SG10201510249PA - Insulinotropic peptide derivative wherein its n-terminal amino acid is modified - Google Patents
Insulinotropic peptide derivative wherein its n-terminal amino acid is modifiedInfo
- Publication number
- SG10201510249PA SG10201510249PA SG10201510249PA SG10201510249PA SG10201510249PA SG 10201510249P A SG10201510249P A SG 10201510249PA SG 10201510249P A SG10201510249P A SG 10201510249PA SG 10201510249P A SG10201510249P A SG 10201510249PA SG 10201510249P A SG10201510249P A SG 10201510249PA
- Authority
- SG
- Singapore
- Prior art keywords
- modified
- amino acid
- terminal amino
- peptide derivative
- insulinotropic peptide
- Prior art date
Links
- 125000000729 N-terminal amino-acid group Chemical group 0.000 title 1
- 230000002473 insulinotropic effect Effects 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20070071071 | 2007-07-16 | ||
US99115507P | 2007-11-29 | 2007-11-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201510249PA true SG10201510249PA (en) | 2016-01-28 |
Family
ID=40260219
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201510245SA SG10201510245SA (en) | 2007-07-16 | 2008-07-16 | Insulinotropic peptide derivative wherein its n-terminal amino acid is modified |
SG10201510249PA SG10201510249PA (en) | 2007-07-16 | 2008-07-16 | Insulinotropic peptide derivative wherein its n-terminal amino acid is modified |
SG2012052114A SG183033A1 (en) | 2007-07-16 | 2008-07-16 | Insulinotropic peptide derivative wherein its n-terminal amino acid is modified |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201510245SA SG10201510245SA (en) | 2007-07-16 | 2008-07-16 | Insulinotropic peptide derivative wherein its n-terminal amino acid is modified |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG2012052114A SG183033A1 (en) | 2007-07-16 | 2008-07-16 | Insulinotropic peptide derivative wherein its n-terminal amino acid is modified |
Country Status (22)
Country | Link |
---|---|
US (1) | US9422349B2 (zh) |
EP (4) | EP2537860B1 (zh) |
JP (7) | JP2009019027A (zh) |
KR (1) | KR101231431B1 (zh) |
CN (2) | CN101778863A (zh) |
AR (1) | AR067555A1 (zh) |
AU (1) | AU2008276762A1 (zh) |
BR (1) | BRPI0814097A8 (zh) |
CA (3) | CA2789123C (zh) |
DK (1) | DK2390265T3 (zh) |
ES (3) | ES2528346T3 (zh) |
HK (1) | HK1207088A1 (zh) |
IL (1) | IL203288A (zh) |
MY (1) | MY167486A (zh) |
NZ (3) | NZ582471A (zh) |
PH (2) | PH12014500923A1 (zh) |
PT (1) | PT2390265E (zh) |
RU (1) | RU2442792C2 (zh) |
SG (3) | SG10201510245SA (zh) |
TW (3) | TWI524896B (zh) |
WO (1) | WO2009011544A2 (zh) |
ZA (1) | ZA201000125B (zh) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009019027A (ja) * | 2007-07-16 | 2009-01-29 | Hanmi Pharmaceutical Co Ltd | アミノ末端のアミノ酸が変異したインスリン分泌ペプチド誘導体 |
RU2495881C2 (ru) * | 2009-03-20 | 2013-10-20 | Ханми Холдингс Ко., Лтд. | Способ регулирования условий для сайт-специфического связывания полипептида и непептидильного полимера |
RU2012126101A (ru) | 2009-11-23 | 2013-12-27 | АМИЛИН ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи,США | Полипептидный конъюгат |
KR101382593B1 (ko) * | 2010-07-21 | 2014-04-10 | 한미사이언스 주식회사 | 신규한 지속형 글루카곤 결합체 및 이를 포함하는 비만 예방 및 치료용 약학적 조성물 |
