SG11201403163QA - Enhanced production of isoprene using host cells having decreased ispa activity - Google Patents
Enhanced production of isoprene using host cells having decreased ispa activityInfo
- Publication number
- SG11201403163QA SG11201403163QA SG11201403163QA SG11201403163QA SG11201403163QA SG 11201403163Q A SG11201403163Q A SG 11201403163QA SG 11201403163Q A SG11201403163Q A SG 11201403163QA SG 11201403163Q A SG11201403163Q A SG 11201403163QA SG 11201403163Q A SG11201403163Q A SG 11201403163QA
- Authority
- SG
- Singapore
- Prior art keywords
- isoprene
- host cells
- enhanced production
- activity
- decreased
- Prior art date
Links
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 title 2
- 230000003247 decreasing effect Effects 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
- C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
- C12Y205/01001—Dimethylallyltranstransferase (2.5.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
- C12Y402/03027—Isoprene synthase (4.2.3.27)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161580163P | 2011-12-23 | 2011-12-23 | |
| US201261639855P | 2012-04-27 | 2012-04-27 | |
| PCT/US2012/071518 WO2013096925A1 (en) | 2011-12-23 | 2012-12-21 | Enhanced production of isoprene using host cells having decreased ispa activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201403163QA true SG11201403163QA (en) | 2014-09-26 |
Family
ID=47522963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201403163QA SG11201403163QA (en) | 2011-12-23 | 2012-12-21 | Enhanced production of isoprene using host cells having decreased ispa activity |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8975051B2 (https=) |
| EP (1) | EP2794863A1 (https=) |
| JP (1) | JP2015510392A (https=) |
| CN (1) | CN104245927A (https=) |
| AU (1) | AU2012358149A1 (https=) |
| BR (1) | BR112014014947A2 (https=) |
| CA (1) | CA2859885A1 (https=) |
| MX (1) | MX2014007623A (https=) |
| SG (1) | SG11201403163QA (https=) |
| WO (1) | WO2013096925A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| EP2885420B1 (en) | 2012-08-17 | 2018-12-05 | Evolva SA | Increased production of terpenes and terpenoids |
| WO2015083769A1 (ja) * | 2013-12-04 | 2015-06-11 | 国立研究開発法人理化学研究所 | 光合成のみによるポリヒドロキシアルカン酸の生産 |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| JP2018014960A (ja) * | 2016-07-29 | 2018-02-01 | 横浜ゴム株式会社 | 発現ベクター、形質転換された藻類、形質転換された珪藻、及び、ポリヌクレオチド |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11549117B2 (en) | 2017-05-11 | 2023-01-10 | Industry-Academic Cooperation Foundation Gyeongsang National University | Marker composition for selecting living modified organism, living modified organism, and transformation method |
| WO2018208116A1 (ko) * | 2017-05-11 | 2018-11-15 | 경상대학교산학협력단 | 형질전환 생물체 선별용 마커 조성물, 형질전환 생물체 및 형질전환 방법 |
| CN110317765B (zh) * | 2018-03-29 | 2020-11-20 | 中国科学院天津工业生物技术研究所 | 一种高产香叶醇葡萄糖苷的大肠杆菌表达菌株及其应用 |
| WO2020112647A1 (en) * | 2018-11-27 | 2020-06-04 | Khona Scientific Llc | Bidirectional multi-enzymatic scaffolds for biosynthesizing cannabinoids |
| US12351850B2 (en) * | 2020-04-30 | 2025-07-08 | Sutro Biopharma, Inc. | Methods of producing full-length antibodies using E. coli |
| CN112553134B (zh) * | 2020-12-30 | 2022-09-06 | 江南大学 | 一种在枯草芽孢杆菌中表达α-淀粉酶的方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19629568C1 (de) | 1996-07-15 | 1998-01-08 | Fraunhofer Ges Forschung | Verfahren zur Herstellung von Isopren |
| JPWO2003095651A1 (ja) | 2002-05-10 | 2005-09-15 | 協和醗酵工業株式会社 | メバロン酸の製造方法 |
| KR101148255B1 (ko) | 2002-10-04 | 2012-08-08 | 다니스코 유에스 인크. | 고수율을 갖는 1,3-프로판디올의 생물학적 제조 방법 |
| RU2004124226A (ru) | 2004-08-10 | 2006-01-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Использование фосфокетолазы для продукции полезных метаболитов |
| WO2007140339A2 (en) * | 2006-05-26 | 2007-12-06 | Amyris Biotechnologies, Inc. | Production of isoprenoids |
| US7947478B2 (en) | 2006-06-29 | 2011-05-24 | The Regents Of The University Of California | Short chain volatile hydrocarbon production using genetically engineered microalgae, cyanobacteria or bacteria |
| JP4986547B2 (ja) | 2006-09-04 | 2012-07-25 | 株式会社Ａｄｅｋａ | 新規なアセトアセチルＣｏＡ合成酵素、それをコードするＤＮＡ配列、当該酵素の製造方法および当該酵素を利用したメバロン酸の製造方法 |
