SG11201502429YA - Use of a pvdf membrane to purify cell-binding agent cytotoxic agent conjugates - Google Patents
Use of a pvdf membrane to purify cell-binding agent cytotoxic agent conjugatesInfo
- Publication number
- SG11201502429YA SG11201502429YA SG11201502429YA SG11201502429YA SG11201502429YA SG 11201502429Y A SG11201502429Y A SG 11201502429YA SG 11201502429Y A SG11201502429Y A SG 11201502429YA SG 11201502429Y A SG11201502429Y A SG 11201502429YA SG 11201502429Y A SG11201502429Y A SG 11201502429YA
- Authority
- SG
- Singapore
- Prior art keywords
- pvdf membrane
- binding agent
- conjugates
- purify cell
- cytotoxic agent
- Prior art date
Links
- 239000011230 binding agent Substances 0.000 title 1
- 229940127089 cytotoxic agent Drugs 0.000 title 1
- 239000002254 cytotoxic agent Substances 0.000 title 1
- 231100000599 cytotoxic agent Toxicity 0.000 title 1
- 239000012528 membrane Substances 0.000 title 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6867—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of a blood cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/265—Adsorption chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/32—Bonded phase chromatography
- B01D15/325—Reversed phase
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/32—Bonded phase chromatography
- B01D15/325—Reversed phase
- B01D15/327—Reversed phase with hydrophobic interaction
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
- B01D71/06—Organic material
- B01D71/30—Polyalkenyl halides
- B01D71/32—Polyalkenyl halides containing fluorine atoms
- B01D71/34—Polyvinylidene fluoride
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261709891P | 2012-10-04 | 2012-10-04 | |
PCT/US2013/063480 WO2014055877A1 (fr) | 2012-10-04 | 2013-10-04 | Utilisation d'une membrane de pvdf pour purifier des conjugués d'agent de liaison cellulaire-agent cytotoxique |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201502429YA true SG11201502429YA (en) | 2015-04-29 |
Family
ID=50435472
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201502429YA SG11201502429YA (en) | 2012-10-04 | 2013-10-04 | Use of a pvdf membrane to purify cell-binding agent cytotoxic agent conjugates |
SG10201702737TA SG10201702737TA (en) | 2012-10-04 | 2013-10-04 | Use of a pvdf membrane to purify cell-binding agent cytotoxic agent conjugates |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201702737TA SG10201702737TA (en) | 2012-10-04 | 2013-10-04 | Use of a pvdf membrane to purify cell-binding agent cytotoxic agent conjugates |
Country Status (15)
Country | Link |
---|---|
US (2) | US10035817B2 (fr) |
EP (1) | EP2904089A4 (fr) |
JP (3) | JP6345181B2 (fr) |
CN (2) | CN109200290A (fr) |
AU (2) | AU2013326881B2 (fr) |
CA (1) | CA2886993A1 (fr) |
HK (1) | HK1213288A1 (fr) |
IL (2) | IL238110B (fr) |
IN (1) | IN2015DN03202A (fr) |
MX (1) | MX359599B (fr) |
NZ (1) | NZ707091A (fr) |
RU (2) | RU2661083C2 (fr) |
SG (2) | SG11201502429YA (fr) |
WO (1) | WO2014055877A1 (fr) |
ZA (1) | ZA201502992B (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ609752A (en) | 2005-08-24 | 2014-08-29 | Immunogen Inc | Process for preparing maytansinoid antibody conjugates |
SI2437790T1 (sl) | 2009-06-03 | 2019-07-31 | Immunogen, Inc. | Konjugacijske metode |
MX369659B (es) | 2011-03-29 | 2019-11-15 | Immunogen Inc | Preparacion de conjugados de maitansinoides y anticuerpos mediante un proceso de una etapa. |
SG11201502429YA (en) | 2012-10-04 | 2015-04-29 | Immunogen Inc | Use of a pvdf membrane to purify cell-binding agent cytotoxic agent conjugates |
KR102511249B1 (ko) | 2014-04-29 | 2023-03-20 | 진콴텀 헬스케어 (쑤저우) 씨오., 엘티디. | 신규한 안정한 항체-약물 복합체, 이의 제조방법 및 이의 용도 |
