SG10201500161XA - Modified rsv f proteins and methods of their use - Google Patents

Modified rsv f proteins and methods of their use

Info

Publication number
SG10201500161XA
SG10201500161XA SG10201500161XA SG10201500161XA SG10201500161XA SG 10201500161X A SG10201500161X A SG 10201500161XA SG 10201500161X A SG10201500161X A SG 10201500161XA SG 10201500161X A SG10201500161X A SG 10201500161XA SG 10201500161X A SG10201500161X A SG 10201500161XA
Authority
SG
Singapore
Prior art keywords
proteins
methods
modified rsv
rsv
modified
Prior art date
Application number
SG10201500161XA
Other languages
English (en)
Inventor
Peter Pushko
Yingyun Wu
Michael Massare
Ye Liu
Gale Smith
Bin Zhou
Original Assignee
Novavax Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42310119&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201500161X(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novavax Inc filed Critical Novavax Inc
Publication of SG10201500161XA publication Critical patent/SG10201500161XA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18523—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18561—Methods of inactivation or attenuation
    • C12N2760/18562—Methods of inactivation or attenuation by genetic engineering
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18571—Demonstrated in vivo effect
SG10201500161XA 2008-12-09 2009-12-09 Modified rsv f proteins and methods of their use SG10201500161XA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12112608P 2008-12-09 2008-12-09
US16907709P 2009-04-14 2009-04-14
US22478709P 2009-07-10 2009-07-10

Publications (1)

Publication Number Publication Date
SG10201500161XA true SG10201500161XA (en) 2015-03-30

Family

ID=42310119

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201500161XA SG10201500161XA (en) 2008-12-09 2009-12-09 Modified rsv f proteins and methods of their use
SG2011041696A SG172022A1 (en) 2008-12-09 2009-12-09 Modified rsv f proteins and methods of their use

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG2011041696A SG172022A1 (en) 2008-12-09 2009-12-09 Modified rsv f proteins and methods of their use

Country Status (23)

