SG10201811729PA - Membrane-penetrating peptides to enhance transfection and compositions and methods for using same - Google Patents
Membrane-penetrating peptides to enhance transfection and compositions and methods for using sameInfo
- Publication number
- SG10201811729PA SG10201811729PA SG10201811729PA SG10201811729PA SG10201811729PA SG 10201811729P A SG10201811729P A SG 10201811729PA SG 10201811729P A SG10201811729P A SG 10201811729PA SG 10201811729P A SG10201811729P A SG 10201811729PA SG 10201811729P A SG10201811729P A SG 10201811729PA
- Authority
- SG
- Singapore
- Prior art keywords
- cargo
- membrane
- compositions
- methods
- peptides
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 8
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 7
- 238000001890 transfection Methods 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- -1 cationic lipid Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
- A61K47/6455—Polycationic oligopeptides, polypeptides or polyamino acids, e.g. for complexing nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361915429P | 2013-12-12 | 2013-12-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201811729PA true SG10201811729PA (en) | 2019-02-27 |
Family
ID=52273587
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201811729PA SG10201811729PA (en) | 2013-12-12 | 2014-12-12 | Membrane-penetrating peptides to enhance transfection and compositions and methods for using same |
| SG11201604697TA SG11201604697TA (en) | 2013-12-12 | 2014-12-12 | Membrane-penetrating peptides to enhance transfection and compositions and methods for using same |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201604697TA SG11201604697TA (en) | 2013-12-12 | 2014-12-12 | Membrane-penetrating peptides to enhance transfection and compositions and methods for using same |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US9856496B2 (https=) |
| EP (2) | EP3079723B1 (https=) |
| JP (2) | JP6912887B2 (https=) |
| KR (1) | KR102532559B1 (https=) |
| CN (2) | CN106456793B (https=) |
| AU (2) | AU2014361806B2 (https=) |
| BR (1) | BR112016013516A8 (https=) |
| CA (1) | CA2933561A1 (https=) |
| ES (1) | ES2808866T3 (https=) |
| SG (2) | SG10201811729PA (https=) |
| WO (1) | WO2015089487A1 (https=) |
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| WO2013166339A1 (en) * | 2012-05-02 | 2013-11-07 | Life Technologies Corporation | High yield transient expression in mammalian cells using unique pairing of high density growth and transfection medium and expression enhancers |
| KR101996592B1 (ko) | 2012-06-15 | 2019-07-04 | 인텔 코포레이션 | 명확화 없는 비순차 load store 큐를 갖는 재정렬된 투기적 명령어 시퀀스들 |
| WO2013188705A2 (en) | 2012-06-15 | 2013-12-19 | Soft Machines, Inc. | A virtual load store queue having a dynamic dispatch window with a unified structure |
| TWI646422B (zh) | 2012-06-15 | 2019-01-01 | 英特爾股份有限公司 | 在處理器中之免消歧義失序載入／儲存佇列方法、微處理器、和非暫態性電腦可讀取儲存媒體 |
| CN104583956B (zh) | 2012-06-15 | 2019-01-04 | 英特尔公司 | 用于实现加载存储重新排序和优化的指令定义 |
| EP2862084A4 (en) | 2012-06-15 | 2016-11-30 | Soft Machines Inc | METHOD AND SYSTEM FOR IMPLEMENTING RECOVERY FROM A SPECULATIVE TRANSMISSION OF FAULT FORECASTS / ERRORS DUE TO THE CHANGE AND OPTIMIZATION OF MEMORY LOADS |
| EP2862062B1 (en) | 2012-06-15 | 2024-03-06 | Intel Corporation | A virtual load store queue having a dynamic dispatch window with a distributed structure |
| SG10201811729PA (en) | 2013-12-12 | 2019-02-27 | Life Technologies Corp | Membrane-penetrating peptides to enhance transfection and compositions and methods for using same |
| JP7199809B2 (ja) | 2015-02-13 | 2023-01-06 | ファクター バイオサイエンス インコーポレイテッド | 核酸製品及びその投与方法 |
| EP3322813A1 (en) | 2015-07-13 | 2018-05-23 | Life Technologies Corporation | System and method for improved transient protein expression in cho cells |
| CN108779074A (zh) * | 2016-03-01 | 2018-11-09 | 分子传递有限公司 | 植物病毒移动蛋白和其使用方法 |
| US10576167B2 (en) | 2016-08-17 | 2020-03-03 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| JP7216641B2 (ja) * | 2016-09-30 | 2023-02-01 | ライフ テクノロジーズ コーポレイション | レンチウイルス製造用無血清懸濁系 |
| EP3675826B1 (en) | 2017-08-31 | 2023-05-31 | Life Technologies Corporation | Cationic lipid compositions for tissue-specific delivery |
| CA3076199A1 (en) | 2017-09-19 | 2019-03-28 | Cannametrix, Llc | Cell-based assay for quantifying the potency and efficacy of cannabinoids and/or terpenoids, and methods of use thereof |