CA2813038C (en) | 2010-09-28 | 2021-12-28 | Amylin Pharmaceuticals, Llc | Highly soluble leptins |
EP2621538B1 (en) | 2010-09-28 | 2015-12-16 | Amylin Pharmaceuticals, LLC | Engineered polypeptides having enhanced duration of action |
EP2714069A4 (en) | 2011-05-25 | 2015-06-24 | Amylin Pharmaceuticals Llc | LONG-TERM CONJUGATES WITH TWO HORMONES |
UA113626C2 (xx) | 2011-06-02 | 2017-02-27 | Композиція для лікування діабету, що містить кон'югат інсуліну тривалої дії та кон'югат інсулінотропного пептиду тривалої дії | |
EP2729481B1 (en) | 2011-07-08 | 2018-10-17 | Amylin Pharmaceuticals, LLC | Engineered polypeptides having enhanced duration of action with reduced immunogenicity |
JP6040464B2 (ja) | 2011-07-08 | 2016-12-07 | アエゲリオン・ファーマシューティカルズ・インコーポレイテッドAegerion Pharmaceuticals, Inc. | 作用持続期間が増大し、免疫原性が減少した操作されたポリペプチド |
KR20130049671A (ko) | 2011-11-04 | 2013-05-14 | 한미사이언스 주식회사 | 생리활성 폴리펩타이드 결합체 제조 방법 |
AR090281A1 (es) | 2012-03-08 | 2014-10-29 | Hanmi Science Co Ltd | Proceso mejorado para la preparacion de un complejo polipeptidico fisiologicamente activo |
CN103130889A (zh) * | 2012-06-15 | 2013-06-05 | 中国药科大学 | 一种Exendin-4类似物及其制备方法和应用 |
US10441665B2 (en) | 2012-07-25 | 2019-10-15 | Hanmi Pharm. Co., Ltd. | Liquid formulation of long acting insulinotropic peptide conjugate |
AR094821A1 (es) | 2012-07-25 | 2015-09-02 | Hanmi Pharm Ind Co Ltd | Formulación líquida de un conjugado de péptido insulinotrópico de acción prolongada |
AR092862A1 (es) | 2012-07-25 | 2015-05-06 | Hanmi Pharm Ind Co Ltd | Formulacion liquida de insulina de accion prolongada y un peptido insulinotropico y metodo de preparacion |
KR20140088837A (ko) * | 2013-01-03 | 2014-07-11 | 한미약품 주식회사 | N-말단 전하가 변형된 인슐린 분비 펩티드 유도체 |
AR096891A1 (es) | 2013-07-12 | 2016-02-03 | Hanmi Pharm Ind Co Ltd | Conjugado de monómero polipéptido biológicamente activo y conjugado de fragmento fc de inmunoglobulina, que muestra aclaramiento mediado por receptor reducido, y el método para la preparación del mismo |
AR096890A1 (es) | 2013-07-12 | 2016-02-03 | Hanmi Pharm Ind Co Ltd | Conjugando fc de inmunoglobulina, que mantiene la afinidad de unión del fragmento fc de la inmunoglobulina a fcrn |
MA43289B1 (fr) | 2014-01-20 | 2019-12-31 | Hanmi Pharm Ind Co Ltd | Insuline à action prolongée et utilisation associée |
AU2015242657B2 (en) | 2014-03-31 | 2020-05-21 | Hanmi Pharm. Co., Ltd. | Method for improving solubility of protein and peptide by using immunoglobulin Fc fragment linkage |
AR100639A1 (es) | 2014-05-29 | 2016-10-19 | Hanmi Pharm Ind Co Ltd | Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada |
AR100695A1 (es) | 2014-05-30 | 2016-10-26 | Hanmi Pharm Ind Co Ltd | Composición para el tratamiento de diabetes mellitus que comprende insulina y un agonista dual glp-1 / glucagón |
US11123436B2 (en) | 2015-07-24 | 2021-09-21 | Hanmi Pharm. Co., Ltd. | Method of preparing physiologically active polypeptide conjugate |
UY36870A (es) | 2015-08-28 | 2017-03-31 | Hanmi Pharm Ind Co Ltd | Análogos de insulina novedosos |
US20190055279A1 (en) * | 2015-10-28 | 2019-02-21 | Tufts University | Novel polypeptides with improved proteolytic stability, and methods of preparing and using same |
WO2018056764A1 (ko) | 2016-09-23 | 2018-03-29 | 한미약품 주식회사 | 인슐린 수용체와의 결합력이 감소된, 인슐린 아날로그 및 이의 용도 |
