SG10202011841WA - Recombinant listeria vaccine strains and methods of producing the same - Google Patents
Recombinant listeria vaccine strains and methods of producing the sameInfo
- Publication number
- SG10202011841WA SG10202011841WA SG10202011841WA SG10202011841WA SG10202011841WA SG 10202011841W A SG10202011841W A SG 10202011841WA SG 10202011841W A SG10202011841W A SG 10202011841WA SG 10202011841W A SG10202011841W A SG 10202011841WA SG 10202011841W A SG10202011841W A SG 10202011841WA
- Authority
- SG
- Singapore
- Prior art keywords
- producing
- methods
- same
- recombinant listeria
- vaccine strains
- Prior art date
Links
- 241000186781 Listeria Species 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/36—Adaptation or attenuation of cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20051—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461983732P | 2014-04-24 | 2014-04-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10202011841WA true SG10202011841WA (en) | 2021-01-28 |
Family
ID=54333010
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10202011841WA SG10202011841WA (en) | 2014-04-24 | 2015-04-14 | Recombinant listeria vaccine strains and methods of producing the same |
SG11201608820WA SG11201608820WA (en) | 2014-04-24 | 2015-04-14 | Recombinant listeria vaccine strains and methods of producing the same |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201608820WA SG11201608820WA (en) | 2014-04-24 | 2015-04-14 | Recombinant listeria vaccine strains and methods of producing the same |
Country Status (15)
Country | Link |
---|---|
US (2) | US10258679B2 (ko) |
EP (1) | EP3134510B1 (ko) |
JP (3) | JP7009061B2 (ko) |
KR (2) | KR102359691B1 (ko) |
CN (1) | CN106459887A (ko) |
AU (1) | AU2015250111A1 (ko) |
BR (1) | BR112016024352A2 (ko) |
CA (1) | CA2946716A1 (ko) |
IL (1) | IL248483A0 (ko) |
MA (1) | MA39849A (ko) |
MX (1) | MX2016013985A (ko) |
RU (1) | RU2016145464A (ko) |
SG (2) | SG10202011841WA (ko) |
TW (2) | TWI692525B (ko) |
WO (1) | WO2015164121A1 (ko) |
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US9012141B2 (en) | 2000-03-27 | 2015-04-21 | Advaxis, Inc. | Compositions and methods comprising KLK3 of FOLH1 antigen |
EP2683400A4 (en) | 2011-03-11 | 2014-09-17 | Advaxis | ADJUVANZIA ON LISTERIA BASE |
SG11201405605VA (en) | 2012-03-12 | 2014-10-30 | Advaxis Inc | SUPPRESSOR CELL FUNCTION INHIBITION FOLLOWING <i>LISTERIA</i> VACCINE TREATMENT |
CA2947358A1 (en) | 2014-02-18 | 2015-08-27 | Advaxis, Inc. | Biomarker directed multi-target immunotherapy |
KR102359691B1 (ko) | 2014-04-24 | 2022-02-10 | 어드박시스, 인크. | 재조합 리스테리아 백신 균주 및 그 생산 방법 |
CN107250366A (zh) * | 2014-10-14 | 2017-10-13 | 宾夕法尼亚大学理事会 | 重组李斯特菌疫苗菌株及其用于癌症免疫疗法的方法 |
MA41644A (fr) | 2015-03-03 | 2018-01-09 | Advaxis Inc | Compositions à base de listeria comprenant un système d'expression de minigènes codant pour des peptides, et leurs procédés d'utilisation |
AU2016369519B2 (en) | 2015-12-16 | 2023-04-20 | Gritstone Bio, Inc. | Neoantigen identification, manufacture, and use |
