CN103717226A - 使用人脐带组织来源细胞和水凝胶治疗椎间盘退变 - Google Patents

使用人脐带组织来源细胞和水凝胶治疗椎间盘退变 Download PDF

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CN103717226A
CN103717226A CN201280024401.XA CN201280024401A CN103717226A CN 103717226 A CN103717226 A CN 103717226A CN 201280024401 A CN201280024401 A CN 201280024401A CN 103717226 A CN103717226 A CN 103717226A
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cells
umbilical cord
cell
cord tissue
isolated
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Chinese (zh)
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B.C.克拉梅
L.J.布朗
A.J.基姆
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DePuy Synthes Products Inc
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DePuy Synthes Products Inc
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Priority to CN201910903413.3A priority Critical patent/CN110841109A/zh
Publication of CN103717226A publication Critical patent/CN103717226A/zh
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
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    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
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CN201280024401.XA 2011-05-19 2012-05-17 使用人脐带组织来源细胞和水凝胶治疗椎间盘退变 Pending CN103717226A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910903413.3A CN110841109A (zh) 2011-05-19 2012-05-17 使用人脐带组织来源细胞和水凝胶治疗椎间盘退变

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/111,933 2011-05-19
US13/111,933 US20110280838A1 (en) 2007-12-27 2011-05-19 Treatment of intervertebral disc degeneration using human umbilical cord tissue-derived cells
PCT/US2012/038407 WO2012158952A1 (en) 2011-05-19 2012-05-17 Treatment of intervertebral disc degeneration using human umbilical cord tissue-derived cells

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CN201910903413.3A Division CN110841109A (zh) 2011-05-19 2012-05-17 使用人脐带组织来源细胞和水凝胶治疗椎间盘退变

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CN103717226A true CN103717226A (zh) 2014-04-09

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CN201910903413.3A Pending CN110841109A (zh) 2011-05-19 2012-05-17 使用人脐带组织来源细胞和水凝胶治疗椎间盘退变
CN201280024401.XA Pending CN103717226A (zh) 2011-05-19 2012-05-17 使用人脐带组织来源细胞和水凝胶治疗椎间盘退变

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US (2) US20110280838A1 (enExample)
EP (1) EP2709637B1 (enExample)
JP (1) JP6100245B2 (enExample)
KR (1) KR101914918B1 (enExample)
CN (2) CN110841109A (enExample)
AU (1) AU2012255270B2 (enExample)
BR (1) BR112013029800B1 (enExample)
CA (1) CA2836637C (enExample)
ES (1) ES2625041T3 (enExample)
MX (1) MX348245B (enExample)
PH (1) PH12013502399B1 (enExample)
PL (1) PL2709637T3 (enExample)
RU (1) RU2645079C2 (enExample)
SG (2) SG194825A1 (enExample)
WO (1) WO2012158952A1 (enExample)
ZA (1) ZA201309546B (enExample)

Cited By (3)

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WO2020200071A1 (en) * 2019-04-05 2020-10-08 The University Of Hong Kong Culture medium for mammalian expanded potential stem cells, composition, and methods thereof
CN112641996A (zh) * 2021-01-11 2021-04-13 常州市第二人民医院 髓核间充质干细胞联合壳聚糖纤维凝胶支架的制备方法
CN118717787A (zh) * 2024-08-13 2024-10-01 江苏省苏北人民医院 罗汉果黄素在制备防治椎间盘退变性疾病药物中的应用