WO2018105988A1 (ko) | 2016-12-05 | 2018-06-14 | 한미약품 주식회사 | 면역반응이 약화된 결합체 |
JP2020506932A (ja) | 2017-02-03 | 2020-03-05 | ハンミ ファーマシューティカル カンパニー リミテッド | 持続性が増加した生理活性物質の結合体及びその用途 |
TWI798209B (zh) | 2017-03-23 | 2023-04-11 | 南韓商韓美藥品股份有限公司 | 對胰島素受體有降低親和性之胰島素類似物之接合物及其用途 |
WO2022266467A2 (en) | 2021-06-17 | 2022-12-22 | Dana-Farber Cancer Institute, Inc. | Recombinant histone polypeptide and uses thereof |
KR20230000682A (ko) | 2021-06-25 | 2023-01-03 | 한미약품 주식회사 | 심혈관 질환 또는 신장 기능장애 발생의 위험을 감소시키기 위한 에페글레나타이드 |
KR20230010571A (ko) | 2021-07-12 | 2023-01-19 | 한미약품 주식회사 | Glp-1 유사체를 함유하는 경구 투여 제형 조성물 |
WO2023194390A1 (en) * | 2022-04-08 | 2023-10-12 | Danmarks Tekniske Universitet | Histidine methyltransferase for increased peptide and protein stability |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7A (en) * | 1836-08-10 | Thomas blanchard | ||
US5545618A (en) | 1990-01-24 | 1996-08-13 | Buckley; Douglas I. | GLP-1 analogs useful for diabetes treatment |
US5424286A (en) | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
US5424686A (en) | 1994-04-20 | 1995-06-13 | Philips Electronics North America Corporation | Negative-resistance-compensated microwave buffer |
US5512549A (en) | 1994-10-18 | 1996-04-30 | Eli Lilly And Company | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use |
TR199802789T2 (xx) | 1996-06-05 | 1999-03-22 | Boehringer Mannheim Gmbh | Eksendin analoglar� bunlar�n �retimi i�in y�ntemler ve bunlar� i�eren farmas�tik m�stahzarlar. |
US7235627B2 (en) | 1996-08-30 | 2007-06-26 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
US6006753A (en) | 1996-08-30 | 1999-12-28 | Eli Lilly And Company | Use of GLP-1 or analogs to abolish catabolic changes after surgery |
UA72181C2 (uk) * | 1996-08-30 | 2005-02-15 | Ново Нордіск А/С | Похідна глюкагоноподібного пептиду-1 (варіанти), фармацевтична композиція та спосіб одержання лікувального засобу (варіанти), спосіб лікування діабету (варіанти) і ожиріння |
JP2002507188A (ja) | 1996-08-30 | 2002-03-05 | イーライ・リリー・アンド・カンパニー | グルカゴン様ペプチド―1(glp―1)またはその同族体における外科処置後の異化変調を防止するための使用 |
JP4798814B2 (ja) | 1997-01-07 | 2011-10-19 | アミリン・ファーマシューティカルズ,インコーポレイテッド | 食物摂取低減用のエキセンジンおよびそのアゴニストの使用 |
EP1938831A1 (en) * | 1997-08-08 | 2008-07-02 | Amylin Pharmaceuticals, Inc. | Novel exendin agonist compounds |
US7157555B1 (en) * | 1997-08-08 | 2007-01-02 | Amylin Pharmaceuticals, Inc. | Exendin agonist compounds |
NZ502592A (en) * | 1997-08-08 | 2002-03-28 | Amylin Pharmaceuticals Inc | Exendin agonist peptides and their use in the treatment of type I and II diabetes |
US7220721B1 (en) * | 1997-11-14 | 2007-05-22 | Amylin Pharmaceuticals, Inc. | Exendin agonist peptides |
US6703359B1 (en) | 1998-02-13 | 2004-03-09 | Amylin Pharmaceuticals, Inc. | Inotropic and diuretic effects of exendin and GLP-1 |
WO1999043708A1 (en) * | 1998-02-27 | 1999-09-02 | Novo Nordisk A/S | Glp-1 derivatives of glp-1 and exendin with protracted profile of action |
WO2000012116A1 (en) | 1998-08-28 | 2000-03-09 | Eli Lilly And Company | Method for administering insulinotropic peptides |
SI1355942T1 (sl) * | 2000-12-07 | 2009-02-28 | Lilly Co Eli | Glp-1 fuzijski proteini |
