SG10201800777PA - Methods of host cell modification - Google Patents
Methods of host cell modificationInfo
- Publication number
- SG10201800777PA SG10201800777PA SG10201800777PA SG10201800777PA SG10201800777PA SG 10201800777P A SG10201800777P A SG 10201800777PA SG 10201800777P A SG10201800777P A SG 10201800777PA SG 10201800777P A SG10201800777P A SG 10201800777PA SG 10201800777P A SG10201800777P A SG 10201800777PA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- host cell
- cell modification
- modification
- host
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/185—Escherichia
- C12R2001/19—Escherichia coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/40—Systems of functionally co-operating vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261713281P | 2012-10-12 | 2012-10-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201800777PA true SG10201800777PA (en) | 2018-02-27 |
Family
ID=49326691
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201502638YA SG11201502638YA (en) | 2012-10-12 | 2013-10-11 | Methods of host cell modification |
| SG10201800777PA SG10201800777PA (en) | 2012-10-12 | 2013-10-11 | Methods of host cell modification |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201502638YA SG11201502638YA (en) | 2012-10-12 | 2013-10-11 | Methods of host cell modification |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20150267207A1 (fr) |
| EP (2) | EP3527663B1 (fr) |
| JP (1) | JP6329554B2 (fr) |
| KR (1) | KR20150068998A (fr) |
| CN (2) | CN110423716A (fr) |
| AU (1) | AU2013328615B2 (fr) |
| BR (1) | BR112015008052A2 (fr) |
| CA (1) | CA2887133C (fr) |
| EA (1) | EA201590488A1 (fr) |
| ES (2) | ES2905107T3 (fr) |
| IL (1) | IL238024A0 (fr) |
| MX (1) | MX365435B (fr) |
| SG (2) | SG11201502638YA (fr) |
| TR (1) | TR201904022T4 (fr) |
| WO (1) | WO2014057109A1 (fr) |
| ZA (1) | ZA201502433B (fr) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3125293A1 (fr) | 2012-11-07 | 2014-05-15 | Glaxosmithkline Biologicals Sa | Production d'un vaccin recombinant dans e. coli par conjugaison enzymatique |
| US9849169B2 (en) | 2013-01-17 | 2017-12-26 | Arsanis Biosciences Gmbh | MDR E. coli specific antibody |
| SG10201707565WA (en) * | 2013-03-14 | 2017-10-30 | Glycobia Inc | Oligosaccharide compositions, glycoproteins and methods to produce the same in prokaryotes |
| MX371513B (es) | 2013-10-11 | 2020-01-31 | Glaxosmithkline Biologicals Sa | Metodos de modificacion de celulas huespedes. |
| FI3110441T3 (fi) | 2014-02-24 | 2024-05-06 | Glaxosmithkline Biologicals Sa | Uusi polysakkaridi ja sen käyttöjä |
| CN106794237B (zh) * | 2014-04-17 | 2022-04-12 | 葛兰素史密丝克莱恩生物有限公司 | 经修饰的宿主细胞及其用途 |
| US11071289B2 (en) * | 2014-08-14 | 2021-07-27 | Biocytogen Boston Corp | DNA knock-in system |
| AU2016224006B8 (en) | 2015-02-26 | 2020-03-19 | Vaxnewmo Llc | Acinetobacter O-oligosaccharyltransferases and uses thereof |
| TWI715617B (zh) | 2015-08-24 | 2021-01-11 | 比利時商葛蘭素史密斯克藍生物品公司 | 對抗腸道外病原性大腸桿菌之免疫保護之方法及組合物 |
| GB201518668D0 (en) | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Immunogenic Comosition |
| GB201610599D0 (en) | 2016-06-17 | 2016-08-03 | Glaxosmithkline Biologicals Sa | Immunogenic Composition |
| AR109621A1 (es) | 2016-10-24 | 2018-12-26 | Janssen Pharmaceuticals Inc | Formulaciones de vacunas contra glucoconjugados de expec |