| CN105368764B (zh) * | 2007-12-13 | 2019-03-12 | 丹尼斯科美国公司 | 用于生产异戊二烯的组合物和方法 |
| US20110045563A1 (en) | 2008-02-06 | 2011-02-24 | The Regents Of The University Of California | Short chain volatile isoprene hydrocarbon production using the mevalonic acid pathway in genetically engineered yeast and fungi |
| WO2009132220A2 (en) | 2008-04-23 | 2009-10-29 | Danisco Us Inc. | Isoprene synthase variants for improved microbial production of isoprene |
| US7632995B2 (en) | 2008-05-09 | 2009-12-15 | Monsanto Technology Llc | Plants and seeds of hybrid corn variety CH852179 |
| MX318543B (es) | 2008-07-02 | 2014-03-18 | Danisco Us Inc | Composiciones y metodos para producir isopreno libre de hidrocarburos de c5 bajo condicion de desacoplamiento y/o intervalos de operacion seguros. |
| EP2340312A2 (en) | 2008-09-15 | 2011-07-06 | Danisco US Inc. | Conversion of prenyl derivatives to isoprene |
| CA2737223A1 (en) | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Reduction of carbon dioxide emission during isoprene production by fermentation |
| WO2010031062A1 (en) | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Increased isoprene production using the archaeal lower mevalonate pathway |
| EP2344629B1 (en) | 2008-09-15 | 2018-01-24 | Danisco US Inc. | Systems using cell culture for production of isoprene |
| MY161071A (en) | 2008-12-30 | 2017-04-14 | Danisco Us Inc | Methods of producing isoprene and a co-product |
| US20100297749A1 (en) | 2009-04-21 | 2010-11-25 | Sapphire Energy, Inc. | Methods and systems for biofuel production |
| AU2010238770A1 (en) | 2009-04-23 | 2011-11-03 | Danisco Us Inc. | Three-dimensional structure of isoprene synthase and its use thereof for generating variants |
| JP4760951B2 (ja) | 2009-05-08 | 2011-08-31 | トヨタ自動車株式会社 | ブタノール生産能を有する組換え微生物及びブタノールの製造方法 |
| TWI434921B (zh) | 2009-06-17 | 2014-04-21 | Danisco Us Inc | 從生物異戊二烯組合物製造燃料成分之方法及系統 |
| TW201412988A (zh) | 2009-06-17 | 2014-04-01 | Danisco Us Inc | 使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造 |
| US20120252054A1 (en) | 2009-09-15 | 2012-10-04 | Sapphire Energy Inc | System for transformation of the chloroplast genome of scenedesmus sp. and dunaliella sp. |
| US8569562B2 (en) | 2009-12-18 | 2013-10-29 | Danisco Us Inc. | Purification of isoprene from renewable resources |
| SG196782A1 (en) | 2009-12-23 | 2014-02-13 | Danisco Us Inc | Compositions and methods for the increased production of isoprene and other products with 6 - phosphogluconolactonase (pgl) |
| US8871488B2 (en) | 2010-06-18 | 2014-10-28 | Butamax Advanced Biofuels Llc | Recombinant host cells comprising phosphoketolases |
| CA2816306A1 (en) | 2010-10-27 | 2012-05-03 | Danisco Us Inc. | Isoprene synthase variants for improved production of isoprene |
-
2012
- 2012-12-21 JP JP2014548993A patent/JP2015510392A/ja active Pending
- 2012-12-21 AU AU2012358149A patent/AU2012358149A1/en not_active Abandoned
- 2012-12-21 MX MX2014007623A patent/MX2014007623A/es unknown
- 2012-12-21 EP EP12813234.7A patent/EP2794863A1/en not_active Withdrawn
- 2012-12-21 CA CA2859885A patent/CA2859885A1/en not_active Abandoned
- 2012-12-21 WO PCT/US2012/071518 patent/WO2013096925A1/en not_active Ceased
- 2012-12-21 CN CN201280070444.1A patent/CN104245927A/zh active Pending
- 2012-12-21 BR BR112014014947-0A patent/BR112014014947A2/pt not_active Application Discontinuation
- 2012-12-21 SG SG11201403163QA patent/SG11201403163QA/en unknown
- 2012-12-21 US US13/725,929 patent/US8975051B2/en not_active Expired - Fee Related
-
2015
- 2015-01-09 US US14/593,860 patent/US9388431B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US9388431B2 (en) | 2016-07-12 |
| EP2794863A1 (en) | 2014-10-29 |
| CN104245927A (zh) | 2014-12-24 |
| US20150218590A1 (en) | 2015-08-06 |
| US8975051B2 (en) | 2015-03-10 |
| BR112014014947A2 (pt) | 2020-10-27 |
| US20130164808A1 (en) | 2013-06-27 |
| CA2859885A1 (en) | 2013-06-27 |
| JP2015510392A (ja) | 2015-04-09 |
| MX2014007623A (es) | 2015-02-04 |
| WO2013096925A1 (en) | 2013-06-27 |
| AU2012358149A1 (en) | 2014-07-03 |
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