MA42561A (fr) | 2014-09-02 | 2018-04-25 | Immunogen Inc | Procédés de formulation de compositions de conjugués anticorps-médicament |
CN105797603A (zh) * | 2016-04-13 | 2016-07-27 | 伊美特(上海)环保科技有限公司 | 一种亲水性中空纤维超滤膜及其制备工艺 |
CN106995639A (zh) * | 2017-04-18 | 2017-08-01 | 安徽省康宇水电机械成套设备有限公司 | 一种低成本水下防腐材料 |
CN108549763B (zh) * | 2018-04-09 | 2021-06-01 | 电子科技大学 | 一种用于离子推进器数值模拟的电荷交换碰撞mcc方法 |
CN112830937A (zh) * | 2019-11-22 | 2021-05-25 | 上海医药集团股份有限公司 | 一种美登素dm1聚合物的制备方法 |
JP2024508976A (ja) | 2021-03-08 | 2024-02-28 | ジーンクアンタム ヘルスケア (スーチョウ) シーオー., エルティーディー. | 抗体-免疫アゴニストコンジュゲート及びその使用 |
JP2024514174A (ja) | 2021-04-14 | 2024-03-28 | ジーンクアンタム ヘルスケア (スーチョウ) シーオー., エルティーディー. | リンカー、コンジュゲート及びその用途 |
Family Cites Families (166)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE430062B (sv) | 1977-03-04 | 1983-10-17 | Pharmacia Fine Chemicals Ab | Kopplings- eller tioleringsreagens |
US4137230A (en) | 1977-11-14 | 1979-01-30 | Takeda Chemical Industries, Ltd. | Method for the production of maytansinoids |
US4307016A (en) | 1978-03-24 | 1981-12-22 | Takeda Chemical Industries, Ltd. | Demethyl maytansinoids |
US4256746A (en) | 1978-11-14 | 1981-03-17 | Takeda Chemical Industries | Dechloromaytansinoids, their pharmaceutical compositions and method of use |
JPS55102583A (en) | 1979-01-31 | 1980-08-05 | Takeda Chem Ind Ltd | 20-acyloxy-20-demethylmaytansinoid compound |
JPS55162791A (en) | 1979-06-05 | 1980-12-18 | Takeda Chem Ind Ltd | Antibiotic c-15003pnd and its preparation |
JPS5645483A (en) | 1979-09-19 | 1981-04-25 | Takeda Chem Ind Ltd | C-15003phm and its preparation |
EP0028683A1 (fr) | 1979-09-21 | 1981-05-20 | Takeda Chemical Industries, Ltd. | Antibiotique C-15003 PHO et sa préparation |
JPS5645485A (en) | 1979-09-21 | 1981-04-25 | Takeda Chem Ind Ltd | Production of c-15003pnd |
WO1982001188A1 (fr) | 1980-10-08 | 1982-04-15 | Takeda Chemical Industries Ltd | Composes 4,5-deoxymaytansinoide et leur procede de preparation |
US4450254A (en) | 1980-11-03 | 1984-05-22 | Standard Oil Company | Impact improvement of high nitrile resins |
US4315929A (en) | 1981-01-27 | 1982-02-16 | The United States Of America As Represented By The Secretary Of Agriculture | Method of controlling the European corn borer with trewiasine |
US4313946A (en) | 1981-01-27 | 1982-02-02 | The United States Of America As Represented By The Secretary Of Agriculture | Chemotherapeutically active maytansinoids from Trewia nudiflora |
US4563304A (en) | 1981-02-27 | 1986-01-07 | Pharmacia Fine Chemicals Ab | Pyridine compounds modifying proteins, polypeptides or polysaccharides |
JPS57192389A (en) | 1981-05-20 | 1982-11-26 | Takeda Chem Ind Ltd | Novel maytansinoid |
US4664911A (en) | 1983-06-21 | 1987-05-12 | Board Of Regents, University Of Texas System | Immunotoxin conjugates employing toxin B chain moieties |
DE3587294T2 (de) | 1985-01-22 | 1993-09-30 | Saint Gobain Vitrage | Verfahren zur Herstellung einer dünnen Metalloxidbeschichtung auf einem Substrat, insbesondere Glas und deren Verwendung als Verglasung. |
GB8600582D0 (en) | 1986-01-10 | 1986-02-19 | Ca Minister Nat Defence | Purifying biological materials |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US4859449A (en) | 1987-09-14 | 1989-08-22 | Center For Molecular Medicine And Immunology | Modified antibodies for enhanced hepatocyte clearance |
US5241078A (en) | 1988-06-14 | 1993-08-31 | Cetus Oncology | Coupling agents and sterically hindered disulfide linked conjugates prepared therefrom |
US5024834A (en) | 1988-07-12 | 1991-06-18 | Cetus Corporation | Thioether linked immunotoxin conjugates |
