SG10202111648YA - Chemical compounds - Google Patents

Chemical compounds

Info

Publication number
SG10202111648YA
SG10202111648YA SG10202111648YA SG10202111648YA SG10202111648YA SG 10202111648Y A SG10202111648Y A SG 10202111648YA SG 10202111648Y A SG10202111648Y A SG 10202111648YA SG 10202111648Y A SG10202111648Y A SG 10202111648YA SG 10202111648Y A SG10202111648Y A SG 10202111648YA
Authority
SG
Singapore
Prior art keywords
chemical compounds
compounds
chemical
Prior art date
Application number
SG10202111648YA
Other languages
English (en)
Inventor
John G Catalano
Pek Yoke Chong
Hamilton D Dickson
Martin R Leivers
Jason Gordon Weatherhead
Original Assignee
Glaxosmithkline Ip Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd
Publication of SG10202111648YA publication Critical patent/SG10202111648YA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG10202111648YA 2017-10-05 2018-10-05 Chemical compounds SG10202111648YA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762568633P 2017-10-05 2017-10-05
US201762570509P 2017-10-10 2017-10-10
US201862681146P 2018-06-06 2018-06-06
US201862683859P 2018-06-12 2018-06-12

Publications (1)

Publication Number Publication Date
SG10202111648YA true SG10202111648YA (en) 2021-11-29

Family

ID=64049476

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202111648YA SG10202111648YA (en) 2017-10-05 2018-10-05 Chemical compounds
SG11202002771XA SG11202002771XA (en) 2017-10-05 2018-10-05 Chemical compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11202002771XA SG11202002771XA (en) 2017-10-05 2018-10-05 Chemical compounds

Country Status (25)

Country Link
US (2) US20200255428A1 (hr)
EP (2) EP3692040B1 (hr)
JP (1) JP7248665B2 (hr)
KR (1) KR20200065024A (hr)
CN (2) CN116942663A (hr)
AU (2) AU2018344926A1 (hr)
BR (1) BR112020006456A2 (hr)
CA (1) CA3078312A1 (hr)
CL (1) CL2020000912A1 (hr)
CO (1) CO2020004202A2 (hr)
DK (1) DK3692040T3 (hr)
ES (1) ES2940263T3 (hr)
FI (1) FI3692040T3 (hr)
HR (1) HRP20230274T1 (hr)
HU (1) HUE061380T2 (hr)
IL (1) IL273769A (hr)
LT (1) LT3692040T (hr)
MX (1) MX2020003382A (hr)
PH (1) PH12020550145A1 (hr)
PL (1) PL3692040T3 (hr)
PT (1) PT3692040T (hr)
RS (1) RS64043B1 (hr)
SG (2) SG10202111648YA (hr)
SI (1) SI3692040T1 (hr)
WO (1) WO2019069293A1 (hr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10738035B2 (en) 2015-05-13 2020-08-11 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
KR102398439B1 (ko) 2016-03-07 2022-05-16 이난타 파마슈티칼스, 인코포레이티드 B형 간염 항바이러스제
KR102556744B1 (ko) 2017-08-28 2023-07-18 이난타 파마슈티칼스, 인코포레이티드 B형 간염 항바이러스제
WO2019143902A2 (en) 2018-01-22 2019-07-25 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
US10729688B2 (en) 2018-03-29 2020-08-04 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2019246427A1 (en) * 2018-06-22 2019-12-26 Arbutus Biopharma Corporation Crystalline forms of pyridinone-containing tricyclic compounds and methods of preparing and using same
AR116474A1 (es) 2018-09-21 2021-05-12 Enanta Pharm Inc DERIVADOS DEL ÁCIDO 6,7-DIHIDRO-2H-BENZOFURO[2,3-a]QUINOLIZIN-3-CARBOXÍLICO COMO AGENTES ANTIVIRALES PARA EL TRATAMIENTO O PREVENCIÓN DE UNA INFECCIÓN POR HBV
AU2019348135A1 (en) 2018-09-30 2021-04-01 Sunshine Lake Pharma Co., Ltd. Fused tetracyclic compounds and uses thereof in medicine
AU2019385477A1 (en) 2018-11-21 2021-06-10 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
CN111217811B (zh) * 2018-11-26 2024-01-16 广东东阳光药业股份有限公司 稠合三环类化合物及其在药物中的应用
TW202104214A (zh) 2019-04-05 2021-02-01 英商葛蘭素史密斯克藍智慧財產發展有限公司 化合物
WO2020247444A1 (en) 2019-06-03 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
US11472808B2 (en) 2019-06-04 2022-10-18 Enanta Pharmaceuticals, Inc. Substituted pyrrolo[1,2-c]pyrimidines as hepatitis B antiviral agents
WO2020247561A1 (en) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
WO2021007488A1 (en) 2019-07-11 2021-01-14 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
US11236108B2 (en) 2019-09-17 2022-02-01 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
WO2021188414A1 (en) 2020-03-16 2021-09-23 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents
CN113173911A (zh) * 2021-04-20 2021-07-27 梯尔希(南京)药物研发有限公司 吡虫啉代谢物5-羟基吡虫啉的合成方法
WO2023144750A1 (en) 2022-01-28 2023-08-03 Glaxosmithkline Intellectual Property Development Limited Combination therapy for treating hepatitis b virus infections