IL141647A0 (en) | 2001-02-26 | 2002-03-10 | Yeda Res & Dev | Synthetic human peptides and pharmaceutical compositions comprising them for the treatment of systemic lupus erythematosus |
US6573237B2 (en) | 2001-03-16 | 2003-06-03 | Eli Lilly And Company | Protein formulations |
ES2614603T3 (es) | 2002-02-20 | 2017-06-01 | Emisphere Technologies, Inc. | Procedimiento de administración de moléculas GLP-1 |
RU2376314C2 (ru) * | 2002-10-02 | 2009-12-20 | Зилэнд Фарма А/С | Стабилизированные соединения эксендина-4 |
US7790681B2 (en) * | 2002-12-17 | 2010-09-07 | Amylin Pharmaceuticals, Inc. | Treatment of cardiac arrhythmias with GLP-1 receptor ligands |
WO2004056313A2 (en) * | 2002-12-17 | 2004-07-08 | Amylin Pharmaceuticals, Inc. | Prevention and treatment of cardiac arrhythmias |
JP2006514649A (ja) * | 2003-12-17 | 2006-05-11 | アミリン・ファーマシューティカルズ,インコーポレイテッド | 腎症の治療および予防のための組成物 |
TW200611704A (en) * | 2004-07-02 | 2006-04-16 | Bristol Myers Squibb Co | Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions |
KR20070120112A (ko) * | 2005-03-18 | 2007-12-21 | 노보 노르디스크 에이/에스 | 연장형 glp-1 화합물 |
JP5693817B2 (ja) * | 2005-08-19 | 2015-04-01 | アミリン・ファーマシューティカルズ, リミテッド・ライアビリティ・カンパニーAmylin Pharmaceuticals, Llc | 糖尿病の治療法および体重の減少法 |
EP1961764B1 (en) | 2005-11-30 | 2011-05-11 | Shionogi Co., Ltd. | Sugar chain adduct of peptide and pharmaceutical comprising the same as active ingredient |
WO2008019147A2 (en) * | 2006-08-04 | 2008-02-14 | Amylin Pharmaceuticals, Inc. | Use of exendins, exendin agonists and glp-1 receptor agonists for altering the concentration of fibrinogen |
JP2008169195A (ja) * | 2007-01-05 | 2008-07-24 | Hanmi Pharmaceutical Co Ltd | キャリア物質を用いたインスリン分泌ペプチド薬物結合体 |
WO2008145721A2 (en) * | 2007-06-01 | 2008-12-04 | Novo Nordisk A/S | N-terminal modification of polypeptides for protection against degradation by aminopeptidases |
JP2009019027A (ja) | 2007-07-16 | 2009-01-29 | Hanmi Pharmaceutical Co Ltd | アミノ末端のアミノ酸が変異したインスリン分泌ペプチド誘導体 |
US9816387B2 (en) | 2014-09-09 | 2017-11-14 | United Technologies Corporation | Attachment faces for clamped turbine stator of a gas turbine engine |
-
2007
- 2007-10-03 JP JP2007259853A patent/JP2009019027A/ja active Pending
-
2008
- 2008-07-16 EP EP12185370.9A patent/EP2537860B1/en active Active
- 2008-07-16 ES ES12185370.9T patent/ES2528346T3/es active Active
- 2008-07-16 US US12/669,372 patent/US9422349B2/en active Active
- 2008-07-16 WO PCT/KR2008/004170 patent/WO2009011544A2/en active Application Filing
- 2008-07-16 BR BRPI0814097A patent/BRPI0814097A8/pt not_active Application Discontinuation
- 2008-07-16 CA CA2789123A patent/CA2789123C/en active Active
- 2008-07-16 NZ NZ582471A patent/NZ582471A/en unknown
- 2008-07-16 DK DK11162132.2T patent/DK2390265T3/da active
- 2008-07-16 SG SG10201510245SA patent/SG10201510245SA/en unknown
- 2008-07-16 AU AU2008276762A patent/AU2008276762A1/en not_active Abandoned
- 2008-07-16 CA CA2693154A patent/CA2693154C/en active Active
- 2008-07-16 ES ES11162132.2T patent/ES2444622T3/es active Active
- 2008-07-16 TW TW101140652A patent/TWI524896B/zh active
- 2008-07-16 NZ NZ594853A patent/NZ594853A/en unknown
- 2008-07-16 CA CA2789112A patent/CA2789112C/en active Active
- 2008-07-16 AR ARP080103043A patent/AR067555A1/es active IP Right Grant
