SG11201405475UA - Pharmaceutical formulations of tnf-alpha antibodies - Google Patents
Pharmaceutical formulations of tnf-alpha antibodiesInfo
- Publication number
- SG11201405475UA SG11201405475UA SG11201405475UA SG11201405475UA SG11201405475UA SG 11201405475U A SG11201405475U A SG 11201405475UA SG 11201405475U A SG11201405475U A SG 11201405475UA SG 11201405475U A SG11201405475U A SG 11201405475UA SG 11201405475U A SG11201405475U A SG 11201405475UA
- Authority
- SG
- Singapore
- Prior art keywords
- tnf
- pharmaceutical formulations
- alpha antibodies
- antibodies
- alpha
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN610MU2012 | 2012-03-07 | ||
IN1606MU2012 | 2012-05-30 | ||
IN3031MU2012 | 2012-10-17 | ||
PCT/IN2013/000129 WO2013164837A1 (fr) | 2012-03-07 | 2013-03-05 | Formulations pharmaceutiques d'anticorps anti-tnf-alpha |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201405475UA true SG11201405475UA (en) | 2014-10-30 |
Family
ID=48901138
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201405475UA SG11201405475UA (en) | 2012-03-07 | 2013-03-05 | Pharmaceutical formulations of tnf-alpha antibodies |
SG10201609982PA SG10201609982PA (en) | 2012-03-07 | 2013-03-05 | Pharmaceutical formulations of tnf-alpha anitbodies |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201609982PA SG10201609982PA (en) | 2012-03-07 | 2013-03-05 | Pharmaceutical formulations of tnf-alpha anitbodies |
Country Status (19)
Country | Link |
---|---|
US (3) | US10093728B2 (fr) |
EP (3) | EP3412310B1 (fr) |
JP (3) | JP2015509526A (fr) |
KR (2) | KR101730694B1 (fr) |
CN (1) | CN104159614A (fr) |
AP (1) | AP2014007922A0 (fr) |
AU (1) | AU2013255413C1 (fr) |
BR (1) | BR112014021325A2 (fr) |
CA (1) | CA2866692A1 (fr) |
CL (1) | CL2014002316A1 (fr) |
EA (1) | EA201491644A1 (fr) |
HK (1) | HK1200709A1 (fr) |
MX (2) | MX363700B (fr) |
NZ (1) | NZ629261A (fr) |
PH (1) | PH12014501988A1 (fr) |
SG (2) | SG11201405475UA (fr) |
TR (1) | TR201810815T4 (fr) |
WO (1) | WO2013164837A1 (fr) |
ZA (1) | ZA201406414B (fr) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
WO2012149197A2 (fr) | 2011-04-27 | 2012-11-01 | Abbott Laboratories | Procédé de contrôle du profil de galactosylation de protéines exprimées de manière recombinante |
US10093728B2 (en) * | 2012-03-07 | 2018-10-09 | Cadila Healthcare Limited | Pharmaceutical formulations of TNF-alpha antibodies |
WO2013158279A1 (fr) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Procédés de purification de protéines pour réduire des espèces acides |
WO2013158273A1 (fr) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Procédés de modulation de la distribution de variant de lysine c-terminal |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
JP2015519382A (ja) * | 2012-06-12 | 2015-07-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 治療用抗体のための医薬処方物 |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
JP6463268B2 (ja) | 2012-09-07 | 2019-01-30 | コヒラス・バイオサイエンシズ・インコーポレイテッド | 安定水性アダリムマブ製剤 |
UA117466C2 (uk) * | 2012-12-13 | 2018-08-10 | Мерк Шарп Енд Доме Корп. | СТАБІЛЬНИЙ СКЛАД У ВИГЛЯДІ РОЗЧИНУ АНТИТІЛА ДО IL-23p19 |
WO2014143205A1 (fr) | 2013-03-12 | 2014-09-18 | Abbvie Inc. | Anticorps humains qui se lient au tnf-alpha et leurs procédés de préparation |
WO2014151878A2 (fr) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Procédés pour la modulation des profils de glycosylation de protéines de traitements à base de protéines recombinantes au moyen de monosaccharides et d'oligosaccharides |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
WO2015051293A2 (fr) | 2013-10-04 | 2015-04-09 | Abbvie, Inc. | Utilisation d'ions métalliques pour moduler les profils de glycosylation des protéines dans le cas de protéines recombinées |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
