SG11201405249QA - Improved analytical methods for analyzing and determining impurities in dianhydrogalactitol - Google Patents
Improved analytical methods for analyzing and determining impurities in dianhydrogalactitolInfo
- Publication number
- SG11201405249QA SG11201405249QA SG11201405249QA SG11201405249QA SG11201405249QA SG 11201405249Q A SG11201405249Q A SG 11201405249QA SG 11201405249Q A SG11201405249Q A SG 11201405249QA SG 11201405249Q A SG11201405249Q A SG 11201405249QA SG 11201405249Q A SG11201405249Q A SG 11201405249QA
- Authority
- SG
- Singapore
- Prior art keywords
- dianhydrogalactitol
- analyzing
- analytical methods
- determining impurities
- improved analytical
- Prior art date
Links
- AAFJXZWCNVJTMK-GUCUJZIJSA-N (1s,2r)-1-[(2s)-oxiran-2-yl]-2-[(2r)-oxiran-2-yl]ethane-1,2-diol Chemical compound C([C@@H]1[C@H](O)[C@H](O)[C@H]2OC2)O1 AAFJXZWCNVJTMK-GUCUJZIJSA-N 0.000 title 1
- 238000004458 analytical method Methods 0.000 title 1
- 229950000758 dianhydrogalactitol Drugs 0.000 title 1
- 239000012535 impurity Substances 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N2030/022—Column chromatography characterised by the kind of separation mechanism
- G01N2030/027—Liquid chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/74—Optical detectors
- G01N2030/743—FTIR
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8872—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample impurities
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/74—Optical detectors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/20—Oxygen containing
- Y10T436/203332—Hydroxyl containing
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Spectroscopy & Molecular Physics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261603464P | 2012-02-27 | 2012-02-27 | |
| PCT/IB2013/000793 WO2013128285A2 (en) | 2012-02-27 | 2013-02-26 | Improved analytical methods for analyzing and determining impurities in dianhydrogalactitol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201405249QA true SG11201405249QA (en) | 2014-10-30 |
Family
ID=49083394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201405249QA SG11201405249QA (en) | 2012-02-27 | 2013-02-26 | Improved analytical methods for analyzing and determining impurities in dianhydrogalactitol |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10145824B2 (enExample) |
| EP (1) | EP2820408A4 (enExample) |
| JP (1) | JP6223364B2 (enExample) |
| KR (1) | KR20140129306A (enExample) |
| CN (1) | CN104428664B (enExample) |
| AU (1) | AU2013227353B2 (enExample) |
| BR (1) | BR112014021163A2 (enExample) |
| CA (1) | CA2865709A1 (enExample) |
| CL (1) | CL2014002276A1 (enExample) |
| HK (1) | HK1208528A1 (enExample) |
| MX (1) | MX2014010312A (enExample) |
| SG (1) | SG11201405249QA (enExample) |
| WO (1) | WO2013128285A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104428664B (zh) | 2012-02-27 | 2018-09-21 | 德玛医药 | 用于分析和测定在卫康醇中杂质的改良分析方法 |
| AU2014348232A1 (en) * | 2013-11-18 | 2016-06-30 | Del Mar Pharmaceuticals | HPLC analysis of impurities in dianhydrogalactitol |
| EP3380462B1 (en) * | 2015-11-25 | 2021-02-17 | Del Mar Pharmaceuticals (BC) Ltd. | Methods for analysis and resolution of preparations of dianhydrogalactitol and derivatives or analogs thereof |
| US10927363B2 (en) | 2016-04-04 | 2021-02-23 | Mie University | DNA sequence and expression vector for alginate lyase |
| CN106596751B (zh) * | 2016-11-04 | 2020-05-19 | 天津大学 | 一种氯代消毒副产物二氯乙酰胺和三氯乙酰胺的高效液相色谱-电喷雾质谱检测方法 |
| JP6988158B2 (ja) * | 2017-05-11 | 2022-01-05 | 株式会社島津製作所 | 液体クロマトグラフ質量分析方法及び液体クロマトグラフ質量分析装置 |
| CN108827998B (zh) * | 2018-05-30 | 2021-06-22 | 中国计量科学研究院 | 一种采用定量核磁共振氢谱准确测量易挥发性物质纯度的方法 |
| JP7527350B2 (ja) * | 2019-08-30 | 2024-08-02 | ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド | 質量分析のための方法 |
| ES3029432T3 (en) * | 2021-04-30 | 2025-06-24 | Hoffmann La Roche | Lc system and method with column backflushing |