CA2006408A1 (fr) | 1988-12-27 | 1990-06-27 | Susumu Iwasa | Anticorps monoclaux bispecifiques, production et utilisation |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5714149A (en) | 1989-02-10 | 1998-02-03 | Celltech Therapeutics Limited | Crosslinked antibodies and processes for their preparation |
CA2026147C (fr) | 1989-10-25 | 2006-02-07 | Ravi J. Chari | Agents cytotoxiques comprenant des maytansinoides et leur usage therapeutique |
US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
US6316003B1 (en) | 1989-12-21 | 2001-11-13 | Whitehead Institute For Biomedical Research | Tat-derived transport polypeptides |
US5137877B1 (en) | 1990-05-14 | 1996-01-30 | Bristol Myers Squibb Co | Bifunctional linking compounds conjugates and methods for their production |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
ES2108048T3 (es) | 1990-08-29 | 1997-12-16 | Genpharm Int | Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos. |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
CA2048078A1 (fr) | 1990-11-15 | 1992-05-16 | Wolfgang A. Wrasidlo | Modification chimique des anticorps pour la creation d'immunoconjugues |
US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
SE9102074D0 (sv) | 1991-07-03 | 1991-07-03 | Kabi Pharmacia Ab | Tomour antigen specific antibody |
SE470006B (sv) | 1991-09-26 | 1993-10-25 | Corline Systems Ab | Nytt konjugat, dess framställning och användning samt substrat preparerat med konjugatet |
ES2341666T3 (es) | 1991-12-02 | 2010-06-24 | Medimmune Limited | Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos. |
ES2149768T3 (es) | 1992-03-25 | 2000-11-16 | Immunogen Inc | Conjugados de agentes enlazantes de celulas derivados de cc-1065. |
US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
US5556623A (en) | 1993-03-30 | 1996-09-17 | Eli Lilly And Company | Antibody-drug conjugates |
IL111748A0 (en) | 1993-12-03 | 1995-01-24 | Zeneca Ltd | Proteins |
US5747446A (en) | 1994-03-22 | 1998-05-05 | Beth Israel Deaconess Medical Center | Modified polypeptides with increased biological activity |
US5580853A (en) | 1994-03-22 | 1996-12-03 | New England Deaconess Hospital | Modified polypeptides with increased biological activity |
US5919758A (en) | 1994-03-22 | 1999-07-06 | Beth Israel Deaconess Medical Center | Modified polypeptides with altered biological activity |
US5612474A (en) | 1994-06-30 | 1997-03-18 | Eli Lilly And Company | Acid labile immunoconjugate intermediates |
AU5908296A (en) | 1995-05-31 | 1996-12-24 | Fred Hutchinson Cancer Research Center | Compositions and methods for targeted delivery of effector m olecules |
US6265150B1 (en) | 1995-06-07 | 2001-07-24 | Becton Dickinson & Company | Phage antibodies |
US5714352A (en) | 1996-03-20 | 1998-02-03 | Xenotech Incorporated | Directed switch-mediated DNA recombination |
US5958872A (en) | 1996-04-01 | 1999-09-28 | Apoptosis Technology, Inc. | Active survival domains of IGF-IR and methods of use |
US6340461B1 (en) | 1996-12-17 | 2002-01-22 | David Stephen Terman | Superantigen based methods and compositions for treatment of diseases |
US6462070B1 (en) | 1997-03-06 | 2002-10-08 | The General Hospital Corporation | Photosensitizer conjugates for pathogen targeting |
US6371975B2 (en) | 1998-11-06 | 2002-04-16 | Neomend, Inc. | Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers |
PT1012280E (pt) | 1997-06-11 | 2005-02-28 | Borean Pharma As | Modulo de trimerizacao |
US6171586B1 (en) | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
US5958677A (en) | 1997-07-28 | 1999-09-28 | The New York Blood Center, Inc. | Method for purifying viral nucleic acids |
WO1999006587A2 (fr) | 1997-08-01 | 1999-02-11 | Morphosys Ag | Nouvelle methode et nouveau phage d'identification d'une sequence d'acide nucleique |