Country Link
US (7) US8715692B2 (fr)
EP (3) EP3718566A1 (fr)
JP (4) JP5813513B2 (fr)
KR (2) KR101801213B1 (fr)
CN (2) CN102307591B (fr)
AU (1) AU2009333484B2 (fr)
BR (1) BRPI0922867B8 (fr)
CA (1) CA2746228C (fr)
CY (2) CY1117757T1 (fr)
DK (2) DK3067064T3 (fr)
ES (2) ES2796725T3 (fr)
HK (1) HK1161690A1 (fr)
HR (2) HRP20160859T1 (fr)
HU (2) HUE051666T2 (fr)
IL (2) IL213450B (fr)
LT (1) LT3067064T (fr)
MX (4) MX358836B (fr)
PL (2) PL3067064T3 (fr)
PT (2) PT3067064T (fr)
RU (1) RU2531510C2 (fr)
SG (2) SG10201500161XA (fr)
SI (2) SI2370099T1 (fr)
WO (1) WO2010077717A1 (fr)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160000902A1 (en) * 2003-07-11 2016-01-07 Novavax, Inc. Combination vaccine for respiratory syncytial virus and influenza
EP2367844A4 (fr) * 2008-11-18 2012-08-01 Ligocyte Pharmaceuticals Inc Vlp rsv f et procédés de fabrication et d utilisation de celui-ci
US11446374B2 (en) 2008-12-09 2022-09-20 Novavax, Inc. Modified RSV F proteins and methods of their use
HUE051666T2 (hu) 2008-12-09 2021-03-29 Novavax Inc Módosított RSV F fehérjék és alkalmazásuk módszerei
WO2011008974A2 (fr) * 2009-07-15 2011-01-20 Novartis Ag Compositions à base de protéine f du vrs et procédés de fabrication associés
US20110097358A1 (en) * 2009-10-12 2011-04-28 Techno Vax, Inc. RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRUS-LIKE PARTICLES (VLPs)
AU2011323090B2 (en) 2010-11-05 2015-02-12 Novavax Inc. Rabies glycoprotein virus-like particles (VLPs)
WO2012089231A1 (fr) * 2010-12-30 2012-07-05 Okairòs Ag Vaccins contre les paramyxovirus
HUE043879T2 (hu) 2011-01-26 2019-09-30 Glaxosmithkline Biologicals Sa RSV-immunizálási rend
EP2739307B1 (fr) * 2011-08-01 2017-09-06 Emory University Vlps contenant des ligands et leurs procédés associés
WO2013031827A1 (fr) 2011-08-29 2013-03-07 国立大学法人徳島大学 Vaccin muqueux contre rsv
CN104080476A (zh) * 2011-09-30 2014-10-01 诺瓦瓦克斯股份有限公司 用于呼吸道合胞病毒的重组纳米颗粒rsv f疫苗
CN103239734B (zh) * 2012-02-10 2016-02-24 北京艾棣维欣生物技术有限公司 用于预防和/或治疗呼吸道合胞病毒感染的疫苗
EA201891945A3 (ru) * 2012-08-01 2019-05-31 Бавариан Нордик А/С Вакцина рекомбинантного модифицированного вируса осповакцины анкара (mva) респираторно-синцитиального вируса (rsv)
SG11201503369RA (en) 2012-11-20 2015-06-29 Glaxosmithkline Biolog Sa Rsv f prefusion trimers
US20140227309A1 (en) * 2013-02-11 2014-08-14 Novavax, Inc. Combination vaccine for respiratory syncytial virus and influenza
DE102013004595A1 (de) * 2013-03-15 2014-09-18 Emergent Product Development Germany Gmbh RSV-Impfstoffe
CA2922258C (fr) 2013-09-19 2022-11-29 Novavax, Inc. Compositions de coronavirus du syndrome respiratoire du moyen-orient (mers-cov) immunogenes et procedes