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* Cited by examiner, † Cited by third party
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WO2007038686A2 (en) 2005-09-27 2007-04-05 Tissuetech, Inc. Amniotic membrane preparations and purified compositions and methods of use
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
BRPI0821489A2 (pt) * 2007-12-27 2015-06-16 Ethicon Inc Tratamento de degeneração do disco intervetebral com o uso de células derivadas de tecido de cordão umbilical humano
US9526770B2 (en) 2011-04-28 2016-12-27 Tissuetech, Inc. Methods of modulating bone remodeling
US8956829B2 (en) 2013-01-25 2015-02-17 Warsaw Orthopedic, Inc. Human recombinant growth and differentiaton factor-5 (rhGDF-5)
US9051389B2 (en) 2013-01-25 2015-06-09 Warsaw Orthopedic, Inc. Expression conditions and methods of human recombinant growth and differentiation factor-5 (rhGDF-5)
US8945872B2 (en) 2013-01-25 2015-02-03 Warsaw Orthopedic, Inc. Methods of purifying human recombinant growth and differentiation factor-5 (rhGDF-5) protein
US9169308B2 (en) 2013-01-25 2015-10-27 Warsaw Orthopedic, Inc. Methods and compositions of human recombinant growth and differentiation factor-5 (rhGDF-5) isolated from inclusion bodies
US9359417B2 (en) 2013-01-25 2016-06-07 Warsaw Orthopedic, Inc. Cell cultures and methods of human recombinant growth and differentiaton factor-5 (rhGDF-5)
US9993506B1 (en) * 2013-03-16 2018-06-12 BioDlogics, Inc. Methods for the treatment of degenerative disc diseases by human birth tissue material composition
WO2016138025A2 (en) 2015-02-23 2016-09-01 Tissuetech, Inc. Apparatuses and methods for treating ophthalmic diseases and disorders
TW201733600A (zh) 2016-01-29 2017-10-01 帝聖工業公司 胎兒扶持組織物及使用方法
US10456423B2 (en) 2016-06-13 2019-10-29 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
US10426796B2 (en) 2016-06-13 2019-10-01 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
US10616914B2 (en) * 2017-01-06 2020-04-07 Qualcomm Incorporated Unicast data transmission on a downlink common burst of a slot using mini-slots
EP3641757A4 (en) 2017-06-23 2021-03-24 New York Society for the Ruptured and Crippled Maintaining the Hospital for Special Surgery COMPOSITION, USES, AND METHOD OF TREATMENTAL DISC DEGENERATION BY A HEDGEHOG SOUND PATH
US11857576B2 (en) 2017-12-07 2024-01-02 Vericel Corporation Compositions and methods for repairing cartilage defects
CN108653328A (zh) * 2018-03-26 2018-10-16 杭州市萧山区中医院 间充质干细胞联合富血小板血浆在制备用于促进肩袖损伤腱骨复合体愈合的药物中的应用
KR102169924B1 (ko) * 2019-03-26 2020-10-26 연세대학교 산학협력단 연골세포 분화 유도용 조성물 및 이의 용도
KR102216035B1 (ko) * 2019-06-19 2021-02-16 박종철 추모를 위한 형상 제조용 골분이 함유된 3d 프린터용 필라멘트 조성물, 이를 이용한 3d 프린터용 필라멘트의 제조방법 및 이로부터 제조되는 3d 프린터용 필라멘트
CN110585243A (zh) * 2019-08-12 2019-12-20 丰泽康生物医药（深圳）有限公司 用于治疗糖皮质激素依赖性皮炎的多潜能细胞活性物与富血小板血浆复合物及制法和应用
US11857170B2 (en) 2022-03-04 2024-01-02 Vericel Corporation Methods and devices for repairing cartilage defects
WO2023209458A1 (en) 2022-04-28 2023-11-02 Iceta - Instituto De Ciências, Tecnologias E Agroambiente Da Universidade Do Porto Process for preparation of human umbilical cord blood plasma and culture media for tissue regeneration
TWI848739B (zh) * 2023-06-07 2024-07-11 精準再生生醫股份有限公司 源自椎間盤的髓核细胞的放大培養方法及其用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047055A (en) * 1990-12-21 1991-09-10 Pfizer Hospital Products Group, Inc. Hydrogel intervertebral disc nucleus
AU2004212942A1 (en) * 2003-02-14 2004-09-02 Depuy Spine, Inc. In-situ formed intervertebral fusion device
US7875272B2 (en) * 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
US11395865B2 (en) * 2004-02-09 2022-07-26 DePuy Synthes Products, Inc. Scaffolds with viable tissue
US20060275273A1 (en) * 2004-02-20 2006-12-07 Seyedin Mitchell S Intervertebral Disc Repair, Methods and Devices Therefor
EP1831355A2 (en) * 2004-12-23 2007-09-12 Ethicon, Inc. Soft tissue repair and regeneration using postpartum-derived cells and cell products
RU2301677C1 (ru) * 2005-12-09 2007-06-27 ЗАО "РеМеТэкс" Биотрансплантат для лечения дегенеративных и травматических заболеваний хрящевой ткани и способ его получения
BRPI0821489A2 (pt) * 2007-12-27 2015-06-16 Ethicon Inc Tratamento de degeneração do disco intervetebral com o uso de células derivadas de tecido de cordão umbilical humano
CN101980714A (zh) * 2008-03-31 2011-02-23 奥古斯蒂努斯·巴德 借助干细胞或骨髓细胞进行组织再生的方法和组合物
KR20190025067A (ko) 2008-06-25 2019-03-08 메소블라스트, 아이엔씨. 추간판의 치료 및/또는 재구성
WO2010095128A2 (en) * 2009-02-20 2010-08-26 Omrix Biopharmaceuticals Ltd. Device for administering an at least two-component substance
TWI434698B (zh) 2009-08-14 2014-04-21 Eu Sol Biotech Co Ltd 人類酸性纖維母細胞生長因子之醫藥用途

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020200071A1 (en) * 2019-04-05 2020-10-08 The University Of Hong Kong Culture medium for mammalian expanded potential stem cells, composition, and methods thereof
CN112641996A (zh) * 2021-01-11 2021-04-13 常州市第二人民医院 髓核间充质干细胞联合壳聚糖纤维凝胶支架的制备方法
CN118717787A (zh) * 2024-08-13 2024-10-01 江苏省苏北人民医院 罗汉果黄素在制备防治椎间盘退变性疾病药物中的应用

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