SG10201914098YA - Chromosomal landing pads and related uses - Google Patents
Chromosomal landing pads and related usesInfo
- Publication number
- SG10201914098YA SG10201914098YA SG10201914098YA SG10201914098YA SG10201914098YA SG 10201914098Y A SG10201914098Y A SG 10201914098YA SG 10201914098Y A SG10201914098Y A SG 10201914098YA SG 10201914098Y A SG10201914098Y A SG 10201914098YA SG 10201914098Y A SG10201914098Y A SG 10201914098YA
- Authority
- SG
- Singapore
- Prior art keywords
- chromosomal
- landing pads
- specific
- gene
- integration
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C12N15/68—Stabilisation of the vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
- C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/106—Plasmid DNA for vertebrates
- C12N2800/107—Plasmid DNA for vertebrates for mammalian
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Reproductive Health (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161516612P | 2011-04-05 | 2011-04-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201914098YA true SG10201914098YA (en) | 2020-02-27 |
Family
ID=46000358
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201602663RA SG10201602663RA (en) | 2011-04-05 | 2012-04-05 | Chromosomal landing pads and related uses |
| SG2013074778A SG194118A1 (en) | 2011-04-05 | 2012-04-05 | Chromosomal landing pads and related uses |
| SG10201914098YA SG10201914098YA (en) | 2011-04-05 | 2012-04-05 | Chromosomal landing pads and related uses |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201602663RA SG10201602663RA (en) | 2011-04-05 | 2012-04-05 | Chromosomal landing pads and related uses |
| SG2013074778A SG194118A1 (en) | 2011-04-05 | 2012-04-05 | Chromosomal landing pads and related uses |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8980579B2 (ja) |
| EP (1) | EP2694661A1 (ja) |
| JP (2) | JP2014511697A (ja) |
| KR (1) | KR101999410B1 (ja) |
| CN (2) | CN105969807A (ja) |
| AU (1) | AU2012240164A1 (ja) |
| CA (1) | CA2832095A1 (ja) |
| SG (3) | SG10201602663RA (ja) |
| WO (1) | WO2012138887A1 (ja) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2832095A1 (en) | 2011-04-05 | 2012-10-11 | The Scripps Research Institute | Chromosomal landing pads and related uses |
| AU2014281472A1 (en) * | 2013-06-19 | 2016-01-21 | Sigma-Aldrich Co. Llc. | Targeted integration |
| JP6668340B2 (ja) | 2014-10-23 | 2020-03-18 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 新規ｃｈｏ組込み部位およびその使用 |
| EP3283617B1 (en) * | 2015-04-13 | 2021-02-17 | President and Fellows of Harvard College | Production and monitoring of metabolites in cells |
| CL2016001661A1 (es) | 2016-06-29 | 2017-03-03 | Univ Chile | Promotor hibrido de ß-actina (de cricetulus griseus) y citomegalovirus (cmv), con región rica en dinucleótidos, citosina-guanina, vectores, líneas celulares, procedimiento para producir proteínas recombinantes. |
| WO2018148196A1 (en) * | 2017-02-07 | 2018-08-16 | Sigma-Aldrich Co. Llc | Stable targeted integration |
| EP3583121A1 (en) * | 2017-02-17 | 2019-12-25 | Lonza Ltd | Multi-site specific integration cells for difficult to express proteins |
| GB201703418D0 (en) | 2017-03-03 | 2017-04-19 | Ge Healthcare Bio Sciences Ab | Method for cell line development |
| WO2018195402A1 (en) | 2017-04-20 | 2018-10-25 | Egenesis, Inc. | Methods for generating genetically modified animals |
