SG10201607689PA - Histidine engineered light chain antibodies and genetically modified non-human animals for generating the same - Google Patents
Histidine engineered light chain antibodies and genetically modified non-human animals for generating the sameInfo
- Publication number
- SG10201607689PA SG10201607689PA SG10201607689PA SG10201607689PA SG10201607689PA SG 10201607689P A SG10201607689P A SG 10201607689PA SG 10201607689P A SG10201607689P A SG 10201607689PA SG 10201607689P A SG10201607689P A SG 10201607689PA SG 10201607689P A SG10201607689P A SG 10201607689PA
- Authority
- SG
- Singapore
- Prior art keywords
- generating
- light chain
- same
- genetically modified
- chain antibodies
- Prior art date
Links
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/20—Pseudochromosomes, minichrosomosomes
- C12N2800/204—Pseudochromosomes, minichrosomosomes of bacterial origin, e.g. BAC
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Environmental Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261611950P | 2012-03-16 | 2012-03-16 | |
US201261736930P | 2012-12-13 | 2012-12-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201607689PA true SG10201607689PA (en) | 2016-10-28 |
Family
ID=48045078
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201607689PA SG10201607689PA (en) | 2012-03-16 | 2013-03-15 | Histidine engineered light chain antibodies and genetically modified non-human animals for generating the same |
SG11201405165UA SG11201405165UA (en) | 2012-03-16 | 2013-03-15 | Histidine engineered light chain antibodies and genetically modified non-human animals for generating the same |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201405165UA SG11201405165UA (en) | 2012-03-16 | 2013-03-15 | Histidine engineered light chain antibodies and genetically modified non-human animals for generating the same |
Country Status (26)
Country | Link |
---|---|
US (3) | US9334334B2 (fr) |
EP (4) | EP3808175A1 (fr) |
JP (5) | JP6185978B2 (fr) |
KR (1) | KR102228296B1 (fr) |
CN (3) | CN107840890A (fr) |
AU (3) | AU2013204579B2 (fr) |
BR (1) | BR112014022850A2 (fr) |
CA (1) | CA2865643A1 (fr) |
CY (2) | CY1120599T1 (fr) |
DK (2) | DK2825036T3 (fr) |
ES (3) | ES2849349T3 (fr) |
HK (2) | HK1200273A1 (fr) |
HR (2) | HRP20180682T1 (fr) |
HU (3) | HUE037659T2 (fr) |
IL (5) | IL234355B (fr) |
LT (3) | LT3348140T (fr) |
MX (1) | MX355732B (fr) |
MY (1) | MY172730A (fr) |
NZ (1) | NZ629639A (fr) |
PL (2) | PL2825036T3 (fr) |
PT (3) | PT3348140T (fr) |
RS (2) | RS57118B1 (fr) |
RU (2) | RU2017135754A (fr) |
SG (2) | SG10201607689PA (fr) |
SI (3) | SI3348140T1 (fr) |
WO (1) | WO2013138680A1 (fr) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11046784B2 (en) | 2006-03-31 | 2021-06-29 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
MX369784B (es) | 2007-09-26 | 2019-11-21 | Chugai Pharmaceutical Co Ltd | Metodo de modificacion del punto isoelectrico de anticuerpos mediante la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr). |
CN107551270A (zh) | 2008-04-11 | 2018-01-09 | 中外制药株式会社 | 与多个分子的抗原反复结合的抗原结合分子 |
RU2658504C9 (ru) | 2010-11-30 | 2018-08-21 | Чугаи Сейяку Кабусики Кайся | Антигенсвязывающая молекула, способная многократно связываться с множеством антигенных молекул |
KR20230005405A (ko) | 2011-02-25 | 2023-01-09 | 추가이 세이야쿠 가부시키가이샤 | FcγRIIb 특이적 Fc 항체 |