WO2015073884A2 (fr) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Compositions de protéines de liaison génétiquement glycomodifiées |
CN104707146B (zh) * | 2013-12-16 | 2019-04-16 | 浙江海正药业股份有限公司 | 一种含有阿达木单抗的药物组合物 |
US9732154B2 (en) | 2014-02-28 | 2017-08-15 | Janssen Biotech, Inc. | Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia |
IN2014MU01248A (fr) | 2014-04-02 | 2015-10-09 | Intas Pharmaceuticals Ltd | |
EP2946767B1 (fr) * | 2014-05-23 | 2016-10-05 | Ares Trading S.A. | Composition pharmaceutique liquide |
RS55548B1 (sr) | 2014-05-23 | 2017-05-31 | Ares Trading Sa | Tečni farmaceutski sastav |
ES2572919T3 (es) * | 2014-05-23 | 2016-06-03 | Ares Trading S.A. | Composición farmacéutica líquida |
US9821059B2 (en) * | 2014-10-17 | 2017-11-21 | Alteogen Inc. | Composition for stabilizing protein and pharmaceutical formulation comprising the same |
HUP1400510A1 (hu) | 2014-10-28 | 2016-05-30 | Richter Gedeon Nyrt | Gyógyászati TNFalfa ellenes antitest készítmény |
WO2016089946A1 (fr) * | 2014-12-02 | 2016-06-09 | Biogen Ma Inc. | Procédés et compositions de lutte contre l'agrégation d'anticorps |
EP3053572A1 (fr) * | 2015-02-06 | 2016-08-10 | Ares Trading S.A. | Composition pharmaceutique liquide |
WO2016162819A1 (fr) | 2015-04-07 | 2016-10-13 | Lupin Limited | Composition pharmaceutique aqueuse stable d'anticorps anti-tnf alpha |
US20170044265A1 (en) | 2015-06-24 | 2017-02-16 | Janssen Biotech, Inc. | Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38 |
US11229702B1 (en) | 2015-10-28 | 2022-01-25 | Coherus Biosciences, Inc. | High concentration formulations of adalimumab |
LT3827845T (lt) * | 2015-11-03 | 2022-06-10 | Janssen Biotech, Inc. | Poodinės anti-cd38 antikūnų kompozicijos ir jų naudojimas |
EP3383435A4 (fr) * | 2015-11-30 | 2019-07-10 | Medimmune, LLC | Rapports optimisés d'acides aminés et de sucres en tant que composés stabilisants amorphes dans des compositions pharmaceutiques contenant des concentrations élevées d'agents thérapeutiques à base de protéine |
AU2016380988B2 (en) * | 2015-12-30 | 2022-07-21 | Genentech, Inc. | Formulations with reduced degradation of polysorbate |
JP6738608B2 (ja) * | 2016-01-22 | 2020-08-12 | 田中貴金属工業株式会社 | クロマトグラフ媒体 |
GB201604124D0 (en) * | 2016-03-10 | 2016-04-27 | Ucb Biopharma Sprl | Pharmaceutical formulation |
US11071782B2 (en) | 2016-04-20 | 2021-07-27 | Coherus Biosciences, Inc. | Method of filling a container with no headspace |
MA45562B1 (fr) * | 2016-06-30 | 2024-05-31 | Celltrion Inc | Préparation pharmaceutique liquide stable |
FR3054444A1 (fr) * | 2016-07-29 | 2018-02-02 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Composition orale d'anticorps anti-tnf alpha |
US11692027B2 (en) | 2016-09-28 | 2023-07-04 | Board Of Regents, The University Of Texas System | Antibody and protein therapeutic formulations and uses thereof |
EP3533441A4 (fr) * | 2016-10-28 | 2019-12-04 | Celltrion Inc. | Formulation pharmaceutique stable |
US10940185B2 (en) | 2016-12-28 | 2021-03-09 | Jcr Pharmaceuticals Co., Ltd. | Lyophilized preparation |
RU2665966C2 (ru) * | 2016-12-30 | 2018-09-05 | Закрытое Акционерное Общество "Биокад" | Водная фармацевтическая композиция рекомбинантного моноклонального антитела к ФНОα |
JOP20190162A1 (ar) * | 2016-12-30 | 2019-06-27 | Biocad Joint Stock Co | تركيبة صيدلانية مائية من جسم مضاد لـ tnf? أحادي النسيلة معاود الارتباط الجيني |
WO2018131893A1 (fr) * | 2017-01-11 | 2018-07-19 | ㈜셀트리온 | Formule liquide stable |
US11608357B2 (en) | 2018-08-28 | 2023-03-21 | Arecor Limited | Stabilized antibody protein solutions |
