SG10201603965VA - Treatment of intervertebral disc degeneration using human umbilical cord tissue-derived cells and hydrogel - Google Patents

Treatment of intervertebral disc degeneration using human umbilical cord tissue-derived cells and hydrogel

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Publication number
SG10201603965VA
SG10201603965VA SG10201603965VA SG10201603965VA SG10201603965VA SG 10201603965V A SG10201603965V A SG 10201603965VA SG 10201603965V A SG10201603965V A SG 10201603965VA SG 10201603965V A SG10201603965V A SG 10201603965VA SG 10201603965V A SG10201603965V A SG 10201603965VA
Authority
SG
Singapore
Prior art keywords
hydrogel
treatment
umbilical cord
intervertebral disc
derived cells
Prior art date
Application number
SG10201603965VA
Other languages
English (en)
Inventor
Brian C Kramer
Laura J Brown
Anthony J Kihm
Original Assignee
Depuy Synthes Products Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Depuy Synthes Products Llc filed Critical Depuy Synthes Products Llc
Publication of SG10201603965VA publication Critical patent/SG10201603965VA/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3878—Nerve tissue, brain, spinal cord, nerves, dura mater
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
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    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
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  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Developmental Biology & Embryology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Reproductive Health (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Botany (AREA)
  • Dispersion Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
SG10201603965VA 2011-05-19 2012-05-17 Treatment of intervertebral disc degeneration using human umbilical cord tissue-derived cells and hydrogel SG10201603965VA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13/111,933 US20110280838A1 (en) 2007-12-27 2011-05-19 Treatment of intervertebral disc degeneration using human umbilical cord tissue-derived cells

Publications (1)

Publication Number Publication Date
SG10201603965VA true SG10201603965VA (en) 2016-07-28

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Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201603965VA SG10201603965VA (en) 2011-05-19 2012-05-17 Treatment of intervertebral disc degeneration using human umbilical cord tissue-derived cells and hydrogel
SG2013082391A SG194825A1 (en) 2011-05-19 2012-05-17 Treatment of intervertebral disc degeneration using human umbilical cord tissue-derived cells

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG2013082391A SG194825A1 (en) 2011-05-19 2012-05-17 Treatment of intervertebral disc degeneration using human umbilical cord tissue-derived cells

Country Status (16)