US5965714A (en) | 1997-10-02 | 1999-10-12 | Connaught Laboratories, Inc. | Method for the covalent attachment of polysaccharides to protein molecules |
DE69830326T2 (de) | 1997-10-03 | 2006-02-02 | Galenica Pharmaceuticals, Inc. | Iminbildende polysaccharide, deren herstellung und verwendung als zusatzmittel und immunstimulierende mittel |
US6121236A (en) | 1998-03-24 | 2000-09-19 | The Children's Medical Center Corporation | Multivalent ligands which modulate angiogenesis |
US6573245B1 (en) | 1998-04-28 | 2003-06-03 | Galenica Pharmaceuticals, Inc. | Modified polysaccharide adjuvant-protein antigen conjugates, the preparation thereof and the use thereof |
US5981564A (en) | 1998-07-01 | 1999-11-09 | Universite Laval | Water-soluble derivatives of paclitaxel, method for producing same and uses thereof |
ES2188202T3 (es) | 1998-07-13 | 2003-06-16 | Univ Texas | Metodos de tratamiento para el cancer usando conjugados terapeuticos que se enlazan con aminofosfolipidos. |
US6780327B1 (en) | 1999-02-25 | 2004-08-24 | Pall Corporation | Positively charged membrane |
TW593241B (en) | 1999-04-20 | 2004-06-21 | Hoffmann La Roche | Carbamic acid derivatives |
AUPQ014799A0 (en) | 1999-05-04 | 1999-05-27 | Access Pharmaceuticals Australia Pty Limited | Amplification of folate-mediated targeting to tumor cells using polymers |
EP1229934B1 (fr) | 1999-10-01 | 2014-03-05 | Immunogen, Inc. | Compositions et methodes de traitement du cancer utilisant des immunoconjugues et des agents chimiotherapeutiques |
EP1242401B1 (fr) | 1999-11-24 | 2006-12-27 | Immunogen, Inc. | Agents cytotoxiques comprenant des taxanes et leur utilisation therapeutique |
NZ518764A (en) | 1999-12-29 | 2004-02-27 | Immunogen Inc | Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use |
CA2398136A1 (fr) | 2000-02-08 | 2001-08-16 | The Penn State Research Foundation | Utilisation du recepteur de l'interleukine 13, sous-unite alpha 2, dans l'immunotherapie |
US6632979B2 (en) | 2000-03-16 | 2003-10-14 | Genentech, Inc. | Rodent HER2 tumor model |
US7097840B2 (en) | 2000-03-16 | 2006-08-29 | Genentech, Inc. | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates |
US6596503B1 (en) | 2000-08-18 | 2003-07-22 | East Carolina University | Monoclonal antibody DS6, tumor-associated antigen CA6, and methods of use thereof |
US6333410B1 (en) | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
US20060062786A1 (en) | 2000-11-08 | 2006-03-23 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
CZ301712B6 (cs) | 2001-01-05 | 2010-06-02 | Pfizer Inc. | Protilátka k receptoru IGF-I a farmaceutický prípravek obsahující tuto protilátku |
NZ527283A (en) | 2001-01-29 | 2006-03-31 | Biogen Idec Inc | Modified antibodies and methods of use |
JP2005507857A (ja) | 2001-02-07 | 2005-03-24 | ベズ イズレイル ディーコネス メディカル センター | 改変psmaリガンド及びそれに関する利用 |
EP1389090A2 (fr) | 2001-04-26 | 2004-02-18 | Board of Regents, The University of Texas System | Compositions d'imagerie diagnostique, leurs methodes de synthese et utilisation |
CA2446806A1 (fr) | 2001-05-11 | 2002-11-21 | Board Of Regents, The University Of Texas System | Therapie a base d'anticorps monoclonaux anti-cd26 contre des affections en lien avec des cellules exprimant le cd26 |
EP1258255A1 (fr) | 2001-05-18 | 2002-11-20 | Boehringer Ingelheim International GmbH | Conjugués d'un anticorps contre CD44 et d'un maytansinoide |
US6441163B1 (en) | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
EP1392360B1 (fr) | 2001-06-01 | 2011-11-30 | Cornell Research Foundation, Inc. | Anticorps modifies diriges contre l'antigene prostatique specifique membranaire et utilisations associees |
TW593239B (en) | 2001-06-04 | 2004-06-21 | Kevin Dale Allen | One-step production of 1,3-propanediol from ethylene oxide and syngas with a catalyst with a phospholanoalkane ligand |