EP2974739A1 (fr) 2014-07-15 2016-01-20 Novartis AG Domaines de trimérisation RSVF
WO2015195961A1 (fr) * 2014-06-18 2015-12-23 Georgia State University And Research Foundation, Inc. Virus rapporteur de vrs recombiné
JP6824154B2 (ja) * 2014-08-08 2021-02-03 ブイエルピー・セラピューティクス・リミテッド・ライアビリティ・カンパニーＶＬＰ Ｔｈｅｒａｐｅｕｔｉｃｓ， ＬＬＣ 修飾エンベロープタンパク質ｅ３を含むウイルス様粒子
US9630994B2 (en) 2014-11-03 2017-04-25 University Of Washington Polypeptides for use in self-assembling protein nanostructures
CN114796474A (zh) * 2015-09-03 2022-07-29 诺瓦瓦克斯股份有限公司 具有改进的稳定性和免疫原性的疫苗组合物
AU2016379097C1 (en) 2015-12-23 2021-04-08 Pfizer Inc. RSV F protein mutants
WO2017174564A1 (fr) * 2016-04-05 2017-10-12 Janssen Vaccines & Prevention B.V. Vaccin contre le rsv
JP2019523644A (ja) 2016-05-30 2019-08-29 ヤンセン ファッシンズ アンド プリベンション ベーフェーＪａｎｓｓｅｎ Ｖａｃｃｉｎｅｓ ＆ Ｐｒｅｖｅｎｔｉｏｎ Ｂ．Ｖ． 安定化された融合前ｒｓｖ ｆタンパク質
CN106011086A (zh) * 2016-06-15 2016-10-12 湖北省农业科学院畜牧兽医研究所 表达信号肽替换的呼吸道合胞病毒f蛋白的重组新城疫耐热疫苗株及制备方法
MA47787A (fr) 2017-03-15 2020-01-22 Modernatx Inc Vaccin contre le virus respiratoire syncytial
EP3601367A4 (fr) * 2017-03-30 2020-09-16 The University of Queensland Molécules chimériques et utilisations associées
CN115947873A (zh) 2017-04-04 2023-04-11 华盛顿大学 显示副粘病毒和/或肺炎病毒f蛋白的自组装蛋白纳米结构及其用途
AU2018285412B2 (en) 2017-06-14 2022-06-23 Universität Zürich Cyclic peptides for protection against respiratory syncytial virus
MA54676A (fr) 2018-01-29 2021-11-17 Modernatx Inc Vaccins à base d'arn contre le vrs
EP3758747A1 (fr) 2018-02-28 2021-01-06 University of Washington Vaccins à base de nanostructures auto-assemblables
AU2019238171A1 (en) 2018-03-19 2020-09-24 Novavax, Inc. Multivalent influenza nanoparticle vaccines
WO2019191623A1 (fr) * 2018-03-30 2019-10-03 Georgia State University Research Foundation, Inc. Vaccins contre le virus respiratoire syncytial (vrs)
KR20200050264A (ko) 2018-11-01 2020-05-11 에스케이바이오사이언스(주) 재조합 호흡기 세포융합 바이러스 f 단백질 및 이를 포함하는 백신 조성물
CA3121724A1 (fr) 2018-12-20 2020-06-25 Virometix Ag Blocs de construction de lipopeptide et particules pseudo-virales synthetiques
EP3932424A4 (fr) 2019-02-28 2022-10-12 KM Biologics Co., Ltd. Vaccin chimérique f/g contre le vrs
MX2022009167A (es) * 2020-01-27 2022-08-17 Novavax Inc Formulaciones para vacuna contra coronavirus.
US10953089B1 (en) 2020-01-27 2021-03-23 Novavax, Inc. Coronavirus vaccine formulations
GB2594365B (en) 2020-04-22 2023-07-05 BioNTech SE Coronavirus vaccine
CN113855796B (zh) * 2021-07-30 2024-01-26 河北医科大学 卡介苗作为呼吸道合胞病毒灭活疫苗佐剂的应用
WO2023062651A1 (fr) * 2021-10-13 2023-04-20 Padmanabh Patil Harshad Particules pseudovirales du virus respiratoire syncytial et leur procédé de préparation
US11878055B1 (en) 2022-06-26 2024-01-23 BioNTech SE Coronavirus vaccine