EP2762493B1 (fr) | 2011-09-30 | 2021-06-09 | Chugai Seiyaku Kabushiki Kaisha | Molécule se liant à l'antigène favorisant la disparition des antigènes ayant une pluralité d'activités biologiques |
LT3216871T (lt) | 2011-10-17 | 2022-03-25 | Regeneron Pharmaceuticals, Inc. | Pelės, turinčios apribotą imunoglobulino sunkiąją grandinę |
RU2739792C1 (ru) | 2011-11-30 | 2020-12-28 | Чугаи Сейяку Кабусики Кайся | Содержащий лекарственное средство переносчик в клетку для формирования иммунного комплекса |
US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
CA2865645A1 (fr) | 2012-03-16 | 2013-09-19 | Regeneron Pharmaceuticals, Inc. | Animaux non humains exprimant des sequences d'immunoglobuline sensibles au ph pour le batiment de l'antigene |
EP2858487B1 (fr) | 2012-06-12 | 2019-10-23 | Regeneron Pharmaceuticals, Inc. | Animaux non humains humanisés avec locus limités de chaîne lourde d'immunoglobuline |
EP3597747B1 (fr) | 2012-08-24 | 2023-03-15 | Chugai Seiyaku Kabushiki Kaisha | Anticorps fc spécifiques fcgammarii de souris |
KR20210084688A (ko) | 2012-08-24 | 2021-07-07 | 추가이 세이야쿠 가부시키가이샤 | FcγRIIb 특이적 Fc영역 개변체 |
ES2876009T3 (es) | 2012-12-27 | 2021-11-11 | Chugai Pharmaceutical Co Ltd | Polipéptido heterodimerizado |
HUE039214T2 (hu) | 2013-02-20 | 2018-12-28 | Regeneron Pharma | Módosított szekvenciájú immunglobulin-nehézlánccal rendelkezõ, nem humán élõlények |
WO2014163101A1 (fr) | 2013-04-02 | 2014-10-09 | 中外製薬株式会社 | Variant de région fc |
SG11201508911PA (en) | 2013-04-29 | 2015-11-27 | Hoffmann La Roche | Human fcrn-binding modified antibodies and methods of use |
MX2016008782A (es) | 2014-01-15 | 2016-09-08 | Hoffmann La Roche | Variantes de region fc con union mejorada de la proteina a. |
TWI681969B (zh) * | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對pd-1的人類抗體 |
TWI680138B (zh) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗pd-l1之人類抗體 |
US10183994B2 (en) | 2014-06-30 | 2019-01-22 | Merck Patent Gmbh | Anti-TNFα antibodies with pH-dependent antigen binding for improved target clearence |
TW201809008A (zh) * | 2014-12-19 | 2018-03-16 | 日商中外製藥股份有限公司 | 抗c5抗體及使用方法 |
TWI808330B (zh) | 2014-12-19 | 2023-07-11 | 日商中外製藥股份有限公司 | 抗肌抑素之抗體、含變異Fc區域之多胜肽及使用方法 |
EP3247723A1 (fr) * | 2015-01-22 | 2017-11-29 | Chugai Seiyaku Kabushiki Kaisha | Combinaison de deux anticorps anti-c5 ou plus et ses procédés d'utilisation |
SG10201907215QA (en) | 2015-02-05 | 2019-09-27 | Chugai Pharmaceutical Co Ltd | Antibodies Comprising An Ion Concentration Dependent Antigen-Binding Domain, Fc Region Variants, Il-8-Binding Antibodies, And Uses Therof |
CN107438622A (zh) | 2015-03-19 | 2017-12-05 | 瑞泽恩制药公司 | 选择结合抗原的轻链可变区的非人动物 |
EP3302553A4 (fr) * | 2015-05-28 | 2019-03-06 | Bio-rad Laboratories, Inc. | Ligands d'affinité et procédés associés |
RU2742606C2 (ru) * | 2015-12-18 | 2021-02-09 | Чугаи Сейяку Кабусики Кайся | Антитела к с5 и способы их применения |
SG10201707267RA (en) * | 2015-12-18 | 2017-10-30 | Chugai Pharmaceutical Co Ltd | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use |
JP7141336B2 (ja) | 2015-12-25 | 2022-09-22 | 中外製薬株式会社 | 抗ミオスタチン抗体および使用方法 |
EP3457840B1 (fr) | 2016-05-20 | 2024-04-10 | Regeneron Pharmaceuticals, Inc. | Procédés pour briser la tolérance immunologique à l'aide de multiples arn de guidage |
