SG10201600234PA - Pluripotent Stem Cells Obtained By Non-Viral Reprogramming - Google Patents
Pluripotent Stem Cells Obtained By Non-Viral ReprogrammingInfo
- Publication number
- SG10201600234PA SG10201600234PA SG10201600234PA SG10201600234PA SG10201600234PA SG 10201600234P A SG10201600234P A SG 10201600234PA SG 10201600234P A SG10201600234P A SG 10201600234PA SG 10201600234P A SG10201600234P A SG 10201600234PA SG 10201600234P A SG10201600234P A SG 10201600234PA
- Authority
- SG
- Singapore
- Prior art keywords
- stem cells
- pluripotent stem
- cells obtained
- viral reprogramming
- reprogramming
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/602—Sox-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/603—Oct-3/4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/604—Klf-4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/605—Nanog
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/606—Transcription factors c-Myc
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/608—Lin28
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Transplantation (AREA)
- Developmental Biology & Embryology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10836208P | 2008-10-24 | 2008-10-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201600234PA true SG10201600234PA (en) | 2016-02-26 |
Family
ID=41698343
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201600234PA SG10201600234PA (en) | 2008-10-24 | 2009-10-23 | Pluripotent Stem Cells Obtained By Non-Viral Reprogramming |
Country Status (10)
Country | Link |
---|---|
US (4) | US8268620B2 (de) |
EP (2) | EP3450545B1 (de) |
JP (5) | JP2012506702A (de) |
CN (2) | CN105802917A (de) |
CA (1) | CA2741090C (de) |
DK (2) | DK3450545T3 (de) |
ES (1) | ES2959327T3 (de) |
IL (1) | IL212433B (de) |
SG (1) | SG10201600234PA (de) |
WO (1) | WO2010048567A1 (de) |
Families Citing this family (78)
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US8129187B2 (en) | 2005-12-13 | 2012-03-06 | Kyoto University | Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 |
EP2208786B1 (de) * | 2005-12-13 | 2018-08-01 | Kyoto University | Nukleärer Reprogrammierungsfaktor |
US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
US20090227032A1 (en) * | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
CN101743306A (zh) | 2007-03-23 | 2010-06-16 | 威斯康星校友研究基金会 | 体细胞重编程 |
JP2008307007A (ja) * | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
US9213999B2 (en) * | 2007-06-15 | 2015-12-15 | Kyoto University | Providing iPSCs to a customer |
CA2695522C (en) * | 2008-05-02 | 2019-01-15 | Kyoto University | Method of nuclear reprogramming |
EP3447128A1 (de) | 2008-06-04 | 2019-02-27 | FUJIFILM Cellular Dynamics, Inc. | Verfahren zur herstellung von ips-zellen unter verwendung eines nicht-viralen ansatzes |
EP3330371A1 (de) * | 2008-08-12 | 2018-06-06 | Cellular Dynamics International, Inc. | Verfahren zur herstellung von ips-zellen |
DK3450545T3 (da) * | 2008-10-24 | 2023-10-02 | Wisconsin Alumni Res Found | Pluripotente stamceller opnået ved ikke-viral omprogrammering |
CA2952805C (en) | 2009-06-05 | 2021-06-01 | Cellular Dynamics International, Inc. | Reprogramming t cells and hematopoietic cells |
US8048675B1 (en) * | 2010-05-12 | 2011-11-01 | Ipierian, Inc. | Integration-free human induced pluripotent stem cells from blood |
EP2582794B2 (de) | 2010-06-15 | 2024-04-24 | FUJIFILM Cellular Dynamics, Inc. | Erzeugung induzierter pluripotenter stammzellen aus kleinen volumina von peripherem blut |