| MA52148A (fr) * | 2018-03-16 | 2021-01-20 | Sarepta Therapeutics Inc | Peptides chimères pour administration d'antisens |
| US20210388393A1 (en) * | 2018-10-12 | 2021-12-16 | Ann & Robert H. Lurie Children's Hospital of Chicago | Plga-peg/pei nanoparticles and methods of use |
| GB201821269D0 (en) | 2018-12-28 | 2019-02-13 | Nippon Shinyaku Co Ltd | Myostatin signal inhibitor |
| AU2020225632A1 (en) | 2019-02-22 | 2021-09-02 | Life Technologies Corporation | Suspension system for adeno associated virus production |
| KR102261371B1 (ko) * | 2019-04-01 | 2021-06-08 | 한양대학교 산학협력단 | CP2c 표적 펩티드 기반 항암제 |
| CN113874029B (zh) | 2019-04-01 | 2025-02-11 | 汉阳大学校产学协力团 | 基于cp2c靶向肽的抗癌剂 |
| BR112022002143A2 (pt) * | 2019-08-05 | 2022-04-19 | Polyplus Transfection | Composição adequada para transfectar uma molécula de ácido nucleico em uma célula, métodos para transfecção in vitro ou ex vivo de células vivas e para a produção e usos in vitro ou ex vivo da composição |
| KR102515464B1 (ko) * | 2020-04-29 | 2023-03-28 | 연세대학교 원주산학협력단 | 핵산 또는 유전자 형질감염 효율을 개선하는 세포독성 완화 막 투과 펩타이드 및 이의 용도 |
| US20260027179A1 (en) * | 2021-02-08 | 2026-01-29 | University Of British Columbia | Anti-synucleinopathy peptide and methods to treat neurodegenerative diseases |
| US20240285547A1 (en) | 2021-07-08 | 2024-08-29 | Nippon Shinyaku Co., Ltd. | Nephrotoxicity reducing agent |
| US20240285770A1 (en) | 2021-07-08 | 2024-08-29 | Nippon Shinyaku Co., Ltd. | Precipitation suppressing agent |
| CN118475355A (zh) | 2021-07-08 | 2024-08-09 | 日本新药株式会社 | 肾毒性减轻剂 |
| CN113563429A (zh) * | 2021-07-19 | 2021-10-29 | 天津大学 | 一种基于烷基化多肽的核酸递送系统及制备方法与应用 |
| WO2023014909A1 (en) * | 2021-08-04 | 2023-02-09 | AJK Biopharmaceutical, LLC | Amphiphilic peptides for nucleic acid and protein delivery |
| CN114106095B (zh) * | 2021-11-11 | 2023-06-09 | 华南理工大学 | 基于聚集诱导发光原理的细胞自噬检测分子探针及其制备方法和应用 |
| CN120129745A (zh) | 2022-03-10 | 2025-06-10 | 日本新药株式会社 | 抗病毒反义低聚物 |
| KR102717793B1 (ko) * | 2022-05-26 | 2024-10-16 | 주식회사 바이오셀트란 | 신규한 미백 펩타이드 및 이를 함유하는 화장료 조성물 |
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-
2014
- 2014-12-12 SG SG10201811729PA patent/SG10201811729PA/en unknown
- 2014-12-12 EP EP14821440.6A patent/EP3079723B1/en active Active
- 2014-12-12 CN CN201480074785.5A patent/CN106456793B/zh active Active
- 2014-12-12 EP EP20176262.2A patent/EP3756690A3/en active Pending
- 2014-12-12 SG SG11201604697TA patent/SG11201604697TA/en unknown
- 2014-12-12 ES ES14821440T patent/ES2808866T3/es active Active
- 2014-12-12 CA CA2933561A patent/CA2933561A1/en active Pending
- 2014-12-12 AU AU2014361806A patent/AU2014361806B2/en active Active
- 2014-12-12 CN CN202110386654.2A patent/CN113105559A/zh active Pending
- 2014-12-12 JP JP2016538724A patent/JP6912887B2/ja active Active
- 2014-12-12 BR BR112016013516A patent/BR112016013516A8/pt not_active Application Discontinuation
- 2014-12-12 US US14/569,583 patent/US9856496B2/en active Active
- 2014-12-12 WO PCT/US2014/070176 patent/WO2015089487A1/en not_active Ceased
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2017
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2019
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| SG11201604697TA (en) | 2016-07-28 |
| AU2014361806A1 (en) | 2016-07-28 |
| JP6985347B2 (ja) | 2021-12-22 |
| CN106456793B (zh) | 2021-04-30 |
| EP3756690A3 (en) | 2021-03-17 |
| BR112016013516A8 (pt) | 2020-05-19 |
| ES2808866T3 (es) | 2021-03-02 |
| KR20160103024A (ko) | 2016-08-31 |
| US20200392537A1 (en) | 2020-12-17 |
| US20150211021A1 (en) | 2015-07-30 |
| US9856496B2 (en) | 2018-01-02 |
| AU2014361806B2 (en) | 2019-12-19 |
| JP2017500856A (ja) | 2017-01-12 |
| AU2020202002B2 (en) | 2021-08-05 |
| CA2933561A1 (en) | 2015-06-18 |
| EP3756690A2 (en) | 2020-12-30 |
| EP3079723B1 (en) | 2020-05-27 |
| BR112016013516A2 (https=) | 2017-08-08 |
| KR102532559B1 (ko) | 2023-05-16 |
| JP6912887B2 (ja) | 2021-08-04 |
| AU2020202002A1 (en) | 2020-04-09 |
| US20250263751A1 (en) | 2025-08-21 |
| US12152248B2 (en) | 2024-11-26 |
| EP3079723A1 (en) | 2016-10-19 |
| US10760098B2 (en) | 2020-09-01 |
| CN113105559A (zh) | 2021-07-13 |
| WO2015089487A1 (en) | 2015-06-18 |
| US20180163231A1 (en) | 2018-06-14 |
| JP2020015747A (ja) | 2020-01-30 |
| CN106456793A (zh) | 2017-02-22 |
| US20250109412A1 (en) | 2025-04-03 |
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