WO2017210586A1 (fr) | 2016-06-03 | 2017-12-07 | Regeneron Pharmaceuticals, Inc. | Animaux non humains exprimant la désoxynucléotidyltransférase terminale exogène |
SG11201801024XA (en) | 2016-08-05 | 2018-05-30 | Chugai Pharmaceutical Co Ltd | Therapeutic or preventive compositions for il-8-related diseases |
GB201707484D0 (en) * | 2017-05-10 | 2017-06-21 | Argenx Bvba | Method of preparing ph-dependent antibodies |
BR112020018235A2 (pt) * | 2018-03-14 | 2020-12-29 | F. Hoffmann-La Roche Ag | Métodos para gerar uma biblioteca de polinucleotídeos, bibliotecas de polinucleotídeos, uso de uma biblioteca, método para gerar uma biblioteca de anticorpos e método de seleção de um anticorpo |
CN116514959A (zh) * | 2018-03-24 | 2023-08-01 | 瑞泽恩制药公司 | 用于产生针对肽-mhc复合物的治疗性抗体的经过基因修饰的非人动物、其制造方法和用途 |
JP7328243B2 (ja) | 2018-03-26 | 2023-08-16 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 治療薬を試験するためのヒト化げっ歯類 |
PL3629720T3 (pl) | 2018-06-14 | 2022-05-02 | Regeneron Pharmaceuticals, Inc. | Zwierzęta inne niż człowiek zdolne do rearanżacji dh-dh w sekwencjach kodujących łańcucha ciężkiego immunoglobuliny |
JP6935383B2 (ja) * | 2018-09-27 | 2021-09-15 | 公益財団法人実験動物中央研究所 | 免疫不全マウス |
CN113825614B (zh) | 2019-04-04 | 2023-12-01 | 日精Asb机械株式会社 | 树脂容器的制造方法、注塑芯模具、注塑模具及树脂容器的制造设备 |
BR112021023683A2 (pt) | 2019-06-05 | 2022-02-01 | Regeneron Pharma | Roedor e camundongo geneticamente modificado, embrião de roedor, célula b do roedor ou camundongo geneticamente modificado, hibridoma, população de células b, célula-tronco embrionária, célula de mamífero, métodos de produção de um anticorpo, de uma cadeia pesada, de um domínio variável, de uma coleção de domínios variáveis, de uma cadeia leve, de uma sequência nucleotídica, de um roedor geneticamente modificado e de células es, de geração de um domínio variável e in vitro para gerar uma célula recombinante de roedor, e, vetor de direcionamento |
CN114761428A (zh) * | 2019-10-28 | 2022-07-15 | 瑞泽恩制药公司 | 抗血凝素抗体及其使用方法 |
TW202221034A (zh) * | 2020-08-04 | 2022-06-01 | 美商西根公司 | 抗cd228抗體和抗體-藥物共軛體 |
IL300975A (en) | 2020-09-03 | 2023-04-01 | Regeneron Pharma | Methods for treating cancer pain by administering a PD-1 inhibitor |
WO2022056276A1 (fr) | 2020-09-11 | 2022-03-17 | Regeneron Pharmaceuticals, Inc. | Identification et production d'anticorps spécifiques à un antigène |
US20240065239A1 (en) | 2020-12-16 | 2024-02-29 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
EP4051700A1 (fr) | 2020-12-23 | 2022-09-07 | Regeneron Pharmaceuticals, Inc. | Acides nucléiques codant pour des anticorps modifiés par ancrage et leurs utilisations |
Family Cites Families (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
WO1991012023A2 (fr) | 1990-02-16 | 1991-08-22 | Boston Biomedical Research Institute | Reactifs hybrides pouvant liberer des molecules de maniere selective dans des cellules |
US7041871B1 (en) | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
DE69133476T2 (de) * | 1990-08-29 | 2006-01-05 | GenPharm International, Inc., Palo Alto | Transgene Mäuse fähig zur Produktion heterologer Antikörper |
US5545806A (en) * | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
US5667988A (en) | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
US7067284B1 (en) | 1992-01-27 | 2006-06-27 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