DE60230670D1 (de) | 2001-12-11 | 2009-02-12 | Merck & Co Inc | Staphylococcus aureus exopolysaccharid und verfahren |
US6716821B2 (en) | 2001-12-21 | 2004-04-06 | Immunogen Inc. | Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same |
JP2005532258A (ja) | 2002-01-03 | 2005-10-27 | スミスクライン・ビーチャム・コーポレイション | 免疫コンジュゲートの調製方法 |
US8877901B2 (en) | 2002-12-13 | 2014-11-04 | Immunomedics, Inc. | Camptothecin-binding moiety conjugates |
US7591994B2 (en) | 2002-12-13 | 2009-09-22 | Immunomedics, Inc. | Camptothecin-binding moiety conjugates |
US6756397B2 (en) | 2002-04-05 | 2004-06-29 | Immunogen, Inc. | Prodrugs of CC-1065 analogs |
US6534660B1 (en) | 2002-04-05 | 2003-03-18 | Immunogen, Inc. | CC-1065 analog synthesis |
EP1501369B1 (fr) | 2002-04-26 | 2015-06-24 | Genentech, Inc. | Purification de proteines basee sur la non affinite |
HUE027590T2 (hu) | 2002-05-02 | 2016-11-28 | Wyeth Holdings Llc | Calicheamicin származék-hordozó konjugátumok |
US20090068178A1 (en) | 2002-05-08 | 2009-03-12 | Genentech, Inc. | Compositions and Methods for the Treatment of Tumor of Hematopoietic Origin |
US6596757B1 (en) | 2002-05-14 | 2003-07-22 | Immunogen Inc. | Cytotoxic agents comprising polyethylene glycol-containing taxanes and their therapeutic use |
CA2490423A1 (fr) | 2002-06-21 | 2003-12-31 | Biogen Idec Inc. | Preparations tamponnees permettant de concentrer des anticorps et procedes pour les utiliser |
US7390898B2 (en) | 2002-08-02 | 2008-06-24 | Immunogen Inc. | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
DE60336149D1 (de) | 2002-08-16 | 2011-04-07 | Immunogen Inc | Vernetzer mit hoher reaktivität und löslichkeit und ihre verwendung bei der herstellung von konjugaten für die gezielte abgabe von kleinmolekularen arzneimitteln |
WO2004032971A1 (fr) | 2002-10-08 | 2004-04-22 | Fresenius Kabi Deutschland Gmbh | Conjugues d'oligosaccharide pharmaceutiquement actifs |
SI2348124T1 (sl) | 2002-10-30 | 2014-04-30 | Nuevolution A/S | Sinteza bifunkcionalnega kompleksa |
CN102875680B (zh) | 2002-11-07 | 2015-04-22 | 伊谬诺金公司 | 抗-cd33抗体和使用其治疗急性髓性白血病的方法 |
CA2930485C (fr) | 2003-05-14 | 2018-04-10 | Immunogen, Inc. | Compositions d'anticorps conjugues a un maytansinoide |
US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
US7276497B2 (en) | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
CR20170291A (es) | 2003-05-20 | 2017-07-27 | Immunogen Inc | Agentes citotoxicos mejorados que comprenden nuevos maitansinóides |
EP1638606B1 (fr) | 2003-06-27 | 2016-01-06 | Amgen Fremont Inc. | Anticorps diriges contre les mutants de deletion du recepteur du facteur de croissance epidermique et utilisations correspondantes |
WO2005002597A1 (fr) | 2003-07-02 | 2005-01-13 | Polycord, Inc. | Methode d'administration de compositions d'agents therapeutiques polymerises et compositions associees |
WO2005044998A2 (fr) | 2003-11-05 | 2005-05-19 | Palingen, Inc. | Cytotoxicite augmentee de l'anticorps de liaison cdim contre les lymphocytes b |
US20050175619A1 (en) | 2004-02-05 | 2005-08-11 | Robert Duffy | Methods of producing antibody conjugates |
US20110064754A1 (en) | 2005-03-03 | 2011-03-17 | Center For Molecular Medicine And Immunology | Immunoconjugates Comprising Poxvirus-Derived Peptides and Antibodies Against Antigen-Presenting Cells for Subunit-Based Poxvirus Vaccines |
WO2005094882A1 (fr) | 2004-03-03 | 2005-10-13 | Millennium Pharmaceuticals, Inc. | Anticorps modifies diriges contre un antigene membranaire specifique de la prostate |
JP2008505853A (ja) | 2004-04-13 | 2008-02-28 | クインテセンス バイオサイエンシーズ インコーポレーティッド | 細胞傷害性薬剤としての非天然のリボヌクレアーゼ複合体 |