| CN106801029B (zh) * | 2017-01-22 | 2020-05-01 | 山东大学 | 一株重组大肠杆菌及其在制备抗志贺氏菌的糖疫苗中的应用 |
| CN109385417A (zh) * | 2017-08-03 | 2019-02-26 | 华东理工大学 | 体内dna无缝组装方法 |
| GB201712678D0 (en) | 2017-08-07 | 2017-09-20 | Glaxosmithkline Biologicals Sa | Process for the manipulation of nucleic acids |
| GB201721582D0 (en) | 2017-12-21 | 2018-02-07 | Glaxosmithkline Biologicals Sa | S aureus antigens and immunogenic compositions |
| GB201721576D0 (en) | 2017-12-21 | 2018-02-07 | Glaxosmithkline Biologicals Sa | Hla antigens and glycoconjugates thereof |
| CA3103474A1 (fr) | 2018-06-16 | 2019-12-19 | Vaxnewmo Llc | Variants de piline comp glycosyles, leurs procedes de fabrication et leurs utilisations |
| US11260119B2 (en) | 2018-08-24 | 2022-03-01 | Pfizer Inc. | Escherichia coli compositions and methods thereof |
| WO2020092704A1 (fr) * | 2018-10-31 | 2020-05-07 | Zymergen Inc. | Ensemble déterministe multiplexé de bibliothèques d'adn |
| AU2020240075A1 (en) | 2019-03-18 | 2021-10-14 | Janssen Pharmaceuticals, Inc. | Methods of producing bioconjugates of e. coli o-antigen polysaccharides, compositions thereof, and methods of use thereof |
| WO2020191082A1 (fr) | 2019-03-18 | 2020-09-24 | Janssen Pharmaceuticals, Inc. | Bioconjugués d'antigènes polysaccharidiques o d'e. coli, procédés de production de ces derniers, et méthodes d'utilisation de ces derniers |
| EP3770269A1 (fr) | 2019-07-23 | 2021-01-27 | GlaxoSmithKline Biologicals S.A. | Quantification de glycosylation de bioconjugués |
| MX2022001606A (es) | 2019-08-09 | 2022-03-11 | Glaxosmithkline Biologicals Sa | Enzimas de oligosacariltransferasa pglb mutada. |
| EP4168040A1 (fr) * | 2020-06-18 | 2023-04-26 | GlaxoSmithKline Biologicals S.A. | Bioconjugué de shigella tétravalente (shigella4v) |
| WO2021259742A1 (fr) | 2020-06-25 | 2021-12-30 | Glaxosmithkline Biologicals Sa | Protéines d'exotoxine a modifiées |
| AU2021342797B2 (en) | 2020-09-17 | 2024-02-08 | Janssen Pharmaceuticals, Inc. | Multivalent vaccine compositions and uses thereof |
| JP2022099419A (ja) * | 2020-12-23 | 2022-07-05 | トヨタ自動車株式会社 | 形質転換用プラスミド及びこれを用いた形質転換体の製造方法、並びに形質転換方法 |
| EP4291673A2 (fr) | 2021-02-11 | 2023-12-20 | GlaxoSmithKline Biologicals SA | Protéine |
| JP2024513914A (ja) | 2021-04-08 | 2024-03-27 | ヤンセン ファーマシューティカルズ，インコーポレーテッド | バイオコンジュゲート生産のためのプロセス |
| CN113528410A (zh) * | 2021-06-23 | 2021-10-22 | 云舟生物科技（广州）有限公司 | 一种用于快速高效诱导表达外源蛋白的大肠杆菌工程菌及其制备方法与应用 |
| WO2023118033A1 (fr) | 2021-12-22 | 2023-06-29 | Glaxosmithkline Biologicals Sa | Vaccin |
| GB202302579D0 (en) | 2023-02-23 | 2023-04-12 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| JP2024139548A (ja) * | 2023-03-27 | 2024-10-09 | 株式会社豊田中央研究所 | 遺伝子発現方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| MX198456B (es) * | 1994-03-09 | 2000-09-05 | Abbott Lab | Animales trangenicos que producen oligosacaridos y glucoconjugados. |
| US6596541B2 (en) * | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| EP1364007A1 (fr) * | 2000-11-07 | 2003-11-26 | Wilfried A. Jefferies | Nouveaux elements circulaires d'adn extra-chromosomique |
| US7126039B2 (en) * | 2001-03-21 | 2006-10-24 | Geron Corporation | Animal tissue with carbohydrate antigens compatible for human transplantation |