NZ255101A (en) | 1992-07-24 | 1997-08-22 | Cell Genesys Inc | A yeast artificial chromosome (yac) vector containing an hprt minigene expressible in murine stem cells and genetically modified rodent therefor |
US5999908A (en) | 1992-08-06 | 1999-12-07 | Abelow; Daniel H. | Customer-based product design module |
WO1996034096A1 (fr) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Anticorps humains derives de xeno-souris immunisees |
ATE352613T1 (de) | 1995-08-29 | 2007-02-15 | Kirin Brewery | Chimäres tier und methode zu dessen herstellung |
JP3876002B2 (ja) | 1997-04-14 | 2007-01-31 | ミクロメート・アクチエンゲゼルシャフト | 抗ヒト抗原受容体を産生するための斬新な方法およびそれらの使用 |
ATE299938T1 (de) | 1997-05-02 | 2005-08-15 | Genentech Inc | Ein verfahren zur herstellung multispezifischer antikörper die heteromultimere und gemeinsame komponenten besitzen |
US20020062010A1 (en) | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
AU750453B2 (en) | 1997-10-03 | 2002-07-18 | Chugai Seiyaku Kabushiki Kaisha | Natural human antibody |
GB9823930D0 (en) | 1998-11-03 | 1998-12-30 | Babraham Inst | Murine expression of human ig\ locus |
MXPA03002046A (es) | 2000-09-08 | 2003-07-24 | Massachusetts Inst Technology | Composiciones analogos de factor estimulador de colonias de granulocitos y metodos para su elaboracion. |
US6596541B2 (en) * | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US20060199204A1 (en) | 2001-10-05 | 2006-09-07 | U.S. Epa | Genetic testing for male factor infertility |
US20030108925A1 (en) | 2001-10-05 | 2003-06-12 | U.S. Epa | Genetic testing for male factor infertility |
CA2468565C (fr) | 2001-11-30 | 2014-06-03 | Abgenix, Inc. | Animaux transgeniques porteurs de genes a chaine legere iglamba d'immunoglobuline humaine |
CA2488836A1 (fr) | 2002-06-12 | 2003-12-24 | Genencor International, Inc. | Methodes et compositions de liaison dependant du milieu d'un agent cible a une cible |
DE60326839D1 (de) | 2002-06-12 | 2009-05-07 | Genencor Int | Verfahren zur verbesserung einer bindungseigenschaft eines moleküls |
PT2314629E (pt) | 2002-07-18 | 2014-01-22 | Merus B V | Produção recombinante de misturas de anticorpos |
EP1439234A1 (fr) | 2003-01-08 | 2004-07-21 | ARTEMIS Pharmaceuticals GmbH | Transgénèse ciblée utilisant le locus 26 |
US8337841B2 (en) | 2003-01-21 | 2012-12-25 | Chugai Seiyaku Kabushiki Kaisha | Methods of screening for antibody light chains |
US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
EP2395017A3 (fr) | 2003-05-30 | 2012-12-19 | Merus B.V. | Conception et utilisation de régions variables appariées de molécules de liaison spécifiques |
EP1644417B1 (fr) | 2003-07-15 | 2014-04-30 | Therapeutic Human Polyclonals, Inc. | Locus d'immunoglobuline humanises |
CN1560081A (zh) | 2004-02-17 | 2005-01-05 | 大连帝恩生物工程有限公司 | 用能产生人IgGl重链-κ轻链小鼠作为制备人源化单克隆抗体和应用 |
AU2005227326B2 (en) | 2004-03-24 | 2009-12-03 | Xencor, Inc. | Immunoglobulin variants outside the Fc region |
US20050260711A1 (en) | 2004-03-30 | 2005-11-24 | Deepshikha Datta | Modulating pH-sensitive binding using non-natural amino acids |
US7294754B2 (en) | 2004-10-19 | 2007-11-13 | Regeneron Pharmaceuticals, Inc. | Method for generating an animal homozygous for a genetic modification |
US7585504B2 (en) | 2004-10-22 | 2009-09-08 | Medimmune, Llc | High affinity antibodies against HMGB1 and methods of use thereof |
AU2006242854A1 (en) | 2005-04-29 | 2006-11-09 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Transgenic animals and methods of making recombinant antibodies |