US20060073528A1 (en) | 2004-05-14 | 2006-04-06 | Jean-Michel Lecerf | Measurement methods |
US7691962B2 (en) | 2004-05-19 | 2010-04-06 | Medarex, Inc. | Chemical linkers and conjugates thereof |
JP4806680B2 (ja) | 2004-05-19 | 2011-11-02 | メダレックス インコーポレイテッド | 自己犠牲リンカー及び薬剤複合体 |
JP5234734B2 (ja) | 2004-06-01 | 2013-07-10 | ジェネンテック, インコーポレイテッド | 抗体−薬物結合体および方法 |
CA2486285C (fr) | 2004-08-30 | 2017-03-07 | Viktor S. Goldmakher | Immunoconjugues ciblant des cellules a expression du syndecan-1 et utilisation de ceux-ci |
SV2006002258A (es) | 2004-10-08 | 2006-09-19 | Wyeth Corp | Inmunoterapia de trastornos autoinmunes |
CA2587589A1 (fr) | 2004-11-29 | 2006-06-22 | Seattle Genetics, Inc. | Anticorps et immunoconjugues mis au point |
MX2007007011A (es) | 2004-12-09 | 2007-09-21 | Johnson & Johnson | Inmunoconjugados anti-integrina, metodos y usos. |
US7408030B2 (en) | 2005-01-13 | 2008-08-05 | North Carolina State University | Purification of immunoglobulins using affinity chromatography and peptide ligands |
AU2006213662B2 (en) | 2005-02-11 | 2010-08-05 | Immunogen, Inc. | Process for preparing stable drug conjugates |
US20110166319A1 (en) | 2005-02-11 | 2011-07-07 | Immunogen, Inc. | Process for preparing purified drug conjugates |
WO2006096653A2 (fr) | 2005-03-04 | 2006-09-14 | Biogen Idec Ma Inc. | Methodes d'humanisation de regions variables d'immunoglobuline par modification rationnelle de residus determinant une complementarite |
EP1868649A4 (fr) | 2005-04-15 | 2011-06-29 | Immunogen Inc | Elimination d'une population de cellules hétérogènes ou mixtes dans des tumeurs |
GB2427360A (en) | 2005-06-22 | 2006-12-27 | Complex Biosystems Gmbh | Aliphatic prodrug linker |
AU2006272405B2 (en) | 2005-07-15 | 2013-02-07 | Angiochem Inc. | Use of aprotinin polypeptides as carriers in pharmaceutical conjugates |
AU2006278573A1 (en) | 2005-08-03 | 2007-02-15 | Immunogen, Inc. | Immunoconjugate formulations |
NZ609752A (en) | 2005-08-24 | 2014-08-29 | Immunogen Inc | Process for preparing maytansinoid antibody conjugates |
WO2007034495A2 (fr) | 2005-09-22 | 2007-03-29 | Hadasit Medical Research Services & Development Limited | Conjugues de compose a activite therapeutique |
EP1940470B1 (fr) | 2005-09-26 | 2013-04-17 | Medarex, Inc. | Conjugués anticorps-medicament et leur utilisation |
CA2629815C (fr) | 2005-11-14 | 2014-08-12 | University Of Southern California | Petites molecules de liaison a une integrine |
US7964415B2 (en) | 2006-04-26 | 2011-06-21 | Cardiogenics Inc. | Stable water-soluble polyethylenimine conjugates and methods of use thereof |
DK2032606T3 (da) | 2006-05-30 | 2014-02-03 | Genentech Inc | Antistoffer og immunkonjugater og anvendelser deraf |
WO2008010101A2 (fr) * | 2006-07-18 | 2008-01-24 | Sanofi-Aventis | Anticorps antagoniste destiné au traitement du cancer |
US20080213349A1 (en) | 2006-09-11 | 2008-09-04 | Deepak Ramesh Thakker | Liposome Complexes Containing Pharmaceutical Agents and Methods |
EP2054521A4 (fr) * | 2006-10-03 | 2012-12-19 | Novo Nordisk As | Méthodes de purification de conjugués de polypeptides |
EP1914242A1 (fr) | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Nouveau anticorps Anti-CD38 pour le traitement du cancer |
DK2019104T3 (da) * | 2007-07-19 | 2013-12-16 | Sanofi Sa | Cytotoksiske midler, der omfatter nye tomaymycinderivater, og terapeutisk anvendelse deraf |
UA108598C2 (xx) | 2008-04-30 | 2015-05-25 | Високоефективні кон'югати та гідрофільні зшиваючі агенти (лінкери) | |
BRPI0910746B8 (pt) * | 2008-04-30 | 2021-05-25 | Immunogen Inc | agente de reticulação, conjugado de agente de ligação celular-fármaco, seu uso, composto e composição farmacêutica |
GB0811743D0 (en) | 2008-06-26 | 2008-07-30 | Hemosol Biopharma Inc | Composition |