US9279107B2 (en) | 2010-08-05 | 2016-03-08 | Wisconsin Alumni Research Foundation | Simplified basic media for human pluripotent cell culture |
AU2011285531B2 (en) * | 2010-08-05 | 2015-04-30 | Wisconsin Alumni Research Foundation | Simplified basic media for human pluripotent cell culture |
WO2012037456A1 (en) | 2010-09-17 | 2012-03-22 | President And Fellows Of Harvard College | Functional genomics assay for characterizing pluripotent stem cell utility and safety |
US9133266B2 (en) | 2011-05-06 | 2015-09-15 | Wisconsin Alumni Research Foundation | Vitronectin-derived cell culture substrate and uses thereof |
EP2732029B1 (de) * | 2011-07-11 | 2019-01-16 | FUJIFILM Cellular Dynamics, Inc. | Verfahren zur zellprogrammierung und genommanipulation |
AU2012326137B2 (en) | 2011-10-17 | 2018-11-29 | Minerva Biotechnologies Corporation | Media for stem cell proliferation and induction |
US10391126B2 (en) | 2011-11-18 | 2019-08-27 | Board Of Regents, The University Of Texas System | CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA |
US8497124B2 (en) | 2011-12-05 | 2013-07-30 | Factor Bioscience Inc. | Methods and products for reprogramming cells to a less differentiated state |
RU2691027C2 (ru) | 2011-12-05 | 2019-06-07 | Фэктор Байосайенс Инк. | Способы и препараты для трансфекции клеток |
US8772460B2 (en) | 2011-12-16 | 2014-07-08 | Wisconsin Alumni Research Foundation | Thermostable FGF-2 mutant having enhanced stability |
US20130266541A1 (en) * | 2012-04-06 | 2013-10-10 | The Johns Hopkins University | Human induced pluripotent stem cells |
KR102596302B1 (ko) | 2012-11-01 | 2023-11-01 | 팩터 바이오사이언스 인크. | 세포에서 단백질을 발현시키는 방법들과 생성물들 |
JP6426110B2 (ja) | 2013-02-01 | 2018-11-21 | ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 人口多能性幹細胞(ipsc)由来の網膜色素上皮(rpe)細胞を生成するための方法 |
JP6697380B2 (ja) | 2013-06-10 | 2020-05-20 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 多能性幹細胞の有用性および安全性を特徴付けるための初期発生ゲノムアッセイ |
WO2015006725A2 (en) | 2013-07-12 | 2015-01-15 | Cedars-Sinai Medical Center | Generation of induced pluripotent stem cells from normal human mammary epithelial cells |
KR101551926B1 (ko) | 2013-09-06 | 2015-09-10 | 가톨릭대학교 산학협력단 | 인간 유래 역분화 줄기세포 및 이를 이용한 인간의 면역계가 발현된 동물 제조 방법 |
US11377639B2 (en) | 2013-11-15 | 2022-07-05 | Wisconsin Alumni Research Foundation | Lineage reprogramming to induced cardiac progenitor cells (iCPC) by defined factors |
ES2787198T3 (es) | 2014-01-31 | 2020-10-15 | Factor Bioscience Inc | ARN sintético para su uso en el tratamiento de la epidermólisis ampollosa distrófica |
CA2945393C (en) | 2014-04-24 | 2021-03-23 | Board Of Regents, The University Of Texas System | Application of induced pluripotent stem cells to generate adoptive cell therapy products |
WO2016069282A1 (en) | 2014-10-31 | 2016-05-06 | The Trustees Of The University Of Pennsylvania | Altering gene expression in modified t cells and uses thereof |
WO2016131052A1 (en) | 2015-02-13 | 2016-08-18 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
SG11201708395VA (en) * | 2015-04-14 | 2017-11-29 | Univ Kyoto | Method for producing stem cell clones suitable for induction of differentiation into somatic cells |
JP6449138B2 (ja) | 2015-07-02 | 2019-01-09 | 株式会社豊田中央研究所 | 遺伝的組換えを誘発する方法及びその利用 |
ES2970537T3 (es) | 2015-09-08 | 2024-05-29 | Us Health | Método para la diferenciación reproducible de células epiteliales del pigmento retiniano de calidad clínica |