EP3372242A1 (fr) | 2017-03-06 | 2018-09-12 | Ares Trading S.A. | Composition pharmaceutique liquide |
EP3372241A1 (fr) | 2017-03-06 | 2018-09-12 | Ares Trading S.A. | Composition pharmaceutique liquide |
JP7109849B2 (ja) * | 2017-03-16 | 2022-08-01 | エルジー・ケム・リミテッド | 抗TNFα抗体の液状製剤 |
CN108686204A (zh) * | 2017-04-07 | 2018-10-23 | 浙江海正药业股份有限公司 | 包含组氨酸缓冲体系的英夫利西单抗组合物 |
CN108686205B (zh) * | 2017-04-07 | 2021-12-10 | 海正生物制药有限公司 | 英夫利西单抗冻干制剂 |
RU2019138507A (ru) | 2017-05-02 | 2021-06-02 | Мерк Шарп И Доум Корп. | Составы антител против lag3 и совместные составы антител против lag3 и антител против pd-1 |
JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
KR20200038507A (ko) * | 2017-08-08 | 2020-04-13 | 체에스엘 베링 아게 | 헤모펙신 제형 |
WO2019089832A1 (fr) | 2017-10-31 | 2019-05-09 | Janssen Biotech, Inc. | Méthodes de traitement du myélome multiple à haut risque |
CN110151988A (zh) * | 2018-02-11 | 2019-08-23 | 百奥泰生物制药股份有限公司 | 一种靶向治疗TNF-α相关疾病的人抗体制剂 |
CN110302377B (zh) * | 2018-02-11 | 2020-04-17 | 百奥泰生物制药股份有限公司 | 一种靶向治疗TNF-α相关疾病的人抗体制剂 |
MA55033A (fr) | 2019-02-18 | 2021-12-29 | Lilly Co Eli | Formulation d'anticorps thérapeutique |
US20220042977A1 (en) * | 2020-08-04 | 2022-02-10 | ProStabilis, Inc. | Protein Solubility Screening Kits and Their Use |
KR20230054395A (ko) * | 2020-08-20 | 2023-04-24 | 모멘타 파머슈티컬스 인코포레이티드 | 시알릴화된 당단백질 |
WO2022111547A1 (fr) * | 2020-11-24 | 2022-06-02 | The University Of Hong Kong | Formulations de poudre inhalées pour l'administration d'anticorps par voie respiratoire |
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CA2243459C (fr) | 1996-02-09 | 2002-09-17 | Basf Aktiengesellschaft | Anticorps humains se fixant au facteur necrosant des tumeurs de type .alpha. |
EP0852951A1 (fr) * | 1996-11-19 | 1998-07-15 | Roche Diagnostics GmbH | Compositions pharmaceutiques stables, lyophilisées d'anticorps monoclonaux ou polyclonaux |
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MXPA04008215A (es) * | 2002-02-27 | 2004-11-26 | Immunex Corp | Formulacion polipeptidica. |
US20040033228A1 (en) * | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
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AU2007212147A1 (en) * | 2006-02-03 | 2007-08-16 | Medimmune, Llc | Protein formulations |
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PE20091174A1 (es) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
EP4104821A1 (fr) * | 2008-10-29 | 2022-12-21 | Ablynx N.V. | Formulations de molécules de liaison d'antigène monodomaines |
PE20120169A1 (es) * | 2008-11-17 | 2012-02-29 | Genentech Inc | Metodo y formulacion para reducir la agregacion de una macromolecula bajo condiciones fisiologicas |
JP2012526121A (ja) | 2009-05-04 | 2012-10-25 | アボツト・バイオテクノロジー・リミテツド | ヒト抗tnfアルファ抗体の安定した高蛋白質濃度製剤 |
KR20120130757A (ko) * | 2010-02-26 | 2012-12-03 | 노보 노르디스크 에이/에스 | 안정한 항체 함유 조성물 |
ES2910305T3 (es) * | 2010-08-19 | 2022-05-12 | Zoetis Belgium S A | Anticuerpos anti-NGF y su uso |
EP2471554A1 (fr) | 2010-12-28 | 2012-07-04 | Hexal AG | Formulation pharmaceutique comprenant un médicament biopharmaceutique |
GB201112429D0 (en) | 2011-07-19 | 2011-08-31 | Glaxo Group Ltd | Antigen-binding proteins with increased FcRn binding |
US10093728B2 (en) * | 2012-03-07 | 2018-10-09 | Cadila Healthcare Limited | Pharmaceutical formulations of TNF-alpha antibodies |
JP2015519382A (ja) | 2012-06-12 | 2015-07-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 治療用抗体のための医薬処方物 |
JP6463268B2 (ja) | 2012-09-07 | 2019-01-30 | コヒラス・バイオサイエンシズ・インコーポレイテッド | 安定水性アダリムマブ製剤 |
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- 2013-03-05 EP EP13742519.5A patent/EP2822591B1/fr not_active Revoked
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