CA2742846A1 (fr) | 2008-11-17 | 2010-05-20 | Enzon Pharmaceuticals, Inc. | Lipides fusogenes liberables pour systemes de delivrance d'acides nucleiques |
NZ594177A (en) | 2009-02-05 | 2014-02-28 | Immunogen Inc | Novel benzodiazepine derivatives |
AR076284A1 (es) | 2009-04-29 | 2011-06-01 | Bayer Schering Pharma Ag | Inmunoconjugados de antimesotelina y usos de los mismos |
SI2437790T1 (sl) | 2009-06-03 | 2019-07-31 | Immunogen, Inc. | Konjugacijske metode |
FR2947269B1 (fr) | 2009-06-29 | 2013-01-18 | Sanofi Aventis | Nouveaux composes anticancereux |
UY32914A (es) * | 2009-10-02 | 2011-04-29 | Sanofi Aventis | Anticuerpos que se usan específicamente al receptor epha2 |
UY32913A (es) | 2009-10-02 | 2011-04-29 | Sanofi Aventis | Nuevos maitansinoides y el uso de dichos maitansinoides para preparar conjugados con un anticuero |
KR20170085143A (ko) | 2010-02-24 | 2017-07-21 | 이뮤노젠 아이엔씨 | 엽산염 수용체 1 항체와 면역접합체 및 이들의 용도 |
DK2544719T3 (da) | 2010-03-12 | 2019-10-14 | Debiopharm Int Sa | Cd37-bindingsmolekyler og immunkonjugater deraf |
WO2012019024A2 (fr) | 2010-08-04 | 2012-02-09 | Immunogen, Inc. | Molécules se liant à her3 et leurs immunoconjugués |
BR112013010569A2 (pt) | 2010-10-29 | 2017-07-04 | Immunogen Inc | moléculas de ligação de egfr não antagonísticas e imunoconjugados das mesma |
AU2011320314B2 (en) | 2010-10-29 | 2015-08-06 | Immunogen, Inc. | Novel EGFR-binding molecules and immunoconjugates thereof |
US20120149732A1 (en) | 2010-12-14 | 2012-06-14 | Alexander Chucholowski | Multifunctional linkers and methods for the use thereof |
ES2717657T3 (es) | 2011-02-15 | 2019-06-24 | Immunogen Inc | Métodos para la preparación de conjugados |
MX369659B (es) | 2011-03-29 | 2019-11-15 | Immunogen Inc | Preparacion de conjugados de maitansinoides y anticuerpos mediante un proceso de una etapa. |
AU2012236403B2 (en) | 2011-03-29 | 2016-08-04 | Immunogen, Inc. | Process for manufacturing conjugates of improved homogeneity |
SG193997A1 (en) | 2011-03-29 | 2013-11-29 | Immunogen Inc | Process for manufacturing conjugates of improved homogeneity |
UA113403C2 (xx) | 2011-04-01 | 2017-01-25 | Спосіб підвищення ефективності folr1 терапії раку | |
US20130071482A1 (en) | 2011-09-20 | 2013-03-21 | The University Of Kentucky Research Foundation | Block copolymer cross-linked nanoassemblies as modular delivery vehicles |
JP2015504869A (ja) | 2011-12-13 | 2015-02-16 | イミュノジェン・インコーポレーテッド | 複合体安定性を改善するためのn−ヒドロキシスクシンイミドの使用 |
WO2014055842A1 (fr) | 2012-10-04 | 2014-04-10 | Immunogen, Inc. | Procédé de préparation de conjugués maytansinoïdes anticorps stables |
SG11201502429YA (en) | 2012-10-04 | 2015-04-29 | Immunogen Inc | Use of a pvdf membrane to purify cell-binding agent cytotoxic agent conjugates |
EP2903450A4 (fr) | 2012-10-04 | 2016-05-11 | Immunogen Inc | Utilisation d'une membrane échangeuse d'ions pour éliminer des impuretés de conjugués agent de fixation aux cellules-agent cytotoxique |
WO2014086835A1 (fr) | 2012-12-05 | 2014-06-12 | Ruprecht-Karls-Universität Heidelberg | Conjugués de protéines et de peptides de pénétration cellulaire multivalents et leurs utilisations |
-
2013
- 2013-10-04 SG SG11201502429YA patent/SG11201502429YA/en unknown
- 2013-10-04 RU RU2015116882A patent/RU2661083C2/ru not_active IP Right Cessation
- 2013-10-04 JP JP2015535823A patent/JP6345181B2/ja active Active
- 2013-10-04 AU AU2013326881A patent/AU2013326881B2/en not_active Ceased
- 2013-10-04 CA CA 2886993 patent/CA2886993A1/fr not_active Abandoned
- 2013-10-04 WO PCT/US2013/063480 patent/WO2014055877A1/fr active Application Filing
- 2013-10-04 SG SG10201702737TA patent/SG10201702737TA/en unknown