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CN105219729B (zh) * | 2015-09-28 | 2018-09-25 | 首都医科大学宣武医院 | 一种利用非整合质粒载体诱导神经干细胞的方法及其用途 |
EP3365433A1 (de) | 2015-10-20 | 2018-08-29 | FUJIFILM Cellular Dynamics, Inc. | Verfahren zur gerichteten differenzierung pluripotenter stammzellen an immunzellen |
EP3455346A1 (de) | 2016-05-12 | 2019-03-20 | Erasmus University Medical Center Rotterdam | Verfahren zur kultivierung myogener zellen, daraus erhaltene kulturen, screening-verfahren und zellkulturmedium |
CN105861447B (zh) * | 2016-06-13 | 2017-12-19 | 广州市搏克生物技术有限公司 | 一种非病毒iPSCs诱导组合物及其试剂盒 |
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AU2017359330B2 (en) | 2016-11-09 | 2022-03-10 | The United States Of America, As Represented By The Secretary Department Of Health And Human Services | 3D vascularized human ocular tissue for cell therapy and drug discovery |
EP3583201B1 (de) | 2017-02-14 | 2024-01-17 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Verfahren zur manipulation menschlicher induzierter pluripotenter stammzellen zur herstellung von lebergewebe |
JP7181219B2 (ja) | 2017-04-18 | 2022-11-30 | フジフィルム セルラー ダイナミクス,インコーポレイテッド | 抗原特異的免疫エフェクター細胞 |
EP3621630A4 (de) | 2017-06-14 | 2021-03-10 | The Children's Medical Center | Hämatopoietische stamm- und vorläuferzellen aus hämogenen endothelzellen durch episomalen plasmid-gentransfer |
US10760057B2 (en) | 2017-07-06 | 2020-09-01 | Wisconsin Alumni Research Foundation | Human pluripotent stem cell-based screening for smooth muscle cell differentiation and disease |
NL2019517B1 (en) | 2017-09-08 | 2019-03-19 | Univ Erasmus Med Ct Rotterdam | New therapy for Pompe disease |
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US20220033778A1 (en) | 2018-11-29 | 2022-02-03 | Board Of Regents, The University Of Texas System | Methods for ex vivo expansion of natural killer cells and use thereof |
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CN117881777A (zh) | 2021-05-26 | 2024-04-12 | 富士胶片细胞动力公司 | 防止多能干细胞中基因快速沉默的方法 |
WO2022251499A1 (en) | 2021-05-28 | 2022-12-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods to generate macular, central and peripheral retinal pigment epithelial cells |
CA3220433A1 (en) | 2021-05-28 | 2022-12-01 | Arvydas Maminishkis | Biodegradable tissue scaffold with secondary matrix to host weakly adherent cells |
KR20240056604A (ko) | 2021-09-13 | 2024-04-30 | 후지필름 셀룰러 다이내믹스, 인코포레이티드 | 수임 심장 전구세포의 제조 방법 |
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Family Cites Families (14)
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GB9223084D0 (en) | 1992-11-04 | 1992-12-16 | Imp Cancer Res Tech | Compounds to target cells |
US5925333A (en) * | 1995-11-15 | 1999-07-20 | Massachusetts Institute Of Technology | Methods for modulation of lipid uptake |
DK1226233T3 (da) * | 1999-08-05 | 2011-10-03 | Abt Holding Co | Multipotente voksne stamceller og fremgangsmåder til isolering heraf |
CA2515108A1 (en) | 2003-02-07 | 2004-08-26 | Wisconsin Alumni Research Foundation | Directed genetic modifications of human stem cells |
US8278104B2 (en) * | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
CN101743306A (zh) * | 2007-03-23 | 2010-06-16 | 威斯康星校友研究基金会 | 体细胞重编程 |
JP2008307007A (ja) * | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
EP2072618A1 (de) | 2007-12-14 | 2009-06-24 | Johannes Gutenberg-Universität Mainz | Verwendung von RNA zur Neuprogrammierung von Körperzellen |