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201691261A1 (ru) * 2014-01-30 2016-11-30 Ф. Хоффманн-Ля Рош Аг Новые дигидрохинолизиноны для лечения и профилактики инфекции, вызванной вирусом гепатита b
CN106459032B (zh) * 2014-05-13 2019-04-05 豪夫迈·罗氏有限公司 治疗和预防乙型肝炎病毒感染的新的二氢喹嗪酮类
US9637485B2 (en) * 2014-11-03 2017-05-02 Hoffmann-La Roche Inc. 6,7-dihydrobenzo[a]quinolizin-2-one derivatives for the treatment and prophylaxis of hepatitis B virus infection
EP3256471B1 (en) * 2015-02-11 2018-12-12 F. Hoffmann-La Roche AG Novel 2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection
WO2017108630A1 (en) * 2015-12-21 2017-06-29 F. Hoffmann-La Roche Ag Combination therapy of an hbsag inhibitor and an hbv capsid assembly inhibitor
TW201811788A (zh) * 2016-09-09 2018-04-01 瑞士商諾華公司 作為抗病毒劑之多環吡啶酮化合物
WO2018085619A1 (en) * 2016-11-07 2018-05-11 Arbutus Biopharma, Inc. Substituted pyridinone-containing tricyclic compounds, and methods using same
CN109369640B (zh) * 2017-01-13 2020-03-27 苏州爱科百发生物医药技术有限公司 一种二氢异喹啉类化合物的制备方法
CN108727378A (zh) 2017-04-19 2018-11-02 银杏树药业(苏州)有限公司 新型异喹啉类化合物及其医药用途

Also Published As

Publication number Publication date
AU2021203650B2 (en) 2022-09-08
CL2020000912A1 (es) 2021-02-19
JP7248665B2 (ja) 2023-03-29
AU2018344926A1 (en) 2020-04-16
FI3692040T3 (fi) 2023-03-29
PL3692040T3 (pl) 2023-04-17
HRP20230274T1 (hr) 2023-04-28
WO2019069293A1 (en) 2019-04-11
CN111433206B (zh) 2023-07-07
ES2940263T3 (es) 2023-05-04
SG11202002771XA (en) 2020-04-29
MX2020003382A (es) 2020-10-05
LT3692040T (lt) 2023-04-25
KR20200065024A (ko) 2020-06-08
CN111433206A (zh) 2020-07-17
US20220144834A1 (en) 2022-05-12
DK3692040T3 (da) 2023-03-13
JP2020536110A (ja) 2020-12-10
CO2020004202A2 (es) 2020-04-24
RU2020118375A (ru) 2021-11-09
SI3692040T1 (sl) 2023-05-31
RS64043B1 (sr) 2023-04-28
HUE061380T2 (hu) 2023-06-28
CN116942663A (zh) 2023-10-27
AU2021203650B9 (en) 2022-10-06
US20200255428A1 (en) 2020-08-13
IL273769A (en) 2020-05-31
PH12020550145A1 (en) 2021-01-04
AU2021203650A1 (en) 2021-07-01
PT3692040T (pt) 2023-04-03
RU2020118375A3 (hr) 2022-04-13
CA3078312A1 (en) 2019-04-11
EP3692040A1 (en) 2020-08-12
BR112020006456A2 (pt) 2020-10-06
EP3692040B1 (en) 2022-12-28
EP4180431A1 (en) 2023-05-17

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