4 (en) MEDICAL PLASTER AND INJECTOR SYSTEM
EP2793953A4 (en) TELODENDRIMERS WITH INCREASED DRUG DELIVERY
PL2870072T3 (pl) Dozownik leków
EP2885028A4 (en) DISPOSABLE INJECTOR
HK1207046A1 (en) Cap and cap portion structure
ZA201405949B (en) Pharmaceutical preparation containing and antivirally active dihydroquinazoline derivative
GB201504945D0 (en) Absobent article with highlighted active barrier
HK1198911A1 (zh) 注射用的穩定消炎溶液
EP2878780A4 (en) INJECTION NOZZLE FOR A UREA SOLUTION
HK1206292A1 (en) Medicament administration
IL235131A0 (en) dispenses medicine
EP2700454B8 (en) Injection nozzle
AP2015008208A0 (en) Pharmaceutical administration forms comprising
PL2852537T3 (pl) Torebka do zaparzania i jej wytwarzanie
HK1205683A1 (en) Pharmaceutical formulation having improved stability
EP2898912A4 (en) INSTRUMENT FOR MEDICINE ADMINISTRATION
IL220794A (en) Medication dispenser
EP2873422A4 (en) PHARMACEUTICAL PREPARATION FOR INJECTION
GB201309474D0 (en) Improvements in and relating to a medication dispenser