RS64043B1 - Hemijska jedinjenja - Google Patents

Hemijska jedinjenja

Info

Publication number
RS64043B1
RS64043B1 RS20230207A RSP20230207A RS64043B1 RS 64043 B1 RS64043 B1 RS 64043B1 RS 20230207 A RS20230207 A RS 20230207A RS P20230207 A RSP20230207 A RS P20230207A RS 64043 B1 RS64043 B1 RS 64043B1
Authority
RS
Serbia
Prior art keywords
chemical compounds
compounds
chemical
Prior art date
Application number
RS20230207A
Other languages
English (en)
Inventor
John G Catalano
Pek Yoke Chong
Hamilton D Dickson
Martin R Leivers
Jason Gordon Weatherhead
Original Assignee
Glaxosmithkline Ip Dev Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd
Publication of RS64043B1 publication Critical patent/RS64043B1/sr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RS20230207A 2017-10-05 2018-10-05 Hemijska jedinjenja RS64043B1 (sr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201762568633P 2017-10-05 2017-10-05
US201762570509P 2017-10-10 2017-10-10
US201862681146P 2018-06-06 2018-06-06
US201862683859P 2018-06-12 2018-06-12
EP18795809.5A EP3692040B1 (en) 2017-10-05 2018-10-05 Chemical compounds
PCT/IB2018/057767 WO2019069293A1 (en) 2017-10-05 2018-10-05 CHEMICAL COMPOUNDS

Publications (1)

Publication Number Publication Date
RS64043B1 true RS64043B1 (sr) 2023-04-28

Family

ID=64049476

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20230207A RS64043B1 (sr) 2017-10-05 2018-10-05 Hemijska jedinjenja

Country Status (25)

Country Link
US (2) US20200255428A1 (sr)
EP (2) EP3692040B1 (sr)
JP (1) JP7248665B2 (sr)
KR (1) KR102705376B1 (sr)
CN (2) CN111433206B (sr)
AU (2) AU2018344926A1 (sr)
BR (1) BR112020006456A2 (sr)
CA (1) CA3078312A1 (sr)
CL (1) CL2020000912A1 (sr)
CO (1) CO2020004202A2 (sr)
DK (1) DK3692040T3 (sr)
ES (1) ES2940263T3 (sr)
FI (1) FI3692040T3 (sr)
HR (1) HRP20230274T1 (sr)
HU (1) HUE061380T2 (sr)
IL (1) IL273769A (sr)
LT (1) LT3692040T (sr)
MX (1) MX2020003382A (sr)
PH (1) PH12020550145A1 (sr)
PL (1) PL3692040T3 (sr)
PT (1) PT3692040T (sr)
RS (1) RS64043B1 (sr)
SG (2) SG10202111648YA (sr)
SI (1) SI3692040T1 (sr)
WO (1) WO2019069293A1 (sr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016183266A1 (en) 2015-05-13 2016-11-17 Enanta Pharmaceuticals, Inc. Ehpatitis b antiviral agents
BR112018067964B1 (pt) 2016-03-07 2024-01-16 Enanta Pharmaceuticals, Inc Composto, composição farmacêutica que o compreende e uso do referido composto
IL272941B2 (en) 2017-08-28 2023-03-01 Enanta Pharm Inc Antiviral agents for viral hepatitis b
US11058678B2 (en) 2018-01-22 2021-07-13 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
US10729688B2 (en) 2018-03-29 2020-08-04 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2019246427A1 (en) * 2018-06-22 2019-12-26 Arbutus Biopharma Corporation Crystalline forms of pyridinone-containing tricyclic compounds and methods of preparing and using same
BR112021005091A2 (pt) 2018-09-21 2021-06-08 Enanta Pharmaceuticals, Inc. heterociclos funcionalizados como agentes antivirais
JP2022511378A (ja) 2018-09-30 2022-01-31 サンシャイン・レイク・ファーマ・カンパニー・リミテッド 縮合四環系化合物および医薬品におけるそれらの使用
CN113271946A (zh) 2018-11-21 2021-08-17 英安塔制药有限公司 官能化杂环化合物作为抗病毒剂
CN111217811B (zh) * 2018-11-26 2024-01-16 广东东阳光药业股份有限公司 稠合三环类化合物及其在药物中的应用
TW202104214A (zh) 2019-04-05 2021-02-01 英商葛蘭素史密斯克藍智慧財產發展有限公司 化合物
US11236111B2 (en) 2019-06-03 2022-02-01 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2020247575A1 (en) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
US11760755B2 (en) 2019-06-04 2023-09-19 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US11738019B2 (en) 2019-07-11 2023-08-29 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
US11236108B2 (en) 2019-09-17 2022-02-01 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
US11802125B2 (en) 2020-03-16 2023-10-31 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents
CN113173911A (zh) * 2021-04-20 2021-07-27 梯尔希(南京)药物研发有限公司 吡虫啉代谢物5-羟基吡虫啉的合成方法
AU2023213173A1 (en) 2022-01-28 2024-08-01 Glaxosmithkline Intellectual Property Development Limited Combination therapy for treating hepatitis b virus infections

