SG10202008961UA - Method for identification and quantification of nucleic acid expression, splice variant, translocation, copy number, or methylation changes - Google Patents

Method for identification and quantification of nucleic acid expression, splice variant, translocation, copy number, or methylation changes

Info

Publication number
SG10202008961UA
SG10202008961UA SG10202008961UA SG10202008961UA SG10202008961UA SG 10202008961U A SG10202008961U A SG 10202008961UA SG 10202008961U A SG10202008961U A SG 10202008961UA SG 10202008961U A SG10202008961U A SG 10202008961UA SG 10202008961U A SG10202008961U A SG 10202008961UA
Authority
SG
Singapore
Prior art keywords
translocation
quantification
identification
nucleic acid
copy number
Prior art date
Application number
SG10202008961UA
Other languages
English (en)
Inventor
Francis Barany
John William Efcavitch
Rueda Cristian Ruiz
Jianmin Huang
Philip B Feinberg
Original Assignee
Univ Cornell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Cornell filed Critical Univ Cornell
Publication of SG10202008961UA publication Critical patent/SG10202008961UA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
    • C12Q2521/331—Methylation site specific nuclease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
SG10202008961UA 2014-10-08 2015-10-08 Method for identification and quantification of nucleic acid expression, splice variant, translocation, copy number, or methylation changes SG10202008961UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462061376P 2014-10-08 2014-10-08
US201562103894P 2015-01-15 2015-01-15

Publications (1)

Publication Number Publication Date
SG10202008961UA true SG10202008961UA (en) 2020-10-29

Family

ID=55653949

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201702831XA SG11201702831XA (en) 2014-10-08 2015-10-08 Method for identification and quantification of nucleic acid expression, splice variant, translocation, copy number, or methylation changes
SG10202008961UA SG10202008961UA (en) 2014-10-08 2015-10-08 Method for identification and quantification of nucleic acid expression, splice variant, translocation, copy number, or methylation changes

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201702831XA SG11201702831XA (en) 2014-10-08 2015-10-08 Method for identification and quantification of nucleic acid expression, splice variant, translocation, copy number, or methylation changes

Country Status (13)

Country Link
US (2) US10344321B2 (pt)
EP (3) EP4026914A1 (pt)
JP (3) JP6871160B2 (pt)
CN (2) CN113481281A (pt)
AU (2) AU2015330844B2 (pt)
BR (1) BR112017007033B1 (pt)
CA (2) CA3187713A1 (pt)
DK (2) DK3204520T3 (pt)
ES (2) ES2784342T3 (pt)
IL (3) IL296204B1 (pt)
PT (2) PT3690060T (pt)
SG (2) SG11201702831XA (pt)
WO (1) WO2016057832A2 (pt)

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US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
JP6659575B2 (ja) 2014-04-21 2020-03-04 ナテラ， インコーポレイテッド 変異の検出および染色体分節の倍数性
WO2016183106A1 (en) 2015-05-11 2016-11-17 Natera, Inc. Methods and compositions for determining ploidy
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
HUE055745T2 (hu) * 2017-04-03 2021-12-28 Qiagen Gmbh Eljárás egy vagy több biomarker RNS molekula expressziójának elemzésére
CN108179176B (zh) * 2018-02-08 2021-08-03 斯格特生物 一种基于miRNA搭桥对两个互不重叠的扩增引物进行双向延伸检测miRNA的方法
US11639928B2 (en) 2018-02-22 2023-05-02 10X Genomics, Inc. Methods and systems for characterizing analytes from individual cells or cell populations
CN112513265A (zh) * 2018-05-22 2021-03-16 博诚研究中心 用于人类癌症检测的修饰核酸的靶向富集和测序
US11525159B2 (en) 2018-07-03 2022-12-13 Natera, Inc. Methods for detection of donor-derived cell-free DNA
CN109385464A (zh) * 2018-07-27 2019-02-26 中山大学附属第六医院 一种dna甲基化检测试剂盒及方法
CN109161594A (zh) * 2018-08-17 2019-01-08 中山大学达安基因股份有限公司 一种检测braf基因突变的方法及其试剂盒
CN108998535B (zh) * 2018-09-11 2021-09-10 广州市宝创生物技术有限公司 一种kras基因多重突变位点检测试剂盒
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WO2020227100A1 (en) * 2019-05-03 2020-11-12 Cornell University Markers for identifying and quantifying of nucleic acid sequence mutation, expression, splice variant, translocation, copy number, or methylation changes
US20220205050A1 (en) * 2019-05-03 2022-06-30 Cornell University Method and markers for identifying and quantifying of nucleic acid sequence, mutation, copy number, or methylation changes
CA3176759A1 (en) * 2020-05-01 2021-11-04 Francis Barany Method and markers for identifying and relative quantifying of nucleic acid sequence, mutation, copy number, or methylation changes using combinations of nuclease, ligation, deamination, dna repair, and polymerase reactions with carryover preventio
JPWO2022149575A1 (pt) * 2021-01-06 2022-07-14
CN117222750A (zh) * 2021-02-17 2023-12-12 行动基因(智财)有限公司 Dna片段接合检测方法及套组
EP4298244A1 (en) 2021-02-23 2024-01-03 10X Genomics, Inc. Probe-based analysis of nucleic acids and proteins
US20230295741A1 (en) * 2022-03-21 2023-09-21 Billiontoone, Inc. Molecule counting of methylated cell-free dna for treatment monitoring

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Also Published As

Publication number Publication date
EP3204520B1 (en) 2020-02-12
JP2021106608A (ja) 2021-07-29
JP7209762B2 (ja) 2023-01-20
US20190316187A1 (en) 2019-10-17
WO2016057832A2 (en) 2016-04-14
CN107002145A (zh) 2017-08-01
ES2784342T3 (es) 2020-09-24
EP3204520A2 (en) 2017-08-16
AU2015330844A1 (en) 2017-04-27
EP3690060B1 (en) 2021-12-08
DK3690060T3 (da) 2022-01-17
IL286496A (en) 2021-10-31
CN107002145B (zh) 2021-07-30
CA2963687A1 (en) 2016-04-14
JP2023040174A (ja) 2023-03-22
CA3187713A1 (en) 2016-04-14
IL296204A (en) 2022-11-01
BR112017007033A2 (pt) 2017-12-12
US10344321B2 (en) 2019-07-09
JP2017533697A (ja) 2017-11-16
AU2022200229A1 (en) 2022-02-10
US20180265917A1 (en) 2018-09-20
PT3204520T (pt) 2020-04-16
EP3204520A4 (en) 2018-03-07
CA2963687C (en) 2023-03-28
ES2904909T3 (es) 2022-04-06
WO2016057832A3 (en) 2016-06-16
IL251513B (en) 2021-10-31
IL296204B1 (en) 2024-04-01
EP4026914A1 (en) 2022-07-13
CN113481281A (zh) 2021-10-08
BR112017007033B1 (pt) 2023-10-31
SG11201702831XA (en) 2017-05-30
AU2015330844B2 (en) 2022-02-03
JP6871160B2 (ja) 2021-05-12
PT3690060T (pt) 2022-01-27
US11466311B2 (en) 2022-10-11
DK3204520T3 (da) 2020-04-20
IL251513A0 (en) 2017-05-29
EP3690060A1 (en) 2020-08-05

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