| WO2018213353A1 (en) * | 2017-05-16 | 2018-11-22 | Cairn Biosciences, Inc. | Multiplex assay |
| GB201712678D0 (en) * | 2017-08-07 | 2017-09-20 | Glaxosmithkline Biologicals Sa | Process for the manipulation of nucleic acids |
| EP3837371A2 (en) * | 2018-08-18 | 2021-06-23 | Cairn Biosciences, Inc. | Stem cell derived lineage barcoding |
| KR102655024B1 (ko) * | 2019-04-02 | 2024-04-04 | 추가이 세이야쿠 가부시키가이샤 | 표적 특이적인 외래 유전자의 도입 방법 |
| CA3136659C (en) * | 2019-04-18 | 2024-06-18 | Sigma-Aldrich Co. Llc | Stable targeted integration |
| CN114727592A (zh) * | 2019-10-09 | 2022-07-08 | 杰克逊实验室 | 高频率靶向动物转基因 |
| GB202019484D0 (en) * | 2020-12-10 | 2021-01-27 | Univ Edinburgh | CHO cell modification |
| CN118401659A (zh) | 2021-10-14 | 2024-07-26 | 阿西莫夫公司 | 整合酶、着陆架架构和包括其的工程化细胞 |
| IL312487A (en) | 2021-11-09 | 2024-07-01 | Asimov Inc | Stable production systems for adeno-associated virus vector production |
| CN113999873B (zh) * | 2021-12-31 | 2022-05-20 | 北京市疾病预防控制中心 | 一种基因修饰的非人动物的构建方法及其应用 |
| WO2024211287A1 (en) * | 2023-04-03 | 2024-10-10 | Seagen Inc. | Production cell lines with targeted integration sites |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5175385A (en) | 1987-09-03 | 1992-12-29 | Ohio University/Edison Animal Biotechnolgy Center | Virus-resistant transgenic mice |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| US20100168016A1 (en) * | 2007-04-11 | 2010-07-01 | The Jackson Laboratory | Diagnosis and treatment of diseases caused by misfolded proteins |
| CA2832095A1 (en) | 2011-04-05 | 2012-10-11 | The Scripps Research Institute | Chromosomal landing pads and related uses |
-
2012
- 2012-04-05 CA CA2832095A patent/CA2832095A1/en not_active Abandoned
- 2012-04-05 EP EP12716865.6A patent/EP2694661A1/en not_active Withdrawn
- 2012-04-05 CN CN201610291074.4A patent/CN105969807A/zh active Pending
- 2012-04-05 JP JP2014503993A patent/JP2014511697A/ja active Pending
- 2012-04-05 SG SG10201602663RA patent/SG10201602663RA/en unknown
- 2012-04-05 WO PCT/US2012/032362 patent/WO2012138887A1/en active Application Filing
- 2012-04-05 US US13/440,661 patent/US8980579B2/en active Active - Reinstated
- 2012-04-05 SG SG2013074778A patent/SG194118A1/en unknown
- 2012-04-05 SG SG10201914098YA patent/SG10201914098YA/en unknown
- 2012-04-05 CN CN201280025685.4A patent/CN103597083B/zh not_active Expired - Fee Related
- 2012-04-05 KR KR1020137028897A patent/KR101999410B1/ko active IP Right Grant
- 2012-04-05 AU AU2012240164A patent/AU2012240164A1/en not_active Abandoned
-
2015
- 2015-02-12 US US14/620,478 patent/US10017786B2/en active Active
-
2017
- 2017-08-24 JP JP2017161272A patent/JP6441425B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| SG194118A1 (en) | 2013-11-29 |
| CN105969807A (zh) | 2016-09-28 |
| SG10201602663RA (en) | 2016-05-30 |
| JP2014511697A (ja) | 2014-05-19 |
| US20120258541A1 (en) | 2012-10-11 |
| US8980579B2 (en) | 2015-03-17 |
| US20150152437A1 (en) | 2015-06-04 |
| CN103597083B (zh) | 2016-05-18 |
| JP2018011602A (ja) | 2018-01-25 |
| KR101999410B1 (ko) | 2019-07-11 |
| WO2012138887A1 (en) | 2012-10-11 |
| CA2832095A1 (en) | 2012-10-11 |
| US10017786B2 (en) | 2018-07-10 |
| EP2694661A1 (en) | 2014-02-12 |
| AU2012240164A1 (en) | 2013-11-14 |
| KR20140019430A (ko) | 2014-02-14 |
| JP6441425B2 (ja) | 2018-12-19 |
| CN103597083A (zh) | 2014-02-19 |
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