AU2006322445B2 (en) | 2005-12-05 | 2011-05-12 | Symphogen A/S | Anti-orthopoxvirus recombinant polyclonal antibody |
JP5514539B2 (ja) | 2006-03-31 | 2014-06-04 | メダレックス・リミテッド・ライアビリティ・カンパニー | ヒト抗体の調製に用いるためのキメラ抗体を発現するトランスジェニック動物 |
EP2374818B1 (fr) | 2006-06-02 | 2012-12-19 | Regeneron Pharmaceuticals, Inc. | Anticorps haute affinité du récepteur IL-6 humain |
CA2664343C (fr) | 2006-10-02 | 2016-04-26 | Regeneron Pharmaceuticals, Inc. | Anticorps humains a haute affinite vis-a-vis du recepteur il-4 humain |
US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
US20100034194A1 (en) | 2006-10-11 | 2010-02-11 | Siemens Communications Inc. | Eliminating unreachable subscribers in voice-over-ip networks |
RU2448979C2 (ru) | 2006-12-14 | 2012-04-27 | Ридженерон Фармасьютикалз, Инк. | Антитела человека к дельта-подобному лиганду-4 человека |
CN101688228B (zh) | 2007-03-13 | 2014-12-24 | 国家犾太健康中心 | 抗体产生的方法 |
ITMI20071522A1 (it) | 2007-07-27 | 2009-01-28 | Areta Internat S R L | Vaccino idiotipico |
EP3124497B1 (fr) | 2007-09-14 | 2020-04-15 | Adimab, LLC | Bibliothèques d'anticorps synthétiques conçus de façon rationnelle et leurs utilisations |
MX369784B (es) | 2007-09-26 | 2019-11-21 | Chugai Pharmaceutical Co Ltd | Metodo de modificacion del punto isoelectrico de anticuerpos mediante la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr). |
JP5591712B2 (ja) | 2007-12-14 | 2014-09-17 | ノボ・ノルデイスク・エー/エス | ヒトnkg2dに対する抗体とその使用 |
CN107551270A (zh) | 2008-04-11 | 2018-01-09 | 中外制药株式会社 | 与多个分子的抗原反复结合的抗原结合分子 |
MX2010011717A (es) * | 2008-05-01 | 2010-11-30 | Amgen Inc | Anticuerpos anti-hepcidina y metodos de uso. |
CA2729095C (fr) | 2008-06-27 | 2018-12-04 | Merus B.V. | Methode de production d'un mammifere murin transgenique |
TWI516501B (zh) | 2008-09-12 | 2016-01-11 | 禮納特神經系統科學公司 | Pcsk9拮抗劑類 |
TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
DK2346994T3 (da) | 2008-09-30 | 2022-02-28 | Ablexis Llc | Knock-in-mus til fremstilling af kimære antistoffer |
JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
MX2011007660A (es) | 2008-12-18 | 2011-08-17 | Kingdon Craig R | Animales transgenicos no humanos que expresan anticuerpos humanizados y usos de los mismos. |
US8808136B2 (en) | 2009-05-07 | 2014-08-19 | Volvo Construction Equipment Ab | Working machine and a method for operating a working machine |
KR101805202B1 (ko) | 2009-05-29 | 2017-12-07 | 모르포시스 아게 | 집합 및 집합의 사용 방법 |
KR101747103B1 (ko) | 2009-06-26 | 2017-06-14 | 리제너론 파마슈티칼스 인코포레이티드 | 천연 면역글로불린 포맷을 가지는 용이하게 분리된 이중특이성 항체 |
WO2011158009A1 (fr) | 2010-06-17 | 2011-12-22 | Kymab Limited | Modèles animaux et molécules thérapeutiques |
DK2517557T4 (da) | 2009-07-08 | 2023-09-25 | Kymab Ltd | Dyremodeller og terapeutiske molekyler |
US20120204278A1 (en) | 2009-07-08 | 2012-08-09 | Kymab Limited | Animal models and therapeutic molecules |
US10106810B2 (en) | 2009-07-16 | 2018-10-23 | Wageningen Universiteit | Regulation of zinc deficiency and tolerance in plants |
GB2472108B (en) | 2009-08-27 | 2011-07-13 | Budha Singh Dhinjan | Wall bead |
ES2595376T3 (es) | 2009-12-10 | 2016-12-29 | Regeneron Pharmaceuticals, Inc. | Ratones que producen anticuerpos de cadena pesada |
HUE029785T2 (en) | 2010-02-08 | 2017-04-28 | Regeneron Pharma | Common mouse light chain |
