SG10201913789VA - Selection of pluripotent cells for production of fertile xy female mice - Google Patents

Selection of pluripotent cells for production of fertile xy female mice

Info

Publication number
SG10201913789VA
SG10201913789VA SG10201913789VA SG10201913789VA SG10201913789VA SG 10201913789V A SG10201913789V A SG 10201913789VA SG 10201913789V A SG10201913789V A SG 10201913789VA SG 10201913789V A SG10201913789V A SG 10201913789VA SG 10201913789V A SG10201913789V A SG 10201913789VA
Authority
SG
Singapore
Prior art keywords
fertile
selection
production
pluripotent cells
female mice
Prior art date
Application number
SG10201913789VA
Other languages
English (en)
Inventor
Jennifer Schmahl
David Frendewey
Junko Kuno
Chia-Jen Siao
Gustavo Droguett
Yu Bai
Wojtek Auerbach
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of SG10201913789VA publication Critical patent/SG10201913789VA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0271Chimeric vertebrates, e.g. comprising exogenous cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0603Embryonic cells ; Embryoid bodies
    • C12N5/0606Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073Stem cells
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00Modified animals
    • A01K2207/12Animals modified by administration of exogenous cells
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00Modified animals
    • A01K2207/35Animals modified by environmental factors, e.g. temperature, O2
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/105Murine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/02Animal zootechnically ameliorated
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/136Screening for pharmacological compounds
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Environmental Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SG10201913789VA 2015-09-17 2016-09-16 Selection of pluripotent cells for production of fertile xy female mice SG10201913789VA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562219927P 2015-09-17 2015-09-17

Publications (1)

Publication Number Publication Date
SG10201913789VA true SG10201913789VA (en) 2020-03-30

Family

ID=57113699

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10201913789VA SG10201913789VA (en) 2015-09-17 2016-09-16 Selection of pluripotent cells for production of fertile xy female mice

Country Status (12)

Country Link
US (2) US10893666B2 (https=)
EP (1) EP3349573B1 (https=)
JP (1) JP6868615B2 (https=)
KR (1) KR102382458B1 (https=)
CN (1) CN108697068B (https=)
AU (1) AU2016324305B2 (https=)
CA (1) CA2998642C (https=)
IL (1) IL257982B2 (https=)
MX (1) MX388475B (https=)
RU (1) RU2729407C1 (https=)
SG (1) SG10201913789VA (https=)
WO (1) WO2017049240A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX388475B (es) 2015-09-17 2025-03-20 Regeneron Pharma Selección de células pluripotentes para producir ratones hembra xy fértiles.
CN108998540A (zh) * 2018-08-18 2018-12-14 兰州大学 绵羊eif2s3y基因的单核苷酸多态性标记及其检测引物、试剂盒、方法及应用
CN110656167A (zh) * 2019-09-27 2020-01-07 中国科学院苏州生物医学工程技术研究所 用于y染色体微缺失检测的引物组、试剂盒及基于数字pcr的检测方法
CN111321232B (zh) * 2020-03-18 2022-08-16 西北农林科技大学 一种快速检测肉牛eif4a2基因拷贝数变异的方法及其应用
CN113558012A (zh) * 2021-08-05 2021-10-29 陈米米 一种哺乳动物繁育雌性多胎的方法
CN114015705A (zh) * 2021-11-28 2022-02-08 华中科技大学同济医学院附属协和医院 一种小鼠体外受精繁育性别选择方法
CN115251007B (zh) * 2022-09-02 2024-01-26 山西医科大学 一种新品系裸大鼠、其培育方法及应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2892997A (en) 1996-04-29 1997-11-19 Leuven Research & Development Vzw Pluripotent rabbit embryonic stem (es) cell lines and their use in the generation of chimeric rabbits
EP1067141A1 (en) 1999-06-11 2001-01-10 Rijksuniversiteit te Leiden A male-specific protein homologue involved in histocompatibility
WO2001032015A1 (en) 1999-11-02 2001-05-10 University Of Massachusetts, As Represented By Its Amherst Campus Use of haploid genomes for genetic diagnosis, modification and multiplication
CA2394812A1 (en) 1999-12-20 2001-06-28 Anthony C.F. Perry A method to produce cloned embryos and adults from cultured cells
CA2477112A1 (en) 2002-02-27 2003-09-04 Yasumitsu Nagao A method for producing germline chimeric animal
WO2003073843A2 (en) 2002-03-05 2003-09-12 Artemis Pharmaceuticals Gmbh Inbred embryonic stem-cell derived mice
EP1516924A1 (en) 2003-09-17 2005-03-23 Fundacion IVI para el Estudio de la reproduccion Humana (FIVIER) Generation of human embryonic stem cells from triploid zygotes
KR101178786B1 (ko) 2004-03-23 2012-09-07 다이이찌 산쿄 가부시키가이샤 다능성 줄기세포의 증식 방법
ES2463476T3 (es) 2004-10-19 2014-05-28 Regeneron Pharmaceuticals, Inc. Método para generar un ratón homocigótico para una modificación genética
MX2009001477A (es) 2006-08-09 2009-02-18 Vivalis Metodo de produccion de un aviar transgenico utilizando celulas progenitoras embrionicas.
GB0623635D0 (en) 2006-11-27 2007-01-03 Stem Cell Sciences Uk Ltd Pluripotent cell growth media
WO2009037337A1 (en) * 2007-09-20 2009-03-26 Novartis Ag Robust and tissue independent gender-specific transcript markers for molecular gender determination
CA2751596A1 (en) 2009-02-08 2010-08-12 The University Of Melbourne Sex-determination and methods of specifying same
JP5843775B2 (ja) 2009-10-13 2016-01-13 ステムセル テクノロジーズ インコーポレーティッド 幹細胞を分化させるための重量オスモル濃度の操作法
MY191870A (en) 2010-06-11 2022-07-18 Regeneron Pharma Production of fertile xy female animals from xy es cells
WO2012022634A1 (en) * 2010-08-16 2012-02-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Classification, diagnosis and prognosis of multiple myeloma
SI3161128T1 (sl) 2014-06-26 2019-02-28 Regeneron Pharmaceuticals, Inc. Postopki in sestavki za ciljano genetsko spremembo in postopki uporabe
BR112017007770A2 (pt) 2014-10-15 2018-01-16 Regeneron Pharma cultura in vitro, população de hipscs, método para modificar um locus-alvo genômico, e, hipsc.
MX388475B (es) 2015-09-17 2025-03-20 Regeneron Pharma Selección de células pluripotentes para producir ratones hembra xy fértiles.