MX2019005685A (es) | 2016-11-30 | 2019-09-04 | Advaxis Inc | Composiciones inmunogenicas contra mutaciones de cancer recurrentes y metodos de uso de las mismas. |
CN106978381A (zh) * | 2017-03-23 | 2017-07-25 | 上海理工大学 | prfA基因缺失单核细胞增生李斯特氏菌及制备方法 |
KR20200044982A (ko) | 2017-09-19 | 2020-04-29 | 어드박시스, 인크. | 박테리아 또는 리스테리아 균주의 동결건조를 위한 조성물 및 방법 |
AU2018348165A1 (en) | 2017-10-10 | 2020-05-21 | Gritstone Bio, Inc. | Neoantigen identification using hotspots |
WO2019086507A1 (en) | 2017-10-31 | 2019-05-09 | Pantarhei Bioscience B.V. | Immunotherapeutic methods for treating and/or preventing lung cancer |
CA3083097A1 (en) | 2017-11-22 | 2019-05-31 | Gritstone Oncology, Inc. | Reducing junction epitope presentation for neoantigens |
MX2020009405A (es) * | 2018-03-09 | 2021-01-08 | Advaxis Inc | Composiciones y métodos para evaluar la atenuación y la infectividad de cepas de listeria. |
CN110408634B (zh) * | 2018-04-27 | 2021-08-03 | 苏州若泰医药科技有限公司 | 一种非整合李斯特菌疫苗及抗肿瘤免疫应答方法 |
US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
WO2021259963A1 (en) | 2020-06-23 | 2021-12-30 | Pandora Endocrine Innovation B.V. | Immunization against wnt4 for treatment and prophylaxis of breast cancer |
WO2023066923A1 (en) | 2021-10-19 | 2023-04-27 | Rahman Nafis | Male contraception |
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WO2016183361A1 (en) | 2015-05-13 | 2016-11-17 | Advaxis, Inc. | Immunogenic listeria-based compositions comprising truncated acta-antigen fusions and methods of use thereof |
EP3302574A4 (en) | 2015-05-26 | 2018-10-17 | Advaxis, Inc. | Personalized delivery vector-based immunotherapy and uses thereof |
MX2018000210A (es) | 2015-06-24 | 2018-06-22 | Advaxis Inc | Dispositivo y proceso de fabricación de inmunoterapia personalizada basada en vectores de suministro. |
MA42841A (fr) | 2015-09-15 | 2018-07-25 | Advaxis Inc | Procédé de fabrication d'une formulation immunothérapeutique comprenant une souche de listeria de recombinaison |
TW201723171A (zh) | 2015-09-15 | 2017-07-01 | 艾法西斯公司 | 基於李斯特菌屬之免疫原性組成物及其於癌症預防與治療中之使用方法 |
EP3349789A2 (en) | 2015-09-17 | 2018-07-25 | Advaxis, Inc. | Recombinant listeria vaccine strains and methods of using the same in cancer immunotherapy |
TW201722444A (zh) | 2015-10-14 | 2017-07-01 | 艾法西斯公司 | 重組李斯特菌疫苗菌株及在癌症免疫治療中使用該菌株之方法 |
WO2017085691A1 (en) | 2015-11-20 | 2017-05-26 | Advaxis, Inc. | Manufacturing device and method of an immunotherapeutic formulation comprising a recombinant listeria strain |
US20180360940A1 (en) | 2015-12-16 | 2018-12-20 | Advaxis, Inc. | Listeria-based immunotherapy and methods of use thereof |
AU2017211387A1 (en) | 2016-01-27 | 2018-08-16 | Advaxis, Inc. | Personalized delivery vector-based immunotherapy and uses thereof |
AU2017293400A1 (en) | 2016-07-05 | 2019-02-07 | Advaxis, Inc. | Listeria-based immunogenic compositions comprising Wilms tumor protein antigens and methods of use thereof |
WO2018085854A1 (en) | 2016-11-07 | 2018-05-11 | Advaxis, Inc. | Combination of listeria-based vaccine with anti-ctla-4 or anti-cd137 antibodies |