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201605970QA (en) * 2014-01-30 2016-08-30 Hoffmann La Roche Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection
WO2015173164A1 (en) * 2014-05-13 2015-11-19 F. Hoffmann-La Roche Ag Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection
US9637485B2 (en) * 2014-11-03 2017-05-02 Hoffmann-La Roche Inc. 6,7-dihydrobenzo[a]quinolizin-2-one derivatives for the treatment and prophylaxis of hepatitis B virus infection
CN107207505B (zh) * 2015-02-11 2018-12-14 豪夫迈·罗氏有限公司 治疗和预防乙型肝炎病毒感染的 2-氧代-6,7-二氢苯并[a]喹嗪-3-甲酸衍生物
WO2017108630A1 (en) * 2015-12-21 2017-06-29 F. Hoffmann-La Roche Ag Combination therapy of an hbsag inhibitor and an hbv capsid assembly inhibitor
TW201811788A (zh) * 2016-09-09 2018-04-01 瑞士商諾華公司 作為抗病毒劑之多環吡啶酮化合物
US10821103B2 (en) * 2016-11-07 2020-11-03 Arbutus Biopharma Corporation Substituted pyridinone-containing trycyclic compounds, and methods using same
CN109369640B (zh) * 2017-01-13 2020-03-27 苏州爱科百发生物医药技术有限公司 一种二氢异喹啉类化合物的制备方法
CN108727378A (zh) * 2017-04-19 2018-11-02 银杏树药业(苏州)有限公司 新型异喹啉类化合物及其医药用途

Also Published As

Publication number Publication date
EP3692040B1 (en) 2022-12-28
EP3692040A1 (en) 2020-08-12
PH12020550145A1 (en) 2021-01-04
SG10202111648YA (en) 2021-11-29
RU2020118375A3 (sr) 2022-04-13
LT3692040T (lt) 2023-04-25
KR20200065024A (ko) 2020-06-08
BR112020006456A2 (pt) 2020-10-06
KR102705376B1 (ko) 2024-09-11
PT3692040T (pt) 2023-04-03
CN111433206B (zh) 2023-07-07
US20200255428A1 (en) 2020-08-13
US20220144834A1 (en) 2022-05-12
DK3692040T3 (da) 2023-03-13
WO2019069293A1 (en) 2019-04-11
IL273769A (en) 2020-05-31
CN111433206A (zh) 2020-07-17
AU2021203650A1 (en) 2021-07-01
CA3078312A1 (en) 2019-04-11
CO2020004202A2 (es) 2020-04-24
RU2020118375A (ru) 2021-11-09
CN116942663A (zh) 2023-10-27
MX2020003382A (es) 2020-10-05
AU2018344926A1 (en) 2020-04-16
AU2021203650B2 (en) 2022-09-08
HUE061380T2 (hu) 2023-06-28
SG11202002771XA (en) 2020-04-29
JP7248665B2 (ja) 2023-03-29
JP2020536110A (ja) 2020-12-10
EP4180431A1 (en) 2023-05-17
ES2940263T3 (es) 2023-05-04
CL2020000912A1 (es) 2021-02-19
PL3692040T3 (pl) 2023-04-17
HRP20230274T1 (hr) 2023-04-28
AU2021203650B9 (en) 2022-10-06
FI3692040T3 (fi) 2023-03-29
SI3692040T1 (sl) 2023-05-31

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