US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
US20130185821A1 (en) | 2010-02-08 | 2013-07-18 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
US20120021409A1 (en) | 2010-02-08 | 2012-01-26 | Regeneron Pharmaceuticals, Inc. | Common Light Chain Mouse |
US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
KR20150002894A (ko) | 2010-03-11 | 2015-01-07 | 리나트 뉴로사이언스 코프. | pH 의존성 항원 결합을 갖는 항체 |
TWI667346B (zh) | 2010-03-30 | 2019-08-01 | 中外製藥股份有限公司 | 促進抗原消失之具有經修飾的FcRn親和力之抗體 |
BR112012033248A2 (pt) | 2010-06-22 | 2017-11-28 | Regeneron Pharma | camundongos expressando uma cadeia leve com variável de lâmbda humana e regiões constantes de camundongo |
DE14176593T1 (de) | 2011-02-25 | 2015-03-05 | Regeneron Pharmaceuticals, Inc. | ADAM6 Mäuse |
PL3572517T3 (pl) | 2011-08-05 | 2021-10-04 | Regeneron Pharmaceuticals, Inc. | Myszy z humanizowanym uniwersalnym łańcuchem lekkim |
MX366269B (es) | 2011-09-30 | 2019-07-04 | Chugai Pharmaceutical Co Ltd | Biblioteca de moleculas de union dependientes de la concentracion ionica. |
GB201122047D0 (en) | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
NZ630637A (en) | 2012-03-06 | 2016-09-30 | Regeneron Pharma | Common light chain mouse |
US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
CA2865645A1 (fr) | 2012-03-16 | 2013-09-19 | Regeneron Pharmaceuticals, Inc. | Animaux non humains exprimant des sequences d'immunoglobuline sensibles au ph pour le batiment de l'antigene |
MX2014014891A (es) | 2012-06-05 | 2015-06-17 | Regeneron Pharma | Metodos para hacer anticuerpos biespecificos completamente humanos usando una cadena ligera comun. |
HUE039214T2 (hu) | 2013-02-20 | 2018-12-28 | Regeneron Pharma | Módosított szekvenciájú immunglobulin-nehézlánccal rendelkezõ, nem humán élõlények |
-
2013
- 2013-03-15 LT LTEP18158960.7T patent/LT3348140T/lt unknown
- 2013-03-15 US US13/832,247 patent/US9334334B2/en active Active
- 2013-03-15 RS RS20180416A patent/RS57118B1/sr unknown
- 2013-03-15 PT PT181589607T patent/PT3348140T/pt unknown
- 2013-03-15 ES ES18158960T patent/ES2849349T3/es active Active
- 2013-03-15 LT LTEP15151655.6T patent/LT2883449T/lt unknown
- 2013-03-15 RU RU2017135754A patent/RU2017135754A/ru not_active Application Discontinuation
- 2013-03-15 DK DK13713652.9T patent/DK2825036T3/en active
- 2013-03-15 ES ES15151655.6T patent/ES2665793T3/es active Active
- 2013-03-15 SG SG10201607689PA patent/SG10201607689PA/en unknown
- 2013-03-15 HU HUE15151655A patent/HUE037659T2/hu unknown
- 2013-03-15 EP EP20208322.6A patent/EP3808175A1/fr active Pending
- 2013-03-15 MX MX2014011051A patent/MX355732B/es active IP Right Grant
- 2013-03-15 RU RU2014141537A patent/RU2644684C2/ru not_active IP Right Cessation
- 2013-03-15 NZ NZ629639A patent/NZ629639A/en not_active IP Right Cessation
- 2013-03-15 PL PL13713652T patent/PL2825036T3/pl unknown
- 2013-03-15 BR BR112014022850A patent/BR112014022850A2/pt not_active Application Discontinuation
- 2013-03-15 ES ES13713652.9T patent/ES2679369T3/es active Active
- 2013-03-15 LT LTEP13713652.9T patent/LT2825036T/lt unknown
- 2013-03-15 EP EP15151655.6A patent/EP2883449B1/fr active Active
- 2013-03-15 SG SG11201405165UA patent/SG11201405165UA/en unknown
- 2013-03-15 HU HUE13713652A patent/HUE039573T2/hu unknown
- 2013-03-15 PT PT151516556T patent/PT2883449T/pt unknown
- 2013-03-15 CN CN201710968748.4A patent/CN107840890A/zh active Pending