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5149650A (en) 1986-01-14 1992-09-22 University Of North Carolina At Chapel Hill Vaccines for human respiratory virus
US4877611A (en) 1986-04-15 1989-10-31 Ribi Immunochem Research Inc. Vaccine containing tumor antigens and adjuvants
US4911928A (en) 1987-03-13 1990-03-27 Micro-Pak, Inc. Paucilamellar lipid vesicles
GB8914968D0 (en) * 1989-06-29 1989-08-23 Connaught Lab Production of virus and purification of viral envelope proteins for vaccine use
US6387373B1 (en) 1993-01-15 2002-05-14 Novavax, Inc. Vaccines containing paucilsmellar lipid vesicles as immunological adjuvants
ES2370937T3 (es) 1993-09-13 2011-12-23 Protein Sciences Corporation Un método para producir vacunas antigripales polivalentes a base de hemaglutinina.
US5629021A (en) 1995-01-31 1997-05-13 Novavax, Inc. Micellar nanoparticles
US6020182A (en) * 1996-07-12 2000-02-01 Connaught Laboratories Limited Subunit respiratory syncytial virus vaccine preparation
WO2001066137A1 (fr) 2000-03-07 2001-09-13 Merck & Co., Inc. Formulations d'adenovirus
KR20030055275A (ko) 2000-10-02 2003-07-02 글락소스미스클라인 바이오로지칼즈 에스.에이. 분할 외피 바이러스 제조물
US20040063188A1 (en) 2002-02-14 2004-04-01 Novavax, Inc. Kit for treating gastrointestinal tract
CA2523657A1 (fr) 2003-04-25 2005-03-31 Medimmune Vaccines, Inc. Systemes d'expression de virus parainfluenza recombinant et vaccins comportant des antigenes heterologues derives du metapneumovirus
EP1668112A4 (fr) * 2003-06-20 2009-04-29 Protein Sciences Corp Vecteurs d'expression d'immunogenes de sras, compositions contenant de tels vecteurs ou leurs produits d'expression, procedes et dosages pour leur production et leur utilisation
EP1713824A2 (fr) 2003-12-10 2006-10-25 The Uab Research Foundation Virus recombinants avec proteines d'enveloppe heterologues
WO2006099360A2 (fr) 2005-03-10 2006-09-21 Medimmune Vaccines, Inc. Souches de metapneumovirus et leur utilisation dans des formulations de vaccin et comme vecteurs pour l'expression de sequences antigeniques et methodes de propagation de virus
US7951384B2 (en) * 2005-08-05 2011-05-31 University Of Massachusetts Virus-like particles as vaccines for paramyxovirus
WO2007149490A1 (fr) 2006-06-19 2007-12-27 Progenics Pharmaceuticals, Inc. Procédés de récupération de formules stabilisées de trimères de protéines d'enveloppe (env) rétrovirale
EP2089515A4 (fr) * 2006-11-16 2011-02-23 Novavax Inc Particules de type viral (vlp) apparentees au virus respiratoire syncytial
WO2008133663A2 (fr) * 2006-11-30 2008-11-06 Government Of The United States Of America, As Represented By The Secretary, Compositions immunogènes à codons modifiés et procédés d'utilisation
EP1972348A1 (fr) * 2007-03-14 2008-09-24 Pierre Fabre Medicament Nouvelle composition de vaccin pour le traitement des maladie respiratoires infectieuses
EP2181121A4 (fr) 2007-03-21 2012-07-11 Id Biomedical Corp Quebec Antigènes chimériques
JP2010533737A (ja) 2007-07-19 2010-10-28 ノババックス，インコーポレイテッド キメラ水痘帯状疱疹ウイルス−ウイルス様粒子
EP3508505A1 (fr) 2007-12-24 2019-07-10 ID Biomedical Corporation of Quebec Antigènes recombinants du rsv
BRPI0908861A2 (pt) 2008-02-25 2018-02-06 Novavax Inc partículas semelhantes a vírus de açucar vitrificado (vlps)
HUE051666T2 (hu) 2008-12-09 2021-03-29 Novavax Inc Módosított RSV F fehérjék és alkalmazásuk módszerei
US11446374B2 (en) 2008-12-09 2022-09-20 Novavax, Inc. Modified RSV F proteins and methods of their use
US20110020388A1 (en) 2009-05-27 2011-01-27 Selecta Biosciences, Inc. Targeted synthetic nanocarriers with ph sensitive release of immunomodulatory agents
PL2445526T3 (pl) * 2009-06-24 2017-08-31 Glaxosmithkline Biologicals S.A. Rekombinowane antygeny rsv
WO2011008974A2 (fr) * 2009-07-15 2011-01-20 Novartis Ag Compositions à base de protéine f du vrs et procédés de fabrication associés
AU2011323090B2 (en) 2010-11-05 2015-02-12 Novavax Inc. Rabies glycoprotein virus-like particles (VLPs)
US11058762B2 (en) 2011-07-06 2021-07-13 Glaxosmithkline Biologicals Sa Immunogenic compositions and uses thereof
CN104080476A (zh) 2011-09-30 2014-10-01 诺瓦瓦克斯股份有限公司 用于呼吸道合胞病毒的重组纳米颗粒rsv f疫苗
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
US20140227309A1 (en) 2013-02-11 2014-08-14 Novavax, Inc. Combination vaccine for respiratory syncytial virus and influenza
CN105188745B (zh) 2013-04-25 2019-10-18 扬森疫苗与预防公司 稳定化的可溶性融合前rsv f多肽
AU2014100888A4 (en) 2014-08-07 2014-09-11 Novartis Ag Virus clearance and protein purification methods
WO2017000105A1 (fr) * 2015-06-29 2017-01-05 尚平 Humidificateur portatif
CN114796474A (zh) 2015-09-03 2022-07-29 诺瓦瓦克斯股份有限公司 具有改进的稳定性和免疫原性的疫苗组合物