- 2013-10-04 IN IN3202DEN2015 patent/IN2015DN03202A/en unknown
- 2013-10-04 CN CN201810870142.1A patent/CN109200290A/zh active Pending
- 2013-10-04 EP EP13844268.6A patent/EP2904089A4/fr not_active Withdrawn
- 2013-10-04 NZ NZ707091A patent/NZ707091A/en not_active IP Right Cessation
- 2013-10-04 MX MX2015004257A patent/MX359599B/es active IP Right Grant
- 2013-10-04 CN CN201380061552.7A patent/CN105209592A/zh active Pending
- 2013-10-04 RU RU2018122734A patent/RU2018122734A/ru not_active Application Discontinuation
- 2013-10-04 US US14/430,701 patent/US10035817B2/en not_active Expired - Fee Related
-
2015
- 2015-04-02 IL IL238110A patent/IL238110B/en active IP Right Grant
- 2015-04-30 ZA ZA201502992A patent/ZA201502992B/en unknown
-
2016
- 2016-02-04 HK HK16101357.7A patent/HK1213288A1/zh unknown
-
2018
- 2018-05-22 JP JP2018097686A patent/JP2018158925A/ja active Pending
- 2018-06-29 US US16/023,005 patent/US20190031712A1/en not_active Abandoned
- 2018-10-03 AU AU2018241056A patent/AU2018241056A1/en not_active Abandoned
-
2019
- 2019-07-31 IL IL268378A patent/IL268378A/en unknown
-
2020
- 2020-02-07 JP JP2020019654A patent/JP2020079294A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
RU2015116882A (ru) | 2016-11-27 |
ZA201502992B (en) | 2019-10-30 |
NZ707091A (en) | 2018-12-21 |
CN109200290A (zh) | 2019-01-15 |
EP2904089A4 (fr) | 2016-05-25 |
HK1213288A1 (zh) | 2016-06-30 |
IL238110A0 (en) | 2015-05-31 |
SG10201702737TA (en) | 2017-05-30 |
MX2015004257A (es) | 2016-02-09 |
AU2013326881A1 (en) | 2015-05-07 |
CN105209592A (zh) | 2015-12-30 |
AU2013326881B2 (en) | 2018-08-02 |
JP2016502501A (ja) | 2016-01-28 |
MX359599B (es) | 2018-09-12 |
US20150225446A1 (en) | 2015-08-13 |
IL238110B (en) | 2019-08-29 |
IN2015DN03202A (fr) | 2015-10-02 |
AU2018241056A1 (en) | 2018-10-25 |
US10035817B2 (en) | 2018-07-31 |
EP2904089A1 (fr) | 2015-08-12 |
US20190031712A1 (en) | 2019-01-31 |
RU2661083C2 (ru) | 2018-07-11 |
JP2020079294A (ja) | 2020-05-28 |
CA2886993A1 (fr) | 2014-04-10 |
WO2014055877A1 (fr) | 2014-04-10 |
JP2018158925A (ja) | 2018-10-11 |
RU2018122734A (ru) | 2018-07-24 |
IL268378A (en) | 2019-09-26 |
JP6345181B2 (ja) | 2018-06-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL268378A (en) | Using a polyvinyl difluoride membrane to purify conjugates of a cytotoxic factor and a cell-binding factor | |
ZA201605918B (en) | Preparation of cell-binding agent cytotoxic agent conjugates | |
HRP20190576T1 (hr) | Postupci pripreme konjugata | |
ZA201500284B (en) | Plants having increased tolerance to herbicides | |
ZA201305262B (en) | Plants having increased tolerance to herbicides | |
ZA201209112B (en) | Plants having increased tolerance to herbicides | |
GB2501687B (en) | Improvements relating to the transmission of energy | |
EP2764325A4 (fr) | Utilisation de la vidéogrammétrie pour fabriquer des pièces | |
GB2492838B (en) | Improvements relating to pipelaying | |
ZA201403938B (en) | Plants having increased tolerance to herbicides | |
ZA201403939B (en) | Plants having increased tolerance to herbicides | |
EP2674265A4 (fr) | Corps de tuyau façonné | |
EP2740420A4 (fr) | Outil thérapeutique | |
IL222228A0 (en) | Hiv vaccine | |
HK1203053A1 (en) | Uses of immunoconjugates targeting cd138 cd138 | |
HK1196060A1 (zh) | 管形繃帶 | |
HK1213148A1 (zh) | 離子交換膜的從細胞結合劑細胞毒性劑綴合物中去除雜質的用途 | |
EP2754451A4 (fr) | Utilisation d'ache comme nucléase | |
GB201112134D0 (en) | Improvements relating to pipelaying | |
EP2819577A4 (fr) | Dispositif de surveillance de co2 de tissu à fin d'expiration | |
AU2012900049A0 (en) | Alternative to a mechanical castration of animals | |
GB201109824D0 (en) | Safe&sound | |
GB201211721D0 (en) | Improvements is or relating to urolgical catheters |