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MX2019005685A (es) | 2016-11-30 | 2019-09-04 | Advaxis Inc | Composiciones inmunogenicas contra mutaciones de cancer recurrentes y metodos de uso de las mismas. |
AR110730A1 (es) | 2017-01-05 | 2019-04-24 | Advaxis Inc | Vacunas de cepas recombinantes de listeria y método para usarlas en inmunoterapia de cáncer |
-
2015
- 2015-04-14 KR KR1020167029990A patent/KR102359691B1/ko active IP Right Grant
- 2015-04-14 AU AU2015250111A patent/AU2015250111A1/en not_active Abandoned
- 2015-04-14 CN CN201580021074.6A patent/CN106459887A/zh active Pending
- 2015-04-14 CA CA2946716A patent/CA2946716A1/en not_active Abandoned
- 2015-04-14 EP EP15782800.5A patent/EP3134510B1/en active Active
- 2015-04-14 US US15/306,289 patent/US10258679B2/en active Active
- 2015-04-14 MA MA039849A patent/MA39849A/fr unknown
- 2015-04-14 RU RU2016145464A patent/RU2016145464A/ru not_active Application Discontinuation
- 2015-04-14 SG SG10202011841WA patent/SG10202011841WA/en unknown
- 2015-04-14 KR KR1020227003655A patent/KR102491332B1/ko active IP Right Grant
- 2015-04-14 JP JP2016564032A patent/JP7009061B2/ja active Active
- 2015-04-14 SG SG11201608820WA patent/SG11201608820WA/en unknown
- 2015-04-14 WO PCT/US2015/025690 patent/WO2015164121A1/en active Application Filing
- 2015-04-14 MX MX2016013985A patent/MX2016013985A/es unknown
- 2015-04-14 BR BR112016024352-8A patent/BR112016024352A2/pt not_active Application Discontinuation
- 2015-04-21 TW TW104112751A patent/TWI692525B/zh not_active IP Right Cessation
- 2015-04-21 TW TW109111533A patent/TWI722858B/zh not_active IP Right Cessation
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2016
- 2016-10-25 IL IL248483A patent/IL248483A0/en unknown
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2019
- 2019-02-14 US US16/276,520 patent/US20190240303A1/en not_active Abandoned
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2020
- 2020-03-18 JP JP2020047632A patent/JP2020099352A/ja not_active Withdrawn
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2022
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EP3134510A4 (en) | 2018-04-25 |
TWI692525B (zh) | 2020-05-01 |
JP2020099352A (ja) | 2020-07-02 |
RU2016145464A (ru) | 2018-05-24 |
JP7009061B2 (ja) | 2022-01-25 |
KR20160145627A (ko) | 2016-12-20 |
MX2016013985A (es) | 2017-01-11 |
AU2015250111A1 (en) | 2016-12-08 |
EP3134510B1 (en) | 2023-11-01 |
BR112016024352A2 (pt) | 2018-01-23 |
JP7300041B2 (ja) | 2023-06-28 |
CA2946716A1 (en) | 2015-10-29 |
KR20220021021A (ko) | 2022-02-21 |
CN106459887A (zh) | 2017-02-22 |
KR102491332B1 (ko) | 2023-01-27 |
IL248483A0 (en) | 2016-12-29 |
WO2015164121A1 (en) | 2015-10-29 |
MA39849A (fr) | 2017-03-01 |
EP3134510A1 (en) | 2017-03-01 |
TWI722858B (zh) | 2021-03-21 |
SG11201608820WA (en) | 2016-11-29 |
JP2017513502A (ja) | 2017-06-01 |
TW202041671A (zh) | 2020-11-16 |
US20170042996A1 (en) | 2017-02-16 |
JP2022105768A (ja) | 2022-07-14 |
US20190240303A1 (en) | 2019-08-08 |
TW201546276A (zh) | 2015-12-16 |
US10258679B2 (en) | 2019-04-16 |
KR102359691B1 (ko) | 2022-02-10 |
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