| US12295919B2 (en) | 2022-03-16 | 2025-05-13 | Mie University | Methods of treatment and prevention using 4-deoxy-L-erythro-5-hexoseulose uronic acid |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04297868A (ja) | 1991-03-27 | 1992-10-21 | Tonen Corp | オリゴ糖の分析方法 |
| JPH09229920A (ja) * | 1996-02-26 | 1997-09-05 | Kao Corp | グラジェント液体クロマトグラフィー溶離液の処理方法 |
| US6060525A (en) | 1996-03-01 | 2000-05-09 | Dionix Corporation | Removal of borate in chromatography |
| US20030060434A1 (en) | 1997-02-18 | 2003-03-27 | Loretta Nielsen | Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms |
| WO2000042225A1 (en) | 1999-01-14 | 2000-07-20 | Board Of Supervisors Of Louisiana State Universityand Agricultural And Mechanical College | Process for the separation of sugars |
| US20020037328A1 (en) * | 2000-06-01 | 2002-03-28 | Brown Dennis M. | Hexitol compositions and uses thereof |
| US20060148732A1 (en) | 2000-11-17 | 2006-07-06 | Gutterman Jordan U | Inhibition of NF-kappaB by triterpene compositions |
| US20030229237A1 (en) * | 2002-04-02 | 2003-12-11 | Haas Michael J. | In situ production of fatty acid alkyl esters |
| JP2004294384A (ja) | 2003-03-28 | 2004-10-21 | National Agriculture & Bio-Oriented Research Organization | １−デオキシノジリマイシンの測定方法 |
| CA2915574C (en) | 2003-07-18 | 2017-02-07 | Oakwood Laboratories, L.L.C. | Prevention of molecular weight reduction of the polymer, impurity formation and gelling in polymer compositions |
| NZ551448A (en) | 2004-05-20 | 2011-02-25 | Novartis Vaccines & Diagnostic | Analysis of liquid chromotography eluates |
| JP2008076340A (ja) | 2006-09-25 | 2008-04-03 | Toppan Printing Co Ltd | 高感度検出方法およびその検出装置 |
| WO2011092120A1 (en) | 2010-01-29 | 2011-08-04 | Nerviano Medical Sciences S.R.L. | 6,7- dihydroimidazo [1,5-a] pyrazin-8 (5h) - one derivatives as protein kinase modulators |
| EP2606020B1 (en) * | 2010-08-18 | 2018-12-26 | Del Mar Pharmaceuticals | Method of synthesis of substituted hexitols such as dianhydrogalactitol |
| CN104428664B (zh) | 2012-02-27 | 2018-09-21 | 德玛医药 | 用于分析和测定在卫康醇中杂质的改良分析方法 |
| US9029164B2 (en) * | 2012-02-27 | 2015-05-12 | Del Mar Pharmaceuticals | Analytical methods for analyzing and determining impurities in dianhydrogalactitol |
-
2013
- 2013-02-26 CN CN201380022154.4A patent/CN104428664B/zh not_active Expired - Fee Related
- 2013-02-26 SG SG11201405249QA patent/SG11201405249QA/en unknown
- 2013-02-26 BR BR112014021163-9A patent/BR112014021163A2/pt not_active Application Discontinuation
- 2013-02-26 EP EP13754722.0A patent/EP2820408A4/en not_active Withdrawn
- 2013-02-26 US US14/380,924 patent/US10145824B2/en active Active
- 2013-02-26 CA CA2865709A patent/CA2865709A1/en not_active Abandoned
- 2013-02-26 JP JP2014558224A patent/JP6223364B2/ja not_active Expired - Fee Related
- 2013-02-26 AU AU2013227353A patent/AU2013227353B2/en not_active Ceased
- 2013-02-26 MX MX2014010312A patent/MX2014010312A/es unknown
- 2013-02-26 HK HK15109084.1A patent/HK1208528A1/xx unknown
- 2013-02-26 WO PCT/IB2013/000793 patent/WO2013128285A2/en not_active Ceased
- 2013-02-26 KR KR1020147027029A patent/KR20140129306A/ko not_active Ceased
- 2013-07-02 US US13/933,844 patent/US9759698B2/en not_active Expired - Fee Related
-
2014
- 2014-08-27 CL CL2014002276A patent/CL2014002276A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US10145824B2 (en) | 2018-12-04 |
| EP2820408A4 (en) | 2015-11-18 |
| EP2820408A2 (en) | 2015-01-07 |
| JP2015508174A (ja) | 2015-03-16 |
| WO2013128285A3 (en) | 2013-12-27 |
| CA2865709A1 (en) | 2013-09-06 |
| US20140017798A1 (en) | 2014-01-16 |
| CN104428664B (zh) | 2018-09-21 |
| US9759698B2 (en) | 2017-09-12 |
| WO2013128285A2 (en) | 2013-09-06 |
| AU2013227353B2 (en) | 2016-06-09 |
| CN104428664A (zh) | 2015-03-18 |
| HK1208528A1 (en) | 2016-03-04 |
| MX2014010312A (es) | 2015-04-14 |
| KR20140129306A (ko) | 2014-11-06 |
| AU2013227353A1 (en) | 2014-09-25 |
| JP6223364B2 (ja) | 2017-11-01 |
| BR112014021163A2 (pt) | 2020-10-27 |
| US20150027206A1 (en) | 2015-01-29 |
| CL2014002276A1 (es) | 2014-12-19 |
| WO2013128285A9 (en) | 2014-02-27 |
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