Also Published As

Publication number Publication date
MX2011006205A (es) 2011-09-01
IL247341B (en) 2018-04-30
EP2370099B1 (fr) 2016-04-20
US20190134187A1 (en) 2019-05-09
PL2370099T3 (pl) 2016-10-31
WO2010077717A1 (fr) 2010-07-08
US20100239617A1 (en) 2010-09-23
US9717786B2 (en) 2017-08-01
SG172022A1 (en) 2011-07-28
JP6462048B2 (ja) 2019-01-30
KR101801213B1 (ko) 2017-11-24
PT3067064T (pt) 2020-06-16
SI3067064T1 (sl) 2020-09-30
EP3718566A1 (fr) 2020-10-07
CN102307591B (zh) 2016-08-03
HRP20160859T1 (hr) 2016-09-23
JP6162751B2 (ja) 2017-07-12
US9731000B2 (en) 2017-08-15
HK1161690A1 (zh) 2012-08-03
AU2009333484A1 (en) 2011-07-21
EP3067064B1 (fr) 2020-05-13
US8715692B2 (en) 2014-05-06
CY1117757T1 (el) 2017-05-17
JP2018007655A (ja) 2018-01-18
PT2370099T (pt) 2016-07-14
IL213450A0 (en) 2011-07-31
KR20160148720A (ko) 2016-12-26
HUE051666T2 (hu) 2021-03-29
CA2746228C (fr) 2021-05-18
ES2796725T3 (es) 2020-11-30
BRPI0922867B8 (pt) 2021-05-25
US20150265698A1 (en) 2015-09-24
CN106146671A (zh) 2016-11-23
CY1123152T1 (el) 2021-10-29
JP2012511579A (ja) 2012-05-24
DK3067064T3 (da) 2020-06-08
KR20110112328A (ko) 2011-10-12
RU2011128371A (ru) 2013-01-20
CN106146671B (zh) 2020-03-31
CA2746228A1 (fr) 2010-07-08
CN102307591A (zh) 2012-01-04
US20140294879A1 (en) 2014-10-02
US11052146B2 (en) 2021-07-06
JP2019069982A (ja) 2019-05-09
HUE029037T2 (en) 2017-01-30
US20150359872A1 (en) 2015-12-17
US20230293667A1 (en) 2023-09-21
EP3067064A1 (fr) 2016-09-14
MX345700B (es) 2017-02-10
BRPI0922867B1 (pt) 2020-09-29
US9675685B2 (en) 2017-06-13
ES2582005T3 (es) 2016-09-08
KR101691574B1 (ko) 2017-01-02
EP2370099A1 (fr) 2011-10-05
MX337932B (es) 2016-03-28
EP2370099A4 (fr) 2013-05-29
JP5813513B2 (ja) 2015-11-17
US10022437B2 (en) 2018-07-17
US20150266930A1 (en) 2015-09-24
BRPI0922867A2 (pt) 2016-09-27
LT3067064T (lt) 2020-09-10
PL3067064T3 (pl) 2020-11-02
HRP20200871T1 (hr) 2020-10-30
SI2370099T1 (sl) 2016-08-31
AU2009333484B2 (en) 2014-12-11
DK2370099T3 (en) 2016-08-01
RU2531510C2 (ru) 2014-10-20
MX358836B (es) 2018-09-05
JP2015171378A (ja) 2015-10-01
JP6782289B2 (ja) 2020-11-11
IL213450B (en) 2018-02-28

Similar Documents

Publication Publication Date Title
HRP20160859T1 (hr) Modificirani proteini rsv f i postupci njihove upotrebe
IL248723A0 (en) Specific antibodies against the bcr complex and methods of using them
LT2373691T (lt) Anti-fxi antikūnai ir jų panaudojimo būdai
EP2373679A4 (fr) Mini peptides d'hépcidine et leurs procédés d'utilisation
HK1147254A1 (en) 5-anilinoimidazopyridines and methods of use 5-
IL211623A0 (en) Anti-notch2 antibodies and methods of use
EP2367844A4 (fr) Vlp rsv f et procédés de fabrication et d utilisation de celui-ci
HK1149933A1 (en) Diazacarbazoles and methods of use
EP2185719A4 (fr) Anticorps anti-rantes et leurs procédés d'utilisation
IL209548A0 (en) Diazacarbazoles and methods of use
IL206125A0 (en) Azaindolizines and methods of use
EP2346521A4 (fr) Peptides et procédés d'utilisation
ZA201100019B (en) Variant hhip1 protein and methods and uses thereof
IL213749A0 (en) Dgati nucleic acids and proteins and methods of use thereof
ZA201007681B (en) Cd4-related polypeptides and methods of use
EP2265117A4 (fr) Inhibiteurs de protéine phosphatase-1 et leurs utilisations