- 2008-07-16 SG SG10201510249PA patent/SG10201510249PA/en unknown
- 2008-07-16 KR KR1020080069234A patent/KR101231431B1/ko active IP Right Grant
- 2008-07-16 EP EP08778827A patent/EP2176289A4/en not_active Withdrawn
- 2008-07-16 TW TW097126905A patent/TWI454276B/zh active
- 2008-07-16 MY MYPI2010000187A patent/MY167486A/en unknown
- 2008-07-16 TW TW101140650A patent/TWI532496B/zh active
- 2008-07-16 JP JP2010516925A patent/JP5481377B2/ja active Active
- 2008-07-16 CN CN200880024892A patent/CN101778863A/zh active Pending
- 2008-07-16 EP EP11162132.2A patent/EP2390265B1/en active Active
- 2008-07-16 SG SG2012052114A patent/SG183033A1/en unknown
- 2008-07-16 CN CN201510053063.8A patent/CN104672319B/zh active Active
- 2008-07-16 EP EP12185376.6A patent/EP2537861B1/en active Active
- 2008-07-16 NZ NZ596828A patent/NZ596828A/en unknown
- 2008-07-16 RU RU2010101232/10A patent/RU2442792C2/ru active
- 2008-07-16 PT PT111621322T patent/PT2390265E/pt unknown
- 2008-07-16 ES ES12185376.6T patent/ES2528347T3/es active Active
-
2010
- 2010-01-07 ZA ZA2010/00125A patent/ZA201000125B/en unknown
- 2010-01-13 IL IL203288A patent/IL203288A/en active IP Right Grant
-
2012
- 2012-09-03 JP JP2012193520A patent/JP6023515B2/ja active Active
- 2012-09-03 JP JP2012193521A patent/JP6023516B2/ja active Active
-
2013
- 2013-12-20 JP JP2013264258A patent/JP2014094948A/ja active Pending
-
2014
- 2014-04-25 PH PH12014500923A patent/PH12014500923A1/en unknown
- 2014-04-25 PH PH12014500922A patent/PH12014500922A1/en unknown
-
2015
- 2015-05-07 JP JP2015095154A patent/JP2015172058A/ja not_active Withdrawn
- 2015-05-07 JP JP2015095145A patent/JP2015166368A/ja not_active Withdrawn
- 2015-08-05 HK HK15107509.2A patent/HK1207088A1/zh unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1207088A1 (zh) | -末端氨基酸經修飾的促胰島素釋放肽衍生物 | |
HK1170941A1 (zh) | 泌酸調節肽類似物 | |
HK1170943A1 (zh) | 泌酸調節肽類似物 | |
EP2250278A4 (en) | METHOD AND COMPOSITIONS ASSOCIATED WITH PEPTIDES AND PROTEINS WITH C-TERMINAL ELEMENTS | |
ZA201003681B (en) | Compositions and methods comprising basic amino acid peptides and proteases | |
IL215348A0 (en) | Novel dicarboxylic acid linked amino acid and peptide prodrugs of opioids and uses thereof | |
HK1134029A1 (en) | Amino acid composition | |
IL198186A (en) | Compounds derived from the phosphosphide peptide1 | |
ZA200810072B (en) | Insulinotropic peptide synthesis | |
HK1210594A1 (zh) | 含有氨基酸組合物的抗疲勞劑 | |
HK1213916A1 (zh) | 有生物學活性的、含 -端精氨酸的肽 | |
EP2270141A4 (en) | Lacritin PART PEPTIDE | |
EP2280024A4 (en) | POLYPEPTIDE SPECIFICALLY COUPLED WITH PHOSPHATIDYLSERIN AND USE THEREOF | |
HK1159074A1 (zh) | 氨基酸衍生物 | |
EP2435468A4 (en) | PEPTIDE OF FIBROMODULIN | |
GB0713189D0 (en) | Amino acid derivatives | |
GB0602780D0 (en) | Amino Acid Derivatives | |
ZA200809190B (en) | Amino acid surrogates for peptide constructs | |
EP2252310A4 (en) | HETEROCYCLIC PEPTIDE CETOAMIDES | |
GB0715712D0 (en) | Amino acid derivatives | |
PT2240200T (pt) | Peptidos terapeuticos da proteína basica da mielina mbp83- 99 ligada a mananos | |
EP2244725A4 (en) | NOVEL PEPTIDES AND PROTEIN AND USE THEREOF | |
GB0812586D0 (en) | Chimaeric peptide | |
EP2123751A4 (en) | NEW PEPTIDE |