Country Link
US (2) US20110280838A1 (enExample)
EP (1) EP2709637B1 (enExample)
JP (1) JP6100245B2 (enExample)
KR (1) KR101914918B1 (enExample)
CN (2) CN103717226A (enExample)
AU (1) AU2012255270B2 (enExample)
BR (1) BR112013029800B1 (enExample)
CA (1) CA2836637C (enExample)
ES (1) ES2625041T3 (enExample)
MX (1) MX348245B (enExample)
PH (1) PH12013502399B1 (enExample)
PL (1) PL2709637T3 (enExample)
RU (1) RU2645079C2 (enExample)
SG (2) SG10201603965VA (enExample)
WO (1) WO2012158952A1 (enExample)
ZA (1) ZA201309546B (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8182841B2 (en) 2005-09-27 2012-05-22 Tissue Tech, Inc. Amniotic membrane preparations and purified compositions and anti-inflammation methods
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
ES2621610T3 (es) * 2007-12-27 2017-07-04 DePuy Synthes Products, Inc. Tratamiento de la degeneración de discos intervertebrales utilizando células derivadas de tejido cordón umbilical humano
WO2012149486A1 (en) 2011-04-28 2012-11-01 Tissuetech, Inc. Methods of modulating bone remodeling
US9359417B2 (en) 2013-01-25 2016-06-07 Warsaw Orthopedic, Inc. Cell cultures and methods of human recombinant growth and differentiaton factor-5 (rhGDF-5)
US9169308B2 (en) 2013-01-25 2015-10-27 Warsaw Orthopedic, Inc. Methods and compositions of human recombinant growth and differentiation factor-5 (rhGDF-5) isolated from inclusion bodies
US8945872B2 (en) 2013-01-25 2015-02-03 Warsaw Orthopedic, Inc. Methods of purifying human recombinant growth and differentiation factor-5 (rhGDF-5) protein
US8956829B2 (en) 2013-01-25 2015-02-17 Warsaw Orthopedic, Inc. Human recombinant growth and differentiaton factor-5 (rhGDF-5)
US9051389B2 (en) 2013-01-25 2015-06-09 Warsaw Orthopedic, Inc. Expression conditions and methods of human recombinant growth and differentiation factor-5 (rhGDF-5)
US9993506B1 (en) * 2013-03-16 2018-06-12 BioDlogics, Inc. Methods for the treatment of degenerative disc diseases by human birth tissue material composition
WO2016138025A2 (en) 2015-02-23 2016-09-01 Tissuetech, Inc. Apparatuses and methods for treating ophthalmic diseases and disorders
TW201733600A (zh) 2016-01-29 2017-10-01 帝聖工業公司 胎兒扶持組織物及使用方法
US10426796B2 (en) 2016-06-13 2019-10-01 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
US10456423B2 (en) 2016-06-13 2019-10-29 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
US10616914B2 (en) * 2017-01-06 2020-04-07 Qualcomm Incorporated Unicast data transmission on a downlink common burst of a slot using mini-slots
JP2020525448A (ja) 2017-06-23 2020-08-27 ニューヨーク ソサエティ フォー ザ ラプチャード アンド クリップルド メインティニング ザ ホスピタル フォー スペシャル サージェリー ソニックヘッジホッグシグナル伝達経路を介する脊椎円板変性を治療する組成物、使用及び方法
JP2021505344A (ja) 2017-12-07 2021-02-18 ヴェリセル コーポレイション 軟骨の欠損を修復するための組成物及び方法
CN108653328A (zh) * 2018-03-26 2018-10-16 杭州市萧山区中医院 间充质干细胞联合富血小板血浆在制备用于促进肩袖损伤腱骨复合体愈合的药物中的应用
KR102169924B1 (ko) * 2019-03-26 2020-10-26 연세대학교 산학협력단 연골세포 분화 유도용 조성물 및 이의 용도
US20220145264A1 (en) * 2019-04-05 2022-05-12 The University Of Hong Kong Culture medium for mammalian expanded potential stem cells, composition, and methods thereof
KR102216035B1 (ko) * 2019-06-19 2021-02-16 박종철 추모를 위한 형상 제조용 골분이 함유된 3d 프린터용 필라멘트 조성물, 이를 이용한 3d 프린터용 필라멘트의 제조방법 및 이로부터 제조되는 3d 프린터용 필라멘트
CN110585243A (zh) * 2019-08-12 2019-12-20 丰泽康生物医药（深圳）有限公司 用于治疗糖皮质激素依赖性皮炎的多潜能细胞活性物与富血小板血浆复合物及制法和应用
CN112641996B (zh) * 2021-01-11 2023-08-01 常州市第二人民医院 髓核间充质干细胞联合壳聚糖纤维凝胶支架的制备方法
JP2025507959A (ja) 2022-03-04 2025-03-21 ヴェリセル コーポレイション 軟骨の欠損を修復するための方法及びデバイス
EP4514367A1 (en) 2022-04-28 2025-03-05 Iceta - Instituto De Ciências, Tecnologias E Agroambiente Da Universidade Do Porto Process for preparation of human umbilical cord blood plasma and culture media for tissue regeneration
TWI848739B (zh) * 2023-06-07 2024-07-11 精準再生生醫股份有限公司 源自椎間盤的髓核细胞的放大培養方法及其用途
CN118717787B (zh) * 2024-08-13 2025-07-15 江苏省苏北人民医院 罗汉果黄素在制备防治椎间盘退变性疾病药物中的应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047055A (en) * 1990-12-21 1991-09-10 Pfizer Hospital Products Group, Inc. Hydrogel intervertebral disc nucleus
JP2006517842A (ja) * 2003-02-14 2006-08-03 デピュイ スパイン、インコーポレイテッド 原位置形成型椎骨間融合の装置および方法
US7875272B2 (en) * 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
US11395865B2 (en) * 2004-02-09 2022-07-26 DePuy Synthes Products, Inc. Scaffolds with viable tissue
US20060275273A1 (en) * 2004-02-20 2006-12-07 Seyedin Mitchell S Intervertebral Disc Repair, Methods and Devices Therefor
WO2006071777A2 (en) * 2004-12-23 2006-07-06 Ethicon Incorporated Soft tissue repair and regeneration using postpartum-derived cells and cell products
RU2301677C1 (ru) * 2005-12-09 2007-06-27 ЗАО "РеМеТэкс" Биотрансплантат для лечения дегенеративных и травматических заболеваний хрящевой ткани и способ его получения
ES2621610T3 (es) * 2007-12-27 2017-07-04 DePuy Synthes Products, Inc. Tratamiento de la degeneración de discos intervertebrales utilizando células derivadas de tejido cordón umbilical humano
CN101980714A (zh) * 2008-03-31 2011-02-23 奥古斯蒂努斯·巴德 借助干细胞或骨髓细胞进行组织再生的方法和组合物
JP5801716B2 (ja) * 2008-06-25 2015-10-28 メゾブラスト，インコーポレーテッド 椎間板の修復および／または再構成
JP5805542B2 (ja) * 2009-02-20 2015-11-04 オムリックス・バイオファーマシューティカルズ・リミテッドＯｍｒｉｘ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ． 少なくとも２成分の薬物を投与する装置
US9198953B2 (en) * 2009-08-14 2015-12-01 Eu Sol Biotech Co., Ltd. Method for repairing neurodegeneration

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US20170065745A1 (en) 2017-03-09
EP2709637A1 (en) 2014-03-26
US20110280838A1 (en) 2011-11-17
KR101914918B1 (ko) 2018-11-05
PH12013502399A1 (en) 2014-01-13
KR20140043398A (ko) 2014-04-09
RU2013156357A (ru) 2015-06-27
SG194825A1 (en) 2013-12-30
US20180344900A9 (en) 2018-12-06
PH12013502399B1 (en) 2019-09-25
CN110841109A (zh) 2020-02-28
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AU2012255270B2 (en) 2017-03-23
PL2709637T3 (pl) 2017-08-31
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WO2012158952A8 (en) 2014-01-03
ES2625041T3 (es) 2017-07-18
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CN103717226A (zh) 2014-04-09
EP2709637B1 (en) 2017-03-22
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AU2012255270A1 (en) 2013-11-28
RU2645079C2 (ru) 2018-02-15

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