Also Published As

Publication number Publication date
KR20180058731A (ko) 2018-06-01
AU2016324305A9 (en) 2019-01-03
AU2016324305A1 (en) 2018-04-12
US12041918B2 (en) 2024-07-23
HK1256687A1 (en) 2019-10-04
EP3349573A1 (en) 2018-07-25
KR102382458B1 (ko) 2022-04-04
MX2018003354A (es) 2018-05-28
IL257982A (en) 2018-05-31
RU2729407C1 (ru) 2020-08-06
CN108697068A (zh) 2018-10-23
EP3349573B1 (en) 2026-02-18
US20210112788A1 (en) 2021-04-22
NZ740899A (en) 2021-11-26
IL257982B2 (en) 2023-05-01
US20170079250A1 (en) 2017-03-23
MX388475B (es) 2025-03-20
WO2017049240A1 (en) 2017-03-23
AU2016324305B2 (en) 2022-03-03
JP6868615B2 (ja) 2021-05-12
CN108697068B (zh) 2022-02-11
CA2998642C (en) 2023-09-12
WO2017049240A8 (en) 2018-05-24
CA2998642A1 (en) 2017-03-23
IL257982B1 (en) 2023-01-01
US10893666B2 (en) 2021-01-19
JP2018527005A (ja) 2018-09-20

Similar Documents

Publication Publication Date Title
IL257982A (en) Selection of pluripotent cells for the production of fertile xy female mice
SG11201801549VA (en) Pluripotent stem cell production system
IL258538A (en) Early isolation after the infection of cells (epic) for the production of biological material
EP3234108A4 (en) Differentiation of pluripotent stem cells to form renal organoids
EP3256439A4 (en) Process for production of acrylic acid
SI3080304T1 (sl) Postopek za proizvodnjo sladkorjev iz biomase
SI3017050T1 (sl) Dvofazni fermentacijski proces za proizvodnjo izoprenoida
SG10201701964SA (en) Improved (Meth)Acrylic Acid Production Process
IL255145B (en) Biomass production of macroalgae
IL239702A0 (en) Production of hybrid seed collections using natural pollination
ZA201707136B (en) Method of production of gonadotrophin
GB2525950B (en) Process for the production of dialkyl succinate
GB2525949B (en) Process for the production of dialkyl succinate
IL247890A0 (en) Methods related to stem cells
GB201303491D0 (en) Culture of leukemia initiating cells
AP2016009357A0 (en) A process for production of soluble sugars from biomass
SG10201914018UA (en) Process of omega-hydroxyl fatty acid production
HUE073098T2 (hu) Madárembrió sejtek termelése
PL3285572T3 (pl) Sposób wytwarzania komórek produkujących insulinę
HUE039087T2 (hu) Extrakciós folyamat nagy biológiai aktivitással bíró hCG kinyerésére
SG11201705095VA (en) Process for the manufacture of solar cells
SG11201700908TA (en) Method for increasing the specific production rate of eukaryotic cells
HK1233679A1 (en) Methods relating to pluripotent cells
GB201413329D0 (en) Methods of obtaining islet cells
GB201420385D0 (en) In vitro production of expanded potential stem cells