| US7674621B2 (en) * | 2004-05-21 | 2010-03-09 | The United States Of America As Represented By The Department Of Health And Human Services | Plasmids and phages for homologous recombination and methods of use |
| WO2006130925A1 (fr) * | 2005-06-10 | 2006-12-14 | Monash University | Manipulation genetique de clostridium difficile |
| ES2388556T3 (es) | 2006-03-23 | 2012-10-16 | Novartis Ag | Compuestos inmunopotenciadores |
| EP2357184B1 (fr) | 2006-03-23 | 2015-02-25 | Novartis AG | Composés d'imidazoquinoxaline en tant qu'immunomodulateurs |
| SG10201400320TA (en) * | 2008-02-20 | 2014-05-29 | Glycovaxyn Ag | Bioconjugates made from recombinant n-glycosylated proteins from procaryotic cells |
| HUE037956T2 (hu) | 2010-05-06 | 2018-09-28 | Glaxosmithkline Biologicals Sa | Kapszuláris Gram-pozitív bakteriális biokonjugátum vakcinák |
-
2013
- 2013-10-11 ES ES19150645T patent/ES2905107T3/es active Active
- 2013-10-11 CA CA2887133A patent/CA2887133C/fr active Active
- 2013-10-11 TR TR2019/04022T patent/TR201904022T4/tr unknown
- 2013-10-11 KR KR1020157012449A patent/KR20150068998A/ko not_active Application Discontinuation
- 2013-10-11 US US14/434,945 patent/US20150267207A1/en not_active Abandoned
- 2013-10-11 WO PCT/EP2013/071328 patent/WO2014057109A1/fr active Application Filing
- 2013-10-11 EP EP19150645.0A patent/EP3527663B1/fr active Active
- 2013-10-11 CN CN201811620603.6A patent/CN110423716A/zh active Pending
- 2013-10-11 SG SG11201502638YA patent/SG11201502638YA/en unknown
- 2013-10-11 CN CN201380065287.XA patent/CN104837984A/zh active Pending
- 2013-10-11 JP JP2015536160A patent/JP6329554B2/ja active Active
- 2013-10-11 EA EA201590488A patent/EA201590488A1/ru unknown
- 2013-10-11 BR BR112015008052A patent/BR112015008052A2/pt not_active Application Discontinuation
- 2013-10-11 MX MX2015004649A patent/MX365435B/es active IP Right Grant
- 2013-10-11 SG SG10201800777PA patent/SG10201800777PA/en unknown
- 2013-10-11 ES ES13774455T patent/ES2720040T3/es active Active
- 2013-10-11 EP EP13774455.3A patent/EP2906681B1/fr active Active
- 2013-10-11 AU AU2013328615A patent/AU2013328615B2/en not_active Expired - Fee Related
-
2015
- 2015-03-30 IL IL238024A patent/IL238024A0/en unknown
- 2015-04-10 ZA ZA2015/02433A patent/ZA201502433B/en unknown
-
2019
- 2019-03-13 US US16/352,462 patent/US20190218561A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX365435B (es) | 2019-06-03 |
| EA201590488A1 (ru) | 2015-09-30 |
| SG11201502638YA (en) | 2015-05-28 |
| AU2013328615A1 (en) | 2015-04-30 |
| ZA201502433B (en) | 2017-11-29 |
| ES2905107T3 (es) | 2022-04-07 |
| EP3527663B1 (fr) | 2021-12-01 |
| CA2887133A1 (fr) | 2014-04-17 |
| EP2906681B1 (fr) | 2019-01-09 |
| MX2015004649A (es) | 2016-01-12 |
| WO2014057109A1 (fr) | 2014-04-17 |
| JP2015533497A (ja) | 2015-11-26 |
| TR201904022T4 (tr) | 2019-04-22 |
| CN110423716A (zh) | 2019-11-08 |
| AU2013328615B2 (en) | 2017-04-20 |
| US20190218561A1 (en) | 2019-07-18 |
| CA2887133C (fr) | 2022-05-03 |
| EP2906681A1 (fr) | 2015-08-19 |
| BR112015008052A2 (pt) | 2017-11-28 |
| JP6329554B2 (ja) | 2018-05-23 |
| KR20150068998A (ko) | 2015-06-22 |
| EP3527663A1 (fr) | 2019-08-21 |
| ES2720040T3 (es) | 2019-07-17 |
| US20150267207A1 (en) | 2015-09-24 |
| CN104837984A (zh) | 2015-08-12 |
| IL238024A0 (en) | 2015-05-31 |
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