CN101250502A (zh) * | 2008-04-01 | 2008-08-27 | 中国科学院上海生命科学研究院 | 一种诱导的多潜能干细胞的制备方法 |
CA2695522C (en) * | 2008-05-02 | 2019-01-15 | Kyoto University | Method of nuclear reprogramming |
EP3447128A1 (de) * | 2008-06-04 | 2019-02-27 | FUJIFILM Cellular Dynamics, Inc. | Verfahren zur herstellung von ips-zellen unter verwendung eines nicht-viralen ansatzes |
WO2009157201A1 (en) * | 2008-06-26 | 2009-12-30 | Osaka University | Method and kit for preparing ips cells |
WO2010012077A1 (en) * | 2008-07-28 | 2010-02-04 | Mount Sinai Hospital | Compositions, methods and kits for reprogramming somatic cells |
DK3450545T3 (da) * | 2008-10-24 | 2023-10-02 | Wisconsin Alumni Res Found | Pluripotente stamceller opnået ved ikke-viral omprogrammering |
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2009
- 2009-10-23 DK DK18200217.0T patent/DK3450545T3/da active
- 2009-10-23 CN CN201610213440.4A patent/CN105802917A/zh active Pending
- 2009-10-23 CA CA2741090A patent/CA2741090C/en active Active
- 2009-10-23 EP EP18200217.0A patent/EP3450545B1/de active Active
- 2009-10-23 CN CN2009801480130A patent/CN102239249A/zh active Pending
- 2009-10-23 WO PCT/US2009/061935 patent/WO2010048567A1/en active Application Filing
- 2009-10-23 JP JP2011533384A patent/JP2012506702A/ja not_active Withdrawn
- 2009-10-23 SG SG10201600234PA patent/SG10201600234PA/en unknown
- 2009-10-23 DK DK09744285.9T patent/DK2356221T3/en active
- 2009-10-23 US US12/605,220 patent/US8268620B2/en active Active
- 2009-10-23 EP EP09744285.9A patent/EP2356221B1/de active Active
- 2009-10-23 ES ES18200217T patent/ES2959327T3/es active Active
-
2011
- 2011-04-17 IL IL212433A patent/IL212433B/en active IP Right Grant
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2012
- 2012-09-07 US US13/607,072 patent/US20130217117A1/en not_active Abandoned
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2015
- 2015-08-24 JP JP2015165051A patent/JP6312638B2/ja active Active
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2016
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2018
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- 2018-12-04 US US16/209,722 patent/US20190330654A1/en not_active Abandoned
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2021
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- 2021-06-21 US US17/352,873 patent/US20220010331A1/en active Pending
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ES2959327T3 (es) | 2024-02-23 |
JP2016220686A (ja) | 2016-12-28 |
EP2356221B1 (de) | 2018-11-21 |
DK3450545T3 (da) | 2023-10-02 |
CA2741090C (en) | 2018-10-16 |
JP2015213522A (ja) | 2015-12-03 |
JP6861189B2 (ja) | 2021-04-21 |
IL212433B (en) | 2019-08-29 |
JP7165228B2 (ja) | 2022-11-02 |
US20130217117A1 (en) | 2013-08-22 |
US20190330654A1 (en) | 2019-10-31 |
EP2356221A1 (de) | 2011-08-17 |
JP6312638B2 (ja) | 2018-04-18 |
CN105802917A (zh) | 2016-07-27 |
JP2021094040A (ja) | 2021-06-24 |
EP3450545B1 (de) | 2023-08-23 |
US20100184227A1 (en) | 2010-07-22 |
WO2010048567A1 (en) | 2010-04-29 |
US20220010331A1 (en) | 2022-01-13 |
JP2012506702A (ja) | 2012-03-22 |
DK2356221T3 (en) | 2019-02-18 |
IL212433A0 (en) | 2011-06-30 |
JP2018174945A (ja) | 2018-11-15 |
CN102239249A (zh) | 2011-11-09 |
EP3450545A1 (de) | 2019-03-06 |
US8268620B2 (en) | 2012-09-18 |
CA2741090A1 (en) | 2010-04-29 |
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