SG10201407781SA - Benzoxepin PI3K Inhibitor Compounds And Methods Of Use - Google Patents
Benzoxepin PI3K Inhibitor Compounds And Methods Of UseInfo
- Publication number
- SG10201407781SA SG10201407781SA SG10201407781SA SG10201407781SA SG10201407781SA SG 10201407781S A SG10201407781S A SG 10201407781SA SG 10201407781S A SG10201407781S A SG 10201407781SA SG 10201407781S A SG10201407781S A SG 10201407781SA SG 10201407781S A SG10201407781S A SG 10201407781SA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- benzoxepin
- compounds
- pi3k inhibitor
- inhibitor compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- LWZYUACNWRVDDJ-UHFFFAOYSA-N 1-benzoxepine Chemical compound O1C=CC=CC2=CC=CC=C12 LWZYUACNWRVDDJ-UHFFFAOYSA-N 0.000 title abstract 2
- 239000012828 PI3K inhibitor Substances 0.000 title abstract 2
- 229940043441 phosphoinositide 3-kinase inhibitor Drugs 0.000 title abstract 2
- 108091000080 Phosphotransferase Proteins 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 150000002632 lipids Chemical class 0.000 abstract 2
- 102000020233 phosphotransferase Human genes 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000038030 PI3Ks Human genes 0.000 abstract 1
- 108091007960 PI3Ks Proteins 0.000 abstract 1
- 102000001708 Protein Isoforms Human genes 0.000 abstract 1
- 108010029485 Protein Isoforms Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US24638609P | 2009-09-28 | 2009-09-28 |
Publications (1)
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SG10201407781SA true SG10201407781SA (en) | 2015-01-29 |
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SG10201407781SA SG10201407781SA (en) | 2009-09-28 | 2010-09-27 | Benzoxepin PI3K Inhibitor Compounds And Methods Of Use |
Country Status (24)
Country | Link |
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US (4) | US8263633B2 (de) |
EP (2) | EP2483277B1 (de) |
JP (2) | JP5546636B2 (de) |
KR (2) | KR20140034948A (de) |
CN (2) | CN102762574B (de) |
AU (1) | AU2010299820A1 (de) |
BR (1) | BR112012006802A2 (de) |
CA (1) | CA2774807C (de) |
CL (1) | CL2012000755A1 (de) |
CO (1) | CO6620072A2 (de) |
CR (1) | CR20120130A (de) |
EC (1) | ECSP12011752A (de) |
ES (1) | ES2558742T3 (de) |
HK (2) | HK1216529A1 (de) |
IL (1) | IL218800A0 (de) |
MA (1) | MA33614B1 (de) |
MX (1) | MX2012003641A (de) |
NZ (1) | NZ599090A (de) |
PE (2) | PE20140918A1 (de) |
RU (2) | RU2015104301A (de) |
SG (1) | SG10201407781SA (de) |
UA (1) | UA108863C2 (de) |
WO (1) | WO2011036284A1 (de) |
ZA (1) | ZA201404552B (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
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US8242104B2 (en) * | 2009-09-28 | 2012-08-14 | F. Hoffman-La Roche Ag | Benzoxazepin P13K inhibitor compounds and methods of use |
AU2010299820A1 (en) * | 2009-09-28 | 2012-04-19 | F. Hoffmann-La Roche Ag | Benzoxepin PI3K inhibitor compounds and methods of use |
WO2012126901A1 (en) | 2011-03-21 | 2012-09-27 | F. Hoffmann-La Roche Ag | Benzoxazepin compounds selective for pi3k p110 delta and methods of use |
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