- 2013-03-15 MY MYPI2014002400A patent/MY172730A/en unknown
- 2013-03-15 RS RS20180718A patent/RS57414B1/sr unknown
- 2013-03-15 DK DK15151655.6T patent/DK2883449T3/en active
- 2013-03-15 KR KR1020147025407A patent/KR102228296B1/ko active IP Right Grant
- 2013-03-15 SI SI201331847T patent/SI3348140T1/sl unknown
- 2013-03-15 EP EP18158960.7A patent/EP3348140B1/fr active Active
- 2013-03-15 SI SI201331088T patent/SI2825036T1/en unknown
- 2013-03-15 CN CN201710968763.9A patent/CN107827979A/zh active Pending
- 2013-03-15 PL PL15151655T patent/PL2883449T3/pl unknown
- 2013-03-15 PT PT137136529T patent/PT2825036T/pt unknown
- 2013-03-15 AU AU2013204579A patent/AU2013204579B2/en active Active
- 2013-03-15 CA CA2865643A patent/CA2865643A1/fr active Pending
- 2013-03-15 CN CN201380025684.4A patent/CN104302169B/zh active Active
- 2013-03-15 WO PCT/US2013/031823 patent/WO2013138680A1/fr active Application Filing
- 2013-03-15 HU HUE18158960A patent/HUE053310T2/hu unknown
- 2013-03-15 SI SI201330992T patent/SI2883449T1/en unknown
- 2013-03-15 EP EP13713652.9A patent/EP2825036B1/fr active Active
- 2013-03-15 JP JP2015500639A patent/JP6185978B2/ja active Active
-
2014
- 2014-07-23 US US14/339,376 patent/US9422370B2/en active Active
- 2014-08-28 IL IL234355A patent/IL234355B/en active IP Right Grant
-
2015
- 2015-01-29 HK HK15101012.5A patent/HK1200273A1/xx unknown
- 2015-07-03 HK HK15106364.8A patent/HK1205642A1/xx unknown
-
2016
- 2016-02-10 IL IL244097A patent/IL244097A/en active IP Right Grant
- 2016-04-13 AU AU2016202323A patent/AU2016202323B2/en active Active
- 2016-07-14 US US15/210,506 patent/US11192947B2/en active Active
-
2017
- 2017-03-17 JP JP2017052358A patent/JP6574802B2/ja active Active
- 2017-08-01 IL IL253775A patent/IL253775B/en active IP Right Grant
-
2018
- 2018-04-30 HR HRP20180682TT patent/HRP20180682T1/hr unknown
- 2018-05-07 CY CY181100476T patent/CY1120599T1/el unknown
- 2018-05-25 AU AU2018203713A patent/AU2018203713B2/en active Active
- 2018-07-31 HR HRP20181228TT patent/HRP20181228T1/hr unknown
- 2018-08-01 CY CY20181100797T patent/CY1120491T1/el unknown
-
2019
- 2019-02-21 JP JP2019029627A patent/JP7304169B2/ja active Active
-
2020
- 2020-01-30 IL IL272357A patent/IL272357B/en active IP Right Grant
- 2020-04-02 JP JP2020066673A patent/JP7199398B2/ja active Active
-
2021
- 2021-04-20 IL IL282452A patent/IL282452B/en unknown
- 2021-11-10 JP JP2021183079A patent/JP2022017547A/ja not_active Withdrawn
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL282452B (en) | Histidine-engineered light chain antibodies, and non-human animals genetically modified for their preparation | |
IL264358A (en) | Histidine engineered light chain antibodies and non-human animals genetically engineered to produce them | |
EP2863736A4 (fr) | Animaux génétiquement modifiés et procédés de production associés | |
EP2678434A4 (fr) | Animaux génétiquement modifiés et procédés pour produire ceux-ci | |
GB201216564D0 (en) | Genetically edited animal | |
DK2989893T3 (da) | Ikke-humane dyr, der udtrykker antistoffer med fælles letkæde | |
HK1205145A1 (en) | Improved antibody light chains | |
IL245306A0 (en) | Preparations and methods for the production of genetically modified animals | |
EP2908625A4 (fr) | Procédé de génération d'animaux génétiquement supérieurs |